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Shujie Yang, PhD

Portrait
Assistant Professor of Pathology

Contact Information

Office
5202 Medical Education Research Facility
375 Newton Road
Iowa City, IA 52242
319-335-0473

Education

BA, Biochemistry, Beijing Normal University, Beijing, China
MS, Biochemistry, Beijing Normal University, Beijing, China
PhD, Biomedical Science, University of New Mexico
Postdoctoral Fellow, Obstetrics and Gynecology, University of Iowa

Education/Training Program Affiliations

Cancer Biology Graduate Program, Department of Pathology Graduate Program, Interdisciplinary Graduate Program in Molecular Medicine

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Cell biology and signaling, cancer biology and targeted therapy,
biochemistry, molecular biology, structural biology, hormonal therapy, epigenetic regulation

Publications

Meng, X., Yang, S. & Camp VJA, (2020). The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles. Frontiers in oncology, 9, 1538. PMID: 32010626.

Bi, J., Areecheewakul, S., Li, Y., Yang, S., Zhang, Y., Ebeid, K., Li, L., Thiel, K. W., Zhang, J., Dai, D., Salem, A. K., Leslie, K. K. & Meng, X. (2019). MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy. Gynecologic Oncology, 155(2), 349-358. PMID: 31477281.

Bi, J., Yang, S., Li, L., Dai, Q., Borcherding, N., Wagner, B. A., Buettner, G. R., Spitz, D. R., Leslie, K. K., Zhang, J. & Meng, X. (2019). Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death and Disease, 10(10), 682. PMID: 31527591.

Meng, X., Yang, S., Zhang, J. & Yu, H. (2019). Contribution of alternative splicing to breast cancer metastasis. Journal of cancer metastasis and treatment, 5. PMID: 31737791.

Li, Y., Gonzalez Bosquet, J., Yang, S., Thiel, K. W., Zhang, Y., Liu, H., Leslie, K. K. & Meng, X. (2017). Role of metadherin in estrogen-regulated gene expression. International journal of molecular medicine, 40(2), 303-310. PMID: 28627585.

Kavlashvili, T., Jia, Y., Dai, D., Meng, X., Thiel, K. W., Leslie, K. K. & Yang, S. (2016). Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS One, 11(2), e0148912. PMID: 26859414.

Reyes, H. D., Carlson, M. J., Devor, E. J., Zhang, Y., Thiel, K. W., Samuelson, M. I., McDonald, M., Yang, S., Stephan, J. M., Savage, E. C., Dai, D., Goodheart, M. J. & Leslie, K. K. (2016). Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices. Gynecol Oncol, 140(1), 152-60. PMID: 26524723.

McCabe Pryor, M., Steinkamp, M. P., Halasz, A. M., Chen, Y., Yang, S., Smith, M. S., Zahoransky-Kohalmi, G., Swift, M., Xu, X. P., Hanien, D., Volkmann, N., Lidke, D. S., Edwards, J. S. & Wilson, B. S. (2015). Orchestration of ErbB3 signaling through heterointeractions and homointeractions. Mol Biol Cell, 26(22), 4109-23. PMID: 26378253.

Zhang, Y., Goodfellow, R., Li, Y., Yang, S., Winters, C. J., Thiel, K. W., Leslie, K. K. & Yang, B. (2015). NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling. Gynecol Oncol, 139(1), 127-33. PMID: 26193427.

Meng, X., Yang, S., Zhang, Y., Wang, X., Goodfellow, R. X., Jia, Y., Thiel, K. W., Reyes, H. D., Yang, B. & Leslie, K. K. (2015). Genetic Deficiency of Mtdh in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs. pp. pii: jbc.M114.627653. J Biol Chem. PMID: 25787082.

Yang, S., Jia, Y., Liu, X., Winters, C., Wang, X., Zhang, Y., Devor, E. J., Hovey, A. M., Reyes, H. D., Xiao, X., Xu, Y., Dai, D., Meng, X., Thiel, K. W., Domann, F. E. & Leslie, K. K. (2014). Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer. Oncotarget, 5(20), 9783-97. PMID: 25229191.

Steinkamp, M., Low-Nam, S., Yang, S., Lidke, K. A., Lidke, D. S. & Wilson, B. S. (2014). ErbB3 is an active tyrosine kinase capable of homo- and hetero-interactions. Mol Cell Biol, 34(17), 965-77.

Leslie, K. K., Thiel, K. W., Reyes, H. D., Yang, S., Zhang, Y., Carlson, M. J., Kumar, N. S. & Dai, D. (2013). The Estrogen Receptor Joins Other Cancer Biomarkers as a Predictor of Outcome. Obstetrics and Gynecology International, 2013 (2013)(Article ID 497541), 5 pages.

Yang, S., Leslie, K. K. & Meng, X. (2013). MTDH and FOXM1, Two Master Regulators in Gynecologic Cancer. (Vols. 1). (2), pp. 1011. Med J Obstet Gynecol.

Yang, S., Xiao, X., Jia, Y., Liu, X., Zhang, Y., Devor, E. J., Meng, X., Thiel, K. W. & Leslie, K. K. (2013). Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells. Current Pharmaceutical Design. PMID: 23888956.

Meng, X., Laidler, L. L., Kosmacek, E. A., Yang, S., Xiong, Z., Zhu, D., Wang, X., Dai, D., Zhang, Y., Wang, X., Brachova, P., Albitar, L., Liu, D., Ianzini, F., Mackey, M. A. & Leslie, K. K. (2013). Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53. Gynecol Oncol, 128(3), 461-9. PMID: 23146687.

Carlson, M. J., Thiel, K. W., Yang, S. & Leslie, K. K. (2012). Progesterone, obesity, and the prevention of endometrial cancer. Discov Med, 14(76), 215-222. PMID: 23021376.

Leslie, K. K., Thiel, K. W., Goodheart, M. J., De Geest, K., Jia, Y. & Yang, S. (2012). Endometrial cancer. (2), pp. 255-68. Obstet Gynecol Clin North Am. PMID: 22640714.

Meng, X., Zhu, D., Yang, S., Wang, X., Xiong, Z., Zhang, Y., Brachova, P. & Leslie, K. K. (2012). Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein. J Biol Chem, 287(7), 4485-91.

Leslie, K. K., Thiel, K. W. & Yang, S. (2012). Endometrial cancer: potential treatment and prevention with progestin-containing intrauterine devices. (Vols. 119). (2 Pt 2), pp. 419-20. Obstet Gynecol. PMID: 22270423.

Milhem, M. M., Knutson, T., Yang, S., Zhu, D., Wang, X., Leslie, K. K. & Meng, X. (2011). Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients. Journal of cancer science & therapy, S5(4). PMID: 23543869.

Yang, S., Thiel, K. W., De Geest, K. & Leslie, K. K. (2011). Reviving progesterone therapy in the molecular age. Discov Med, 12(64), 205-12. PMID: 21955848.

Meng, X., Brachova, P., Yang, S., Xiong, Z., Zhang, Y., Thiel, K. W. & Leslie, K. K. (2011). Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. PLoS One, 6(6), e20920. PMID: 21687633.

Yang, S., Thiel, K. W. & Leslie, K. K. (2011). Progesterone: the ultimate endometrial tumor suppressor. Trends Endocrinol Metab, 22(4), 145-52.

Yang, S., Xiao, X., Meng, X. & Leslie, K. K. (2011). A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS One, 6(10), e26343. PMID: 22039466.

Hsieh, M. Y., Yang, S., Raymond-Stinz, M. A., Edwards, J. S. & Wilson, B. S. (2010). Spatio-temporal modeling of signaling protein recruitment to EGFR. BMC Syst Biol 2010, 4(57). PMID: 20459599.

Hsieh, M. Y., Yang, S., Raymond-Stinz, M. A., Steinberg, S., Vlachos, D. G., Shu, W., Wilson, B. & Edwards, J. S. (2008). Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation. IET Syst Biol 2, 2(5), 256-72. PMID: 19045821.

Yang, S., Raymond-Stinz, M. A., Ying, W., Zhang, J., Lidke, D. S., Steinberg, S. L., Williams, L., Oliver, J. M. & Wilson, B. S. (2007). Mapping ErbB receptors on breast cancer cell membranes during signal transduction. J Cell Sci 120,(Pt 16), 2763-73. PMID: 17652160.

Roybal, C. N., Yang, S., Sun, C. W., Hurtado, D., Vander Jagt, D. L., Townes, T. M. & Abcouwer, S. F. (2004). Homocysteine increases the expression of VEGF by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem, 279(15), 14844-52. PMID: 14747470.

Luo, S., Baumeister, P., Yang, S., Abcouwer, S. F. & Lee, A. S. (2003). Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem, 278(39), 37375-85. PMID: 12871976.

Xiang, B., Liu, P., Jiang, G., Zou, K., Yi, F., Yang, S. & Wei, Q. (2003). The catalytically active domain in the A subunit of calcineurin. Biol Chem, 384(10-11), 1429-34. PMID: 14669985.

Yang, S., Zhang, L. & Wei, Q. (2000). Activities and properties of calcineurin catalytic domain. Chinese Science Bulletin, 45(15), 1394-1399.

Wei, Q., Cui, L. & Yang, S. (2000). The Experimental Guide for Molecular Biology. Chinese High Education Press.