Vladimir Badovinac, PhD
Professor of Pathology
Introduction
Our main (and everchanging) research goals are to:
Determine the factors that influence generation, maintenance and function of memory CD8 T cells;
Characterize CD8 T cells responding to multiple rounds of antigenic stimulations;
Establish relevant experimental models to study antigen-experienced CD8 T cells in vivo;
Investigate the alterations in T cell-mediated immunity that occur after sepsis;
Define sepsis-induced state of immunoparalysis and explore treatments to restore immunity in sepsis survivors.
Current Positions
- Professor of Pathology
- Endowed Professor in Infection & Immunity Research, Pathology
Education
- BS in Molecular Biology and Physiology, University of Belgrade, Yugoslavia
- PhD in Immunology, Institute for Biological Research and School of Medicine, University of Belgrade, Yugoslavia
- Postdoctoral Fellow, University of Iowa, Department of Microbiology
Graduate Program Affiliations
Center, Program and Institute Affiliations
Selected Publications
- Unsinger J, Osborne D, Walton AH, Han E, Sheets L, Mazer MB, Remy KE, Griffith TS, Rao M, Badovinac VP, Brackenridge SC, Turnbull I, Efron PA, Moldawer LL, Caldwell CC, Hotchkiss RS. (2024) Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot. Shock. May 3; DOI: 10.1097/SHK.0000000000002377. PMID: 38754032.
- Carey A, Nguyen K, Kandikonda P, Kruglov V, Bradley C, Dahlquist KJV, Cholensky S, Swanson W, Badovinac VP, Griffith TS, Camell CD. (2024) Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis. Cell Rep. Mar 26; 43(3):113967. DOI: 10.1016/j.celrep.2024.113967. PMID: 38492219. PMCID: PMC11014686.
- Kannan SK, Kim CY, Heidarian M, Berton RR, Jensen IJ, Griffith TS, Badovinac VP. (2024) Mouse Models of Sepsis. Curr Protoc. Mar; 4(3):4997. DOI: 10.1002/cpz1.997. PMID: 38439603. PMCID: PMC10917121.
- Hassert M, Pewe LL, He R, Heidarian M, Phruttiwanichakun P, van de Wall S, Mix MR, Salem AK, Badovinac VP, Harty JT. (2024) Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure. J Exp Med. Mar 4; 4:221(3):e20231144. DOI: 10.1084/jem.20231144. PMID: 38363548. PMCID: PMC10873130.
- Silva EE, Moioffer SJ, Hassert M, Berton RR, Smith MG, van de Wall S, Meyerholz DK, Griffith TS, Harty JT, Badovinac VP. (2024) Defining Parameters that Modulate Susceptibility and Protection to Respiratory Murine Coronavirus MHV1 Infection. J Immunol. Feb 15; 212(4):563-575. DOI: 10.4049/jimmunol.2300434. PMID: 38149923. PMCID: PMC10872354
- Martin MD, Skon-Hegg C, Kim CY, Xu J, Kucaba TA, Swanson W, Pierson MJ, Williams JW, Badovinac VP, Shen SS, Ingersoll MA, Griffith TS. (2023) CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis. Cell Rep. Nov 28; 42(11):113345. DOI: 10.1016/j.celrep.2023.113345. PMID: 38111515. PMCID: PMC10727454.
- Barrios EL, Mazer MB, McGonagill PW, Bergmann CB, Goodman MD, Gould RW, Rao M, Polcz VE, Davis RJ, Del Toro DE, Dirain MLs, Dram A, Hale LO, Heidarian M, Kim CY, Kucaba TA, Lanz JP, McCray AE, Meszaros S, Miles S, Nelson CR, Rocha IL, Silva EE, Ungaro RF, Walton AH, Xu J, Zeumer-Spataro L, Drewry AM, Liang M, Bible LE, Loftus TJ, Turnbull IR, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC. (2024) Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-gamma ELISpot. JCI Insight. Jan 23; 9(2):e175785. DOI: 10.1172/jci.insight.175785. PMID: 38100268. PMCID: PMC10906237.
- Berton RR, McGonagil PW, Jensen IJ, Ybarra TK, Bishop GA, Harty JT, Griffith TS, Badovinac VP. (2023) Sepsis leads to lasting changes in phenotype and function of naive CD8 T cells. PLoS Pathog. Oct 12; 19(10):e1011720. DOI: 10.1371/journal.ppat.1011720. PMID: 37824591. PMCID: PMC10597476.
- Silva EE, Skon-Hegg C, Badovinac VP, Griffith TS. (2023) (Review) The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity. J. Immunol. Sep 1; 211(5):711-719. DOI: 10.4049/jimmunol.2300171. PMID: 37603859. PMCID: PMC10449360.
- Heidarian M, Jensen IJ, Kannan SK, Pewe LL, Hassert M, Park SR, Xue H-H, Harty JT, Badovinac VP. (2023) Sublethal whole-body irradiation induced permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations. Proc Natl Acad Sci U S A. Jul 4; 120(27):e2302785120. DOI: 10.1073/pnas.2302785120. PMID: 37364124. PMCID: PMC10318958.