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Melanie Wellington, MD, PhD

Portrait
Associate Hospital Epidemiologist
Clinical Associate Professor of Pediatrics - Infectious Disease

Contact Information

Primary Office
2040B Medical Laboratories (ML)
200 Hawkins Drive
Iowa City, IA 52242
319-356-2270

Education

BS, Biology, Brown University
MS, Cell Biology, Duke University
MD, Medicine, Duke University
PhD, Microbiology and Immunology, University of Rochester
Resident, University of Rochester School of Medicine & Dentistry
Fellow, University of Rochester School of Medicine and Dentistry

Licensure and Certifications

American Board of Pediatrics; Pediatric Infectious Disease
American Board of Pediatrics; General Pediatrics

Publications

O'Meara, T. R., Duah, K., Guo, C. X., Maxson, M. E., Gaudet, R. G., Koselny, K., Wellington, M., Powers, M. E., MacAlpine, J., O'Meara, M. J., Veri, A. O., Grinstein, S., Noble, S. M., Krysan, D., Gray-Owen, S. D. & Cowen, L. E. (2018). High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. mBio, 9(4). PMID: 30131363.

Koselny, K., Mutlu, N., Minard, A. Y., Kumar, A., Krysan, D. J. & Wellington, M. (2018). A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis. mBio, 9(4). PMID: 30065091.

Glazier, V. E., Murante, T., Koselny, K., Murante, D., Esqueda, M., Wall, G. A., Wellington, M., Hung, C. Y., Kumar, A. & Krysan, D. J. (2018). Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes. G3 (Bethesda, Md.), 8(4), 1299-1314. PMID: 29472308.

Chang, Y. L., Yu, S. J., Heitman, J., Wellington, M. & Chen, Y. L. (2017). New facets of antifungal therapy. Virulence, 8(2), 222-236. PMID: 27820668.

Krysan, D. J., Sutterwala, F. S. & Wellington, M. (2014). Catching fire: Candida albicans, macrophages, and pyroptosis. PLoS pathogens, 10(6), e1004139. PMID: 24967821.

Harrison, B. D., Hashemi, J., Bibi, M., Pulver, R., Bavli, D., Nahmias, Y., Wellington, M., Sapiro, G. & Berman, J. (2014). A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. PLoS biology, 12(3), e1001815. PMID: 24642609.

Butts, A., Koselny, K., Chabrier-Roselló, Y., Semighini, C. P., Brown, J. C., Wang, X., Annadurai, S., DiDone, L., Tabroff, J., Childers, Jr, W. E., Abou-Gharbia, M., Wellington, M., Cardenas, M. E., Madhani, H. D., Heitman, J. & Krysan, D. J. (2014). Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. mBio, 5(1), e00765-13. PMID: 24520056.

Wellington, M., Koselny, K., Sutterwala, F. S. & Krysan, D. J. (2014). Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryotic cell, 13(2), 329-40. PMID: 24376002.

Butts, A., DiDone, L., Koselny, K., Baxter, B. K., Chabrier-Rosello, Y., Wellington, M. & Krysan, D. J. (2013). A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis. Eukaryotic cell, 12(2), 278-87. PMID: 23243064.

Wellington, M., Koselny, K. & Krysan, D. J. (2012). Candida albicans morphogenesis is not required for macrophage interleukin 1ß production. mBio, 4(1), e00433-12. PMID: 23269828.

Kajfasz, J. K., Mendoza, J. E., Gaca, A. O., Miller, J. H., Koselny, K. A., Giambiagi-Demarval, M., Wellington, M., Abranches, J. & Lemos, J. A. (2012). The Spx regulator modulates stress responses and virulence in Enterococcus faecalis. Infection and immunity, 80(7), 2265-75. PMID: 22508863.

Mitra, S., Dolan, K., Foster, T. H. & Wellington, M. (2010). Imaging morphogenesis of Candida albicans during infection in a live animal. (Vols. 15). (1), pp. 010504. Journal of biomedical optics. PMID: 20210419.

Van Alst, N. E., Wellington, M., Clark, V. L., Haidaris, C. G. & Iglewski, B. H. (2009). Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa. Infection and immunity, 77(10), 4446-54. PMID: 19651860.

Dolan, K., Montgomery, S., Buchheit, B., Didone, L., Wellington, M. & Krysan, D. J. (2009). Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization. Antimicrobial agents and chemotherapy, 53(8), 3337-46. PMID: 19487443.

Wellington, M., Dolan, K. & Krysan, D. J. (2009). Live Candida albicans suppresses production of reactive oxygen species in phagocytes. Infection and immunity, 77(1), 405-13. PMID: 18981256.

Wellington, M., Dolan, K. & Haidaris, C. G. (2007). Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition. FEMS immunology and medical microbiology, 51(1), 70-83. PMID: 17610517.

Wellington, M., Kabir, M. A. & Rustchenko, E. (2006). 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans. Mycologia, 98(3), 393-8. PMID: 17040068.

Wellington, M. A., Bonnez, W. (2005). Consultation with the specialist: genital warts. Pediatrics in review, 26(12), 467-71. PMID: 16330462.

Wellington, M., Rustchenko, E. (2005). 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans. Yeast (Chichester, England), 22(1), 57-70. PMID: 15635674.

Wang, Y. K., Das, B., Huber, D. H., Wellington, M., Kabir, M. A., Sherman, F. & Rustchenko, E. (2004). Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans. Yeast (Chichester, England), 21(8), 685-702. PMID: 15197733.

Wellington, M., Bliss, J. M. & Haidaris, C. G. (2003). Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infection and immunity, 71(12), 7228-31. PMID: 14638823.

Bliss, J. M., Wellington, M. & Gigliotti, F. (2003). Antifungal pharmacotherapy for neonatal candidiasis. Seminars in perinatology, 27(5), 365-74. PMID: 14626500.

Wellington, M., Hall, C. B. (2002). Pacifier as a risk factor for acute otitis media. (Vols. 109). (2), pp. 351-2; author reply 353. Pediatrics. PMID: 11826228.

Wellington, M., Gigliotti, F. (2001). Update on antifungal agents. The Pediatric infectious disease journal, 20(10), 993-5. PMID: 11642635.