Ted Abel, PhD

Portrait
Professor of Psychological and Brain Sciences
Professor of Molecular Physiology and Biophysics
Professor of Psychiatry
Professor of Biochemistry

Contact Information

Primary Office
2312 PBDB
169 Newton Road
Iowa City, Iowa 52242
319-353-4534

Lab
2400 PBDB
169 Newton Road
Iowa City, IA 52242
319-353-4535

Office
2-471B BSB
51 Newton Road
Iowa City, IA 52242
319-335-7946

Education

BA, Chemistry, Swarthmore College
M Phil, Biochemistry, University of Cambridge
PhD, Biochemistry and Molecular Biology, Harvard University
Postdoctoral Fellow, Neurobiology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, HHMI

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Center, Program and Institute Affiliations

Iowa Neuroscience Institute

Research Summary

Research in the Abel lab focuses on the molecular mechanisms of memory storage and the molecular basis of neurodevelopmental and psychiatric disorders. We use mouse models to examine the role of molecular signaling pathways as well as transcriptional and epigenetic regulation of gene expression in defining how neural circuits mediate behavior.

Publications

Grissom, N. M., McKee, S. E., Schoch, H., Bowman, N., Havekes, R., O'Brien, W. T., Mahrt, E., Siegel, S., Commons, K., Portfors, C., Nickl-Jockschat, T., Reyes, T. M. & Abel, T. (2018). Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders. Molecular psychiatry, 23(3), 544-555. PMID: 29038598.

Koberstein, J. N., Poplawski, S. G., Wimmer, M. E., Porcari, G., Kao, C., Gomes, B., Risso, D., Hakonarson, H., Zhang, N. R., Schultz, R. T., Abel, T. & Peixoto, L. (2018). Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism. Science Signaling, 11(513). DOI: 10.1126/scisignal.aan6500.

Kronberg, G., Bridi, M., Abel, T., Bikson, M. & Parra, L. C. (2017). Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects. Brain stimulation, 10(1), 51–58.

Li, J., Zhang, W., Yang, H., Howrigan, D. P., Wilkinson, B., Souaiaia, T., Evgrafov, O. V., Genovese, G., Clementel, V. A., Tudor, J. C., Abel, T., Knowles, J. A., Neale, B. M., Wang, K., Sun, F. & Coba, M. P. (In Press). Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nature Neuroscience.

Cierna, A. V., Kramar, E. A., Matheos, D. P., Havekes, R., Helmstedt, T. J., Magnan, C. N., Sakata, K., Tran, A., Azzawi, S., Lopez, A., Dang, R., Wang, W., Trieu, B., Tong, J., Barrett, R. M., Post, R. J., Baldi, P., Abel, T., Lynch, G., Wood, M. A. (2017). Mutation of neuron-specific chromatin remodeling subunit BAF53b: Rescue of plasticity and memory by manipulating actin remodeling. Learning and Memory, 24, 199-209.

Gunther, A., Luczak, V., Abel, T. & Baumann, A. (2017). Caspase-3 and GFAP as markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity. Journal of Experimental Biology, 220, 1400-1404.

Havekes, R., Abel, T. (2017). The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function. Current Opinion in Neurobiology, 44, 13-19.

Mews, P., Drake, A., Luczak, V., Abel, T. & Berger, S. (2017). Acetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory. Nature, 546, 381-386.

Park, A. J., Havekes, R., Fu, X., Hansen, R., Tudor, J. C., Peixoto, L., Li, Z., Wu, Y., Poplawski, S. G., Baraban, J. M. & Abel, T. (2017). Learning induces the translin/trax RNase complex to express activin receptors for persistent memory. ELIFE, 6, e27872. DOI: 10.7554/eLife.27872.

Havekes, R., Park, A. J., Tudor, J. C., Luczak, V. G., Hansen, R. T., Ferri, S. L., Bruinenberg, V. M., Poplawski, S. G., Day, J. P., Aton, S. J., Radwanska, K., Meerlo, P., Houslay, M. D., Biillie, G. S. & Abel, T. (2016). Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. Elife, 5, e13424.

Tudor, J. C., Davis, E. J., Peixoto, L., Wimmer, M. E., van Tilborg, E., Park, A. J., Poplawski, S. G., Chung, C. W., Havekes, R., Huang, J., Gatti, E., Pierre, P. & Abel, T. (2016). Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Science signaling, 9(425), ra41–ra41.

Beamer, M., Tummala, S. R., Gullotti, D., Kopil, K., Gorka, S., Abel, T., Bass, C. R., Morrison, III., B., Cohen, A. S. & Meaney, D. F. (2016). Primary blast injury causes cognitive impairments and hippocampal circuit alterations. Experimental Neurology, 283, 16-28.

Poplawski, S. G., Peixoto, L., Porcari, G. S., Wimmer, M. E., McNally, A. G., Mizuno, K., Giese, K. P., Risso, D., Speed, T. P., Abel, T. (2016). Contextual fear conditioning induces differential alternative splicing. Neurobiology of Learning and Memory, 134(Pt B), 221-235.

Barz, C. S., Bessaih, T., Abel, T., Feldmeyer, D. & Contreras, D. (2016). Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1. Brain Structure and Function, 221, 4383-98.

McNally, A. G., Poplawski, S. G., Mayweather, B. A., White, K. M. & Abel, T. (2016). Characterization of a novel chromatin sorting tool reveals importance of histone variant H3.3 in contextual fear memory and motor learning. Frontiers in Molecular Neuroscience, 9(11), 1-11.

Schoch, H., Kreibich, A. S., Ferri, S., White, R. S., Bohorquez, D., Banerjee, A., Port, R. G., Dow, H. C., Cordero, L., Pallathra, A. A., Kim, H., Li, H., Bilker, W. B., Hirano, S., Schultz, R. T., Borgmann-Winter, K., Hahn, C. G., Feldmeyer, D., Carlson, G. C., Abel, T. & Brodkin, E. S. (2016). Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene. Biological Psychiatry, 81, 193-202.

Havekes, R., Park, A. J., Tolentino, R. E., Bruinenberg, V. M., Tudor, J. C., Lee, Y., Hansen, R. T., Guercio, L. A., Linton, E., Neves-Zaph, S. R., Meerlo, P., Baillie, G. S., Houslay, M. D. & Abel, T. (2016). Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36, 8936-8946.

Chen, C., Xi, C., Liang, X., Ma, J., Su, D., Abel, T. & Liu, R. (2016). The role of ? opioid receptor in brain ischemia. Critical Care Medicine, 44, e1219-e1225.

Weljie, A. M., Meerlo, P., Goel, N., Sengupta, A., Kayser, M. S., Abel, T., Birnbaum, M. J., Dinges, D. F. & Sehgal, A. (2015). Oxalic acid and diacylglycerol 36: 3 are cross-species markers of sleep debt. Proceedings of the National Academy of Sciences, 112(8), 2569–2574.

Havekes, R., Meerlo, P. & Abel, T. (2015). Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms. In Sleep, Neuronal Plasticity and Brain Function. pp. 183–206. Springer.

Peixoto, L., Risso, D., Poplawski, S. G., Wimmer, M. E., Speed, T. P., Wood, M. A. & Abel, T. (2015). How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets. Nucleic acids research, 43(16), 7664–7674.

Peixoto, L. L., Wimmer, M. E., Poplawski, S. G., Tudor, J. C., Kenworthy, C. A., Liu, S., Mizuno, K., Garcia, B. A., Zhang, N. R., Giese, K. P. & others, (2015). Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression. BMC genomics, 16(5), S5.

Barz, C. S., Bessaih, T., Abel, T., Feldmeyer, D. & Contreras, D. (2015). Sensory encoding in Neuregulin 1 mutants. Brain Structure and Function, 221(2), 1067-1081.

Vecsey, C. G., Park, A. J., Khatib, N. & Abel, T. (2015). Effects of sleep deprivation and aging on long-term and remote memory in mice. Learning & Memory, 22(4), 197-202.

Havekes, R., Meerlo, P. & Abel, T. (2015). Animal studies on the role of sleep in memory: From behavioral performance to molecular mechanisms. Current Topics in Behavioral Neuroscience, 25, 183-206.

Kreutzmann, J. C., Havekes, R., Abel, T. & Meerlo, P. (2015). Sleep deprivation and hippocampal vulnerability: Changes in neuronal plasticity, neurogenesis and cognitive function. Neuroscience, 309, 173-190.

Chen, R. J., Kelly, G., Sengupta, A., Heydendael, W., Nicholas, B., Beltrami, S., Luz, S., Peixoto, L., Abel, T. & Bhatnagar, S. (2015). microRNAs as biomarkers of resilience or vulnerability to stress. Neuroscience, 305, 36-48.

Prince, T., Wimmer, M., Choi, J., Havekes, R., Aton, S. & Abel, T. (2014). Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory. Neurobiology of learning and memory, 109, 122–130.

Shilling, D., Müller, M., Takano, H., Mak, D. D., Abel, T., Coulter, D. A. & Foskett, J. K. (2014). Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer’s disease pathogenesis. Journal of Neuroscience, 34(20), 6910–6923.

Chen, Y., Mao, H., Yang, K. H., Abel, T. & Meaney, D. F. (2014). A modified controlled cortical impact technique to model mild traumatic brain injury mechanics in mice. Frontiers in neurology, 5.

Park, A. J., Havekes, R., Choi, J. H., Luczak, V., Nie, T., Huang, T. & Abel, T. (2014). A presynaptic role for PKA in synaptic tagging and memory. Neurobiology of learning and memory, 114, 101–112.

Patel, T. P., Gullotti, D. M., Hernandez, P., O’Brien, W. T., Capehart, B. P., Morrison, III, B., Bass, C., Eberwine, J. E., Abel, T. & Meaney, D. F. (2014). An open-source toolbox for automated phenotyping of mice in behavioral tasks. Frontiers in behavioral neuroscience, 8.

Ingalhalikar, M., Parker, D., Ghanbari, Y., Smith, A., Hua, K., Mori, S., Abel, T., Davatzikos, C. & Verma, R. (2014). Connectome and maturation profiles of the developing mouse brain using diffusion tensor imaging. Cerebral Cortex, 25(9), 2696–2706.

Kumar, M., Duda, J. T., Hwang, W., Kenworthy, C., Ittyerah, R., Pickup, S., Brodkin, E. S., Gee, J. C., Abel, T. & Poptani, H. (2014). High resolution magnetic resonance imaging for characterization of the neuroligin-3 knock-in mouse model associated with autism spectrum disorder. PloS one, 9(10), e109872.

Poplawski, S. G., Schoch, H., Wimmer, M. E., Hawk, J. D., Walsh, J. L., Giese, K. P. & Abel, T. (2014). Object-location training elicits an overlapping but temporally distinct transcriptional profile from contextual fear conditioning. Neurobiology of learning and memory, 116, 90–95.

Schoch, H., Abel, T. (2014). Transcriptional co-repressors and memory storage. Neuropharmacology, 80, 53–60.

Havekes, R., Bruinenberg, V. M., Tudor, J. C., Ferri, S. L., Baumann, A., Meerlo, P. & Abel, T. (2014). Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss. Journal of Neuroscience, 34(47), 15715–15721.

Kenworthy, C. A., Sengupta, A., Luz, S. M., Ver Hoeve, E. S., Meda, K., Bhatnagar, S. & Abel, T. (2014). Social defeat induces changes in histone acetylation and expression of epigenetic enzymes in the ventral hippocampus, the prefrontal cortex, and the dorsal raphe nucleus. Neuroscience, 264, 88-98.

Poplawski, S. G., Schoch, H., Wimmer, M. & Abel, T. (2014). Object-location training elicits an overlapping, but temporally distinct transcriptional profile from contextual fear conditioning. Neurobiology of Learning and Memory, 116, 90-95.

Chen, C., Cui, X., Matunaga, F., Ma, J., Ma, N., Abel, T. & Liu, R. (2014). Salvinorin A decreases mortality and improves neurological outcome in a neonatal mouse hypoxia model. Translational Perioperative and Pain Medicine, 1, 9-13.

Abel, T., Poplawski, S. (2014). Epigenetic advances in clinical neuroscience. Dialogues in Clinical Neuroscience, 16, 273-275.

Abel, T., Havekes, R., Saletin, J. M. & Walker, M. P. (2013). Sleep, plasticity and memory from molecules to whole-brain networks. Current biology, 23(17), R774–R788.

Peixoto, L., Abel, T. (2013). The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology, 38(1), 62–76.

Prince, T., Abel, T. (2013). The impact of sleep loss on hippocampal function. Learning & Memory, 20(10), 558–569.

Wimmer, M. E., Rising, J., Galante, R. J., Wyner, A., Pack, A. I. & Abel, T. (2013). Aging in mice reduces the ability to sustain sleep/wake states. PloS one, 8(12), e81880.

Vecsey, C. G., Wimmer, M. E., Havekes, R., Park, A. J., Perron, I. J., Meerlo, P. & Abel, T. (2013). Daily acclimation handling does not affect hippocampal long-term potentiation or cause chronic sleep deprivation in mice. Sleep, 36(4), 601–607.

Fairless, A. H., Katz, J. M., Vijayvargiya, N., Dow, H. C., Kreibich, A. S., Berrettini, W. H., Abel, T. & Brodkin, E. S. (2013). Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice. Behavioural brain research, 237, 338–347.

Bridi, M. S., Abel, T. (2013). The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity. Neurobiology of learning and memory, 105, 151–158.

Bridi, M., Abel, T. (2013). The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity. Neurobiology of Learning and Memory, 105, 151-158.

Multani, P. K., Hodeg, R., Estevez, M. A., Abel, T., Kung, H., Alter, M., Brookshire, B., Lucki, I., Nall, A. H., Talbot, K., Doyle, G. A. & Lohoff, F. W. (2013). VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination. Neuroscience, 232, 32-44.

Abel, T., Klann, E. (2013). Molecular and Cellular Cognition: Neurobiology of Learning and Memory Special Issue 2013. Neurobiology of Learning and Memory, 105, 1-2.

Wimmer, M. E., Hernandez, P. J., Blackwell, J. & Abel, T. (2012). Aging impairs hippocampus-dependent long-term memory for object location in mice. Neurobiology of aging, 33(9), 2220–2224.

Leach, P. T., Poplawski, S. G., Kenney, J. W., Hoffman, B., Liebermann, D. A., Abel, T. & Gould, T. J. (2012). Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learning & Memory, 19(8), 319–324.

Vecsey, C. G., Peixoto, L., Choi, J. H., Wimmer, M., Jaganath, D., Hernandez, P. J., Blackwell, J., Meda, K., Park, A. J., Hannenhalli, S. & others, (2012). Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus. Physiological genomics, 44(20), 981–991.

Hawk, J. D., Bookout, A. L., Poplawski, S. G., Bridi, M., Rao, A. J., Sulewski, M. E., Kroener, B. T., Manglesdorf, D. J. & Abel, T. (2012). NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. The Journal of clinical investigation, 122(10), 3593-3602.

Havekes, R., Vecsey, C. G. & Abel, T. (2012). The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity. Cellular signalling, 24(6), 1251–1260.

Havekes, R., Canton, D. A., Park, A. J., Huang, T., Nie, T., Day, J. P., Guercio, L. A., Grimes, Q., Luczak, V., Gelman, I. H. & others, (2012). Gravin orchestrates protein kinase A and ß2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience, 32(50), 18137–18149.

Kaphzan, H., Hernandez, P., Jung, J. I., Cowansage, K. K., Deinhardt, K., Chao, M. V., Abel, T. & Klann, E. (2012). Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in Angelman syndrome model mice by ErbB inhibitors. Biological psychiatry, 72(3), 182–190.

Kim, S., Pickup, S., Fairless, A. H., Ittyerah, R., Dow, H. C., Abel, T., Brodkin, E. S. & Poptani, H. (2012). Association between sociability and diffusion tensor imaging in BALB/cJ mice. NMR in biomedicine, 25(1), 104–112.

Kumar, M., Kim, S., Pickup, S., Chen, R., Fairless, A. H., Ittyerah, R., Abel, T., Brodkin, E. S. & Poptani, H. (2012). Longitudinal in-vivo diffusion tensor imaging for assessing brain developmental changes in BALB/cJ mice, a model of reduced sociability relevant to autism. Brain research, 1455, 56–67.

Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H. & others, (2012). Sociability and brain development in BALB/cJ and C57BL/6J mice. Behavioural brain research, 228(2), 299–310.

Florian, C., Vecsey, C. G., Halassa, M. M., Haydon, P. G. & Abel, T. (2011). Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice. Journal of Neuroscience, 31(19), 6956–6962.

Lester, B. M., Tronick, E., Nestler, E., Abel, T., Kosofsky, B., Kuzawa, C. W., Marsit, C. J., Maze, I., Meaney, M. J., Monteggia, L. M. & others, (2011). Behavioral epigenetics. Annals of the New York Academy of Sciences, 1226(1), 14–33.

Hawk, J. D., Florian, C. & Abel, T. (2011). Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. Learning & Memory, 18(6), 367–370.

Oliveira, A. M., Estévez, M. A., Hawk, J. D., Grimes, S., Brindle, P. K. & Abel, T. (2011). Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learning & memory, 18(3), 161–169.

Havekes, R., Abel, T. & Van der Zee, Eddy A, (2011). The cholinergic system and neostriatal memory functions. Behavioural brain research, 221(2), 412–423.

Hawk, J. D., Abel, T. (2011). The role of NR4A transcription factors in memory formation. Brain research bulletin, 85(1), 21–29.

Hernandez, P. J., Abel, T. (2011). A molecular basis for interactions between sleep and memory. Sleep medicine clinics, 6(1), 71–84.

Kim, M., Park, A. J., Havekes, R., Chay, A., Guercio, L. A., Oliveira, R. F., Abel, T. & Blackwell, K. T. (2011). Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS computational biology, 7(6), e1002084.

Estevez, M. A., Abel, T. (2011). Epigenetic mechanisms of memory consolidation. In A. Petronis , J. Mill (Eds.) Brain, Behavior and Epigenetics. pp. 267-286. New York: Springer.

Oliveira, A. M., Hawk, J. D., Abel, T. & Havekes, R. (2010). Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learning & memory, 17(3), 155–160.

Gandy, S., Simon, A. J., Steele, J. W., Lublin, A. L., Lah, J. J., Walker, L. C., Levey, A. I., Krafft, G. A., Levy, E., Checler, F. & others, (2010). Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-$ß$ oligomers. Annals of neurology, 68(2), 220–230.

Kim, M., Huang, T., Abel, T. & Blackwell, K. T. (2010). Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS computational biology, 6(2), e1000691.

Kenney, J. W., Florian, C., Portugal, G. S., Abel, T. & Gould, T. J. (2010). Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine. Neuropsychopharmacology, 35(2), 483.

Hellman, K., Hernandez, P., Park, A. & Abel, T. (2010). Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations. Sleep, 33(1), 19–28.

Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S., Abel, T., Haydon, P. G. & Frank, M. G. (2009). Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron, 61(2), 213–219.

Vecsey, C. G., Baillie, G. S., Jaganath, D., Havekes, R., Daniels, A., Wimmer, M., Huang, T., Brown, K. M., Li, X., Descalzi, G. & others, (2009). Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 461(7267), 1122–1125.

Tretter, V., Revilla-Sanchez, R., Houston, C., Terunuma, M., Havekes, R., Florian, C., Jurd, R., Vithlani, M., Michels, G., Couve, A. & others, (2009). Deficits in spatial memory correlate with modified ?-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proceedings of the National Academy of Sciences, 106(47), 20039–20044.

Lee, J., Jang, D., Lee, N., Ko, H., Kim, H., Kim, Y., Kim, B., Son, J., Kim, S. H., Chung, H. & others, (2009). Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. Journal of Neuroscience, 29(26), 8493–8505.

Ehrlichman, R. S., Luminais, S. N., White, S. L., Rudnick, N. D., Ma, N., Dow, H. C., Kreibich, A. S., Abel, T., Brodkin, E. S., Hahn, C. & others, (2009). Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain research, 1294, 116–127.

Amann, L. C., Halene, T. B., Ehrlichman, R. S., Luminais, S. N., Ma, N., Abel, T. & Siegel, S. J. (2009). Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials. Neurobiology of disease, 35(2), 311–317.

Ma, N., Abel, T. & Hernandez, P. J. (2009). Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A. Learning & memory, 16(6), 367–370.

Havekes, R., Abel, T. (2009). Genetic dissection of neural circuits and behavior in Mus musculus. Advances in genetics, 65, 1–38.

Hock, B. J., Lattal, K. M., Kulnane, L. S., Abel, T. & Lamb, B. T. (2009). Pathology associated memory deficits in Swedish mutant genome-based amyloid precursor protein transgenic mice. Current aging science, 2(3), 205–213.

Kelly, M. P., Stein, J. M., Vecsey, C. G., Favilla, C., Yang, X., Bizily, S. F., Esposito, M. F., Wand, G., Kanes, S. J. & Abel, T. (2009). Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Molecular Psychiatry, 14, 398-415.

Abel, T., Zukin, R. S. (2008). Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Current opinion in pharmacology, 8(1), 57–64.

Abel, T., Nguyen, P. V. (2008). Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase. Progress in brain research, 169, 97–115.

Hernandez, P. J., Abel, T. (2008). Decades of debate: Forging past the protein synthesis impasse. Neurobiology of learning and memory, 89(3), 293–311.

Vessey, J. P., Macchi, P., Stein, J. M., Mikl, M., Hawker, K. N., Vogelsang, P., Wieczorek, K., Vendra, G., Riefler, J., Tübing, F. & others, (2008). A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis. Proceedings of the National Academy of Sciences, 105(42), 16374–16379.

Gelinas, J. N., Tenorio, G., Lemon, N., Abel, T. & Nguyen, P. V. (2008). Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus. Learning & Memory, 15(5), 281–289.

Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T. & Brodkin, E. S. (2008). Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain research, 1230, 211–217.

Baloch, S., Verma, R., Huang, H., Khurd, P., Clark, S., Yarowsky, P., Abel, T., Mori, S. & Davatzikos, C. (2008). Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images. Cerebral cortex, 19(3), 675–687.

Wu, L., Steenland, H. W., Kim, S. S., Isiegas, C., Abel, T., Kaang, B. & Zhuo, M. (2008). Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Molecular pain, 4(1), 40.

Isiegas, C., McDonough, C., Huang, T., Havekes, R., Fabian, S., Wu, L., Xu, H., Zhao, M., Kim, J., Lee, Y. & others, (2008). A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. Journal of Neuroscience, 28(24), 6220–6230.

Favilla, C., Abel, T. & Kelly, M. P. (2008). Chronic Gas signaling in the striatum increases anxiety-related behaviors independent of developmental effects. Journal of Neuroscience, 28(51), 13952–13956.

Kelly, M. P., Cheung, Y., Favilla, C., Siegel, S. J., Kanes, S. J., Houslay, M. D. & Abel, T. (2008). Constitutive activation of the G-protein subunit Gas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression. Learning & Memory, 15(2), 75–83.

Brennan, F. X., Abel, T. (2008). The cAMP/PKA signaling pathway and the modeling of human memory disorders in mice. Advances in Psychology, 139, 301-316.

Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S. A., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. & others, (2007). Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation. Journal of Neuroscience, 27(23), 6128–6140.

Oliveira, A. M., Wood, M. A., McDonough, C. B. & Abel, T. (2007). Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learning & memory, 14(9), 564–572.

Kelly, M. P., Isiegas, C., Cheung, Y., Tokarczyk, J., Yang, X., Esposito, M. F., Rapoport, D. A., Fabian, S. A., Siegel, S. J., Wand, G. & others, (2007). Constitutive activation of Gas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP. Neuropsychopharmacology, 32(3), 577–588.

Hellman, K., Abel, T. (2007). Fear conditioning increases NREM sleep. Behavioral neuroscience, 121(2), 310.

Nie, T., McDonough, C. B., Huang, T., Nguyen, P. V. & Abel, T. (2007). Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. Journal of Neuroscience, 27(38), 10278–10288.

Yang, S., Farias, M., Kapfhamer, D., Tobias, J., Grant, G., Abel, T. & Bucan, M. (2007). Biochemical, molecular and behavioral phenotypes of Rab3a mutations in the mouse. Genes, Brain and Behavior, 6, 77-96.

Kanes, S. J., Tokarczyk, J., Siegel, S. J., Bilker, W., Abel, T. & Kelly, M. P. (2007). Rolipram: A specific PDE4 inhibitor with potential antipsychotic activity. Neuroscience, 144, 239-246.

Lee, E. B., Leng, L. Z., Zhang, B., Kwong, L., Trojanowski, J. Q., Abel, T. & Lee, V. M. (2006). Targeting amyloid-ß peptide (Aß) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in A$ß$ precursor protein (APP) transgenic mice. Journal of Biological Chemistry, 281(7), 4292–4299.

Wood, M. A., Attner, M. A., Oliveira, A. M., Brindle, P. K. & Abel, T. (2006). A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learning & Memory, 13(5), 609–617.

Wood, M. A., Hawk, J. D. & Abel, T. (2006). Combinatorial chromatin modifications and memory storage: a code for memory?. Learning & Memory, 13(3), 241–244.

Stein, J. M., Bergman, W., Fang, Y., Davison, L., Brensinger, C., Robinson, M. B., Hecht, N. B. & Abel, T. (2006). Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. Journal of Neuroscience, 26(8), 2184–2196.

Huang, T., McDonough, C. B. & Abel, T. (2006). Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation. European journal of cell biology, 85(7), 635–642.

Oliveira, A. M., Abel, T., Brindle, P. K. & Wood, M. A. (2006). Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behavioral neuroscience, 120(3), 724.

Keeley, M. B., Wood, M. A., Isiegas, C., Stein, J., Hellman, K., Hannenhalli, S. & Abel, T. (2006). Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learning & memory, 13(2), 135–142.

Young, J. Z., Isiegas, C., Abel, T. & Nguyen, P. V. (2006). Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging. European Journal of Neuroscience, 23(7), 1784–1794.

Isiegas, C., Park, A., Kandel, E. R., Abel, T. & Lattal, K. M. (2006). Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction. Journal of Neuroscience, 26(49), 12700–12707.

Bourtchouladze, R., Patterson, S. L., Kelly, M. P., Kreibich, A., Kandel, E. R. & Abel, T. (2006). Chronically increased Gsa signaling disrupts associative and spatial learning. Learning & Memory, 13(6), 745–752.

Hussain, R. J., Stumpo, D. J., Blackshear, P. J., Lenox, R. H., Abel, T. & McNamara, R. K. (2006). Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation. Hippocampus, 16(5), 495–503.

Maxwell, C. R., Ehrlichman, R. S., Liang, Y., Gettes, D. R., Evans, D. L., Kanes, S. J., Abel, T., Karp, J. & Siegel, S. J. (2006). Corticosterone modulates auditory gating in mouse. Neuropsychopharmacology, 31(5), 897–903.

Maxwell, C. R., Liang, Y., Kelly, M. P., Kanes, S. J. & Abel, T. (2006). Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients. Neuroscience, 141, 1257-1264.

Wood, M. A., Kaplan, M. P., Park, A., Blanchard, E. J., Oliveira, A. M., Lombardi, T. L. & Abel, T. (2005). Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learning & memory, 12(2), 111–119.

Zhang, B., Veasey, S. C., Wood, M. A., Leng, L. Z., Kaminski, C., Leight, S., Abel, T., Lee, V. M. & Trojanowski, J. Q. (2005). Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer’s disease with injury to pedunculopontine cholinergic neurons. The American journal of pathology, 167(5), 1361–1369.

Wood, M. A., Kaplan, M. P., Brensinger, C. M., Guo, W. & Abel, T. (2005). Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Hippocampus, 15(5), 610–621.

McNamara, R. K., Hussain, R. J., Simon, E. J., Stumpo, D. J., Blackshear, P. J., Abel, T. & Lenox, R. H. (2005). Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice. Hippocampus, 15(5), 675–683.

Sommovilla, J., Bilker, W. B., Abel, T. & Schultz, R. M. (2005). Embryo culture does not affect the longevity of offspring in mice. Reproduction, 130(5), 599–601.

Keeley, M. B., Busch, J., Singh, R. & Abel, T. (2005). Novel tTA hybrid transcription factors report kinase activity and are inhibited by doxycycline. Biotechniques, 39, 529-536.

Lattal, K. M., Abel, T. (2004). Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4667–4672.

Ecker, D. J., Stein, P., Xu, Z., Williams, C. J., Kopf, G. S., Bilker, W. B., Abel, T. & Schultz, R. M. (2004). Long-term effects of culture of preimplantation mouse embryos on behavior. Proceedings of the National Academy of Sciences of the United States of America, 101(6), 1595–1600.

Ouyang, M., Hellman, K., Abel, T. & Thomas, S. A. (2004). Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep. Journal of neurophysiology, 92(4), 2071–2082.

Maxwell, C. R., Liang, Y., Weightman, B. D., Kanes, S. J., Abel, T., Gur, R. E., Turetsky, B. I., Bilker, W. B., Lenox, R. H. & Siegel, S. J. (2004). Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential. Neuropsychopharmacology, 29(4), 739.

Connolly, P. M., Maxwell, C., Liang, Y., Kahn, J. B., Kanes, S. J., Abel, T., Gur, R. E., Turetsky, B. I. & Siegel, S. J. (2004). The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components. Neurochemical research, 29(6), 1179–1188.

Lattal, K. M., Honarvar, S. & Abel, T. (2004). Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference. Behavioural brain research, 153(2), 327–339.

Gould, T. J., Bizily, S. P., Tokarczyk, J., Kelly, M. P., Siegel, S. J., Kanes, S. J. & Abel, T. (2004). Sensorimotor Gating Deficits in Transgenic Mice Expressing a Constitutively Active Form of Gs [alpha]. Neuropsychopharmacology, 29(3), 494.

Maxwell, C. R., Kanes, S. J. & Siegel, S. J. (2004). Phosphodiesterase inhibitors: A novel mechanism for non-receptor antipsychotic medications. Neurosciences, 129, 101-107.

Graves, L. A., Heller, E. A., Pack, A. I. & Abel, T. (2003). Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning. Learning & memory, 10(3), 168–176.

Graves, L. A., Hellman, K., Veasey, S., Blendy, J. A., Pack, A. I. & Abel, T. (2003). Genetic evidence for a role of CREB in sustained cortical arousal. Journal of neurophysiology, 90(2), 1152–1159.

Lattal, K. M., Mullen, M. T. & Abel, T. (2003). Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze. Behavioral neuroscience, 117(5), 1017–1027.

Connolly, P. M., Maxwell, C. R., Kanes, S. J., Abel, T., Liang, Y., Tokarczyk, J., Bilker, W. B., Turetsky, B. I., Gur, R. E. & Siegel, S. J. (2003). Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains. Brain research, 992(1), 85–95.

Chennathukuzhi, V., Stein, J. M., Abel, T., Donlon, S., Yang, S., Miller, J. P., Allman, D. M., Simmons, R. A. & Hecht, N. B. (2003). Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Molecular and cellular biology, 23(18), 6419–6434.

Woo, N. H., Duffy, S. N., Abel, T. & Nguyen, P. V. (2003). Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase. Hippocampus, 13(2), 293–300.

Abel, T., Kaplan, M. P. (2003). Genetic approaches to the study of synaptic plasticity and memory storage. CNS spectrums, 8(8), 597–610.

Scharf, M. T., Woo, N. H., Lattal, K. M., Young, J. Z., Nguyen, P. V. & Abel, T. (2002). Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training. Journal of Neurophysiology, 87(6), 2770–2777.

Bucan, M., Abel, T. (2002). The mouse: genetics meets behaviour. Nature Reviews Genetics, 3(2), 114–123.

Woo, N. H., Abel, T. & Nguyen, P. V. (2002). Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP. European Journal of Neuroscience, 16(10), 1871–1876.

Graves, L., Dalvi, A., Lucki, I., Blendy, J. A. & Abel, T. (2002). Behavioral analysis of the CREB alpha delta mutation on a B6/129 F1 hybrid background. Hippocampus, 12, 18-26.

Duffy, S. N., Craddock, K. J., Abel, T. & Nguyen, P. V. (2001). Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory. Learning & Memory, 8(1), 26–34.

Abel, T., Lattal, K. M. (2001). Molecular mechanisms of memory acquisition, consolidation and retrieval. Current opinion in neurobiology, 11(2), 180–187.

Graves, L., Pack, A. & Abel, T. (2001). Sleep and memory: a molecular perspective. Trends in neurosciences, 24(4), 237–243.

Lattal, K. M., Abel, T. (2001). Different requirements for protein synthesis in acquisition and extinction of spatial preferences and context-evoked fear. Journal of Neuroscience, 21(15), 5773–5780.

Wand, G., Levine, M., Zweifel, L., Schwindinger, W. & Abel, T. (2001). The cAMP–protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. Journal of Neuroscience, 21(14), 5297–5303.

Lattal, K. M., Abel, T. (2001). An immediate-shock freezing deficit with discrete cues: a possible role for unconditioned stimulus processing mechanisms. Journal of Experimental Psychology: Animal Behavior Processes, 27(4), 394.

Nie, T., Abel, T. (2001). Fear conditioning in inbred mouse strains: an analysis of the time course of memory. Behavioral neuroscience, 115(4), 951.

Nguyen, P. V., Abel, T., Kandel, E. R. & Bourtchouladze, R. (2000). Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice. Learning & Memory, 7(3), 170–179.

Rotenberg, A., Abel, T., Hawkins, R. D., Kandel, E. R. & Muller, R. U. (2000). Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity. Journal of Neuroscience, 20(21), 8096–8102.

Woo, N. H., Duffy, S. N., Abel, T. & Nguyen, P. V. (2000). Genetic and pharmacological demonstration of differential recruitment of cAMP-dependent protein kinases by synaptic activity. Journal of Neurophysiology, 84(6), 2739–2745.

Cardin, J. A., Abel, T. (1999). Memory suppressor genes: enhancing the relationship between synaptic plasticity and memory storage. Journal of neuroscience research, 58(1), 10–23.

Bourtchouladze, R., Abel, T., Berman, N., Gordon, R., Lapidus, K. & Kandel, E. R. (1998). Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learning & Memory, 5(4), 365–374.

Abel, T., Martin, K. C., Bartsch, D. & Kandel, E. R. (1998). Memory suppressor genes: inhibitory constraints on the storage of long-term memory. Science, 279(5349), 338–341.

Abel, T., Kandel, E. (1998). Positive and negative regulatory mechanisms that mediate long-term memory storage. Brain Research Reviews, 26(2), 360–378.

Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A., Kandel, E. R. & Bourtchouladze, R. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell, 88(5), 615–626.

Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F. & others, (1997). Mutant mice and neuroscience: recommendations concerning genetic background. Neuron, 19(4), 755–759.

Patterson, S. L., Abel, T., Deuel, T. A., Martin, K. C., Rose, J. C. & Kandel, E. R. (1996). Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron, 16(6), 1137–1145.

Yan-You Huang, P. V., Nguyen, T. A. & Kandel, E. R. (1996). Long-lasting forms of synaptic potentiation in the mammalian hippocampus. Learning & Memory.

Kandel, E., Abel, T. (1995). Neuropeptides, adenylyl cyclase, and memory storage. Science, 268(5212), 825.

Mayford, M., Abel, T. & Kandel, E. R. (1995). Transgenic approaches to cognition. Current opinion in neurobiology, 5(2), 141–148.

Abel, T., Alberini, C., Ghirardi, M., Huang, Y., Nguyen, P. & Kandel, E. R. (1995). Steps toward a molecular definition of memory consolidation. Memory distortions: How minds, brains, and societies reconstruct the past, 298–325.

Nguyen, P. V., Abel, T. & Kandel, E. R. (1994). Requirement of a critical period of transcription for induction of late phase LTP. Science, 265(5175), 1104–1108.

Abel, T., Michelson, A. M. & Maniatis, T. (1993). A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development, 119(3), 623–633.

Winick, J., Abel, T., Leonard, M. W., Michelson, A. M., Chardon-Loriaux, I., Holmgren, R. A., Maniatis, T. & Engel, J. D. (1993). A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development, 119(4), 1055–1065.

Abel, T., Bhatt, R. & Maniatis, T. (1992). A Drosophila CREB/ATF transcriptional activator binds to both fat body-and liver-specific regulatory elements. Genes & Development, 6(3), 466–480.

Abel, T., Maniatis, T. (1989). Gene regulation. Action of leucine zippers. Nature, 341(6237), 24–25.