Aliye Uc, MD
Introduction
Dr. Uc is a Pediatric Gastroenterologist with clinical and research focus in Cystic Fibrosis (CF)-related pancreatic disease, and acute and chronic pancreatitis in children. Her laboratory focuses on dissecting the mechanisms of pancreatic damage and inflammation in CF pigs and development of gene therapies to the pig pancreas. She described that the CF pigs had an increased immune and inflammatory response in their pancreas that could be responsible of ongoing injury. She coauthored publications with Dr. Michael Welsh's group describing the phenotype of CF pig model. She is collaborating with Drs. Engelhardt and Norris on better understanding the pathogenesis of CF-related diabetes (CFRD) using the CF pig and ferret models. She is also the chair and the founding member of INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cure) with the task of studying the epidemiology, etiology, natural history and outcomes of pediatric pancreatitis, a disease without clear diagnostic parameters and treatment alternatives in children. In this context, she is developing a data registry, sample repository, and longitudinal studies on pediatric pancreatitis. University of Iowa is the coordinating center for this NIH-funded multicenter study with 14 other centers providing patients, data and biological samples. This constitutes the first initiative to create a multi-center approach to systematically characterize pancreatitis in children.
Current Positions
- Professor of Pediatrics - Gastroenterology
- Professor of Radiation Oncology
- Division Director, Pediatric Gastroenterology, Hepatology, Pancreatology and Nutrition
- Center Director, National Pancreas Foundation, Pancreatitis Center of Excellence
Education
- MD in Medicine, Istanbul University School of Medicine, Istanbul, Turkey
- Resident in Pediatrics, Hacettepe University Children's Hospital, Ankara, Turkey
- Resident in PL3, Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa
- Fellow in Pediatric Gastroenterology, University of Iowa Children's Hospital, Iowa City, Iowa
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- 1. To understand the mechanisms of exocrine and endocrine pancreatic disease in cystic fibrosis using pig and ferret models.
- 2. To develop diagnostic modalities, prognostic factors, and innovative treatment approaches for pediatric acute recurrent and chronic pancreatitis.
Licenses & Certifications
- FLEX
- FMGEMS
- Board Certification in Pediatrics, Turkey
- Turkey Permanent Medical License
- Arkansas Medical License (lapsed)
- American Board of Pediatrics
- Iowa Permanent Medical License
- Iowa Medical License
- American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
Selected Publications
- Freeman AJ, Ng K, Wang F, Abu-El-Haija MA, Chugh A, Cress GA, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska TY, Grover AS, Lindblad D, Liu QY, Maqbool A, Mark JA, McFerron BA, Mehta MS, Morinville VD, Noel RA, Ooi CY, Perito ER, Schwarzenberg SJ, Sellers ZM, Wilschanski M, Zheng Y, Yuan Y, Andersen DK, Lowe ME, Uc A; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Pancreatic Enzyme Use Reduces Pancreatitis Frequency in Children With Acute Recurrent or Chronic Pancreatitis: A Report From INSPPIRE. Am J Gastroenterol. 2024 Oct 1;119(10):2094-2102. doi: 10.14309/ajg.0000000000002772. Epub 2024 Mar 22. PMID: 38517077.
- Sellers ZM, Giefer MJ, Wang F, Cress GA, Abu-El-Haija MA, Chugh A, Cohen RZ, Downs EM, Fishman DS, Freeman AJ, Gariepy CE, Gonska TY, Grover AS, Lindblad D, Liu QY, Maqbool A, Mark JA, McFerron BA, Mehta MS, Morinville VD, Ng K, Noel RA, Ooi CY, Perito ER, Phadke MY, Ruan W, Schwarzenberg SJ, Troendle DM, Wilschanski M, Zheng Y, Yuan Y, Lowe ME, Uc A; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Impact of Elevated Serum Triglycerides on Children with Acute Recurrent or Chronic Pancreatitis from INSPPIRE-2. J Pediatr. 2024 Sep 12;276:114298. doi: 10.1016/j.jpeds.2024.114298. Epub ahead of print. PMID: 39277078.
- Cress GA, Scudiero KT, Wang F, Patrick VB, Wood PM, Yuan Y, Lowe ME, Uc A; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). PATIENT AND FAMILY INPUT TO DETERMINE EXPERIENCES AND RESEARCH INTERESTS IN PEDIATRIC PANCREATITIS: AN INSPPIRE-2 STUDY. Pancreas. 2024 Sep 12. doi: 10.1097/MPA.0000000000002390. Epub ahead of print. PMID: 39259842.
- Sándor M, Scheers I, Masamune A, Witt H, LaRusch J, Chen JM, Németh BC, Geisz A, Uc A, Sahin-Tóth M. AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases. Gut. 2024 Sep 10:gutjnl-2024-333697. doi: 10.1136/gutjnl-2024-333697. Epub ahead of print. PMID: 39256032.
- Uc A, Lowe ME. What's in the life of children with chronic pancreatitis? Pancreatology. 2024 Sep;24(6):815-816. doi: 10.1016/j.pan.2024.08.012. Epub 2024 Aug 15. PMID: 39168773.
- Freeman AJ, Ng K, Wang F, Yuan Y, Lowe ME, Uc A; INSPPIRE and CPDPC Study Teams. Reply to Yi et al. Am J Gastroenterol. 2024 Jul 12. doi: 10.14309/ajg.0000000000002888. Epub ahead of print. PMID: 38994839.
- Subramani SS, Berg AC, Kral LA, Murad MH, Smith A, Phillips AE, Yadav D, Uc A, Imdad A. Analgesia for the treatment of acute pancreatitis: a protocol for a systematic review and network meta-analysis. BMJ Open. 2024 May 13;14(5):e081971. doi: 10.1136/bmjopen-2023-081971. PMID: 38740508.
- Abu-El-Haija M, Hornung L, Ellery K, Fishman DS, Gonska TY, Gariepy C, Lowe M, Larson Ode K, Maqbool A, Mascarenhas M, Morinville VD, Ooi CY, Perito ER, Schwarzenberg SJ, Sellers ZM, Zemel BS, Yuan Y, Wang F, Uc A, Kalkwarf HJ; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis. Pancreatology. 2023 Nov;23(7):755-760. doi: 10.1016/j.pan.2023.08.006. Epub 2023 Aug 31. PMID: 37723006.
- O'Malley Y, Zarei K, Vanegas OGC, Singh P, Apak TI, Coleman M, Thornell IM, Uc A. Pancreatic duct organoid swelling is chloride-dependent. J Cyst Fibros. 2024 Jan;23(1):169-171. doi: 10.1016/j.jcf.2023.08.003. Epub 2023 Aug 24. PMID: 37633792.
- Morinville VD, Husain SZ, Wang F, Cress GA, Abu-El-Haija M, Chugh A, Downs E, Ellery K, Fishman DS, Freeman AJ, Gariepy CE, Giefer M, Gonska T, Liu Q, Maqbool A, Mark J, Mcferron BA, Mehta M, Nathan JD, Ng K, Ooi CY, Perito E, Ruan W, Schwarzenberg SJ, Sellers ZM, Serrano J, Troendle DM, Wilschanski M, Zheng Y, Yuan Y, Lowe M, Uc A; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC). Pediatric Drug-Associated Pancreatitis Reveals Concomitant Risk Factors and Poor Reliability of Causality Scoring: Report From INSPPIRE. J Pediatr Gastroenterol Nutr. 2023 Oct 1;77(4):540-546. doi: 10.1097/MPG.0000000000003898. Epub 2023 Jul 27. PMID: 37496124.