Melanie Wellington, MD, PhD
Introduction
Dr. Wellington is a physician scientist whose research focuses on the interaction of the host with human fungal pathogens. Her research uses novel confocal microscopy techniques to directly visualize fungal organisms growing within host tissue. This allows for the study of fungal genetic factors that regulate pathogenesis in the mammalian host. She also studies host inflammatory responses to fungi, including the role of interleukin-1 alpha and beta in host responses to Candida albicans.
Dr. Wellington also has a clinical and research interest in prevention of healthcare associated infections. She is a member of the UIHC Program of Hospital Epidemiology and is the Associate Hospital Epidemiologist who focuses on infection prevention in the Stead Family Children’s Hospital.
Current Positions
- Clinical Professor of Pediatric - Infectious Diseases
- Associate Hospital Epidemiologist
Education
- ScB in Biology, Brown University, Providence, Rhode Island
- MS in Cell Biology, Duke University, Durham, North Carolina
- MD in Medicine, Duke University, Durham, North Carolina
- PhD in Microbiology and Immunology, University of Rochester, Rochester, New York
- Pediatrics, University of Rochester School of Medicine & Dentistry, Rochester, New York
- Pediatric Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester, New York
Research Interests
- Programmed Cell Death Pathways in Phagocyte Responses to Candida
- Development of Novel Antifungal Drugs
- Host Pathogen Interactions in Candida infections
Licenses & Certifications
- American Board of Pediatrics; Pediatric Infectious Diseases
- American Board of Pediatrics; General Pediatrics
- American Board of Pediatrics; Pediatric Infectious Disease
- New York State Medical Board
- Iowa Board of Medicine
Selected Publications
- Santhanam H, Muthukumarasamy N, Hsieh MK, Brust K, Wellington M, Naito T, Samuelson RJ, Marra AR, Kobayashi T. Systematic review and meta-analysis of the impact of infectious diseases consultation on outcomes of Staphylococcus aureus bacteremia in children. Antimicrob Steward Healthc Epidemiol. 2024 Nov 11;4(1):e199. doi: 10.1017/ash.2024.450. PMID: 39563922.
- Abosi OJ, Trannel A, Schwartzhoff P, Ackman M, Zilles B, Marra AR, Dains A, Naito T, Salinas JL, Diekema DJ, Hanna B, Murphy JP, Wellington M, Brust K, Kobayashi T. A review of extended coronavirus disease 2019 (COVID-19) isolation duration among inpatients in a tertiary-care hospital-Iowa, 2020-2022. Infect Control Hosp Epidemiol. 2024 Jan;45(1):110-113. doi: 10.1017/ice.2023.154. Epub 2023 Aug 2. PMID: 37528757.
- Kramara J, Kim M-J, Ollinger TL, Ristow LC, Wakade RS, Zarnowski R, Wellington M, Andes DR, Mitchell AG, Krysan DJ. Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in vitro and in vivo. mBio. 2024 Aug 14;15(8):e0124924. doi: 10.1128/mbio.01249-24. Epub 2024 Jul 1. PMID: 38949302.
- Wakade RS, Wellington M, Krysan DJ. Temporal dynamics of Candida albicans morphogenesis and gene expression reveals distinctions between in vitro and in vivo filamentation. mSphere. 2024 Apr 23;9(4):e0011024. doi: 10.1128/msphere.00110-24. Epub 2024 Mar 19. PMID: 38501830.
- Harrington EM, Trautman K, Davis MB, Varzavand K, Meacham H, Dains A, Marra AR, McDanel J, Kenne L, Hanna B, Murphy JP, Diekema DJ, Wellington M, Brust KB, Kobayashi T, Abosi OJ. Descriptive epidemiology of central line-associated bloodstream infections at an academic medical center in Iowa, 2019-2022. Am J Infect Control. 2024 Apr;52(4):436-442. doi: 10.1016/j.ajic.2023.09.021. Epub 2023 Oct 10. PMID: 37827243.
- Wakade RS, Wellington M, Krysan DJ. The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent. mSphere. 2024 Mar 26;9(3):e0078523. doi: 10.1128/msphere.00785-23. Epub 2024 Feb 20. PMID: 38376205.
- Nielson JA, Jezewski AJ, Wellington M, Davis JM. Survival in macrophages induces enhanced virulence in Cryptococcus. mSphere. 2024 Jan 30;9(1):e0050423. doi: 10.1128/msphere.00504-23. Epub 2023 Dec 11. PMID: 38073033.
- Glazier VE, Kramara J, Ollinger T, Solis NV, Zarnowski R, Wakade RS, Kim MJ, Weigel GJ, Liang SH, Bennett RJ, Wellington M, Andes DR, Stamnes MA, Filler SG, Krysan DJ. The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism. bioRxiv [Preprint]. 2023 Jun 17:2023.06.17.545405. doi: 10.1101/2023.06.17.545405. Update in: mBio. 2023 Sep 22;:e0152123. PMID: 37398495.
- Wakade RS, Ristow LC, Wellington M, Krysan DJ. Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection. Elife. 2023 Feb 27;12:e85114. doi: 10.7554/eLife.85114. PMID: 36847358.
- Kobayashi T, Trannel A, Heinemann J, Marra AR, Etienne W, Abosi OJ, Holley S, Dains A, Jenn KE, Meacham H, Schuessler BA, Wendt L, Ten Eyck P, Hanna B, Salinas JL, Hartley PG, Ford B, Wellington M, Brust KB, Diekema DJ. Association between job role and coronavirus disease 2019 (COVID-19) among healthcare personnel, Iowa, 2021. Antimicrob Steward Healthc Epidemiol. 2022 Dec 1;2(1):e188. doi: 10.1017/ash.2022.349. PMID: 36505945.