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Andrean Simons-Burnett, PhD

Associate Professor and Director - Free Radical and Radiation Biology Program

Introduction

Signaling pathways and oxidative stress in cancer progression.

Current Positions

  • Associate Professor of Radiation Oncology
  • Director - Free Radical and Radiation Biology Program
  • Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics

Education

  • Chemistry, Michigan Technology University, Houghton, Michigan
  • BS in Biochemistry, Iowa State University, Ames, Iowa
  • PhD in Toxicology and Food Science and Technology, Iowa State University, Ames, Iowa
  • Postdoctoral Fellow in Free Radical and Radiation Biology, University of Iowa, Carver College of Medicine

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Role of NADPH oxidase (NOX) enzymes in HNSCC therapy
  • Novel delivery approaches for therapeutic cytokines
  • Involvement of inflammation and TIR signaling in drug resistance
  • Novel prognostic and predictive biomarkers for OSCC patients
  • Therapy for premalignant oral lesions

Selected Publications

  • Wongpattaraworakul W, Choi A, Buchakjian MR, Lanzel EA, Kd AR, Simons AL. Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma. BMC Cancer. 2024 Jun 26;24(1):766. doi: 10.1186/s12885-024-12539-5. PMID: 38926643; PMCID: PMC11201865.
  • Ibarra B, Hasibuzzaman MM, Khan IN, Lemke CD, Weiner GJ, Simons AL. Role of Endosomal Toll-Like Receptors in Immune Cell Activation. Presented at the 2022 University of Iowa Summer Undergraduate Research Conference. July 27th, 2022. Iowa City, IA.
  • Ibarra B, Hasibuzzaman MM, Khan IN, Lemke CD, Weiner GJ, Simons AL. Role of Endosomal Toll-Like Receptors in Immune Cell Activation. Presented at the 2022 CURE Summer Cancer Research Training Program. July 26th, 2022. Iowa City, IA
  • Wongpattaraworakul W, Gibson-Corley KN, Choi A, Lanzel E, Buchakjian M, Rajan A, Simons AL. Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous cell Carcinoma. Presented at the 2022 Academy of Oral and Maxillofacial Pathology (AAOMP) Annual Meeting. April 8-13, 2022, Charlotte, NC.
  • Khan IN, Gibson-Corley KN, Coppock JD, Simons AL. Association of nuclear interleukin-1 alpha expression with head and neck tumor aggression. Presented at the 2021 Central States -  Society of Toxicology meeting. Oct 21-22, 2021. WebEx
  • Cheng Y, Lemke CD, Weiner GJ, Simons AL. In Situ immunization with a TLR9-agoinst combined with anti-PD1 therapy enhances survival in HNSCC. Presented at the Holden Comprehensive Cancer Center Research Retreat, June 19TH, 2019. Presented at 2020 Head and Neck Research Symposium. May 4th, 2020. Iowa City, IA.
  • Wongpattaraworakul W, Gibson-Corley KN, Choi A, Ofori-Amanfo G, Rajan A, Simons AL. Prognostic Role of Combined EGFR and T cell markers in Oral Squamous Cell Carcinoma. Presented at 2020 Head and Neck Research Symposium. May 4th, 2020. Iowa City, IA.
  • Ogunsakin A, Cheng Y, Simons AL. Influence of Gender on the Anti-tumor Efficacy of a TLR8 Agonist in Combination with Cetuximab. Presented at the 2019 University of Iowa Summer Undergraduate Research Conference. July 24th, 2019. Iowa City, IA
  • Ogunsakin A, Cheng Y, Simons AL. Influence of Gender on the Anti-tumor Efficacy of a TLR8 Agonist in Combination with Cetuximab. Presented at the 2019 CURE Summer Cancer Research Training Program. July 23rd, 2019. Iowa City, IA
  • Cheng Y, Lemke CD, Weiner GJ, Simons AL. In Situ immunization with a TLR9-agoinst combined with anti-PD1 therapy enhances survival in HNSCC. Presented at the Holden Comprehensive Cancer Center Research Retreat, June 19TH, 2019