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John Dagle, MD, PhD

Professor of Pediatrics-Neonatology

Introduction

Dr. Dagle studied chemistry at Creighton University in Omaha, Nebraska (1984) before earning his Doctor of Medicine and Doctor of Philosophy in Biochemistry degrees at the UI Carver College of Medicine in 1991. After graduation, he completed his Pediatrics residency (1994) and Neonatal-Perinatal Medicine fellowship (1997) at University of Iowa Health Care.

Dr. Dagle joined the faculty of Pediatrics in 1998 with additions to the Biochemistry Department in 2006 and Epidemiology in 2018. He has previously served in leadership of the Neonatal Transport Program (1998-2012) and Neonatal-Perinatal Medicine Fellowship Program (2010-2019). Currently, he is the Co-Director of the Iowa Statewide Perinatal Care Program (2019 to present) and Interim Medical Director for the NICU.

His clinical interests include optimization of nutrition in the late preterm infant, understanding the synergistic roles of probiotics and breast milk in the newborn, and promoting public health initiatives to improve the outcomes of infants across Iowa.

Current Positions

  • Professor of Pediatrics - Neonatology
  • Professor of Epidemiology
  • Co-Director, Iowa Statewide Perinatal Care Program
  • Interim Medical Director, Neonatal Intensive Care Unit

Education

  • BS in Chemistry, Creighton University, Omaha, Nebraska
  • PhD in Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa
  • MD in Medicine, University of Iowa College of Medicine, Iowa City, Iowa
  • Resident in Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa
  • Fellow in Neonatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Graduate Program Affiliations

Research Interests

  • Genetic risk factors for the morbidities of prematurity
  • Genetics of premature delivery
  • Evaluation of environmental and genetic factors associated with preterm delivery and its complications

Licenses & Certifications

  • Iowa Medical License
  • Neonatal Perinatal Medicine, American Board of Pediatrics
  • Iowa Permanent License
  • American Board of Pediatrics, Sub-board of Neonatal-Perinatal Medicine
  • American Board of Pediatrics

Selected Publications

  • Barnard C. R., Peters M., Sindler A. L., Farrell E. T., Baker K. R., Palta M., Stauss H. M., Dagle J. M., Segar J., Pierce G. L., Eldridge M.W., Bates M.L. (2020) Increased aortic stiffness and elevated blood pressure in response to exercise in adult survivors of prematurity. Physiol Rep (12):e14462 PMID: 32562387 DOI: 10.14814/phy2.14462
  • Dagle, J. M., Bell, E. F., Colaizy, T. T. & Watkins, P. L. (2019). Outcomes at 18 to 22 Months of Corrected Age for Infants Born at 22 to 25 Weeks of Gestation in a Center Practicing Active Management. The Journal of pediatrics. PMID: 31606151. DOI: 10.1016/j.jpeds.2019.08.028.
  • Smith, C. J., Jasper, E. A., Baer, R. J., Breheny, P. J., Paynter, R. A., Bao, W., Robinson, J. G., Dagle, J. M., Jelliffe-Pawlowski, L. L. & Ryckman, K. K. (2019). Genetic Risk Scores for Maternal Lipid Levels and Their Association with Preterm Birth. Lipids 54 (10) 641-650. DOI: 10.1002/lipd.12186. PMID: 31468542.
  • Rooney, S. R., Shelton, E. L., Aka, I., Shaffer, C. M., Clyman, R. I., Dagle, J. M., Ryckman, K., Lewis, T. R., Reese, J., Van Driest, S. L. & Kannankeril, P. J. (2019). CYP2C9*2 is associated with indomethacin treatment failure for patent ductus arteriosus. Pharmacogenomics 20 (13) 939-946. DOI: 10.2217/pgs-2019-0079. PMID: 31486736. PMCID: PMC6817966.
  • Smith, C. J., Baer, R. J., Oltman, S. P., Breheny, P. J., Bao, W., Robinson, J. G., Dagle, J. M., Liang, L., Feuer, S. K., Chambers, C. D., Jelliffe-Pawlowski, L. L. & Ryckman, K. K. (2018). Maternal dyslipidemia and risk for preterm birth. PloS one 13 (12) e0209579. DOI: 10.1371/journal.pone.0209579. PMID: 30576377. PMCID: PMC6303099.
  • Dagle, J. M., Ryckman, K. K., Spracklen, C. N., Momany, A. M., Cotten, C. M., Levy, J., Page, G. P., Bell, E. F., Carlo, W. A., Shankaran, S., Goldberg, R. N., Ehrenkranz, R. A., Tyson, J. E., Stoll, B. J. & Murray, J. C. (2018). Genetic variants associated with patent ductus arteriosus in extremely preterm infants. Journal of perinatology : official journal of the California Perinatal Association. DOI: 10.1038/s41372-018-0285-6. PMID: 30518802.
  • Segar, D. E., Segar, E. K., Harshman, L. A., Dagle, J. M., Carlson, S. J. & Segar, J. L. (2018). Physiological Approach to Sodium Supplementation in Preterm Infants. American journal of perinatology 35 (10) 994-1000. DOI: 10.1055/s-0038-1632366. PMID: 29486497. PMCID: PMC6059989.
  • Kaluarachchi, D. C., Smith, C. J., Klein, J. M., Murray, J. C., Dagle, J. M. & Ryckman, K. K. (2018). Polymorphisms in urea cycle enzyme genes are associated with persistent pulmonary hypertension of the newborn. Pediatric research 83 (1-1) 142-147. DOI: 10.1038/pr.2017.143. PMID: 28609431. PMCID: PMC5811332.
  • Smith, C. J., Ryckman, K. K., Bahr, T. M. & Dagle, J. M. (2017). Polymorphisms in CYP2C9 are associated with response to indomethacin among neonates with patent ductus arteriosus. Pediatric research 82 (5) 776-780. DOI: 10.1038/pr.2017.145. PMID: 28609430. PMCID: PMC5645220.
  • Boghossian, N. S., Do, B. T., Bell, E. F., Dagle, J. M., Brumbaugh, J. E., Stoll, B. J., Vohr, B. R., Das, A., Shankaran, S., Sanchez, P. J., Wyckoff, M. H. & Bethany Ball, M. (2017). Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infants. Early human development 113 10-17. DOI: 10.1016/j.earlhumdev.2017.07.011. PMID: 28697406. PMCID: PMC5654678.