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Sterling B. Ortega, PhD

Portrait
Associate of Pathology

Contact Information

Primary Office
1171 Medical Laboratories
25 S. Grand Avenue
Iowa City, IA 52242
319-335-2250

Education

BS, Biology, University of Dallas
MS, Biomedical Sciences, Barry University
PhD, Integrative Biology, University of Texas Southwestern Medical Center

Center, Program and Institute Affiliations

Iowa Neuroscience Institute

Publications

Roa, J. A., Sarkar, D., Zanaty, M., Ishii, D., Lu, Y., Karandikar, N. J., Hasan, D. M., Ortega, S. B. & Samaniego, E. A. (2020). Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Scientific reports, 10(1), 11809. PMID: 32678268.

Ortega, S. B., Torres, V. O., Latchney, S. E., Whoolery, C. W., Noorbhai, I. Z., Poinsatte, K., Selvaraj, U. M., Benson, M. A., Meeuwissen AJM,, Plautz, E. J., Kong, X., Ramirez, D. M., Ajay, A. D., Meeks, J. P., Goldberg, M. P., Monson, N. L., Eisch, A. J. & Stowe, A. M. (2020). B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID: 32051245.

Ortega, S. B., Pandiyan, P., Windsor, J., Torres, V. O., Selvaraj, U. M., Lee, A., Morriss, M., Tian, F., Raman, L. & Stowe, A. M. (2019). A Pilot Study Identifying Brain-Targeting Adaptive Immunity in Pediatric Extracorporeal Membrane Oxygenation Patients With Acquired Brain Injury. Critical care medicine. PMID: 30640221.

Poinsatte, K., Smith, E. E., Torres, V. O., Ortega, S. B., Huebinger, R. M., Cullum, C. M., Monson, N. L., Zhang, R. & Stowe, A. M. (2019). T and B cell subsets differentially correlate with amyloid deposition and neurocognitive function in patients with amnestic mild cognitive impairment after one year of physical activity. Exercise immunology review, 25, 34-49. PMID: 30785868.

Poinsatte, K., Ortega, S. B., Selvaraj, U. M., Meeuwissen, A. J., Kong, X., Plautz, E. J., Monson, N. L., Zhang, R. & Stowe, A. M. (2019). Detraining ablates exercise-induced modulation of the immune system after stroke. Conditioning Medicine, 2(2), 50-60.

Stowe, A. M., Ireland, S. J., Ortega, S. B., Chen, D., Huebinger, R. M., Tarumi, T., Harris, T. S., Cullum, C. M., Rosenberg, R., Monson, N. L. & Zhang, R. (2017). Adaptive lymphocyte profiles correlate to brain Aß burden in patients with mild cognitive impairment. Journal of Neuroinflammation, 14(1), 149. PMID: 28750671.

Selvaraj, U. M., Ortega, S. B., Hu, R., Gilchrist, R., Kong, X., Partin, A., Plautz, E. J., Klein, R. S., Gidday, J. M. & Stowe, A. M. (2017). Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 37(3), 801-813. PMID: 27006446.

Selvaraj, U. M., Poinsatte, K., Torres, V., Ortega, S. B. & Stowe, A. M. (2016). Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair. Neurotherapeutics : The Journal of the American Society for Experimental NeuroTherapeutics, 13(4), 729-747. PMID: 27492770.

Ortega, S. B., Kong, X., Venkataraman, R., Savedra, A. M., Kernie, S. G., Stowe, A. M. & Raman, L. (2016). Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity. Journal of Leukocyte biology, 99(1), 21-9. PMID: 26038434.

Ortega, S. B., Kashi, V. P., Cunnusamy, K., Franco, J. & Karandikar, N. J. (2015). Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants. Neurology(R) Neuroimmunology & Neuroinflammation, 2(6), e170. PMID: 26587555.

Poinsatte, K., Selvaraj, U. M., Ortega, S. B., Plautz, E. J., Kong, X., Gidday, J. M. & Stowe, A. M. (2015). Quantification of neurovascular protection following repetitive hypoxic preconditioning and transient middle cerebral artery occlusion in mice. Journal of Visualized Experiments : JoVE,(99), e52675. PMID: 25993394.

Ortega, S. B., Noorbhai, I., Poinsatte, K., Kong, X., Anderson, A., Monson, N. L. & Stowe, A. M. (2015). Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens. Discovery Medicine, 19(106), 381-92. PMID: 26105701.

Sinha, S., Crawford, M. P., Ortega, S. B. & Karandikar, N. J. (2015). Multiparameter Flow Cytometric Assays to Quantify Effector and Regulatory T-Cell Function in Multiple Sclerosis. Journal of Multiple Sclerosis, 2(1). PMID: 26137595.

Kashi, V. P., Ortega, S. B. & Karandikar, N. J. (2014). Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function. PloS One, 9(8), e105763. PMID: 25144738.

Cunnusamy, K., Baughman, E. J., Franco, J., Ortega, S. B., Sinha, S., Chaudhary, P., Greenberg, B. M., Frohman, E. M. & Karandikar, N. J. (2014). Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells. Clinical Immunology (Orlando, Fla.), 152(1-2), 115-26. PMID: 24657764.

Monson, N. L., Ortega, S. B., Ireland, S. J., Meeuwissen, A. J., Chen, D., Plautz, E. J., Shubel, E., Kong, X., Li, M. K., Freriks, L. H. & Stowe, A. M. (2014). Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke. Journal of Neuroinflammation, 11, 22. PMID: 24485041.

Chen, D., Blazek, M., Ireland, S., Ortega, S., Kong, X., Meeuwissen, A., Stowe, A., Carter, L., Wang, Y., Herbst, R. & Monson, N. L. (2014). Single dose of glycoengineered anti-CD19 antibody (MEDI551) disrupts experimental autoimmune encephalomyelitis by inhibiting pathogenic adaptive immune responses in the bone marrow and spinal cord while preserving peripheral regulatory mechanisms. Journal of Immunology, 193(10), 4823-4832. DOI: 10.4049/jimmunol.1401478.

Ortega, S. B., Kashi, V. P., Tyler, A. F., Cunnusamy, K., Mendoza, J. P. & Karandikar, N. J. (2013). The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950), 191(1), 117-26. PMID: 23733879.

Gutierrez, T., Mayeux, J. M., Ortega, S. B., Karandikar, N. J., Li, Q. Z., Rakheja, D., Zhou, X. J. & Satterthwaite, A. B. (2013). IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice. European Journal of Immunology, 43(2), 382-93. PMID: 23169140.

Biegler, B. W., Yan, S. X., Ortega, S. B., Tennakoon, D. K., Racke, M. K. & Karandikar, N. J. (2011). Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis. Journal of Neuroimmunology, 234(1-2), 131-40. PMID: 21397340.

Baughman, E. J., Mendoza, J. P., Ortega, S. B., Ayers, C. L., Greenberg, B. M., Frohman, E. M. & Karandikar, N. J. (2011). Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis. Journal of Autoimmunity, 36(2), 115-24. PMID: 21257291.

York, N. R., Mendoza, J. P., Ortega, S. B., Benagh, A., Tyler, A. F., Firan, M. & Karandikar, N. J. (2010). Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 35(1), 33-44. PMID: 20172692.

Sathe, A., Ortega, S. B., Mundy, D. I., Collins, R. H. & Karandikar, N. J. (2007). In vitro methotrexate as a practical approach to selective allodepletion. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 13(6), 644-54. PMID: 17531774.

Pillai, V., Ortega, S. B., Wang, C. K. & Karandikar, N. J. (2007). Transient regulatory T-cells: a state attained by all activated human T-cells. Clinical Immunology (Orlando, Fla.), 123(1), 18-29. PMID: 17185041.

Averill, L., Lee, W. M. & Karandikar, N. J. (2007). Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clinical immunology (Orlando, Fla.), 123(1), 40-9. PMID: 17239662.

Biegler, B. W., Yan, S. X., Ortega, S. B., Tennakoon, D. K., Racke, M. K. & Karandikar, N. J. (2006). Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis. Journal of Neuroimmunology, 180(1-2), 159-71. PMID: 16935352.

Tennakoon, D. K., Mehta, R. S., Ortega, S. B., Bhoj, V., Racke, M. K. & Karandikar, N. J. (2006). Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950), 176(11), 7119-29. PMID: 16709875.

Karandikar, N. J., Kroft, S. H., Yegappan, S., Rogers, B. B., Aquino, V. M., Lee, K. M., Kumar, V., Guenaga, F. J., Jaffe, E. S., Douek, D. C. & McKenna, R. W. (2004). Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis. Blood, 104(7), 2007-9. PMID: 15205266.

Crawford, M. P., Yan, S. X., Ortega, S. B., Mehta, R. S., Hewitt, R. E., Price, D. A., Stastny, P., Douek, D. C., Koup, R. A., Racke, M. K. & Karandikar, N. J. (2004). High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood, 103(11), 4222-31. PMID: 14976054.