Siegfried Janz, MD, DSc

Endowed Professor in Cancer Research
Professor of Pathology

Contact Information

Primary Office
2202 Medical Education Research Facility
Iowa City, IA 52242


Diploma, Master of Medicine, University of Leipzig Medical School
MD, University of Leipzig Medical School
DSc, University of Leipzig Medical School
Resident, Clinical Immunology, University of Leipzig Medical School, Germany

Licensure and Certifications

Clinical Immunologist - Leipzig, Saxony, Germany
Physician - Leipzig, Saxony, Germany

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Immunology, Medical Scientist Training Program

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Molecular genetics of B cell and plasma cell neoplasms.


Wang, W., Zhang, Y., Chen, R., Tian, Z., Zhai, Y., Janz, S., Gu, C. & Yang, Y. (2017). Chromosomal instability and acquired drug resistance in multiple myeloma. Oncotarget, 8(44), 78234-78244. PMID: 29100463.

Hao, M., Machin, R. F., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F. (2017). NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma. Leukemia. PMID: 28400617.

Tompkins, V. S., Sompallae, R., Rosean, T. R., Walsh, S., Acevedo, M., Kovalchuk, A. L., Han, S. S., Jing, X., Holman, C., Rehg, J. E., Herms, S., Sunderland, J. S., Morse, H. C. & Janz, S. (2016). Transgenic mouse model of IgM+ lymphoproliferative disease mimicking Waldenström macroglobulinemia. Blood cancer journal, 6(11), e488. PMID: 27813533.

Janz, S. (2016). Mouse model of MYD88L265P-dependent DLBCL. Blood, 127(22), 2660-1. PMID: 27257177.

Rabellino, A., Melegari, M., Tompkins, V. S., Chen, W., Van Ness, B. G., Teruya-Feldstein, J., Conacci-Sorrell, M., Janz, S. & Scaglioni, P. P. (2016). PIAS1 Promotes Lymphomagenesis through MYC Upregulation. Cell reports. PMID: 27239040.

Rosean, T. R., Holman, C. J., Tompkins, V. S., Jing, X., Krasowski, M. D., Rose-John, S. & Janz, S. (2016). KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. Blood cancer journal, 6, e398. PMID: 26918362.

Gu, C., Yang, Y., Sompallae, R., Xu, H., Tompkins, V. S., Holman, C., Hose, D., Goldschmidt, H., Tricot, G., Zhan, F. & Janz, S. (2015). FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia. PMID: 26648534.

Zhang, L., Blackwell, K., Workman, L. M., Chen, S., Pope, M. R., Janz, S. & Habelhah, H. (2015). RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-?B Activation and Lymphoma Survival. Molecular and cellular biology, 35(19), 3324-38. PMID: 26195820.

Franqui-Machin, R., Wendlandt, E. B., Janz, S., Zhan, F. & Tricot, G. (2015). Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?. Oncotarget. PMID: 26415231.

Yang, Y., Shi, J., Gu, Z., Salama, M. E., Das, S., Wendlandt, E., Xu, H., Huang, J., Tao, Y., Hao, M., Franqui, R., Levasseur, D., Janz, S., Tricot, G. & Zhan, F. (2015). Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myeloma. Cancer research, 75(3), 594-604. PMID: 25589346.

Han, S. S., Tompkins, V. S., Son, D. J., Han, S., Yun, H., Kamberos, N. L., Dehoedt, C. L., Gu, C., Holman, C., Tricot, G., Zhan, F. & Janz, S. (2015). CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma. Experimental hematology & oncology, 4, 9. PMID: 25838973.

Rosean, T. R., Tompkins, V. S., Olivier, A. K., Sompallae, R., Norian, L. A., Morse, H. C., Waldschmidt, T. J. & Janz, S. (2015). The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice. Leukemia, 29(1), 233-7. PMID: 25257990.

Yang, Y., Zhou, W., Xia, J., Gu, Z., Wendlandt, E., Zhan, X., Janz, S., Tricot, G. & Zhan, F. (2014). NEK2 mediates ALDH1A1 induced drug-resistance in multiple myeloma. Oncotarget, [Epub ahead of print]. PMID: 25230277.

Reed, S. M., Hagen, J., Muniz, V. P., Rosean, T. R., Borcherding, N., Sciegienka, S., Goeken, J. A., Naumann, P. W., Zhang, W., Tompkins, V. S., Janz, S., Meyerholz, D. K. & Quelle, D. E. (2014). NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas. PLoS One, 9(11), e112126. PMID: 25393878.

Rosean, T. R., Tompkins, V. S., Tricot, G., Holman, C. J., Olivier, A. K., Zhan, F. & Janz, S. (2014). Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma. Immunologic research [Epub ahead of print]. PMID: 24845460.

Duncan, K., Rosean, T. R., Tompkins, V. S., Olivier, A., Sompallae, R., Zhan, F., Tricot, G., Acevedo, M. R., Ponto, L. L., Walsh, S. A., Tygrett, L. T., Berger, A. J., Waldschmidt, T. J., Morse, H. C., Sunderland, J. J. & Janz, S. (2013). (18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib. Blood Cancer Journal, 3, e165. PMID: 24292417.

Zhou, W., Yang, Y., Gu, Z., Wang, H., Xia, J., Wu, X., Zhan, X., Levasseur, D., Zhou, Y., Janz, S., Tricot, G., Shi, J. & Zhan, F. (2013). ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma. Leukemia [epub ahead of print]. PMID: 24365790.

Tompkins, V. S., Han, S. S., Olivier, A., Syrbu, S., Bair, T., Button, A., Jacobus, L., Wang, Z., Lifton, S., Raychaudhuri, P., Morse, H. C., Weiner, G., Link, B., Smith, B. J. & Janz, S. (2013). Identification of candidate B-lymphoma genes by cross-species gene expression profiling. PLoS One, 8(10), e76889. PMID: 24130802.

Han, S. S., Tompkins, V. S., Son, D. J., Kamberos, N. L., Stunz, L. L., Halwani, A., Bishop, G. A. & Janz, S. (2013). Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. Biochemical and biophysical research communications, 436(4), 660-5. PMID: 23764397.

Han, S. S., Son, D. J., Yun, H., Kamberos, N. L. & Janz, S. (2013). Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. Leukemia research, 37(2), 146-54. PMID: 23237561.

Stessman, H. A., Baughn, L. B., Sarver, A., Xia, T., Deshpande, R., Mansoor, A., Walsh, S. A., Sunderland, J. J., Dolloff, N. G., Linden, M. A., Zhan, F., Janz, S., Myers, C. L. & Van Ness, B. G. (2013). Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. Molecular cancer therapeutics, 12(6), 1140-50. PMID: 23536725.

Stessman, H. A., Mansoor, A., Zhan, F., Janz, S., Linden, M. A., Baughn, L. B. & Van Ness, B. (2013). Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib. Leukemia, 27(10), 2075-2077. PMID: 23728080.

Janz, S. (2013). Waldenström Macroglobulinemia: Clinical and Immunological Aspects, Natural History, Cell of Origin, and Emerging Mouse Models. ISRN hematology [eCollection], 815325. PMID: 24106612.

Janz, S., Qi, C. F., Kim, Y. S., Xiang, S., Abdullaev, Z., Torrey, T. A., Janz, S., Kovalchuk, A. L., Sun, J., Chen, D., Cho, W. C., Gu, W. & Morse, H. C. (2012). Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms. International journal of molecular sciences, 13(5), 6204-19. PMID: 22754359.

LeGrand, J., Park, E. S., Wang, H., Gupta, S., Owens, J. D., Nelson, P. J., DuBois, W., Bair, T., Janz, S. & Mushinski, J. F. (2012). Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia. Blood, 119(4), 1018-28. PMID: 22147894.

Suthaus, J., Stuhlmann-Laeisz, C., Tompkins, V. S., Rosean, T. R., Klapper, W., Tosato, G., Janz, S., Scheller, J. & Rose-John, S. (2012). HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood, 119(22), 5173-81. PMID: 22490805.

Janz, S., Bommert, K. S., Effenberger, M., Leich, E., Küspert, M., Murphy, D., Langer, C., Moll, R., Janz, S., Mottok, A., Weissbach, S., Rosenwald, A., Bargou, R. & Bommert, K. (2012). The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. Leukemia, 27(2), 441-450. PMID: 22772059.

Berger, A., Manfredi, M. G., Bolen, J., Janz, S., Lee, E. C., Fitzgerald, M., Bannerman, B., Donelan, J., Bano, K., Terkelsen, J., Bradley, D. P., Subakan, O., Silva, M. D., Liu, R., Pickard, M., Li, Z., Tayber, O., Li, P., Hales, P., Carsillo, M., Neppalli, V. T., Berger, A. J., Kupperman, E., Manfredi, M., Bolen, J. B., Van Ness, B. & Janz, S. (2011). Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, 17(23), 7313-23. PMID: 21903769.

de Jong, D., Janz, S. (2010). Anaplastic plasmacytoma of mouse-establishing parallels between subtypes of mouse and human plasma cell neoplasia. The Journal of pathology, 221(3), 242-7. PMID: 20527018.

Zingone, A., Cultraro, C. M., Shin, D. M., Bean, C. M., Morse, H. C., Janz, S. & Kuehl, W. M. (2010). Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms. Leukemia, 24(6), 1171-8. PMID: 20393505.

Takizawa, M., Kim, J. S., Tessarollo, L., McNeil, N., Waldschmidt, T. J., Casellas, R., Ried, T. & Janz, S. (2010). Genetic reporter system for oncogenic Igh-Myc translocations in mice. Oncogene, 29(28), 4113-20. PMID: 20453890.

Rutsch, S., Neppalli, V. T., Shin, D. M., DuBois, W., Morse, H. C., Goldschmidt, H. & Janz, S. (2010). IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood, 115(9), 1746-54. PMID: 20018915.

Han, S. S., Yun, H., Son, D. J., Tompkins, V. S., Peng, L., Chung, S. T., Kim, J. S., Park, E. S. & Janz, S. (2010). NF-kB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma. Molecular cancer, 9, 97. PMID: 20433747.

Janz, S., Dolken, G., Schüler, F., Dölken, L., Hirt, C., Kiefer, T., Berg, T., Fusch, G., Weitmann, K., Hoffmann, W., Fusch, C., Janz, S., Rabkin, C. S. & Dölken, G. (2009). Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals. International journal of cancer, 124(4), 958-63. PMID: 19030176.

Khuda, S. E., Loo, W. M., Janz, S., Van Ness, B. & Erickson, L. D. (2008). Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. Journal of immunology, 181(11), 7537-49. PMID: 19017943.

Janz, S. (2008). Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice. Journal of the National Cancer Institute - Monographs,(39), 37-40. PMID: 18648000.

Rabkin, C. S., Janz, S. (2008). Mechanisms and consequences of chromosomal translocation. Cancer epidemiology, biomarkers & prevention, 17(8), 1849-51. PMID: 18708370.

Rabkin, C. S., Janz, S. (2008). Overview of mechanisms and consequences of chromosomal translocation. Journal of the National Cancer Institute. Monographs,(39), 1. PMID: 18647992.

Rabkin, C. S., Hirt, C., Janz, S. & Dölken, G. (2008). t(14;18) Translocations and risk of follicular lymphoma. Journal of the National Cancer Institute - Monographs,(39), 48-51. PMID: 18648003.

Boylan, K. L., Gosse, M. A., Staggs, S. E., Janz, S., Grindle, S., Kansas, G. S. & Van Ness, B. G. (2007). A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma. Cancer research, 67(9), 4069-78. PMID: 17483317.

Janz, S., Ried, M., Kovalchuk, A. L., duBois, W., Mushinski, E., McNeil, N. E., Hirt, C., Qi, C. F., Li, Z., Janz, S., Honjo, T., Muramatsu, M., Ried, T., Behrens, T. & Potter, M. (2007). AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. The Journal of experimental medicine, 204(12), 2989-3001. PMID: 17998390.

Janz, S., Qi, C. F., Zhou, J. X., Lee, C. H., Naghashfar, Z., Xiang, S., Kovalchuk, A. L., Fredrickson, T. N., Hartley, J. W., Roopenian, D. C., Davidson, W. F., Janz, S. & Morse, H. C. (2007). Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer research, 67(6), 2439-47. PMID: 17363561.

Fujita, K., Janz, S. (2007). Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Molecular cancer, 6, 71. PMID: 17971207.

Hirt, C., Dölken, G., Janz, S. & Rabkin, C. S. (2007). Distribution of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in healthy individuals. British journal of haematology, 138(3), 349-53. PMID: 17614821.

Janz, S., Park, E. S., Shaughnessy, J. D., Gupta, S., Wang, H., Lee, J. S., Woo, H. G., Zhan, F., Owens, J. D., Potter, M., Janz, S. & Mushinski, J. F. (2007). Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. BMC genomics, 8, 302. PMID: 17764563.

Yan, Y., Park, S. S., Janz, S. & Eckhardt, L. A. (2007). In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development. Genes, chromosomes & cancer, 46(10), 950-9. PMID: 17639584.

Janz, S., Crouch, E. E., Li, Z., Takizawa, M., Fichtner-Feigl, S., Gourzi, P., Montaño, C., Feigenbaum, L., Wilson, P., Janz, S., Papavasiliou, F. N. & Casellas, R. (2007). Regulation of AID expression in the immune response. The Journal of experimental medicine, 204(5), 1145-56. PMID: 17452520.

Han, S. S., Peng, L., Chung, S. T., DuBois, W., Maeng, S. H., Shaffer, A. L., Sporn, M. B. & Janz, S. (2006). CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. Molecular cancer, 5, 22. PMID: 16759389.

Janz, S. (2006). Distinct MYC Thresholds in Hematopoietic Neoplasia. Blood (Inside Capsule), 108(2), 413.

Kim, J. S., Han, S. S., Park, S. S., McNeil, N. & Janz, S. (2006). Plasma cell tumour progression in iMycEmu gene-insertion mice. The Journal of pathology, 209(1), 44-55. PMID: 16482495.

Janz, S. (2006). TCL1-Induced Germinal Center B Lymphomas in Mice. Blood (Inside Capsule), 108(6), 1791-1792.

Zhu, D., Qi, C. F., Morse, H. C., Janz, S. & Stevenson, F. K. (2005). Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells. Blood, 105(5), 2135-7. PMID: 15522957.

McNeil, N., Kim, J. S., Ried, T. & Janz, S. (2005). Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation. Genes, chromosomes & cancer, 43(2), 137-46. PMID: 15751044.

Park, S. S., Kim, J. S., Tessarollo, L., Owens, J. D., Peng, L., Han, S. S., Tae Chung, S., Torrey, T. A., Cheung, W. C., Polakiewicz, R. D., McNeil, N., Ried, T., Mushinski, J. F., Morse, H. C. & Janz, S. (2005). Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer research, 65(4), 1306-15. PMID: 15735016.

Park, S. S., Shaffer, A. L., Kim, J. S., duBois, W., Potter, M., Staudt, L. M. & Janz, S. (2005). Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice. Cancer research, 65(17), 7644-52. PMID: 16140930.

Silva, S., Wiener, F., Klein, G. & Janz, S. (2005). Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations. Genes, chromosomes & cancer, 42(4), 416-26. PMID: 15645495.

Janz, S., Han, S. S., Shaffer, A. L., Peng, L., Chung, S. T., Lim, J. H., Maeng, S., Kim, J. S., McNeil, N., Ried, T., Staudt, L. M. & Janz, S. (2005). Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1. Molecular cancer, 4, 40. PMID: 16277667.

Rockwood, L. D., Felix, K. & Janz, S. (2004). Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma. Mutation research, 548(2-Jan), 117-25. PMID: 15063142.

Felix, K., Polack, A., Pretsch, W., Jackson, S. H., Feigenbaum, L., Bornkamm, G. W. & Janz, S. (2004). Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice. Cancer research, 64(2), 530-7. PMID: 14744766.

Cheung, W. C., Kim, J. S., Linden, M., Peng, L., Van Ness, B., Polakiewicz, R. D. & Janz, S. (2004). Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. The Journal of clinical investigation, 113(12), 1763-73. PMID: 15199411.

Felix, K., Gerstmeier, S., Kyriakopoulos, A., Howard, O. M., Dong, H. F., Eckhaus, M., Behne, D., Bornkamm, G. W. & Janz, S. (2004). Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice. Cancer research, 64(8), 2910-7. PMID: 15087411.

Felix, K., Rolink, A., Melchers, F. & Janz, S. (2003). Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes. Mutation research, 522(2-Jan), 135-44. PMID: 12517419.

Silva, S., Kovalchuk, A. L., Kim, J. S., Klein, G. & Janz, S. (2003). BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Cancer research, 63(24), 8656-63. PMID: 14695177.

Hausmann, M., Winkler, R., Hildenbrand, G., Finsterle, J., Weisel, A., Rapp, A., Schmitt, E., Janz, S. & Cremer, C. (2003). COMBO-FISH: specific labeling of nondenatured chromatin targets by computer-selected DNA oligonucleotide probe combinations. BioTechniques, 35(3), 564-70, 572-7. PMID: 14513562.

Kovalchuk, A. L., Kim, J. S. & Janz, S. (2003). E mu/S mu transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells. Oncogene, 22(18), 2842-50. PMID: 12743607.

Rockwood, L. D., Nussenzweig, A. & Janz, S. (2003). Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair. Mutation research, 529(2-Jan), 51-8. PMID: 12943919.

Felix, K., Rockwood, L. D., Pretsch, W., Bornkamm, G. W. & Janz, S. (2003). Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free radical biology & medicine, 34(2), 226-32. PMID: 12521604.

Kovalchuk, A. L., Kim, J. S., Park, S. S., Coleman, A. E., Ward, J. M., Morse, H. C., Kishimoto, T., Potter, M. & Janz, S. (2002). IL-6 transgenic mouse model for extraosseous plasmacytoma. Proceedings of the National Academy of Sciences of the United States of America, 99(3), 1509-14. PMID: 11805288.

Kovalchuk, A. L., Janz, S. (2002). Isotype switch-mediated CH deletions are a recurrent feature of Myc/CH translocations in peritoneal plasmacytomas in mice. International journal of cancer, 101(5), 423-6. PMID: 12216069.

Felix, K., Rockwood, L. D., Pretsch, W., Nair, J., Bartsch, H., Bornkamm, G. W. & Janz, S. (2002). Moderate G6PD deficiency increases mutation rates in the brain of mice. Free radical biology & medicine, 32(7), 663-73. PMID: 11909700.

Esa, A., Coleman, A. E., Edelmann, P., Silva, S., Cremer, C. G. & Janz, S. (2001). Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes. Cancer genetics and cytogenetics, 127(2), 168-73. PMID: 11425458.

Felix, K., Kovalchuk, A. L., Park, S. S., Coleman, A. E., Ramsay, E. S., Qian, M., Kelliher, K. A., Jones, G. M., Ried, T., Bornkamm, G. W. & Janz, S. (2001). Inducible mutagenesis in TEPC 2372, a mouse plasmacytoma cell line that harbors the transgenic shuttle vector lambdaLIZ. Mutation research, 473(1), 121-36. PMID: 11166031.

Hori, M., Xiang, S., Qi, C. F., Chattopadhyay, S. K., Fredrickson, T. N., Hartley, J. W., Kovalchuk, A. L., Bornkamm, G. W., Janz, S., Copeland, N. G., Jenkins, N. A., Ward, J. M. & Morse, H. C. (2001). Non-Hodgkin lymphomas of mice. Blood cells, molecules & diseases, 27(1), 217-22. PMID: 11358382.

Kovalchuk, A. L., Esa, A., Coleman, A. E., Park, S. S., Ried, T., Cremer, C. C. & Janz, S. (2001). Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610. Genes, chromosomes & cancer, 30(3), 283-91. PMID: 11170286.

Kovalchuk, A. L., Qi, C. F., Torrey, T. A., Taddesse-Heath, L., Feigenbaum, L., Park, S. S., Gerbitz, A., Klobeck, G., Hoertnagel, K., Polack, A., Bornkamm, G. W., Janz, S. & Morse, H. C. (2000). Burkitt lymphoma in the mouse. The Journal of experimental medicine, 192(8), 1183-90. PMID: 11034608.

Coleman, A. E., Ried, T. & Janz, S. (2000). Chromosomes 1 and 5 harbor plasmacytoma progressor genes in mice. Genes, chromosomes & cancer, 29(1), 70-4. PMID: 10918396.

Kovalchuk, A. L., Mushinski, E. B. & Janz, S. (2000). Clonal diversification of primary BALB/c plasmacytomas harboring T(12;15) chromosomal translocations. Leukemia, 14(5), 909-21. PMID: 10803525.

Kovalchuk, A. L., Kishimoto, T. & Janz, S. (2000). Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc. Leukemia, 14(6), 1127-35. PMID: 10865979.

Coleman, A. E., Forest, S. T., McNeil, N., Kovalchuk, A. L., Ried, T. & Janz, S. (1999). Cytogenetic analysis of the bipotential murine pre-B cell lymphoma, P388, and its derivative macrophage-like tumor, P388D1, using SKY and CGH. Leukemia, 13(10), 1592-600. PMID: 10516761.

Felix, K., Kelliher, K. A., Bornkamm, G. W. & Janz, S. (1999). Elevated mutant frequencies in lymphoid tissues persist throughout plasmacytoma development in BALB/c.lambdaLIZ mice. Cancer research, 59(15), 3621-6. PMID: 10446972.

Coleman, A. E., Kovalchuk, A. L., Janz, S., Palini, A. & Ried, T. (1999). Jumping translocation breakpoint regions lead to amplification of rearranged Myc. Blood, 93(12), 4442-4. PMID: 10391697.

Felix, K., Kelliher, K., Bornkamm, G. W. & Janz, S. (1998). Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice. Cancer research, 58(8), 1616-9. PMID: 9563470.

Felix, K., Lin, S., Bornkamm, G. W. & Janz, S. (1998). Tetravinyl-tetramethylcyclo-tetrasiloxane (tetravinyl D4) is a mutagen in Rat2lambda lacI fibroblasts. Carcinogenesis, 19(2), 315-20. PMID: 9498283.

Kovalchuk, A. L., Müller, J. R. & Janz, S. (1997). Deletional remodeling of c-myc-deregulating chromosomal translocations. Oncogene, 15(19), 2369-77. PMID: 9393881.

Felix, K., Lin, S. & Janz, S. (1997). Elevated mutant frequencies in gene lacI in splenic lipopolysaccharide blasts after exposure to activated phagocytes in vitro. European journal of immunology, 27(9), 2160-4. PMID: 9341754.

Müller, J. R., Mushinski, E. B., Jones, G. M., Williams, J. A., Janz, S., Hausner, P. F. & Potter, M. (1997). Generation of immunoglobulin/c-myc recombinations in murine Peyer's patch follicles. Current topics in microbiology and immunology, 224, 251-5. PMID: 9308248.

Felix, K., Potter, M., Bornkamm, G. W. & Janz, S. (1997). In vitro mutagenicity of the plasmacytomagenic agent pristane (2,6,10,14-tetramethylpentadecane). Cancer letters, 113(2-Jan), 71-6. PMID: 9065804.

Müller, J. R., Jones, G. M., Janz, S. & Potter, M. (1997). Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice. Blood, 89(1), 291-6. PMID: 8978304.

Rabkin, C. S., Janz, S., Lash, A., Coleman, A. E., Musaba, E., Liotta, L., Biggar, R. J. & Zhuang, Z. (1997). Monoclonal origin of multicentric Kaposi's sarcoma lesions. The New England journal of medicine, 336(14), 988-93. PMID: 9077377.

Coleman, A. E., Schröck, E., Weaver, Z., du Manoir, S., Yang, F., Ferguson-Smith, M. A., Ried, T. & Janz, S. (1997). Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping. Cancer research, 57(20), 4585-92. PMID: 9377573.

Janz, S., Roschke, V. V. (1996). Completion of the DNA sequence determination of the Igh2 locus of the mouse: the 5'-IA region. Immunogenetics, 43(2-Jan), 101-4. PMID: 8537111.

Müller, J. R., Jones, G. M., Potter, M. & Janz, S. (1996). Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction. Cancer research, 56(2), 419-23. PMID: 8542601.

Kovalchuk, A. L., Potter, M. & Janz, S. (1996). DNA sequence analysis of the genetic recombination between Igh6 and Myc in an uncommon BALB/c plasmacytoma, TEPC 1194. Immunogenetics, 44(2), 151-6. PMID: 8662079.

Liyanage, M., Coleman, A., du Manoir, S., Veldman, T., McCormack, S., Dickson, R. B., Barlow, C., Wynshaw-Boris, A., Janz, S., Wienberg, J., Ferguson-Smith, M. A., Schröck, E. & Ried, T. (1996). Multicolour spectral karyotyping of mouse chromosomes. Nature genetics, 14(3), 312-5. PMID: 8896561.

Müller, J. R., Janz, S. & Potter, M. (1995). Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations. Cancer research, 55(21), 5012-8. PMID: 7585544.

Janz, S., Shacter, E. (1995). Disposition of the plasmacytomagenic alkane pristane (2,6,10,14-tetramethylpentadecane) in mice. Cancer biochemistry biophysics, 15(1), 25-34. PMID: 8536217.

Janz, S., Jones, G. M., Müller, J. R. & Potter, M. (1995). Genomic instability in B-cells and diversity of recombinations that activate c-myc. Current topics in microbiology and immunology, 194, 373-80. PMID: 7895512.

Müller, J. R., Janz, S., Goedert, J. J., Potter, M. & Rabkin, C. S. (1995). Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men. Proceedings of the National Academy of Sciences of the United States of America, 92(14), 6577-81. PMID: 7604036.

Janz, S., Gawrisch, K. & Lester, D. S. (1995). Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane. Cancer research, 55(3), 518-24. PMID: 7834620.

Müller, J. R., Potter, M. & Janz, S. (1994). Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells. Proceedings of the National Academy of Sciences of the United States of America, 91(25), 12066-70. PMID: 7991585.

Janz, S., Shacter, E. & Herrmann, A. (1994). Fusion between enveloped viruses and erythrocyte membranes is induced by the isoprenoid alkane pristane (2,6,10,14-tetramethylpentadecane). Cancer biochemistry biophysics, 14(1), 14-Jan. PMID: 7796384.

Müller, J., Janz, S. (1994). In vitro cytotoxicity of neutrophil-like human HL-60 cells undergoing an oxidative burst with Escherichia coli reporter strains. Toxicology in vitro, 8(3), 437-40. PMID: 20692935.

Janz, S., Shacter, E. (1993). Activated murine neutrophils induce unscheduled DNA synthesis in B lymphocytes. Mutation research, 293(2), 173-86. PMID: 7678145.

Janz, S., Müller, J., Shaughnessy, J. & Potter, M. (1993). Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America, 90(15), 7361-5. PMID: 8346257.

Raabe, F., Janz, S., Wolff, G., Merten, H., Landrock, A., Birkenfeld, T. & Herzschuh, R. (1993). Genotoxicity assessment of waste products of aluminum plasma etching with the SOS chromotest. Mutation research, 300(2), 99-109. PMID: 7685499.

Müller, J., Janz, S. (1993). Modulation of the H2O2-induced SOS response in Escherichia coli PQ300 by amino acids, metal chelators, antioxidants, and scavengers of reactive oxygen species. Environmental and molecular mutagenesis, 22(3), 157-63. PMID: 8404875.

Müller, J., Janz, S. (1992). Assessment of oxidative DNA damage in the oxyR-deficient SOS chromotest strain Escherichia coli PQ300. Environmental and molecular mutagenesis, 20(4), 297-306. PMID: 1425609.

Janz, S., Krumbiegel, M. & Gawrisch, K. (1992). The fluidity of DOPC bilayers and membrane fractions prepared from murine plasmacytoma cells is unchanged after incorporation of pristane (2,6,10,14-tetramethylpentadecane) as assessed by fluorescence polarization analysis. Cancer biochemistry biophysics, 13(2), 85-92. PMID: 1343851.

Muller, J., Brede, O. & Janz, S. (1991). A Gamma-Radiolysis Study on the Potential Involvement of a Genotoxic Metabolite in Pristane Induced Plasmacytomagenesis. Central Institute of Isotope and Radiation Research Press, Leipzig, Germany,(5th), 131-137.

Janz, S., Shacter, E. (1991). A new method for delivering alkanes to mammalian cells: preparation and preliminary characterization of an inclusion complex between beta-cyclodextrin and pristane (2,6,10,14-tetramethylpentadecane). Toxicology, 69(3), 301-15. PMID: 1949053.

Janz, S., Brede, O. & Müller, J. (1991). The reaction of pristane (2,6,10,14-tetramethylpentadecane) with radiolytically generated reactive oxygen intermediates results in a stable genotoxic compound as assessed by the SOS chromotest. Carcinogenesis, 12(7), 1241-6. PMID: 2070489.

Gawrisch, K., Janz, S. (1991). The uptake of pristane (2,6,10,14-tetramethylpentadecane) into phospholipid bilayers as assessed by NMR, DSC, and tritium labeling methods. Biochimica et biophysica acta, 1070(2), 409-18. PMID: 1764453.

Janz, S., Raabe, F. & Wolff, G. (1990). Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. Zentralblatt für Mikrobiologie, 145(3), 177-82. PMID: 2196748.

Shacter, E., Lopez, R. L., Beecham, E. J. & Janz, S. (1990). DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals. The Journal of biological chemistry, 265(12), 6693-9. PMID: 2157707.

Raabe, F., Janz, S. & Wolff, G. (1990). The effect of non-ionic surfactants on the SOS-inducing potency of 4-nitroquinoline-1-oxide in Escherichia coli PQ37. Journal of basic microbiology, 30(6), 435-42. PMID: 2126282.

Klimm, W., Janz, S. & Gabert, A. (1989). Experimental research on the genotoxicity of various root canal antiseptics in the SOS chromotest. Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt, 77(2), 128-30. PMID: 2526434.

Janz, S., Birkenfeld, T., Herzschuh, R. & Storch, H. (1989). Gas chromatographic-mass spectrometric investigation of four commercial pristane ( preparations used for plasmacytoma induction in BALB/c mice. Archiv für Geschwulstforschung, 59(6), 415-22. PMID: 2596957.

Janz, S., Rassmann, B., Raabe, F. & Storch, H. (1989). Histologic studies of paraproteinemic nephropathy in BALB/c mice with mineral oil-induced plasmacytoma. Zeitschrift für Urologie und Nephrologie, 82(12), 671-8. PMID: 2629422.

Janz, S., Wolff, G., Huttunen, T., Raabe, F. & Storch, H. (1989). Quantitation of the relationship between tester cell number inoculated and SOS-inducing potency of 4-nitroquinoline-1-oxide (4-NQO) in an automated version of the SOS chromotest. Journal of basic microbiology, 29(7), 403-11. PMID: 2513384.

Janz, S., Huttunen, T., Herzschuh, R. & Storch, H. (1988). Genotoxicity assessment of the plasmacytomagenic agent pristane ( and four related alkanes by the SOS chromotest. Archiv für Geschwulstforschung, 58(2), 73-8. PMID: 3288166.

Janz, S., Wolff, G. & Storch, H. (1988). SOS chromotest, a quantitative short-term bacterial assay for the detection of genotoxic compounds in an automated version adapted to Bioscreen Analyzer System. Zentralblatt für Mikrobiologie, 143(8), 645-9. PMID: 3149098.

Janz, S., Herzschuh, R. & Storch, H. (1987). Evidence for high purity of a commercial pristane (2,6,10,14-tetramethylpentadecane) preparation used for plasmocytoma induction in BALB/c mice. Experimental pathology, 31(4), 253-5. PMID: 3622726.

Janz, S., Püschel, W., Raabe, F. & Storch, H. (1987). Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA). Archiv für Geschwulstforschung, 57(1), 25-30. PMID: 3566462.