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Polly J. Ferguson, MD

Professor of Pediatrics-Rheumatology, Allergy and Immunology

Introduction

Research Interests: Genetic Aspects of Inflammatory Disorders, current research projects focus on determining the genetic basis of Chronic Recurrent Multifocal Osteomyelitis, SAPHO Syndrome and Lupus.

Current Positions

  • Marjorie K. Lamb Professor of Pediatrics - Rheumatology, Allergy and Immunology
  • Division Director, Pediatric Rheumatology, Allergy and Immunology
  • Executive Vice Chair, Stead Family Department of Pediatrics

Education

  • BS, University of Iowa, Iowa City, Iowa
  • MD, University of Iowa, Iowa City, Iowa
  • Internship in Pediatrics, University of Virginia, Charlottesville, Virginia
  • Resident in Pediatrics, University of Virginia, Charlottesville, Virginia
  • Fellow in Pediatric Rheumatology and Immunology, University of Virginia, Charlottesville, Virginia
  • Postdoctoral Fellow in Research Fellow, University of Virginia, Charlottesville, Virginia
  • Postdoctoral Fellow in Research Associate, Pediatric Fellow, University of Virginia, Charlottesville, Virginia

Center, Program and Institute Affiliations

Research Interests

  • Autoinflammatory bone disorders
  • Other Rare Familial Disorders
  • CARRA/Rare Disorders Section/CRMO working group
  • CARRA (Childhood Arthritis & Rheumatology Research Alliance) Registry
  • CARRA/Rare Disorders Section/Linear Scleroderma working group

Licenses & Certifications

  • Iowa Medical License
  • American Board of Pediatrics - Pediatric Rheumatology
  • American Board of Pediatrics - General Pediatrics
  • Federal Licensure Examination
  • Alabama License
  • Virginia License

Selected Publications

  • Ulland, T. K., Jain, N., Hornick, E. E., Elliott, E. I., Clay, G. M., Sadler, J. J., Mills, K. A., Janowski, A. M., Volk, A. P., Wang, K., Legge, K. L., Gakhar, L., Bourdi, M., Ferguson, P. J., Wilson, M. E., Cassel, S. L. & Sutterwala, F. S. (2016). Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nature Communications 7 13180. DOI: 10.1038/ncomms13180. PMID: 27779193. PMCID: PMC5093323.
  • Rao, A. P., Gopalakrishna, D. B., Bing, X. & Ferguson, P. J. (2016). Phenotypic Variability in Majeed Syndrome. The Journal of Rheumatology 43 (6) 1258–1259. DOI: 10.3899/jrheum.151193. PMID: 27252506.
  • Moorthy, L. N., Muscal, E., Riebschleger, M., Klein-Gitelman, M., Nigrovic, L. E., Horon, J. R., Rouster-Stevens, K., Ferguson, P. J., Eberhard, B. A., Brunner, H. I., Prahalad, S., Schneider, R., Nigrovic, P. A., American College of Rheumatology Special Committee on Pediatrics & the Investigators of the Childhood Arthritis & Rheumatology Research Alliance (2016). Efficacy of an Interinstitutional Mentoring Program Within Pediatric Rheumatology. Arthritis Care & Research 68 (5) 645–651. DOI: 10.1002/acr.22732. PMID: 26414673.
  • Prahalad, S., McCracken, C. E., Ponder, L. A., Angeles-Han, S. T., Rouster Stevens, K. A., Vogler, L. B., Langefeld, C. D., Thompson, S. D. & Ferguson (listed as 1 of 119 collaborators), P. (2016). Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry. Pediatric rheumatology online journal 14 (1) 14. DOI: 10.1186/s12969-016-0075-7. PMID: 26965173.
  • Whitmore, L. C., Hook, J. S., Philiph, A. R., Hilkin, B. M., Bing, X., Ahn, C., Wong, H. R., Ferguson, P. J. & Moreland, J. G. (2016). A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis. Journal of Immunology (Baltimore, Md.: 1950) 196 (3) 1376–1386. DOI: 10.4049/jimmunol.1500856. PMID: 26729809.
  • Korman, B., Wei, J., Laumann, A., Ferguson, P. & Varga, J. (2016). Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant. Case Reports in Dermatological Medicine 2016 2483041. DOI: 10.1155/2016/2483041. PMID: 27382493.
  • Korman, B., Wei, J., Laumann, A., Ferguson, P. & Varga, J. (2016). Novel LEMD3 mutation associated with osteopoikilosis and adult-onset scleroderma: an Ollendorf-Buschke syndrome variant?.
  • Anand, P. R., Dharmanand, B. G., Bing, X. & Ferguson, P. J. (2016). Phenotypic variation and variable disease severity in Majeed syndrome.
  • Ferguson, P. J. & Laxer, R. M. (2016). Autoinflammatory Bone Disorders. In Cassidy, J. T. (Eds.) Textbook of Pediatric Rheumatology. (7), pp. 627–641.e5. Philadelphia, PA: Elsevier.
  • Ferguson, P. J. & Laxer, R. M. (2015). New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice. Seminars in Immunopathology 37 (4) 407–412. DOI: 10.1007/s00281-015-0488-2. PMID: 25894861.