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Bing Li, PhD

Professor of Pathology

Introduction

The goals of our research program are to understand the role of fatty acid binding proteins (FABPs) that regulate immune cell lipid metabolism and function in the setting of high fat diet (HFD)-induced obesity and obesity-associated chronic inflammation, cancer risk and other diseases.

Current Projects:

  • High fat diet-induced obesity and immunoregulation

  • Adipose FABP (A-FABP) in linking obesity-associated breast cancer risk

  • Targeting A-FABP for treatment of obesity-associated diseases.

  • Epidermal FABP (E-FABP) in the pathogenesis of psoriasis and other inflammatory skin diseases

Current Positions

  • Professor of Pathology
  • Endowed Professor in Cancer Immunology

Education

  • MS in Immunology, Southeast University School of Medicine, Nanjing, China
  • PhD in Immunology, Peking University Health Science Center, Beijing, China
  • Postdoctoral Fellow, University of Louisville School of Medicine, Louisville, KY

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Yu J, Hao J, Yorek MS, Han X, Avellino A, Jiang X, Liu S, Wang J, Li B. (2024) Determination of the FABP5 expression profile in skin lesions of an IMQ-induced psoriasis mouse model using flow cytometry. STAR Protoc. Apr 12; 5(2):103018. DOI: 10.1016/j.xpro.2024.103018. PMID: 38613778. PMCID: PMC11026830.
  • Hao J, Yu J, Yorek MS, Yu C-L, Pope RM, Chimenti MS, Xiong Y, Klingelhutz A, Jabbari A, Li B. (2023) Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis. Cell Rep. Nov 28; 42(11):113449. DOI: 10.1016/j.celrep.2023.113449. PMID: 37967009. PMCID: PMC10729729.
  • Jin R, Hao J, Yi Y, Yin D, Hua Y, Li X, Bao H, Han X, Egilmez NK, Sauter ER, Li B. Dietary fats high in linoleic acids impair anti-tumor T cell responses by inducing E-FABP-mediated mitochondrial dysfunction. Cancer Research, 2021 Oct 15;81(20):5296-5310.
  • Li B, Hao J, Zeng J, Sauter ER. SnapShot: FABP functions. Cell, 2020 Aug 20;182(4):1066-1066.
  • Lianliang Liu, Jiaqing Hao, Rong Jin, Jun Zeng, Mingming Zhu, Anita Mandal, Yuan Hua, Chin K. Ng, Nejat K. Egilmez, Edward R. Sauter and Li B. Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages. Cancer Research, 2020 Jun 15;80(12):2564-2574.
  • Jun Zeng, Edward Sauter, LI B. FABP4: a new player in obesity-associated breast cancer. Trends in Molecular Medicine, 2020, 26, 5: 437-440.
  • Hao J, Zhang Y, Yan XF, Yan F, Sun Y, Zeng J, Waigel S, Yin Y, Fraig MM, Egilmez NK, Suttles J, Kong M, Liu S, Cleary MP, Sauter E, Li B. Circulating Adipose Fatty Acid Binding Protein Promotes Obesity-Associated Breast/Mammary Tumor Development. Cell Metabolism, 2018, Nov 6;28(5):689-705.
  • Zhang Y, Hao J, Zeng J, Li Q, Rao E, Sun Y, Liu L, Mandal A, Landers VD, Morris RJ, Cleary MP, Suttles J, Li B. Epidermal fatty acid binding protein prevents chemical-induced skin tumorigenesis by regulation of TPA-induced IFN/p53/SOX2 pathway in keratinocytes. J Invest Dermatol. 2018 Sep;138(9):1925-1934.
  • Hao J, Yan F, Zhang Y, Triplett A, Zhang Y, Schultz DA, Sun Y, Zeng J, Silverstein KAT, Zheng Q, Bernlohr DA, Cleary MP, Egilmez NK, Sauter E, Liu S, Suttles J, Li B. Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression. Cancer Research. 2018 May 1;78(9):2343-2355.
  • Zhang Y, Rao E, Zeng J, Hao J, Sun Y, Liu S, Sauter ER, Bernlohr DA, Cleary MP, Suttles J, Li, B. Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production. J Immunol. 2017 Jan 15;198(2):798-807.