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Andrean Simons-Burnett, PhD

Associate Professor of Radiation Oncology
Associate Professor of Pharmaceutical Sciences and Experimental Therapeutics
Associate Professor of Pathology

Contact Information

Primary Office
1161 Medical Laboratories (ML)
Iowa City, IA 52242


Michigan Technology University
BS, Biochemistry, Iowa State University
PhD, Toxicology and Food Science and Technology, Iowa State University
Postdoctoral Fellow, Free Radical and Radiation Biology, University of Iowa, Carver College of Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Human Toxicology

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Signaling pathways and oxidative stress in cancer progression.


Cheng, Y., Borcherding, N., Ogunsakin, A., Lemke-Miltner, C. D., Gibson-Corley, K. N., Rajan, A., Choi, A. B., Wongpattaraworakul, W., Chan CHF,, Salem, A. K., Weiner, G. J. & Simons, A. L. (2021). The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent. Scientific reports, 11(1), 1535. PMID: 33452311.

Cheng, Y., Lemke-Miltner, C. D., Wongpattaraworakul, W., Wang, Z., Chan CHF,, Salem, A. K., Weiner, G. J. & Simons, A. L. (2020). In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy. Journal for immunotherapy of cancer, 8(2). PMID: 33060147.

Espinosa-Cotton, M., Fertig, E. J., Stabile, L. P., Gaither-Davis, A., Bauman, J. E., Schmitz, S., Gibson-Corley, K. N., Cheng, Y., Jensen, I. J., Badovinac, V. P., Laux, D. & Simons, A. L. (2019). A preliminary analysis of interleukin-1 ligands as potential predictive biomarkers of response to cetuximab. Biomarker research, 7, 14. PMID: 31346466.

Rajan, A., Gibson-Corley, K. N., Choi, A. B., Ofori-Amanfo, G. K., Ten Eyck, P., Espinosa-Cotton, M., Sperry, S. M. & Simons, A. L. (2019). Impact of Nuclear Interleukin-1 Alpha and EGFR Expression on Recurrence and Survival Outcomes in Oral Squamous Cell Carcinomas. Journal of oncology, 2019, 5859680. PMID: 31320902.

Espinosa-Cotton, M., Rodman, Iii, S. N., Ross, K. A., Jensen, I. J., Sangodeyi-Miller, K., McLaren, A. J., Dahl, R. A., Gibson-Corley, K. N., Koch, A. T., Fu, Y. X., Badovinac, V. P., Laux, D., Narasimhan, B. & Simons, A. L. (2019). Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 7(1), 79. PMID: 30890189.

Chitphet, K., Geary, S. M., Chan, C. H., Simons, A. L., Weiner, G. J. & Salem, A. K. (2019). Combining Doxorubicin-Loaded PEGylated Poly(Lactide-co-glycolide) Nanoparticles with Checkpoint Inhibition Safely Enhances Therapeutic Efficacy in a Melanoma Model. ACS Biomaterials Science and Engineering. DOI: 10.1021/acsbiomaterials.9b01108.

Gilbertson-White, S., Perkhounkova, Y., Saeidzadeh, S., Hein, M., Dahl, R. & Simons-Burnett, A. (2019). Understanding Symptom Burden in Patients with Advanced Cancer Living in Rural Areas. Oncology Nursing Forum, 46(4), 428-441. DOI: 10.1188/19.ONF.428-441.

Stanam, A., Gibson-Corley, K. N., Love-Homan, L., Ihejirika, N. & Simons, A. L. (2016). Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma. Oncotarget, 7(46), 76087-76100. PMID: 27738319.

Sobhakumari, A., Orcutt, K. P., Love-Homan, L., Kowalski, C. E., Parsons, A. D., Knudson, C. M. & Simons, A. L. (2016). 2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells. Oncology research, 24(1), 55-64. PMID: 27178822.

Stanam, A., Love-Homan, L., Joseph, T. S., Espinosa-Cotton, M. & Simons, A. L. (2015). Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma. Molecular oncology, 9(7), 1371-83. PMID: 25888065.

Koch, A. T., Love-Homann, L., Espinosa-Cotton, M., Stanam, A. & Simons, A. L. (2015). MyD88-dependent signaling decreases the anti-tumor efficacy of epidermal growth factor receptor inhibition in head and neck cancer cells. Cancer research, 75(8), 1657-67. PMID: 25712126.

Fletcher, E. V., Love-Homan, L., Sobhakumari, A., Feddersen, C. R., Koch, A. T., Goel, A. & Simons, A. L. (2013). Epidermal growth factor receptor inhibition induces pro-inflammatory cytokines via NOX4 in head and neck cancer cells. Molecular cancer research, 11(12), 1574-84. PMID: 24048704.

Sobhakumari, A., Schickling, B. M., Love-Homan, L., Raeburn, A., Fletcher, E. V., Case, A. J., Domann, F. E., Miller Jr, F. J. & Simons, A. L. (2013). NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. Toxicology and applied pharmacology, 272(3), 736-45. PMID: 23917044.

Du, J., Nelson, E. S., Simons-Burnett, A. L., Olney, K. E., Moser, J. C., Schrock, H. E., Wagner, B. A., Buettner, G. R., Smith, B. J., Teoh, M. L., Tsao, M. S. & Cullen, J. J. (2013). Regulation of pancreatic cancer growth by superoxide. Molecular carcinogenesis, 52(7), 555-67. PMID: 22392697.

Simons-Burnett, A. L., Lu, P., Gibson-Corley, K. N., Robinson, R. A., Meyerholz, D. K. & Colgan, J. D. (2013). The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Laboratory Investigation, 93(6), 711-9. PMID: 23608756.

Kang, M. A., So, E. Y., Simons-Burnett, A. L., Spitz, D. R. & Ouchi, T. (2012). DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. Cell death & disease, 3, e249. PMID: 22237206.

Sobhakumari, A., Love-Homan, L., Fletcher, E. V., Martin, S. M., Parsons, A. D., Spitz, D. R., Knudson, C. M. & Simons-Burnett, A. L. (2012). Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. PLoS One, 7(10), e48175. PMID: 23118946.

Orcutt, K. P., Parsons, A. D., Sibenaller, Z. A., Scarbrough, P. M., Zhu, Y., Sobhakumari, A., Wilke, W. W., Kalen, A. L., Goswami, P., Miller, F. J., Spitz, D. R. & Simons-Burnett, A. L. (2011). Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. Cancer research, 71(11), 3932-40. PMID: 21482679.

Simons-Burnett, A. L., Renouf, M., Murphy, P. A. & Hendrich, S. (2010). Greater apparent absorption of flavonoids is associated with lesser human fecal flavonoid disappearance rates. Journal of agricultural and food chemistry, 58(1), 141-7. PMID: 19921837.

Simons-Burnett, A. L., Mattson, D. M., Dornfeld, K. & Spitz, D. R. (2009). Glucose deprivation-induced metabolic oxidative stress and cancer therapy. Journal of cancer research and therapeutics, 5 Suppl 1, S2-6. PMID: 20009288.

Fath, M. A., Diers, A. R., Aykin-Burns, N., Simons-Burnett, A., Hua, L. & Spitz, D. R. (2009). Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer biology & therapy, 8(13), 1228-36. PMID: 19411865.

Mattson, D. M., Ahmad, I. M., Dayal, D., Parsons, A. D., Aykin-Burns, N., Li, L., Orcutt, K. P., Spitz, D. R., Dornfeld, K. J. & Simons-Burnett, A. L. (2009). Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free radical biology & medicine, 46(2), 232-7. PMID: 18983911.

Simons-Burnett, A. L., Parsons, A. D., Foster, K. A., Orcutt, K. P., Fath, M. A. & Spitz, D. R. (2009). Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells. Journal of Oncology, 2009, 519563. PMID: 19746172.

Ahmad, I. M., Abdalla, M. Y., Aykin-Burns, N., Simons-Burnett, A. L., Oberley, L. W., Domann, F. E. & Spitz, D. R. (2008). 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free radical biology & medicine, 44(5), 826-34. PMID: 18155176.

Simons-Burnett, A. L., Fath, M. A., Mattson, D. M., Smith, B. J., Walsh, S. A., Graham, M. M., Hichwa, R. D., Buatti, J. M., Dornfeld, K. & Spitz, D. R. (2007). Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. International journal of radiation oncology, biology, physics, 69(4), 1222-30. PMID: 17967311.

Simons-Burnett, A. L., Ahmad, I. M., Mattson, D. M., Dornfeld, K. J. & Spitz, D. R. (2007). 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer research, 67(7), 3364-70. PMID: 17409446.

Simons-Burnett, A. L., Renouf, M., Hendrich, S. & Murphy, P. A. (2005). Metabolism of glycitein (7,4'-dihydroxy-6-methoxy-isoflavone) by human gut microflora. Journal of agricultural and food chemistry, 53(22), 8519-25. PMID: 16248547.

Lee, S. O., Simons-Burnett, A. L., Murphy, P. A. & Hendrich, S. (2005). Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters. Experimental biology and medicine, 230(7), 472-8. PMID: 15985622.

Simons-Burnett, A. L., Renouf, M., Hendrich, S. & Murphy, P. A. (2005). Human gut microbial degradation of flavonoids: structure-function relationships. Journal of agricultural and food chemistry, 53(10), 4258-63. PMID: 15884869.

Lang'at-Thoruwa, C., Song, T. T., Hu, J., Simons-Burnett, A. L. & Murphy, P. A. (2003). A simple synthesis of 7,4'-dihydroxy-6-methoxyisoflavone, glycitein, the third soybean isoflavone. Journal of natural products, 66(1), 149-51. PMID: 12542367.