Daniel O'Leary, PhD

Portrait
Professor of Psychiatry - Psychology

Contact Information

Office: T209 General Hospital
Iowa City, IA 52242
319-356-3897

Education

BA, Psychology, Bellarmine College, Louisville, KY
MA, Psychology, University of Louisville, Louisville, KY
PhD, Cognitive Psychology, University of Louisville, Louisville, KY

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

Current research explores the neural basis of the genetic vulnerability of children (ages 13 - 18 of alcoholics). Another project assesses the effects of marijuana on brain blood flow and cognition. Both research areas involve purely behavioral assessment of cognitive functions such as attention and memory, as well as neuroimaging studies performed during cognitive task performance. We are assessing blood flow with positron emission tomography (PET) during cognitive task performance in schizophrenic patients, normal volunteers, and marijuana users.

Publications

Keator, D. B., van Erp, T. G., Turner, J. A., Glover, G. H., Mueller, B. A., Liu, T. T., Voyvodic, J. T., Rasmussen, J., Calhoun, V. D., Lee, H. J., Togar, A. W., McEwen, S., Ford, J. M., Mathalon, D. H., Diaz, M., O'Leary, D. S., Bockholt, H. J., Gadde, S., Preda, A., Wible, C. G., Stern, H. S., Belger, A., McCarthy, G., Ozyurt, B., Potkin, S. G. & FBIRN, (2016). The function biomedical informatics research network data repository. NeuroImage, 124, 1074-1079. PMID: 4651841.

Parker, K. L., Andreasen, N. C., Liu, D., Freeman, J. H. & O'Leary, D. S. (2013). Eyeblink conditioning in unmedicated schizophrenia patients: A positron emission tomography study. Psychiatry Res, 214(3), 402-9. PMID: 24090512.

Gollub, R. L., Shoemaker, J. M., King, M. D., White, T., Ehrlich, S., Sponheim, S. R., Clark, V. P., Turner, J. A., Mueller, B. A., Magnotta, V., O'Leary, D., Ho, B. C., Brauns, S., Manoach, D. S., Seidman, L., Bustillo, J. R., Lauriello, J., Bockholt, J., Lim, K. O., Rosen, B. R., Schultz, S. C., Calhoun, V. D. & Andreasen, N. C. (2013). The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics, 11(3), 367-88. PMID: 23760817.

Vaidya, J. G., Knutson, B., O'Leary, D. S., Block, R. L. & Magnotta, B. (2013). Neural sensitivity to absolute and relative anticipated reward in adolescents. PLoS One, 8(3), e58708. PMID: 23544046.

Vaidya, J. G., Block, R. I., O'Leary, D. S., Ponto, L. B., Ghoneim, M. M. & Bechara, A. (2012). Effects of chronic marijuana use on brain activity during monetary decision-making. Neuropsychopharmacology, 37(3), 618-29. PMID: 21956445.

Parker, K. L., Andreasen, N. C., Liu, D., Freeman, J. H., Ponto, L. L. & O'Leary, D. S. (2012). Eyeblink conditioning in healthy adults: a positron emission tomography study. Cerebellum, 11(4), 946-56. PMID: 22430943.

Sponheim, S. R., Jung, R. E., Seidman, L. J., Mesholam-Gately, R. I., Manoach, D. S., O'Leary, D. S., Ho, B. C., Andreasen, N. C., Lauriello, J. & Schulz, S. C. (2010). Cognitive deficits in recent-onset and chronic schizophrenia. Journal of psychiatric research, 44(7), 421-8. PMID: 19878956.

Anderson, B. M., Rizzo, M., Block, R. I., Pearlson, G. D. & O'Leary, D. S. (2010). Sex differences in the effects of marijuana on simulated driving performance. Journal of psychoactive drugs, 42(1), 19-30. PMID: 20464803.

Anderson, B. M., Rizzo, M., Block, R. I., Pearlson, G. D. & O'Leary, D. S. (2010). Sex, drugs, and cognition: effects of marijuana. Journal of psychoactive drugs, 42(4), 413-24. PMID: 21305906.

Ford, J. M., Roach, B. J., Jorgensen, K. W., Turner, J. A., Brown, G. G., Notestine, R., Bischoff-Grethe, A., Greve, D., Wible, C., Lauriello, J., Belger, A., Mueller, B. A., Calhoun, V., Preda, A., Keator, D., O'Leary, D. S., Lim, K. O., Glover, G., Potkin, S. G. & Mathalon, D. H. (2009). Tuning in to the voices: a multisite FMRI study of auditory hallucinations. Schizophrenia bulletin, 35(1), 58-66. PMID: 18987102.

Potkin, S. G., Turner, J. A., Brown, G. G., McCarthy, G., Greve, D. N., Glover, G. H., Manoach, D. S., Belger, A., Diaz, M., Wible, C. G., Ford, J. M., Mathalon, D. H., Gollub, R., Lauriello, J., O'Leary, D., van Erp, T. G., Toga, A. W., Preda, A. & Lim, K. O. (2009). Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophrenia bulletin, 35(1), 19-31. PMID: 19042912.

Brown, G. G., McCarthy, G., Bischoff-Grethe, A., Ozyurt, B., Greve, D., Potkin, S. G., Turner, J. A., Notestine, R., Calhoun, V. D., Ford, J. M., Mathalon, D., Manoach, D. S., Gadde, S., Glover, G. H., Wible, C. G., Belger, A., Gollub, R. L., Lauriello, J., O'Leary, D. & Lim, K. O. (2009). Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophrenia bulletin, 35(1), 32-46. PMID: 19023127.

Wible, C. G., Lee, K., Molina, I., Hashimoto, R., Preus, A. P., Roach, B. J., Ford, J. M., Mathalon, D. H., McCarthey, G., Turner, J. A., Potkin, S. G., O'Leary, D., Belger, A., Diaz, M., Voyvodic, J., Brown, G. G., Notestine, R., Greve, D. & Lauriello, J. (2009). fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study. Schizophrenia bulletin, 35(1), 47-57. PMID: 18990710.

Kim, D. I., Manoach, D. S., Mathalon, D. H., Turner, J. A., Mannell, M., Brown, G. G., Ford, J. M., Gollub, R. L., White, T., Wible, C., Belger, A., Bockholt, H. J., Clark, V. P., Lauriello, J., O'Leary, D., Mueller, B. A., Lim, K. O., Andreasen, N., Potkin, S. G. & Calhoun, V. D. (2009). Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Human brain mapping, 30(11), 3795-811. PMID: 19434601.

Kim, D. I., Mathalon, D. H., Ford, J. M., Mannell, M., Turner, J. A., Brown, G. G., Belger, A., Gollub, R., Lauriello, J., Wible, C., O'Leary, D., Lim, K., Toga, A., Potkin, S. G., Birn, F. & Calhoun, V. D. (2009). Auditory oddball deficits in schizophrenia: an independent component analysis of the fMRI multisite function BIRN study. Schizophrenia bulletin, 35(1), 67-81. PMID: 19074498.

Andreasen, N. C., Calarge, C. A., Calage, C. A. & O'Leary, D. S. (2008). Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients. Schizophrenia bulletin, 34(4), 708-19. PMID: 18559406.

Marvel, C. L., Turner, B. M., O'Leary, D. S., Johnson, H. J., Pierson, R. K., Ponto, L. L. & Andreasen, N. C. (2007). The neural correlates of implicit sequence learning in schizophrenia. Neuropsychology, 21(6), 761-77. PMID: 17983290.

O'Leary, D. S., Block, R. I., Koeppel, J. A., Schultz, S. K., Magnotta, V. A., Ponto, L. B., Watkins, G. L. & Hichwa, R. D. (2007). Effects of smoking marijuana on focal attention and brain blood flow. Human psychopharmacology, 22(3), 135-48. PMID: 17397099.

Ho, B. C., Milev, P., O'Leary, D. S., Librant, A., Andreasen, N. C. & Wassink, T. H. (2006). Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Archives of general psychiatry, 63(7), 731-40. PMID: 16818862.

Bigelow, N. O., Turner, B. M., Andreasen, N. C., Paulsen, J. S., O'Leary, D. S. & Ho, B. C. (2006). Prism adaptation in schizophrenia. Brain and cognition, 61(3), 235-42. PMID: 16510223.

White, T., Ho, B. C., Ward, J., O'Leary, D. & Andreasen, N. C. (2006). Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects. Biological psychiatry, 60(5), 463-71. PMID: 16566898.

Ho, B. C., Wassink, T. H., O'Leary, D. S., Sheffield, V. C. & Andreasen, N. C. (2005). Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Molecular psychiatry, 10(3), 229, 287-98. PMID: 15668720.

Torres, I. J., O'Leary, D. S. & Andreasen, N. C. (2004). Symptoms and interference from memory in schizophrenia: evaluation of Frith's model of willed action. Schizophrenia research, 69(1), 35-43. PMID: 15145469.

Ponto, L. L., O'Leary, D. S., Koeppel, J., Block, R. I., Watkins, G. L., Richmond, J. C., Ward, C. A., Clermont, D. A., Schmitt, B. A. & Hichwa, R. D. (2004). Effect of acute marijuana on cardiovascular function and central nervous system pharmacokinetics of [(15)O]water: effect in occasional and chronic users. Journal of clinical pharmacology, 44(7), 751-66. PMID: 15199080.

Oyegbile, T., Hansen, R., Magnotta, V., O'leary, D., Bell, B., Seidenberg, M. & Hermann, B. P. (2004). Quantitative measurement of cortical surface features in localization-related temporal lobe epilepsy. Neuropsychology, 18(4), 729-37. PMID: 15506841.

Hermann, B., Seidenberg, M., Bell, B., Rutecki, P., Sheth, R. D., Wendt, G., O'Leary, D. & Magnotta, V. (2003). Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy. Journal of the International Neuropsychological Society : JINS, 9(3), 353-62. PMID: 12666760.

Hermann, B., Hansen, R., Seidenberg, M., Magnotta, V. & O'Leary, D. (2003). Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy. NeuroImage, 18(2), 284-92. PMID: 12595183.

Ho, B. C., Alicata, D., Ward, J., Moser, D. J., O'Leary, D. S., Arndt, S. & Andreasen, N. C. (2003). Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia. The American journal of psychiatry, 160(1), 142-8. PMID: 12505813.

Kim, J. J., Crespo-Facorro, B., Andreasen, N. C., O'Leary, D., Magnotta, V. & Nopoulos, P. (2003). Morphology of the lateral superior temporal gyrus in neuroleptic naive patients with schizophrenia: relationship to symptoms. Schizophrenia research, 60(2-3), 173-81. PMID: 12591581.

O'Leary, D. S., Block, R. I., Turner, B. M., Koeppel, J., Magnotta, V. A., Ponto, L. B., Watkins, G. L., Hichwa, R. D. & Andreasen, N. C. (2003). Marijuana alters the human cerebellar clock. Neuroreport, 14(8), 1145-51. PMID: 12821798.

Griffith, H. R., Pyzalski, R. W., O'Leary, D., Magnotta, V., Bell, B., Dow, C., Hermann, B. & Seidenberg, M. (2003). A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performance. Journal of clinical and experimental neuropsychology, 25(8), 1117-27. PMID: 14566585.

Calarge, C., Andreasen, N. C. & O'Leary, D. S. (2003). Visualizing how one brain understands another: a PET study of theory of mind. The American journal of psychiatry, 160(11), 1954-64. PMID: 14594741.

Paradiso, S., Andreasen, N. C., Crespo-Facorro, B., O'Leary, D. S., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (2003). Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography. The American journal of psychiatry, 160(10), 1775-83. PMID: 14514490.

Franck, N., O'Leary, D. S., Flaum, M., Hichwa, R. D. & Andreasen, N. C. (2002). Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia. The Journal of neuropsychiatry and clinical neurosciences, 14(3), 277-82. PMID: 12154151.

Schultz, S. K., O'Leary, D. S., Boles Ponto, L. L., Arndt, S., Magnotta, V., Watkins, G. L., Hichwa, R. D. & Andreasen, N. C. (2002). Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex. The Journal of neuropsychiatry and clinical neurosciences, 14(1), 19-24. PMID: 11884650.

Pierson, R., Westmoreland Corso, P., Sears, L., Alicata, D., Magnotta, V., O'Leary, D. S. & Andreasen, N. C. (2002). Manual and semiautomated measurement of cerebellar subregions on MR images. NeuroImage, 17, 61-76.

O'Leary, D. S. (2002). Effects of Attention on Hemispheric Asymmetry. In Brain Asymmetry. MIT Press.

Magnotta, V. A., Harris, G., Andreasen, N. C., O'Leary, D. S., Yuh, W. T. & Heckel, D. (2002). Structural MR image processing using the BRAINS2 toolbox. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society, 26(4), 251-64. PMID: 12074920.

O'Leary, D. S., Block, R. I., Koeppel, J. A., Flaum, M., Schultz, S. K., Andreasen, N. C., Ponto, L. B., Watkins, G. L., Hurtig, R. R. & Hichwa, R. D. (2002). Effects of smoking marijuana on brain perfusion and cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 26(6), 802-16. PMID: 12007751.

Hermann, B., Seidenberg, M., Bell, B., Rutecki, P., Sheth, R., Ruggles, K., Wendt, G., O'Leary, D. & Magnotta, V. (2002). The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia, 43(9), 1062-71. PMID: 12199732.

Getz, K., Hermann, B., Seidenberg, M., Bell, B., Dow, C., Jones, J., Woodard, A., Rutecki, P., Sheth, R., O'Leary, D. & Magnotta, V. (2002). Negative symptoms in temporal lobe epilepsy. The American journal of psychiatry, 159(4), 644-51. PMID: 11925304.

Corson, P. W., O'Leary, D. S., Miller, D. D. & Andreasen, N. C. (2002). The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naïve and medicated states. Biological psychiatry, 52(9), 855-62. PMID: 12399138.

Block, R. I., O'Leary, D. S., Hichwa, R. D., Augustinack, J. C., Boles Ponto, L. L., Ghoneim, M. M., Arndt, S., Hurtig, R. R., Watkins, G. L., Hall, J. A., Nathan, P. E. & Andreasen, N. C. (2002). Effects of frequent marijuana use on memory-related regional cerebral blood flow. Pharmacology, biochemistry, and behavior, 72(1-2), 237-50. PMID: 11900794.

Fuller, R., Nopoulos, P., Arndt, S., O'Leary, D., Ho, B. C. & Andreasen, N. C. (2002). Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance. The American journal of psychiatry, 159(7), 1183-9. PMID: 12091197.

Crespo-Facorro, B., Wiser, A. K., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (2001). Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography study. Human brain mapping, 12(4), 219-31. PMID: 11241873.

White, T., O'Leary, D., Magnotta, V., Arndt, S., Flaum, M. & Andreasen, N. C. (2001). Anatomic and functional variability: the effects of filter size in group fMRI data analysis. NeuroImage, 13(4), 577-88. PMID: 11305887.

Miller, D. D., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (2001). Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia. Biological psychiatry, 49(8), 704-15. PMID: 11313038.

Torres, I. J., Flashman, L. A., O'Leary, D. S. & Andreasen, N. C. (2001). Effects of retroactive and proactive interference on word list recall in schizophrenia. Journal of the International Neuropsychological Society : JINS, 7(4), 481-90. PMID: 11396550.

Crespo-Facorro, B., Paradiso, S., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (2001). Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors. JAMA : the journal of the American Medical Association, 286(4), 427-35. PMID: 11466121.

Stephan, K. E., Magnotta, V. A., White, T., Arndt, S., Flaum, M., O'Leary, D. S. & Andreasen, N. C. (2001). Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task. Psychological medicine, 31(6), 1065-78. PMID: 11513374.

Block, R. I., O'Leary, D. S., Ehrhardt, J. C., Augustinack, J. C., Ghoneim, M. M., Arndt, S. & Hall, J. A. (2000). Effects of frequent marijuana use on brain tissue volume and composition. Neuroreport, 11(3), 491-6. PMID: 10718301.

Nopoulos, P., Flaum, M., O'Leary, D. & Andreasen, N. C. (2000). Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry research, 98(1), 1-3. PMID: 10708922.

Pantel, J., O'Leary, D. S., Cretsinger, K., Bockholt, H. J., Keefe, H., Magnotta, V. A. & Andreasen, N. C. (2000). A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus, 10(6), 752-8. PMID: 11153720.

O'Leary, D. S., Block, R. I., Flaum, M., Schultz, S. K., Boles Ponto, L. L., Watkins, G. L. & Hichwa, R. D. (2000). Acute marijuana effects on rCBF and cognition. Soc Neurosci, 26, 281.

Wiser, A. K., Andreasen, N., O'Leary, D. S., Crespo-Facorro, B., Boles-Ponto, L. L., Watkins, G. L. & Hichwa, R. D. (2000). Novel vs. well-learned memory for faces: a positron emission tomography study. Journal of cognitive neuroscience, 12(2), 255-66. PMID: 10771410.

O'Leary, D. S., Flaum, M., Kesler, M. L., Flashman, L. A., Arndt, S. & Andreasen, N. C. (2000). Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia. The Journal of neuropsychiatry and clinical neurosciences, 12(1), 4-15. PMID: 10678506.

Kim, J. J., Crespo-Facorro, B., Andreasen, N. C., O'Leary, D. S., Zhang, B., Harris, G. & Magnotta, V. A. (2000). An MRI-based parcellation method for the temporal lobe. NeuroImage, 11(4), 271-88. PMID: 10725184.

Crespo-Facorro, B., Kim, J., Andreasen, N. C., O'Leary, D. S., Bockholt, H. J. & Magnotta, V. (2000). Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients. Schizophrenia research, 46(1), 35-43. PMID: 11099884.

Crespo-Facorro, B., Kim, J., Andreasen, N. C., Spinks, R., O'Leary, D. S., Bockholt, H. J., Harris, G. & Magnotta, V. A. (2000). Cerebral cortex: a topographic segmentation method using magnetic resonance imaging. Psychiatry research, 100(2), 97-126. PMID: 11114495.

Block, R. I., O'Leary, D. S., Hichwa, R. D., Augustinack, J. C., Ponto, L. L., Ghoneim, M. M., Arndt, S., Ehrhardt, J. C., Hurtig, R. R., Watkins, G. L., Hall, J. A., Nathan, P. E. & Andreasen, N. C. (2000). Cerebellar hypoactivity in frequent marijuana users. Neuroreport, 11(4), 749-53. PMID: 10757513.

O'Leary, D. S., Block, R. I., Flaum, M., Schultz, S. K., Boles Ponto, L. L., Watkins, G. L., Hurtig, R. R., Andreasen, N. C. & Hichwa, R. D. (2000). Acute marijuana effects on rCBF and cognition: a PET study. Neuroreport, 11(17), 3835-41. PMID: 11117500.

Sears, L. L., Andreasen, N. C. & O'Leary, D. S. (2000). Cerebellar functional abnormalities in schizophrenia are suggested by classical eyeblink conditioning. Biological psychiatry, 48(3), 204-9. PMID: 10924663.

Kim, J. J., Mohamed, S., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (2000). Regional neural dysfunctions in chronic schizophrenia studied with positron emission tomography. The American journal of psychiatry, 157(4), 542-8. PMID: 10739412.

Crespo-Facorro, B., Kim, J., Andreasen, N. C., O'Leary, D. S. & Magnotta, V. (2000). Regional frontal abnormalities in schizophrenia: a quantitative gray matter volume and cortical surface size study. Biological psychiatry, 48(2), 110-9. PMID: 10903407.

Kim, J. J., Andreasen, N. C., O'Leary, D. S., Wiser, A. K., Ponto, L. L., Watkins, G. L. & Hichwa, R. D. (1999). Direct comparison of the neural substrates of recognition memory for words and faces. Brain : a journal of neurology, 122 ( Pt 6), 1069-83. PMID: 10356060.

Mohamed, S., Paulsen, J. S., O'Leary, D., Arndt, S. & Andreasen, N. (1999). Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Archives of general psychiatry, 56(8), 749-54. PMID: 10435610.

Paradiso, S., Johnson, D. L., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1999). Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects. The American journal of psychiatry, 156(10), 1618-29. PMID: 10518175.

Schultz, S. K., O'Leary, D. S., Boles Ponto, L. L., Watkins, G. L., Hichwa, R. D. & Andreasen, N. C. (1999). Age-related changes in regional cerebral blood flow among young to mid-life adults. Neuroreport, 10(12), 2493-6. PMID: 10574358.

Andreasen, N. C., Nopoulos, P., O'Leary, D. S., Miller, D. D., Wassink, T. & Flaum, M. (1999). Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biological psychiatry, 46(7), 908-20. PMID: 10509174.

Gold, S., Arndt, S., Nopoulos, P., O'Leary, D. S. & Andreasen, N. C. (1999). Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. The American journal of psychiatry, 156(9), 1342-8. PMID: 10484943.

Andreasen, N. C., O'Leary, D. S., Paradiso, S., Cizadlo, T., Arndt, S., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1999). The cerebellum plays a role in conscious episodic memory retrieval. Human brain mapping, 8(4), 226-34. PMID: 10619416.

Wiser, A. K., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (1998). Dysfunctional cortico-cerebellar circuits cause 'cognitive dysmetria' in schizophrenia. Neuroreport, 9(8), 1895-9. PMID: 9665622.

Andreasen, N. C., Paradiso, S. & O'Leary, D. S. (1998). Cognitive dysmetria as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?. Schizophrenia bulletin, 24(2), 203-18. PMID: 9613621.

Cizadlo, T., Harris, G., Heckel, D., Flaum, M., Christian, B., O'Leary, D. S. & Andreasen, N. C. (1997). An automated method to quantify the area, depth, and convolutions of the cerebral cortex from MR data: (BRAINSURF). NeuroImage, 5, 402.

Piven, J., O'Leary, D. S. (1997). Neuroimaging in autism.

O'Leary, D. S., Andreasen, N. C., Hurtig, R. R., Arndt, S., Flaum, M. & Hichwa, R. D. (1997). A PET study of auditory attention deficits in patients with schizophrenia: A replication and extension of previous findings. Schizophrenia research, 24(1,2), 170.

Flaum, M., O'Leary, D. S., Johnson, D., Arndt, S., Cizadlo, T., Hichwa, R. D. & Andreasen, N. C. (1997). Relationship between symptom dimensions and cerebral blood flow in schizophrenia as assessed by 15H2O PET. Schizophrenia research, 24, 165.

O'Leary, D. S., Andreasen, N. C., Hichwa, R. D., Hurtig, R., Watkins, G. L. & Boles Ponto, L. L. (1997). A positron emission tomography study of modality-specific, spatial attention. Human Brain Mapping, 5(6), 422-436.

Paradiso, S., Crespo Facorro, B., Andreasen, N. C., O'Leary, D. S., Watkins, L. G., Boles Ponto, L. & Hichwa, R. D. (1997). Brain activity assessed with PET during recall of word lists and narratives. Neuroreport, 8(14), 3091-6. PMID: 9331920.

Miller, D. D., Andreasen, N. C., O'Leary, D. S., Rezai, K., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1997). Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 17(4), 230-40. PMID: 9326747.

Paradiso, S., Andreasen, N. C., O'Leary, D. S., Arndt, S. & Robinson, R. G. (1997). Cerebellar size and cognition: correlations with IQ, verbal memory and motor dexterity. Neuropsychiatry, neuropsychology, and behavioral neurology, 10(1), 1-8. PMID: 9118192.

Torres, I. J., Flashman, L. A., O'Leary, D. S., Swayze, V. & Andreasen, N. C. (1997). Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls. Biological psychiatry, 42(12), 1087-96. PMID: 9426878.

Andreasen, N. C., O'Leary, D. S., Flaum, M., Nopoulos, P., Watkins, G. L., Boles Ponto, L. L. & Hichwa, R. D. (1997). Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients. Lancet, 349(9067), 1730-4. PMID: 9193383.

Gold, S., Arndt, S., Johnson, D., O'Leary, D. S. & Andreasen, N. C. (1997). Factors that influence effect size in 15O PET studies: a meta-analytic review. NeuroImage, 5(4 Pt 1), 280-91. PMID: 9345557.

Andreasen, N. C., O'Leary, D. S., Arndt, S., Cizadlo, T., Hurtig, R., Rezai, K., Watkins, G. L., Ponto, L. B. & Hichwa, R. D. (1996). Neural substrates of facial recognition. The Journal of neuropsychiatry and clinical neurosciences, 8(2), 139-46. PMID: 9081548.

Andreasen, N. C., O'Leary, D., Arndt, S., Cizadlo, P., Nopolous, P. & Flaum, M. (1996). Neural substrates of frontal function in schizophrenia.

O'Leary, D. S., Andreasen, N. C., Hichwa, R. D., Cizadlo, T., Hurtig, R., Boles Ponto, L. L., Watkins, G. L. & Kesler, M. (1996). Variability in brain activation: The relationship between indidual and group PET images of regional cerebral blood flow. NeuroImage, 3, 3,86.

Andreasen, N. C., Rajarethinam, R., Cizadlo, T., Arndt, S., Swayze, V. W., Flashman, L. A., O'Leary, D. S., Ehrhardt, J. C. & Yuh, W. T. (1996). Automatic atlas-based volume estimation of human brain regions from MR images. Journal of computer assisted tomography, 20(1), 98-106. PMID: 8576490.

Arndt, S., Rajarethinam, R., Cizadlo, T., O'Leary, D. S., Downhill, J. & Andreasen, N. C. (1996). Landmark-based MR image registration measurement: A reliability and validation study. Psychiatry research, 67, 145-154.

Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Ponto, L. L., Watkins, G. L. & Hichwa, R. D. (1996). Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9985-90. PMID: 8790444.

O'Leary, D. S., Andreasen, N. C., Hurtig, R. D., Hichwa, R. D., Watkins, G. L., Boles Ponto, L. L., Rogers, M. & Kirchner, P. T. (1996). A regional cerebral blood flow study of language and auditory attention. Brain and Language, 53, 20-39.

Andreasen, N. C., Arndt, S., Cizadlo, T., O'Leary, D. S., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1996). Sample size and statistical power in [15O]H2O studies of human cognition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 16(5), 804-16. PMID: 8784225.

O'Leary, D. S., Andreasen, N. C., Hurtig, R. R., Kesler, M. L., Rogers, M., Arndt, S., Cizadlo, T., Watkins, G. L., Ponto, L. L., Kirchner, P. T. & Hichwa, R. D. (1996). Auditory attentional deficits in patients with schizophrenia. A positron emission tomography study. Archives of general psychiatry, 53(7), 633-41. PMID: 8660130.

Arndt, S., Cizadlo, T., O'Leary, D., Gold, S. & Andreasen, N. C. (1996). Normalizing counts and cerebral blood flow intensity in functional imaging studies of the human brain. NeuroImage, 3(3 Pt 1), 175-84. PMID: 9345488.

Arndt, S., Cizadlo, T., Andreasen, N. C., Heckel, D., Gold, S. & O'Leary, D. S. (1996). Tests for comparing images based on randomization and permutation methods. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 16(6), 1271-9. PMID: 8898701.

O'Leary, D. S., Andreasen, N. C., Hurtig, R., Flashman, L. A., Torres, I. & Hichwa, R. D. (1995). A PET study of auditory and visual attention. Society for Neuroscience, 21, 1998.

Hichwa, R. D., O'Leary, D. S., Boles Ponto, L. L., Arndt, S., Cizadlo, T., Hurtig, R., Watkins, G. L., Wollenweber, S. D. & Andreasen, N. C. (1995). Counts versus Flow: When does it matter?. In Quantification of Brain Function Using PET. Academic Press.

Miller, D. D., O'Leary, D. S., Hichwa, R. D., Nopoulos, P. & Andreasen, N. C. (1995). The effect of antipsychotic medication on PET studies of regional cerebral blood flow during tasks assessing language and memory in schizophrenics. Schizophrenia research, 15, 92.

O'Leary, D. S., Kesler, M., Mosnik, D., Tranel, A., Hurtig, R., Hichwa, R. D. & Andreasen, N. C. (1995). Regional cerebral blood flow (rCBF) within Heschl's gyris and the planum temporale in schizophrenic patients and controls during language tasks: An MRI and PET study. Schizophrenia research, 15(1-2), 94.

Flaum, M., O'Leary, D. S., Swayze, V. W., Miller, D. D., Arndt, S. & Andreasen, N. C. (1995). Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. Journal of psychiatric research, 29(4), 261-76. PMID: 8847654.

Arndt, S., Cizadlo, T., Andreasen, N. C., Zeien, G., Harris, G., O'Leary, D. S., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1995). A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies. The Journal of neuropsychiatry and clinical neurosciences, 7(2), 155-68. PMID: 7626958.

Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1995). II. PET studies of memory: novel versus practiced free recall of word lists. NeuroImage, 2(4), 296-305. PMID: 9343614.

Andreasen, N. C., O'Leary, D. S., Arndt, S., Cizadlo, T., Hurtig, R., Rezai, K., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1995). Short-term and long-term verbal memory: a positron emission tomography study. Proceedings of the National Academy of Sciences of the United States of America, 92(11), 5111-5. PMID: 7761457.

Andreasen, N. C., O'Leary, D. S., Arndt, S., Cizadlo, T., Rezai, K., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1995). I. PET studies of memory: novel and practiced free recall of complex narratives. NeuroImage, 2(4), 284-95. PMID: 9343613.

Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Watkins, G. L., Ponto, L. L. & Hichwa, R. D. (1995). Remembering the past: two facets of episodic memory explored with positron emission tomography. The American journal of psychiatry, 152(11), 1576-85. PMID: 7485619.

Flaum, M., Swayze, V. W., O'Leary, D. S., Yuh, W. T., Ehrhardt, J. C., Arndt, S. V. & Andreasen, N. C. (1995). Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. The American journal of psychiatry, 152(5), 704-14. PMID: 7726310.

O'Leary, D. S., Andreasen, N. C. & Hurtig, R. (1994). A Positron Emission Tomography study of regional cerebral blood flow (rCBF) during long- and short-term verbal memory. Soc Neurosci, 20, 1290.

Cizadlo, T., Andreasen, N. C., Zeien, G., Rajarethinam, R., Harris, G., O'Leary, D. S., Swayze, V. & Arndt, S. (1994). Image registration issues in the analysis of multiple-injection 15O H2O PET studies: BRAINFIT. Proceedings of the National Academy of Sciences of the United States of America,(2168), 234-245.

Andreasen, N. C., Harris, G., Cizadlo, T., Arndt, S., O'Leary, D. S., Swayze, V. & Flaum, M. (1994). Techniques for measuring sulcal/gyral patterns in the brain as visualized through magnetic resonance scanning: BRAINPLOT and BRAINMAP. Proceedings of the National Academy of Sciences of the United States of America, 91(1), 93-7. PMID: 8278413.

Arndt, S., Swayze, V., Cizadlo, T., O'Leary, D., Cohen, G., Yuh, W. T., Ehrhardt, J. C. & Andreasen, N. C. (1994). Evaluating and validating two methods for estimating brain structure volumes: tessellation and simple pixel counting. NeuroImage, 1(3), 191-8. PMID: 9343570.

DiGiulio, D. V., Seidenberg, M., O'Leary, D. S. & Raz, N. (1994). Procedural and declarative memory: a developmental study. Brain and cognition, 25(1), 79-91. PMID: 8043268.

Andreasen, N. C., Arndt, S., Swayze, V., Cizadlo, T., Flaum, M., O'Leary, D., Ehrhardt, J. C. & Yuh, W. T. (1994). Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science (New York, N.Y.), 266(5183), 294-8. PMID: 7939669.

Hurtig, R. R., Hichwa, R. D., O'Leary, D. S., Boles Ponto, L. L., Narayana, S., Watkins, G. L. & Andreasen, N. C. (1994). Effects of timing and duration of cognitive activation in [15O]water PET studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 14(3), 423-30. PMID: 8163584.

Andreasen, N. C., Cizadlo, T., Harris, G., Swayze, V., O'Leary, D. S., Cohen, G., Ehrhardt, J. & Yuh, W. T. (1993). Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. The Journal of neuropsychiatry and clinical neurosciences, 5(2), 121-30. PMID: 8508032.

Andreasen, N. C., O'Leary, D. S. & Arndt, S. (1993). Neuroimaging and clinical neuroscience: Basic issues and principles. In Review of Psychiatry. pp. 9-48. American Psychiatric Press.

Madsen, M. T., O'Leary, D. S., Andreasen, N. C. & Kirchner, P. T. (1993). Dual isotope brain SPECT imaging for monitoring cognitive activation: physical considerations. Nuclear medicine communications, 14(5), 391-6. PMID: 8510880.

Andreasen, N. C., Flaum, M., Swayze, V., O'Leary, D. S., Alliger, R., Cohen, G., Ehrhardt, J. & Yuh, W. T. (1993). Intelligence and brain structure in normal individuals. The American journal of psychiatry, 150(1), 130-4. PMID: 8417555.

Rezai, K., Andreasen, N. C., Alliger, R., Cohen, G., Swayze, V. & O'Leary, D. S. (1993). The neuropsychology of the prefrontal cortex. Archives of neurology, 50(6), 636-42. PMID: 8503801.

O'Leary, D. S., Madsen, M. T., Hurtig, R., Kirchner, P. T., Rezai, K., Rogers, M. & Andreasen, N. C. (1993). Dual isotope brain SPECT imaging for monitoring cognitive activation: initial studies in humans. Nuclear medicine communications, 14(5), 397-404. PMID: 8510881.

Andreasen, N. C., Rezai, K., Alliger, R., Swayze, V. W., Flaum, M., Kirchner, P., Cohen, G. & O'Leary, D. S. (1992). Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Archives of general psychiatry, 49(12), 943-58. PMID: 1360199.

Fiducia, D., O'Leary, D. S. (1990). Development of a behavior attributed to the frontal lobes in normal children. Developmental Neuropsychology, 6(2), 85-94.

Pahl, J., Rezai, K., O'Leary, D. S. & Andreasen, N. C. (1990). The study of schizophrenia with SPECT.

O'Leary, D. S. (1990). Neuropsychological development in the child and adolescent: Functional maturation of the CNS. In Advances in Psychology, Developmental Psychology: Cognitive Perceptuo-Motor, and Neuropsychological Perspectives. Elsevier Science Publishers.

Zeitlin, S. B., Lane, R. D., O'Leary, D. S. & Schrift, M. J. (1989). Interhemispheric transfer deficit and alexithymia. The American journal of psychiatry, 146(11), 1434-9. PMID: 2817114.

Mittenberg, W., Seidenberg, M., O'Leary, D. S. & DiGiulio, D. V. (1989). Changes in cerebral functioning associated with normal aging. Journal of clinical and experimental neuropsychology, 11(6), 918-32. PMID: 2592531.

Seidenberg, M., Beck, N., Geisser, M. & O'Leary, D. (1988). Neuropsychological correlates of academic achievement of children with epilepsy. J Epilepsy, 1, 23-29.

Giordani, B., Berent, S., Sackellares, J. C., Rourke, D., Seidenberg, M., O'Leary, D. S., Dreifuss, F. E. & Boll, T. J. (1985). Intelligence test performance of patients with partial and generalized seizures. Epilepsia, 26(1), 37-42. PMID: 3918859.

Boll, T. J., O'Leary, D. S. & Barth, J. T. (1984). A quantitative and qualitative approach to neuropsychological evaluation. In Medical Psychology: A New Perspective. Academic Press.

O'Leary, D. S., Boll, T. J. (1984). Neuropsychological correlates of early generalized brain dysfunction. In Early brain damage: Research orientations and clinical observations. Academic Press.

Giordani, B., Sackellares, J. C., Miller, S., Berent, S., Sutula, T., Seidenberg, M., Boll, T. J., O'Leary, D. & Dreifuss, F. E. (1983). Improvement in neuropsychological performance in patients with refractory seizures after intensive diagnostic and therapeutic intervention. Neurology, 33(4), 489-93. PMID: 6682196.

Giordani, B., Berent, S., Sackellares, J. C., Boll, T. J., Seidenberg, M. & O'Leary, D. S. (1983). Intelligence and academic achievement in patients with partial, generalized, and partial secondarily-generalized seizures. Epilepsia, 24, 258-259.

Berent, S., Giordani, B., Sackellares, J. C., O'Leary, D. & Boll, T. J. (1983). Cerebrally lateralized epileptogenic foci and performance on a verbal and visual-graphic learning task. Perceptual and motor skills, 56(3), 991-1001. PMID: 6410353.

O'Leary, D. S., Lovell, M. R., Sackellares, J. C., Berent, S., Giordani, B., Seidenberg, M. & Boll, T. J. (1983). Effects of age of onset of partial and generalized seizures on neuropsychological performance in children. The Journal of nervous and mental disease, 171(10), 624-9. PMID: 6413648.

O'Leary, D. S. (1982). Hemispheric specialization and cognitive mode: A developmental perspective. In Language and Cognitive Style. Zeitlinger and Swets.

Seidenberg, M., O'Leary, D. S., Berent, S. & Boll, T. (1981). Changes in seizure frequency and test-retest scores on the Wechsler Adult Intelligence Scale. Epilepsia, 22(1), 75-83. PMID: 7472301.

Seidenberg, M., O'Leary, D. S., Giordani, B., Berent, S. & Boll, T. J. (1981). Test-retest IQ changes of epilepsy patients: assessing the influence of practice effects. Journal of clinical neuropsychology, 3(3), 237-55. PMID: 7328177.

O'Leary, D. S., Seidenberg, M., Berent, S. & Boll, T. J. (1981). Effects of age of onset of tonic-clonic seizures on neuropsychological performance in children. Epilepsia, 22(2), 197-204. PMID: 7472307.

Neuger, G. J., O'Leary, D. S., Fishburne, F. J., Barth, J. T., Berent, S., Giordani, B. & Boll, T. J. (1981). Order effects on the Halstead-Reitan Neuropsychological Test Battery and allied procedures. Journal of consulting and clinical psychology, 49(5), 722-30. PMID: 7287982.

O'Leary, D. S. (1980). A developmental study of interhemispheric transfer in children aged five to ten. Child development, 51(3), 743-50. PMID: 7418510.

Nakinsky, I., Oescher, D. & O'Leary, D. S. (1977). Stimulus memory and contextual cues in the abstraction process. Can J Psychol, 31, 102-122.

O'Leary, D. S. (1977). The development of functional perceptual asymmetries in the cerebral hemispheres of man. Lektos, 2, 1-52.