Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Chen Zhao, MD, PhD

Associate Professor of Pathology

Contact Information

Primary Office
1163 Medical Laboratories
Iowa City, IA 52242


MD, China Medical University, No. 92, Shenyang, P.R.C.
PhD, Keio University School of Medicine, Tokyo, Japan
Fellow, Department of Pharmacology and Cancer Biology, Duke University Medical Center
Resident, Department of Pathology and Laboratory Medicine, University of Rochester, NY
Fellow, Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, PA


Xiu, Y., Dong, Q., Fu, L., Bossler, A., Tang, X., Boyce, B., Borcherding, N., Leidinger, M., Sardina, J. L., Xue, H. H., Li, Q., Feldman, A., Aifantis, I., Boccalatte, F., Wang, L., Jin, M., Khoury, J., Wang, W., Hu, S., Yuan, Y., Wang, E., Yuan, J., Janz, S., Colgan, J., Habelhah, H., Waldschmidt, T., Müschen, M., Bagg, A., Darbro, B. & Zhao, C. (2020). Coactivation of NF-?B and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion. Blood, 135(2), 108-120. PMID: 31697816.

Sun, X., Wang, S., Gai, J., Guan, J., Li, J., Li, Y., Zhao, J., Zhao, C., Fu, L. & Li, Q. (2019). SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway. Frontiers in oncology, 9, 754. PMID: 31456942.

Viana, A., Zhao, C., Rosa, T., Couto, A., Neves, D. D., Araújo-Melo, M. H. & Capasso, R. (2019). The Effect of Sedating Agents on Drug-Induced Sleep Endoscopy Findings. Laryngoscope, 129(2), 506-513. DOI: 10.1002/lary.27298.

Li, F., He, B., Ma, X., Yu, S., Bhave, R. R., Lentz, S. R., Tan, K., Guzman, M. L., Zhao, C. & Xue, H. H. (2017). Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell stem cell, 21(3), 359-373.e5. PMID: 28844837.

Werner, M. T., Zhao, C., Zhang, Q. & Wasik, M. A. (2017). Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target. Blood, 129(7), 823-831. PMID: 27879258.

Xiu, Y., Xue, W. Y., Lambertz, A., Leidinger, M., Gibson-Corley, K. & Zhao, C. (2016). Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure. Stem cells, 35, 777-786. PMID: 27733012.

Zhao, J., Zhao, J., Mangalam, A. K., Channappanavar, R., Fett, C., Meyerholz, D. K., Agnihothram, S., Baric, R. S., David, C. S. & Perlman, S. (2016). Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity, 44(6), 1379-91. PMID: 27287409.

Chen, Z., Wang, W., Cortes, J. E., Liu, E., Miranda, R. N., Zhao, C., Yuan, J., Lu, X., Yang, W., Ameri, M. D., Kantarjian, H. M., Medeiros, L. J. & Hu, S. (2016). Differential clinical and prognostic impact of myeloid sarcoma vs medullary myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood cancer journal, 6(6), e418. PMID: 27152845.

Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L. & Boyce, B. F. (2014). Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. The Journal of clinical investigation, 124(1), 297-310. PMID: 24316970.

Lento, W., Ito, T., Zhao, C., Harris, J. R., Huang, W., Jiang, C., Owzar, K., Piryani, S., Racioppi, L., Chao, N. & Reya, T. (2014). Loss of ß-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes & development, 28(9), 995-1004. PMID: 24788518.

Zhang, H., Hilton, M. J., Anolik, J. H., Welle, S. L., Zhao, C., Yao, Z., Li, X., Wang, Z., Boyce, B. F. & Xing, L. (2014). NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-?B. Journal of clinical investigation, 124(7), 3200-14. PMID: 24892805.

Kurokawa, M., Ito, T., Yang, C. S., Zhao, C., Macintyre, A. N., Rizzieri, D. A., Rathmell, J. C., Deininger, M. W., Reya, T. & Kombluth, S. (2013). Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences, 110(6), 2300-2305. PMID: 23324740.

Venigalla, S., Zhao, C. & Miyamoto, H. (2013). Histopathologic features of atypical glands on prostate biopsy: nucleolar size is a predictor of subsequent detection of prostatic adenocarcinoma. Prostate, 73(4), 376-381. PMID: 22926960.

Fereshteh, M., Ito, T., Kovacs, J. J., Zhao, C., Kwon, H. Y., Konuma, V., Chen, M., Lefkowitz, R. J. & Reya, T. (2012). ß-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences, 109(31), 12532-12537. PMID: 22773819.

Zhao, C., Xiu, Y., Ashton, J., Xing, L., Morita, Y., Jordan, C. T. & Boyce, B. F. (2012). Noncanonical NF-?B signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Stem cells, 30(4), 709-718. PMID: 22290873.

Zhao, C., Venigalla, S. & Miyamoto, H. (2012). Chronic inflammation on initial benign prostate biopsy is a negative predictor of subsequent cancer detection. (Vols. 62). (11), pp. 774-776. Pathology international. PMID: 23121611.

Ito, T., Kwon, H. Y., Zimdahl, B., Congdon, K. L., Blum, J., Lento, W. E., Zhao, C., Lagoo, A., Gerrard, G., Foroni, L., Goldman, J., Goh, H., Kim, S. H., Kim, D. W., Chuah, C., Oehler, V. G., Radich, J. P., Jordan, C. T. & Reya, T. (2010). Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature, 466(7307), 765-768. PMID: 20639863.

Dai, S. D., Wang, Y., Jiang, G. Y., Zhang, P. X., Dong, X. J., Wei, Q., Xu, H. T., Li, Q. C., Zhao, C. & Wang, E. H. (2010). Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn. Lung Cancer, 67(2), 205-215. PMID: 19615783.

Zhao, C., Chen, A., Jamieson, C. H., Fereshteh, M., Abrahamsson, A., Blum, J., Kwon, H. Y., Kim, J., Chute, J. P., Rizzieri, D., Munchhof, M., VanArsdale, T., Beachy, P. A. & Reya, T. (2009). Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature, 458(7239), 776-779. PMID: 19169242.

Liu, Y., Li, Q. C., Miao, Y., Xu, H. T., Dai, S. D., Wei, Q., Dong, Q. Z., Dong, X. J., Zhao, Y., Zhao, C. & Wang, E. H. (2009). Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells. Cancer Science, 100(3), 441-448. PMID: 19154401.

Liu, Y., Wang, Y., Zhang, Y., Miao, Y., Zhao, Y., Zhang, P. X., Jiang, G. Y., Zhang, J. Y., Han, Y., Lin, X. Y., Yang, L. H., Li, Q. C., Zhao, C. & Wang, E. H. (2009). Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer, 63(3), 375-382. PMID: 19162367.

Liu, Y., Dong, Q. Z., Zhao, Y., Dong, X. J., Miao, Y., Dai, S. D., Yang, Z. Q., Zhang, D., Wang, Y., Li, Q. C., Zhao, C. & Wang, E. H. (2009). P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells. Experimental cell research, 315(5), 890-898. PMID: 19150613.

Wei, Q., Zhao, Y., Yang, Z. Q., Dong, Q. Z., Dong, X. J., Han, Y., Zhao, C. & Wang, E. H. (2008). Disheveled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Lung Cancer, 62(2), 181-192. PMID: 18692936.

Kurokawa, M., Zhao, C., Reya, T. & Kombluth, S. (2008). Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Molecular and cellular biology, 28(17), 5494-5506. PMID: 18591256.

Congdon, K. L., Voermans, C., Ferguson, E. C., DiMascio, L. N., Ugoezwa, M., Zhao, C. & Reya, T. (2008). Activation of Wnt signaling in hematopoietic regeneration. Stem Cells, 26(5), 1202-1210. PMID: 18308947.

Zhao, C., Blum, J., Chen, A., Kwon, H. Y., Jung, S. H., Cook, J. M., Lagoo, A. & Reya, T. (2007). Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 12(6), 528-541. PMID: 18068630.

Wu, M., Kwon, H. Y., Rattis, F., Blum, J., Zhao, C., Ashkenazi, R., Jackson, T. L., Gaiano, N., Oliver, T. & Reya, T. (2007). Imaging hematopoietic precursor division in real time. Cell Stem Cell, 1(5), 541-554. PMID: 18345353.

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T. & Matsuo, K. (2006). Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell metabolism, 4(2), 111-121. PMID: 16890539.

Nishiwaki, T., Yamaguchi, T., Zhao, C., Amano, H., Hankenson, K. D., Bornstein, P., Toyama, Y. & Matsuo, K. (2006). Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. Journal of bone and mineral research, 21(4), 596-604. PMID: 16598380.

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N. & Reya, T. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nature immunology, 6(3), 314-322. PMID: 15665828.

Zhao, C., Wang, E. (2004). Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. Cellular signalling, 16(3), 313-321. PMID: 14687661.

Matsuo, K., Galson, D. L., Zhao, C., Peng, L., Laplace, C., Wang, K. Z., Backler, M. A., Amano, H., Aburatani, H., Ishikawa, H. & Wagner, E. F. (2004). Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Journal of biological chemistry, 279(25), 26475-26480. PMID: 15073183.

Sano, M., Kikuchi, K., Zhao, C., Kobayashi, M., Nakanishi, Y. & Nemoto, N. (2004). Osteoclastogenesis in human breast carcinoma. Virchows Archiv, 444(5), 470-472. PMID: 15014987.

Zhao, C., Hashiguchi, A., Kondoh, K., Du, W., Hata, J. & Yamada, T. (2002). Exogenous expression of heat shock protein 90kDa retards the cell cycle and impairs the heat shock response. Experimental cell research, 275(2), 200-214. PMID: 11969290.

Ueno, K., Tanaka, M., Miyakoshi, K., Zhao, C., Shinmoto, H., Nishimura, G. & Yoshimura, Y. (2002). Prenatal diagnosis of atelosteogenesis type I at 21 weeks' gestation. Prenatal diagnosis, 22(12), 1071-1075. PMID: 12454961.

Zhao, C., Yamada, T., Kuramochi, S., Yamazaki, K., Mukai, M., Kameyama, K. & Hata, J. (2000). Two cases of ectopic hamartomatous thymoma. Virchows Archiv, 437(6), 643-647. PMID: 11193476.