Munir R. Tanas, MD

Co-Leader, Sarcoma Multi-disciplinary Oncology Group and Molecular Epidemiology Research Core
Assistant Professor of Pathology

Contact Information

Primary Office
106A Medical Research Center
25 S. Grand Avenue
Iowa City, IA 52242


BS, Biochemistry, Whitworth College, Spokane, WA
MD, University of Washington, Seattle, WA
Resident, Anatomic Pathology, University of Washington, Seattle, WA
Fellow, Surgical Pathology, University of Washington, Seattle, WA
Fellow, Bone and Soft Tissue Pathology, Cleveland Clinic, Cleveland, OH
Postdoctoral Fellow, Molecular Genetics, Cleveland Clinic, Cleveland, OH

Licensure and Certifications

Doctor of Medicine - State Medical Board of Ohio
Board Certification in Anatomic Pathology - American Board of Pathology

Research Summary

Activation and mechanism of action of TAZ (WWTR1) and YAP1 in cancer.


Merritt, N. M., Fullenkamp, C. A., Hall, S. L., Qian, Q., Desai, C., Thomason, J., Lambertz, A. M., Dupuy, A. J., Darbro, B. & Tanas, M. R. (2018). A comprehensive evaluation of Hippo pathway silencing in sarcomas. Oncotarget, 9(60), 31620-31636. PMID: 30167083.

White, K. A., Swier, V. J., Cain, J. T., Kohlmeyer, J. L., Meyerholz, D. K., Tanas, M. R., Uthoff, J., Hammond, E., Li, H., Rohret, F. A., Goeken, A., Chan, C. H., Leidinger, M. R., Umesalma, S., Wallace, M. R., Dodd, R. D., Panzer, K., Tang, A. H., Darbro, B. W., Moutal, A., Cai, S., Li, W., Bellampalli, S. S., Khanna, R., Rogers, C. S., Sieren, J. C., Quelle, D. E. & Weimer, J. M. (2018). A porcine model of neurofibromatosis type 1 that mimics the human disease. JCI insight, 3(12). PMID: 29925695.

Abarca, T., Gao, Y., Monga, V., Tanas, M. R., Milhem, M. M. & Miller, B. J. (2018). Improved survival for extremity soft tissue sarcoma treated in high-volume facilities. Journal of surgical oncology, 117(7), 1479-1486. PMID: 29633281.

Monga, V., Swami, U., Tanas, M., Bossler, A., Mott, S. L., Smith, B. J. & Milhem, M. (2018). A Phase I/II Study Targeting Angiogenesis Using Bevacizumab Combined with Chemotherapy and a Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas. Cancers, 10(2). PMID: 29462961.

Buchakjian, M. R., Merritt, N. M., Moose, D. L., Dupuy, A. J., Tanas, M. R. & Henry, M. D. (2017). A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PloS one, 12(8), e0183469. PMID: 28841687.

Guseva, N. V., Jaber, O., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J., Fillman, A. N., Miller, B. J., Bossler, A. D. & Ma, D. (2017). Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. Genes, chromosomes & cancer, 56(4), 266-277. PMID: 27910166.

Bean, G. R., Kremer, J. C., Prudner, B. C., Schenone, A. D., Yao, J. C., Schultze, M. B., Chen, D. Y., Tanas, M. R., Adkins, D. R., Bomalaski, J., Rubin, B. P., Michel, L. S. & Van Tine, B. A. (2016). A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas. Cell death & disease, 7(10), e2406. PMID: 27735949.

Guseva, N. V., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J. C., Bossler, A. D., Bellizzi, A. M. & Ma, D. (2016). The NAB2-STAT6 gene fusion in solitary fibrous tumor can be reliably detected by anchored multiplexed PCR for targeted next-generation sequencing. Cancer genetics, 209(7-8), 303-12. PMID: 27292373.

Fullenkamp, C. A., Hall, S. L., Jaber, O. I., Pakalniskis, B. L., Savage, E. C., Savage, J. M., Ofori-Amanfo, G. K., Lambertz, A. M., Ivins, S. D., Stipp, C. S., Miller, B. J., Milhem, M. M. & Tanas, M. R. (2016). TAZ and YAP are frequently activated oncoproteins in sarcomas. Oncotarget. PMID: 27129148.

Patel, N. R., Salim, A. A., Sayeed, H., Sarabia, S. F., Hollingsworth, F., Warren, M., Jakacky, J., Tanas, M., Oliveira, A. M., Rubin, B. P., Lazar, A. J., López-Terrada, D. & Wang, W. L. (2015). Molecular characterization of epithelioid haemangioendotheliomas identifies novel WWTR1-CAMTA1 fusion variants. Histopathology. PMID: 25817592.

Tanas, M. R., Ma, S., Jadaan, F. O., Ng, C. K., Weigelt, B., Reis-Filho, J. S. & Rubin, B. P. (2015). Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein. Oncogene, [Epub ahead of print]. PMID: 25961935.

Cheah, A. L., Billings, S. D., Goldblum, J. R., Carver, P., Tanas, M. Z. & Rubin, B. P. (2014). STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology, 46(5), 389-95. PMID: 24977739.

Bohman, S. L., Goldblum, J. R., Rubin, B. P., Tanas, M. R. & Billings, S. D. (2014). Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. Pathology, 46(3), 199-204. PMID: 24614712.

Tanas, M. R., Sboner, A., Oliveira, A. M., Erickson-Johnson, M. R., Hespelt, J., Hanwright, P. J., Flanagan, J., Luo, Y., Fenwick, K., Natrajan, R., Mitsopoulos, C., Zvelebil, M., Hoch, B. L., Weiss, S. W., Debiec-Rychter, M., Sciot, R., West, R. B., Lazar, A. J., Ashworth, A., Reis-Filho, J. S., Lord, C. J., Gerstein, M. B., Rubin, M. A. & Rubin, B. P. (2011). Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Science translational medicine, 3(98), 98ra82. PMID: 21885404.

Tanas, M. R., Rubin, B. P., Montgomery, E. A., Turner, S. L., Cook, J. R., Tubbs, R. R., Billings, S. D. & Goldblum, J. R. (2010). Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases. Modern pathology, 23(1), 93-7. PMID: 19801966.

Tanas, M. R., Rubin, B. P., Tubbs, R. R., Billings, S. D., Downs-Kelly, E. & Goldblum, J. R. (2010). Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Archives of pathology & laboratory medicine, 134(12), 1797-803. PMID: 21128778.

Tanas, M. R., Goldblum, J. R. (2009). Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review. Advances in anatomic pathology, 16(6), 383-91. PMID: 19851129.

Tanas, M. R., Rubin, B. P. (2009). Malignant neuroectodermal tumor with melanocytic and rhabdomyoblastic differentiation. Rare tumors, 1(2), e26. PMID: 21139905.

Tanas, M. R., Sthapanachai, C., Nonaka, D., Melamed, J., Oliveiera, A. M., Erickson-Johnson, M. R. & Rubin, B. P. (2009). Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma. Modern pathology, 22(9), 1196-1200. PMID: 19525929.

Wolf, P. S., Flum, D. R., Tanas, M. R., Rubin, B. P. & Mann, G. N. (2008). Epithelioid sarcoma: the University of Washington experience. American journal of surgery, 196(3), 407-12. PMID: 18436180.

Rubin, B. P., Antonescu, C. R., Scott-Browne, J. P., Comstock, M. L., Gu, Y., Tanas, M. R., Ware, C. B. & Woodell, J. (2005). A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. Cancer research, 65(15), 6631-9. PMID: 16061643..

Badjou, S., Powers, G. D. & Tanas, M. R. (1997). Proceedings. Ultrasonic Measurement of Postural Stability andControl. Tenth IEEE Symposium on Computer-based Medical Systems, 164-165.