Active Grant Awards

Dr. Marco Hefti received a five-year NIH K23 grant from the National Institutes of Health/ National Institute of Neurological Disease and Stroke (NIH/NINDS). The title of the project is Novel Tau-based Diagnostics for Neonatal Hypoxic-ischemic Injury. The total direct costs for this award are $880,000. The funding period for this project is September 30, 2019 to August 31, 2024.

Dr. Nitin Karandikar received a Shared Equipment Award from the Department of Veteran Affairs. The grant is entitled ShEEP Request for Cytek AURORA Spectral Flow Cytometer. The total direct costs for this award are $422,500. The entire period for this award is September 1, 2019 through September 30, 2020.

Dr. Vladimir Badovinac received a two-year NIH R21 grant from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of the project is Differentiation of Pathogen-Specific Memory CD8 T Cell Responses. The total direct costs for this award are $275,000. The entire period for this project is May 22, 2019 through April 30, 2021.

Dr. Ling-Zhi Liu was awarded a Pilot Grant Award from the Environmental Health Sciences Research Center (EHSRC) at the University of Iowa. The title of the project is Establishment of a Cr(VI) Exposure Animal Model to Study Abnormal miR-27/Nrf2 and CXCL5 Pathways and Epigenetic Regulation. The total direct costs for this award are $40,000. The funding period for this project is April 1, 2019 to March 31, 2020.

Dr. Dao-Fu Dai received a five-year NIH K08 grant from the National Institutes of Health/National Heart, Lung and Blood Institute (NIH/NHLBI). The title of the project is The Role of Energy Sensor Signaling in Mitochondrial Cardiomyopathy. The total direct costs for this award are $803,140. The funding period for this project is February 1, 2019 to December 31, 2023.

Dr. Chen Zhao received a four-year Merit Award grant from the Department of Veteran Affairs. The title of this project is Synergy of NF-kB and Notch signaling in B cell lymphomatous transformation and B cell plasticity. The total direct costs for this award are $650,000. The funding period for this project is January 1, 2019 to December 31, 2022.

Dr. Dao-Fu Dai received a seed grant from the Holden Comprehensive Cancer Center’s Institutional Research Grant program sponsored by the American Cancer Society. The title of the project is The spectrum of myeloma associated kidney diseases and the role of mitochondrial oxidative stress. The total direct costs for this award are $30,000. The funding period for this project is September 1, 2018 to August 31, 2019.

Dr. Ashu Mangalam and Dr. Edward Filardo ( Department of Surgery) received a seed grant award from the Center for Biocatalysis and Bioprocessing (CBB) at the University of Iowa. The title of the project is Harnessing Gut Microbiome-mediated Metabolism of the Natural Isoflavone Daidzein to Treat Breast Cancer. The total funding for this award is $35,000 and the project period is August 1, 2018 through July 31, 2019.

Drs. Vladimir Badovinac and Kevin Legge were awarded a Carver Trust Collaborative Pilot Grant from the College of Medicine. The title of the project is Impairment and Recovery of Dendritic Cell Immunity after Sepsis. The total funding for this award is $50,000 and the project period is July 1, 2018 through June 30, 2020.

Dr. Bing-Hua Jiang received R01 grant funding from the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS). The title of the grant is Chromium in carcinogenesis and angiogenesis. The total direct funding for this award is $1,085,880 and the project period is July 1, 2018 through June 30, 2023.

Drs. Bing-Hua Jiang and Ling-Zhi Liu (Co-PIs) received R01 grant funding from the National Institutes of Health/National Cancer Institute (NIH/NCI). The title of the grant is Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatments. The total direct funding for this award is $1,977,035 and the project period is July 1, 2018 through June 30, 2023.

Dr. Michael Knudson received contract award funding from Terumo Corporation as part of a multi-institutional study investigating platelet transfusions. The title of the award is Clinical Effectiveness of Conventional Versus Mirasol-treated Apheresis Platelets in Patients with Hypoproliferative Thrombocytopenia (MIPLATE). The total direct funding for this award is $1,100,000 and the project period is December 13, 2017 through December 31, 2020.

Dr. Ling-Zhi Liu received a five-year NIH K02 award from the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/ NIEHS). The title of this project is New Mechanism of Arsenic Carcinogenesis. The total direct costs for this award are $567,190. The entire period for this project is April 1, 2018 through March 31, 2023.

Dr. Ashu Mangalam received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of the grant is Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune Encephalitis. The total direct funding for this award is $1,000,000 and the project period is February 15, 2018 through January 31, 2023.

Drs. Kevin Legge and Thomas Waldschmidt received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this grant is Nanovaccine-Mediated Immune Protection Against Influenza Virus. The total direct funding for this award is $2,226,287 and the project period is June 1, 2017 through May 31, 2022.

Dr. Hasem Habelhah received a two-year NIH R21 grant from the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS). The title of this project is HtrA2-mediated RIP1 Cleavage Regulates Neuronal Inflammation and Death. The total direct costs for this award are $275,000. The entire period for this project is June 1, 2017 through May 31, 2020.

Dr. Nitin Karandikar received Merit Award grant funding from the Department of Veteran Affairs. The title of this project is Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease. The total direct costs for this award are $650,000. The entire period for this project is July 1, 2017 through June 30, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Regulation of Innate Immune System Sensing of C. Albicans Infections. The total direct costs for this award are $1,395,000. The entire period for this project is April 1, 2016 through March 31, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is NEDD4 in T Helper Cell Development and Autoimmunity. The total direct costs for this award are $1,657,000. The entire period for this project is June 20, 2016 through May 31, 2021.

Dr. Jian Zhang received grant funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Role of Protein Ubiquitination in Sepsis. The total direct costs for this award are $1,125,000. The entire period for this project is June 24, 2016 through May 31, 2021.

Dr. Munir Tanas received Merit Award grant funding from the Department of Veteran Affairs. The title of this project is Upstream regulation of TAZ and YAP in sarcomas: towards combinatorial therapy targeting the Hippo Pathway. The total direct costs for this award are $631,572. The entire period for this project is January 1, 2017 through December 31, 2020.

Dr. Nitin Karandikar received grant funding from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). The title of this project is Immune Dysregulation During Multiple Sclerosis Relapse. The total direct costs for this award are $2,401,480. The period for this project is May 19, 2016 through April 30, 2021.

Dr. David Meyerholz has a new research contract negotiated with the Children’s Tumor Foundation for a research project titled The NF1 Porcine Model Collaborative Research Program. The contract total is $931,395. This contract is for the period of October 1, 2015 through August 31, 2019.

Dr. Vladimir Badovinac received grant funding from the National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS). The title of this project is Impairment and Recovery of CD8 T Cell Responses after Sepsis. This funding total is $1,203,872 and is for the period of September 1, 2015 and should be complete by July 31, 2019.

Dr. Hasem Habelhah received grant funding from the US Department of Defense/Congressionally Directed Medical Research Program (DOD/CDMRP). The title of this project is Therapeutic Efficacy of Combined TBK1 and AKT Inhibition in Breast Cancer. This funding total is $531,875 and is for the period of September 1, 2015 and should be complete by August 31, 2019.

Dr. Vladimir Badovinac received a Co-PI grant funding with Dr. John Harty from the Department of Microbiology.  The grant was awarded from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID).  The title of this project is Memory CD8 T cell localization and protection from influenza.   This funding total is $1,900,000 and is for the period of November 1, 2014 and should be complete by October 31, 2019.

Dr. Andrean Simons-Burnett received grant funding from the National Institutes of Health/National Institute of Dental & Craniofacial Research (NIH/NIDCR). The title of this project is Role of inflammation in resistance to EGFR inhibitors in head and neck cancer. This funding total is $1,878,808 and is for the period of July 2, 2014 and should be complete by April 30, 2020.