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Xiangbing Meng, PhD

Portrait
Research Associate Professor of Pathology

Contact Information

Primary Office
5202 Medical Education Research Facility
375 Newton Road
Iowa City, IA 52242
319-335-0437

Education

BS, Biochemistry, Beijing Normal University, China
MS, Biochemistry and Molecular Biology, Beijing Normal University, China
PhD, Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Academy of Military Medicine, Beijing, China
Postdoctoral Fellow, Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio
Postdoctoral Fellow, Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico

Research Summary

New prognosis biomarkers and potential therapeutic targets in gynecology; Synthetic lethal studies in gynecology; Mitotic Catastrophe induction in ovarian and endometrial cancer

Publications

Bi, J., Areecheewakul, S., Li, Y., Yang, S., Zhang, Y., Ebeid, K., Li, L., Thiel, K. W., Zhang, J., Dai, D., Salem, A. K., Leslie, K. K. & Meng, X. (2019). MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy. Gynecologic Oncology, 155(2), 349-358. DOI: 10.1016/j.ygyno.2019.08.014.

Bi, J., Yang, S., Li, L., Dai, Q., Borcherding, N., Wagner, B. A., Buettner, G. R., Spitz, D. R., Leslie, K. K., Zhang, J. & Meng, X. (2019). Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death and Disease, 10(10). DOI: 10.1038/s41419-019-1897-2.

Meng, X., Yang, S., Zhang, J. & Yu, H. (2019). Contribution of alternative splicing to breast cancer metastasis. Journal of cancer metastasis and treatment, 5. PMID: 31737791.

Meng, X., Yang, S., Li, Y., Li, Y., Devor, E. J., Bi, J., Wang, X., Umesalma, S., Quelle, D. E., Thiel, W. H., Thiel, K. W. & Leslie, K. K. (2018). Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations. Dis Markers, eCollection 2018. PMID: 30647797.

Meng, X., Bi, J., Li, Y., Yang, S., Zhang, Y., Li, M., Liu, H., Li, Y., McDonald, M. E., Thiel, K. W., Wen, K. K., Wang, X., We, M. & Leslie, K. K. (2018). AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations. Cancers (Basel), 10(5). PMID: 29783721.

Ebeid, K., Meng, X., Thiel, K. W., Do, A. V., Geary, S. M., Morris, A. S., Pham, E. L., Wongrakpanich, A., Chhonker, Y. S., Murry, D. J., Leslie, K. K. & Salem, A. K. (2018). Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol, 13(1), 72-81. PMID: 29203914.

Kavlashvilli, T., Jia, Y., Dai, D., Meng, X., Thiel, K. W., Leslie, K. K. & Yang, S. (2016). Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS One, 11(2), e0148912. PMID: 26859414.

Meng, X., Yang, S., Zhang, Y., Wang, X., Goodfellow, R. X., Jia, Y., Thiel, K. W., Reyes, H. D., Yang, B. & Leslie, K. K. (2015). Genetic Deficiency of Mtdh in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs. J Biol Chm, pii: jbc.M114.627653. PMID: 25787082.

Yang, S., Jia, Y., Liu, X., Winters, C., Wang, X., Zhang, Y., Devor, E. J., Hovey, A. M., Reyes, H. D., Xiao, X., Xu, Y., Dai, D., Meng, X., Thiel, K. W., Domann, F. E. & Leslie, K. K. (2014). Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer. Oncotarget, 5(20), 9783-97. PMID: 25229191.

Meng, X., Devor, E. J., Yang, S., Schickling, B. M. & Leslie, K. K. (2014). Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma, Diseases. Diseases, 2(3), 209-225. DOI: 10.3390/diseases2030209.

Yang, S., Meng, X. (2014). Advances and Perspectives in the Treatment of High-Grade Serous Ovarian Cancer. Journal of Women's Health and Gynecology, 1, 1-3.

Yang, S., Xiao, X., Liu, X., Jia, Y., Zhang, X., Devor, E. J., Meng, X., Thiel, K. W. & Leslie, K. K. (2014). Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells. Curr Pharm Des, 20(11), 1874-80. PMID: 23888956.

Meng, X., Dizon, D. S., Yang, S., Wang, X., Zhu, D., Thiel, T. K. & Leslie, K. K. (2013). Strategies for molecularly enhanced chemotherapy to achieve synthetic lethality in endometrial tumors with mutant p53. Obstet Gynecol Int 2013, 2013(828165). PMID: 24381593.

Yang, S., Leslie, K. K. & Meng, X. (2013). MTDH and FOXM1, Two Master Regulators in Gynecologic Cancer. Med J Obstet Gynecol, 1(2), 1009.

Meng, X., Thiel, K. W. & Leslie, K. K. (2013). Drug Resistance Mediated by MTDH/AEG-1/Lyric, Advances in Cancer Research, 1st Edition, AEG-1/MTDH/Lyric Implicated in Multiple Human Cancers. PMID: 23889990.

Meng, X., Laidler, L. L., Kosmacek, E. A., Yang, S., Xiong, Z., Zhu, D., Wang, X., Dai, D., Zhang, Y., Wang, X., Brachova, P., Albitar, L., Liu, D., Ianzini, F., Mackey, M. & Leslie, K. K. (2012). Induction of Mitotic Cell Death in Cancer Cells with Non-Functional p53: a New Therapeutic Strategy. Gynecol Oncol, 128(3), 461-9. PMID: 23146687.

Meng, X., Zhu, D., Yang, S., Wang, X., Xiong, Z., Zhang, Y., Brachova, P. & Leslie, K. K. (2012). Cytoplasmic Metadherin (MTDH) Provides Survival Advantage Under Conditions of Stress by Acting as RNA-Binding Protein. The Journal of Biological Chemistry, 287(7), 4485-91. PMID: 22199357.

Milhem, M. M., Knutson, T., Yang, S., Zhu, D., Wang, X., Leslie, K. K. & Meng, X. (2011). Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients. Journal of Cancer Science & Therapy, S5(4). PMID: 23543869.

Meng, X., Matlawska-Wasowska, K., Girodon, F., Mazel, T., Willman, C. L., Atlas, S., Chen, I. M., Harvey, R. C., Hunger, S. P., Ness, S. A., Winter, S. S. & Wilson, B. S. (2011). GSI-I (Z-LLNle-CHO) Inhibits Gamma-Secretase and the Proteosome to Trigger Cell Death in Precursor-B Acute Lymphoblastic Leukemia. Leukemia, 25(7), 1135-46. PMID: 21494254.

Yang, S., Xiao, X., Meng, X. & Leslie, K. K. (2011). A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors. PloS One, 6(10), e26343. PMID: 22039466.

Meng, X., Brachova, P., Yang, S., Xiong, Z., Zhang, Y., Thiel, K. W. & Leslie, K. K. (2011). Knockdown of Metadherin Sensitizes Cell Death Receptor Ligand TRAIL and HDAC Inhibitor LBH589 Co-Treatment. PLoS One, 6(6), e20920.

Fan, J., Wray, J., Meng, X. & Shen, Z. (2009). BCCIP is Required for the Nuclear Localization of the p21 Protein. Cell Cycle, 8(18), 3019-24.

Meng, X., Martinez, M. A., Raymond-Stintz, M. A., Winter, S. S. & Wilson, B. S. (2009). IKK Inhibitor Bay 11-7082 Induces Necroptotic Cell Death in Precursor-B Acute Lymphoblastic Leukaemic Blasts. Br J Haematol, 148(3), 487-90.

Russell, T., Oliver, J. M., Wilson, B. S., Tarleton, C. A., Winter, S. S. & Meng, X. (2008). Differential Expression of Ikaros Isoforms in Monozygotic Twins with MLL-rearranged Precursor-B Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology, 30(12), 941-4. PMID: 19131787.

Meng, X., Fan, J. & Shen, Z. (2007). Roles of BCCIP in Chromosome Stability and Cytokinesis. Oncogene, 26(43), 6253-60. PMID: 17452982.

Meng, X., Yue, J., Liu, Z. & Shen, Z. (2007). Abrogation of the Transactivation Activity of p53 by BCCIP Down-Regulation. The Journal of Biological Chemistry, 282(3), 1570-6. PMID: 17135243.

Lu, H., Yue, J., Meng, X., Nickoloff, J. & Shen, Z. (2007). BCCIP Regulates Homologous Recombination by Distinct Domains and Suppresses Spontaneous DNA Damage. Nucleic Acid Res, 35(21), 7160-70.

Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J., Nickoloff, J. A. & Shen, Z. (2005). The BRCA2-Interacting Protein BCCIP Functions in RAD51 and BRCA2 Focus Formation and Homologous Recombinational Repair. Molecular and Cellular Biology, 25(5), 1949-57. PMID: 15713648.

Meng, X., Lu, H. & Shen, Z. (2004). BCCIP Functions Through p53 to Regulate the Expression of p21Waf1/Cip1. Cell Cycle (Georgetown, Tex.), 3(11), 1457-62. PMID: 15539944.

Meng, X., Liu, J. & Shen, Z. (2004). Inhibition of G1 to S Cell Cycle Progression by BCCIPß. Cell Cycle (Georgetown, Tex.), 3(3), 343-8. PMID: 14726710.

Meng, X., Yuan, Y., Maestas, A. & Shen, Z. (2004). Recovery from DNA Damage-Induced G2 Arrest Requires Actin-Binding Protein Filamin-Actin-Binding Protein 280. The Journal of Biological Chemistry, 279(7), 6098-6105. PMID: 14660646.

Meng, X., Liu, J. & Shen, Z. (2003). Genomic Structure of the Human BCCIP Gene and Its Expression in Cancer. Gene, 302(2-Jan), 139-46. PMID: 12527204.

Liu, J., Meng, X. & Shen, Z. (2002). Association of Human RAD52 Protein with Transcription Factors. Biochemical and Biophysical Research Communications, 297(5), 1191-6. PMID: 12372413.

Meng, X., Dong, Y. & Sun, Z. (1999). ATM Plays a Role in DNA Damage Signal Transduction by Catalyzing Proteins Phosphorylation. Chinese Science Bulletin, 44(19), 1790-1794.

Meng, X., Dong, Y. & Sun, Z. (1999). Gadd45 transcription activated by p53 take roles in DNA damage surveillance in diverse ways. SCIENCE IN CHINA(Series C), 42(4), 428-434.

Meng, X., Gong, B., Mao, J., Dong, Y. & Sun, Z. (1999). LD-PCR Amplification Full Length cDNA of ATM. Bulletin of the Academy of Military Medical Sciences, 23(2), 160.

Meng, X., Sun, Z. (1999). Molecular Mechanism of Enhancement of Cellular Radiosensitivity by Wortmannin. Chinese Journal of Biochemistry and Molecular Biology, 15(4), 613-619.

Meng, X., Dong, Y. & Sun, Z. (1999). p21, Gadd45 Transcription Activated by p53 Take Roles in DNA Damage Surveillance in Diverse Ways. Science in China (Series C), 42(4), 428-434.

Meng, X., Sun, Z. (1999). Roles of p21 and Gadd45 in Human Cellular Spindle Checkpoint Regulation. Bulletin of the Academy of Military Medical Sciences, 23(2), 160-163.

Meng, X., Sun, Z. (1998). Effects of Wortmannin and 3-AB on G2 Delay and MPF Transient Failure to Dephosphorylation Induced by Radiation. Chinese Science Bulletin, 43(18), 1550-1555.

Meng, X., Ye, C. (1996). Multiple Roles of p21 in Cellular Proliferation Regulation. Progress of Biochemistry and Biophysics, 23(3), 224-228.

Meng, X., Wei, Q. (1994). Endogenous Substrates of Calcineurin (CaN) in Mice Brains. Chinese Science Bulletin, 39(12), 1750-1754.

Meng, X., Wei, Q. (1994). Proteins Phosphorylation and Dephosphorylation in Ischemia and Normal Mice Brains. Chinese Journal of Biochemistry, 10(6), 717-721.

Meng, X., Wei, Q. (1993). Calmodulin Binding Proteins in Ischemia and Control Mice Brains. Chinese Science Bulletin, 38(15), 2083-2087.