Sarah Haskell, DO
Associate Professor of Pediatrics-Critical Care
Introduction
Laboratory work is focused on how the fetal environment impacts cardiovascular development and disease. In the United States, currently 10% of pregnant women are treated with selective serotonin reuptake inhibitors (SSRIs). Because SSRIs cross the placenta, the safety of these medications is of concern to the developing fetus. We are currently using an exposure model to investigate the effects of the antidepressant sertraline on cardiac development.
My clinical research interest is in optimizing pediatric cardiopulmonary arrest care in both in-patient and out-patient settings. We are currently part of a multi-center study investigating the quality of pediatric resuscitation.
Current Positions
- Division Director - Critical Care
- Associate Professor of Pediatrics - Critical Care
- Program Director, Pediatric Critical Care Fellowship, Department of Pediatrics
Education
- BS in Exercise Science, University of Nebraska, Lincoln, Nebraska
- DO, Kansas City University of Medicine and Biosciences, Kansas City, Missouri
- Resident in Pediatrics, University of Iowa Children's Hospital, Iowa City, Iowa
- Fellow in Pediatric Critical Care, University of Iowa Children's Hospital, Iowa City, Iowa
Research Interests
- Effects of SSRI Exposure on Cardiac Development
- Effects of SSRI Exposure on Heart Rate Variability and Morphology in Infants
- My laboratory utilizes an intrauterine mouse model to investigate the effects of SSRI exposure on cardiac development and the programming of adult cardiovascular disease. We are assessing the role of SSRIs and serotonin on heart cell proliferation, signaling pathways, and hemodynamics
- Effectiveness of Public Access Defibrillation Sites in Community Settings
- Use of Automated External Defibrillators in Children
- Effects of Sertraline Exposure on Programming of Adult Cardiovascular Disease
Licenses & Certifications
- Pediatrics Critical Care Medicine, Board Certified
- American Board of Pediatrics, Board Certified
- Iowa Medical License
Selected Publications
- Haskell, S. E. & Atkins, D. L. (2016). Pediatric Out-of-Hospital Cardiac Arrest: Pushing for Progress in Public Response. JAMA pediatrics. DOI: 10.1001/jamapediatrics.2016.3694. PMID: 27837586.
- Haskell, S. E., Peotta, V., Reinking, B. E., Zhang, C., Zhu, V., Kenkel, E. J. & Roghair, R. D. (2016). Oral estrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice. Clinical science (London, England : 1979) 130 (8) 613-23. DOI: 10.1042/CS20150693. PMID: 26795436.
- Engelstad, H. J., Roghair, R. D., Calarge, C. A., Colaizy, T. T., Stuart, S. & Haskell, S. E. (2014). Perinatal outcomes of pregnancies complicated by maternal depression with or without SSRI therapy. Neonatology 105 (2) 149-154.
- Haskell, S. E., Peotta, V. A., Reinking, B. E., Herman, G. H. & Roghair, R. D. (2013). Impact of neonatal sertraline exposure on the post-myocardial infarction outcomes of adult male mice. Journal of Cardiovascular Pharmacology 62 (5) 479-484.
- Haskell, S., Hermann, G. M., Reinking, B., Volk, K. A., Peotta, V. A., Zhu, V. & Roghair, R. (2013). Sertraline exposure leads to a small left heart syndrome in adult male mice. Pediatric Research 73 (3) 286-293.
- Kummet, G. J., Haskell, S., Hermann, G. M., Ni, C., Volk, K. A., Younes, A. K., Miller, A. K. & Roghair, R. (2012). Neonatal SSRI exposure programs a hypermetabolic state in adult mice. Journal of Nutrition and Metabolism 431574.
- Haskell, S. E. (2012). Pediatric Critical Care Reference Guide (PICU Charts). Iowa City, IA: University of Iowa Stead Family Children's Hospital.
- Hermann, G. M., Dallas, L. M., Haskell, S. & Roghair, R. (2010). Neonatal macrosomia is an independent risk factor for adult metabolic syndrome. Neonatology 98 (3) 238-244.
- Haskell, S. & Atkins, D. (2010). Defibrillation in children. Journal of Emergencies, Trauma, and Shock 3 261-6.
- Haskell, S. E. (2010). PICU Handbook : a practical guide to surviving your PICU rotations. (Revised) Iowa City, IA: University of Iowa Stead Family Children's Hospital.