Aliye Uc, MD

Division Director
Professor of Pediatrics - Gastroenterology
Professor of Radiation Oncology

Contact Information

Primary Office
1120-C Boyd Tower
200 Hawkins Drive
Iowa City, IA 52242


MD, Medicine, Istanbul University School of Medicine
Resident, Pediatrics, Hacettepe University Children's Hospital
Resident, PL3, Pediatrics, University of Iowa Hospitals and Clinics
Fellow, Pediatric Gastroenterology, University of Iowa Children's Hospital

Licensure and Certifications

Board Certification in Pediatrics, Turkey
Turkey Permanent Medical License

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases

Research Summary

Dr. Uc is a Pediatric Gastroenterologist with clinical and research focus in Cystic Fibrosis (CF)-related pancreatic disease, and acute and chronic pancreatitis in children. Her laboratory focuses on dissecting the mechanisms of pancreatic damage and inflammation in CF pigs and development of gene therapies to the pig pancreas. She described that the CF pigs had an increased immune and inflammatory response in their pancreas that could be responsible of ongoing injury. She coauthored publications with Dr. Michael Welsh’s group describing the phenotype of CF pig model. She is collaborating with Drs. Engelhardt and Norris on better understanding the pathogenesis of CF-related diabetes (CFRD) using the CF pig and ferret models. She is also the chair and the founding member of INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cure) with the task of studying the epidemiology, etiology, natural history and outcomes of pediatric pancreatitis, a disease without clear diagnostic parameters and treatment alternatives in children. In this context, she is developing a data registry, sample repository, and longitudinal studies on pediatric pancreatitis. University of Iowa is the coordinating center for this NIH-funded multicenter study with 14 other centers providing patients, data and biological samples. This constitutes the first initiative to create a multi-center approach to systematically characterize pancreatitis in children.