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Robert Roghair, MD

Professor of Pediatrics-Neonatology

Introduction

Dr. Robert Roghair studied Pharmacy in his undergraduate degree at the University of Iowa College of Pharmacy. Continuing at Iowa, he earned his medical degree at the Carver College of Medicine (1999) and completed his Pediatrics residency and Neonatal-Perinatal Medicine fellowship at Stead Family Children's Hospital (2002, 2005). Since 2014, he has served as the director for the Iowa Medical Student Research Program at the University of Iowa Carver College of Medicine.

The Roghair lab investigates the developmental origins of adult cardiometabolic disease across a number of model systems. This work originated with the realization that an adverse perinatal environment increases the risk of adult hypertension and obesity.

Current Positions

  • Professor of Pediatrics - Neonatology
  • Director, Physician Scientist Training Program (PSTP)
  • Director, Neonatal Outreach

Education

  • BS in Pharmacy, University of Iowa College of Pharmacy, Iowa City, Iowa
  • MD in Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
  • Resident in Pediatrics, University of Iowa Children's Hospital, Iowa City, Iowa
  • Fellow in Neonatology, University of Iowa Children's Hospital, Iowa City, Iowa

Center, Program and Institute Affiliations

Research Interests

  • Developmental origins of adult sympathetic activation and cardiovascular disease
  • Effects of neonatal leptin deficiency and neonatal antidepressant exposure

Licenses & Certifications

  • Iowa Medical License
  • Neonatal Perinatal Medicine, American Board of Pediatrics
  • General Pediatrics, American Board of Pediatrics

Selected Publications

  • Peotta, V., Rahmouni, K., Segar, J., Morgan, D., Pitz, K., Rice, O. & Roghair, R. (2016). Neonatal Growth Restriction-Related Leptin Deficiency Enhances Leptin-Triggered Sympathetic Activation and Central Angiotensin II Receptor-Dependent Stress-Evoked Hypertension. Pediatric Research.
  • Haskell, S. E., Peotta, V., Reinking, B. E., Zhang, C., Zhu, V., Kenkel, E. J. & Roghair, R. D. (2016). Oral Estrogen Reverses Ovariectomy-Induced Morning Surge Hypertension in Growth Restricted Mice. Clinical science (London, England : 1979). DOI: 10.1042/CS20150693. PMID: 26795436.
  • Mueller, C. A., Eme, J., Burggren, W. W., Roghair, R. D. & Rundle, S. D. (2015). Challenges and opportunities in developmental integrative physiology. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 184 113-24. DOI: 10.1016/j.cbpa.2015.02.013. PMID: 25711780.
  • Meyer, L. R., Zhu, V., Miller, A. & Roghair, R. D. (2014). Growth restriction, leptin, and the programming of adult behavior in mice. Behavioural brain research 275 131-5. DOI: 10.1016/j.bbr.2014.08.054. PMID: 25196633.
  • Guo, J. J., Stoltz, D. A., Zhu, V., Volk, K. A., Segar, J. L., McCray, Jr, P. B. & Roghair, R. D. (2014). Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 13 (3) 251-9. DOI: 10.1016/j.jcf.2013.10.009. PMID: 24183914.
  • Dexter, B. C., Rahmouni, K., Cushman, T., Hermann, G. M., Ni, C., Nopoulos, P. C., Thedens, D. L. & Roghair, R. D. (2014). Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice. Behavioural brain research 263 115-21. DOI: 10.1016/j.bbr.2014.01.021. PMID: 24472638.
  • Peotta, V. A., Bhandary, P., Ogu, U., Volk, K. A. & Roghair, R. D. (2014). Reduced blood pressure of CFTR-F508del carriers correlates with diminished arterial reactivity rather than circulating blood volume in mice. PloS one 9 (5) e96756. DOI: 10.1371/journal.pone.0096756. PMID: 24801204.
  • Engelstad, H. J., Roghair, R. D., Calarge, C. A., Colaizy, T. T., Stuart, S. & Haskell, S. E. (2014). Perinatal outcomes of pregnancies complicated by maternal depression with or without selective serotonin reuptake inhibitor therapy. Neonatology 105 (2) 149-54. DOI: 10.1159/000356774. PMID: 24356332.
  • Haskell, S. E., Peotta, V. A., Reinking, B. E., Hermann, G. M. & Roghair, R. D. (2013). Impact of neonatal sertraline exposure on the post-myocardial infarction outcomes of adult male mice. Journal of cardiovascular pharmacology 62 (5) 479-84. DOI: 10.1097/FJC.0b013e3182a4db90. PMID: 23921310.
  • Haskell, S. E., Hermann, G. M., Reinking, B. E., Volk, K. A., Peotta, V. A., Zhu, V. & Roghair, R. D. (2013). Sertraline exposure leads to small left heart syndrome in adult mice. Pediatric research 73 (3) 286-93. DOI: 10.1038/pr.2012.183. PMID: 23232669.