Lyndsay Harshman, MD, MS
Introduction
Chronic kidney disease (CKD) is characterized by disruption of somatic growth, bone/mineral metabolism, nutritional derangement, and electrolyte disturbances. These patterns of change can be seen even in early CKD with emerging data to suggest that there is also an association with change in neurocognitive function in even mild to moderate CKD. Specifically, children with CKD may be at risk for deficits in executive function and academic achievement with advancing disease, although the mechanisms related to this are unclear. Even more unclear is whether or not there are structural and/or functional changes within the brain in parallel with these observed neurocognitive deficits. My research focuses on linking neuroimaging and neurocognitive assessments in this population to inform greater understanding of changes that may be occurring in the developing brain in parallel with progression of CKD. A greater understanding of the neurocognitive changes observed in this population will allow for targeted provider assistance with patient/family medical decision-making and medication compliance.
Current Positions
- Associate Professor of Pediatrics - Nephrology, Dialysis and Transplantation
- Medical Director, Pediatric Kidney Transplant
- Director, Pediatrics Physician Scientist Training Pathway
- Assistant Professor of Radiation Oncology
Education
- BS in Bachelor of Science in Psychology, University of Iowa, Iowa City, Iowa, United States
- MD in Doctor of Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
- Masters in Translational Biomedicine in Translational Biomedicine, University of Iowa, Iowa City, Iowa, United States
- Fellow in Doris Duke Clinical Research Fellowship, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
- Resident in Physician Scientist Training Pathway, University of Iowa Stead Family Department of Pediatrics, Iowa City, Iowa, United States
- Fellow in Division of Pediatric Nephrology, Dialysis and Transplantation, University of Iowa Stead Family Department of Pediatrics, Iowa City, Iowa, United States
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Neurocognitive Outcomes and Neuroimaging in Chronic Kidney Disease
Licenses & Certifications
- Medical License of Iowa
- Federal DEA
- Board Certified - American Board of Pediatrics
- Basic Life Support
- Medical License
- Board Certified - American Board of Pediatrics, Certification of Pediatric Nephrology
Selected Publications
- Varnell C Jr, Harshman LA, Liu C, Smith L, Al-Akash S, Barletta GM, Brakeman P, Chaudhuri A, Fadakar P, Galea L, Garro R, Gluck C, Kershaw DB, Matossian D, Patel HP, Peterson C, Pruette C, Ranabothu S, Rodig N, Singer P, Sebestyen VanSickle J, Weng PL, Danziger-Isakov L, Seifert ME, Hooper DK. COVID-19 in pediatric kidney transplantation: a follow-up report of the Improving Renal Outcomes Collaborative. Pediatr Nephrol. 2023 Feb;38(2):537-547. doi: 10.1007/s00467-022-05570-w. Epub 2022 May 11. PMID: 35538239; PMCID: PMC9090538.
- Swanson MB, Weidemann DK, Harshman LA. The impact of rural status on pediatric chronic kidney disease. Pediatr Nephrol. 2024 Feb;39(2):435-446. doi: 10.1007/s00467-023-06001-0. Epub 2023 May 13. PMID: 37178207; PMCID: PMC10182542.
- Harshman LA, Ward RC, Matheson MB, Dawson A, Kogon AJ, Lande MB, Molitor SJ, Johnson RJ, Wilson C, Warady BA, Furth SL, Hooper SR. The Impact of Pediatric CKD on Educational and Employment Outcomes. Kidney360. 2023 Oct 1;4(10):1389-1396. doi: 10.34067/KID.0000000000000206. Epub 2023 Jul 7. PMID: 37418621; PMCID: PMC10615373.
- Carlson J, Gerson AC, Matheson MB, Manne S, Lande M, Harshman L, Johnson RJ, Shinnar S, Kogon AJ, Warady B, Furth S, Hooper S. Longitudinal changes of health-related quality of life in childhood chronic kidney disease. Pediatr Nephrol. 2023 Dec;38(12):4127-4136. doi: 10.1007/s00467-023-06069-8. Epub 2023 Jul 10. PMID: 37428223; PMCID: PMC10591962.
- Verhofste SL, Conrad AL, Johnson RJ, Steinbach EJ, Staber JM, Harshman LA. Self-concept and academic achievement in children with chronic kidney disease. Pediatr Nephrol. 2024 Mar;39(3):819-827. doi: 10.1007/s00467-023-06106-6. Epub 2023 Aug 18. PMID: 37594577; PMCID: PMC10999179.
- Engen RM, Bartosh SM, Smith JM, Perkins JD, Harshman LA. Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy. Am J Transplant. 2024 Jan;24(1):37-45. doi: 10.1016/j.ajt.2023.08.007. Epub 2023 Aug 16. PMID: 37595842.
- Lullmann O, van der Plas E, Harshman LA. Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature. Pediatr Transplant. 2023 Dec;27(8):e14597. doi: 10.1111/petr.14597. Epub 2023 Sep 4. PMID: 37664967; PMCID: PMC11034761.
- Rheault MN, Amaral S, Bock M, Chambers ET, Chavers B, Ters ME, Garro R, Gbadegesin R, Govil A, Harshman L, Amer H, Hooper DK, Israni AK, Riad S, Sageshima J, Shapiro R, Seifert M, Smith J, Sung R, Thomas CP, Wang Q, Verghese PS. A randomized controlled trial of preemptive rituximab to prevent recurrent focal segmental glomerulosclerosis post-kidney transplant (PRI-VENT FSGS): protocol and study design. Front Nephrol. 2023 May 15;3:1181076. doi: 10.3389/fneph.2023.1181076. PMID: 37675355; PMCID: PMC10479749.
- Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A, Burns A, Orange JS; NPSCW. National Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists. Pediatr Res. 2024 Jan;95(1):70-74. doi: 10.1038/s41390-023-02795-9. Epub 2023 Sep 8. PMID: 37684431.
- Moudgil A, Sgambat K, Benoit E, Seifert ME, Bharadwaj M, Jain A, Mansuri A, Harshman L, Katsoufis C, Somers M. Prevalence of mycophenolate mofetil discontinuation and subsequent outcomes in pediatric kidney transplant recipients: A PNRC study. Pediatr Transplant. 2024 Feb;28(1):e14628. doi: 10.1111/petr.14628. Epub 2023 Oct 25. PMID: 37877312.