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Carol J. Holman, MD, PhD

Clinical Professor of Pathology

Introduction

Dr. Holman has broad interests in many areas of hematopathology, including clinical diagnosis of patients with leukemia and lymphoma, as well as optimal laboratory testing for detection of minimal residual disease following therapy. She has research interests in the pathogenesis of Epstein-Barr virus infection and its role in a variety of diseases including post-transplant lymphoproliferative disorder, lymphomatoid granulomatosis, and infectious mononucleosis.

Current Positions

  • Clinical Professor of Pathology
  • Medical Director of Hematopathology, Pathology
  • Director, Hematopathology Fellowship Program, Pathology
  • Director of Leukemia Pathology, Holden Comprehensive Cancer Center

Education

  • PhD in Biochemistry, University of Illinois, Urbana-Champaign, IL
  • MD, University of Illinois, Urbana-Champaign, IL
  • Resident in Pathology, University of Minnesota
  • Fellow in Hematopathology, University of Minnesota

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Epstein Barr Virus infection and disease
  • Myeloma, including detection of minimal residual disease
  • Comparative histology between mouse and human Burkitt-like tumors.
  • Lymphoma characterization

Licenses & Certifications

  • State of Iowa Medical License, Iowa Board of Medicine, Iowa
  • Hematology, American Board of Pathology
  • Anatomic and Clinical Pathology, American Board of Pathology

Selected Publications

  • Chopra S, Karandikar NJ, Holman CJ. (2023) Systematic Evaluation of Hematologis Parameters and Blood Smear Findings in Patients with SARS-CoV-2 vs Other Viral Respiratory Infections. Am J Clin Pathol. Oct 3; 160(4):331-334. DOI: 10.1093/aajcp/aqad061. PMID: 37289433.
  • Abukhiran, I., Syrbu, S. I. & Holman, C. J. (2021). Markers of Follicular Helper T Cells Are Occasionally Expressed in T-Cell or Histiocyte-Rich Large B-Cell Lymphoma, Classic Hodgkin Lymphoma, and Atypical Paracortical HyperplasiaA Diagnostic Pitfall For T-Cell Lymphomas of T Follicular Helper Origin. American journal of clinical pathology. DOI: 10.1093/ajcp/aqaa249. PMID: 33624021.
  • Chopra, S., Dunham, T., Syrbu, S. I., Karandikar, N. J., Darbro, B. W. & Holman, C. J. (2021). Utility of Flow Cytometry and Fluorescence In Situ Hybridization in Follow-up Monitoring of Plasma Cell Myeloma. Am J Clin Pathol. DOI: 10.1093/ajcp/aqaa224. PMID: 33437993.
  • Gu, C., Jing, X., Holman, C., Sompallae, R., Zhan, F., Tricot, G., Yang, Y. & Janz, S. (2019). Correction to: Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma (BMC Cancer (2018) 18 (1152) DOI: 10.1186/s12885-018-5015-0). (Vols. 19). (1) BMC Cancer. DOI: 10.1186/s12885-019-6443-1.
  • Schouweiler, K. E., Karandikar, N. J. & Holman, C. J. (2019). Immunophenotypic Heterogeneity of Polytypic Plasma Cells and the Impact on Myeloma Minimal Residual Disease Detection by Multiparameter Flow Cytometry. Cytometry Part B - Clinical Cytometry 96 (4) 310-318. DOI: 10.1002/cyto.b.21789.
  • Laderian, B., Koehn, K., Holman, C., Lyckholm, L. & Furqan, M. (2019). Association of Hemophagocytic Lymphohistiocytosis and Programmed Death 1 Checkpoint Inhibitors. (Vols. 14). (4), pp. e77-e78. Journal of Thoracic Oncology. DOI: 10.1016/j.jtho.2018.11.035.
  • Gu, C., Jing, X., Holman, C., Sompallae, R., Zhan, F., Tricot, G., Yang, Y. & Janz, S. (2018). Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma. BMC Cancer 18 (1). DOI: 10.1186/s12885-018-5015-0.
  • Gu, C., Sompallae, R., Jing, X., Tomasson, M., Hose, D., Seckinger, A., Zhan, F., Tricot, G., Goldschmidt, H., Yang, Y., Janz, S. & Holman, C. (2018). Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome. Blood cancer journal 8 (2) 22. PMID: 29449574. DOI: 10.1038/s41408-018-0060-0.
  • Gupta, S., Karandikar, N. J., Ginader, T., Bellizzi, A. M. & Holman, C. J. (2018). Flow cytometric aberrancies in plasma cell myeloma and MGUS - correlation with laboratory parameters. Cytometry. Part B, Clinical cytometry. DOI: 10.1002/cyto.b.21624. PMID: 29316245.
  • Tompkins, V. S., Sompallae, R., Rosean, T. R., Walsh, S., Acevedo, M., Kovalchuk, A. L., Han, S. S., Jing, X., Holman, C., Rehg, J. E., Herms, S., Sunderland, J. S., Morse, H. C. & Janz, S. (2016). Transgenic mouse model of IgM+ lymphoproliferative disease mimicking Waldenström macroglobulinemia. Blood Cancer Journal 6 (11). DOI: 10.1038/bcj.2016.95.