Eric A. Epping, MD, PhD

Portrait
Clinical Associate Professor of Psychiatry

Contact Information

Office: 2-202 Medical Education Building
Iowa City, IA 52242
319-384-1168

Education

BS, Biochemistry and Economics, Honors, University of Iowa, Iowa City, Iowa
MD, Physiology and Biophysics, University of Iowa Carver College of Medicine
PhD, Physiology and Biophysics, University of Iowa Carver College of Medicine

Carver College of Medicine
Resident, Psychiatry, Department of Psychiatry, University of Iowa Hospitals and Clinics
Fellow, Genetics of Schizophrenia and Autism (Research), Department of Psychiatry, University of Iowa

Licensure and Certifications

ABPN Certification in Psychiatry - American Board of Psychiatry and Neurology

Publications

Moser, A. D., Epping, E., Espe-Pfeifer, P., Martin, E., Zhorne, L., Mathews, K., Nance, M., Hudgell, D., Quarrell, O. & Nopoulos, P. (2017). A survey-based study identifies common but unrecognized symptoms in a large series of juvenile Huntington's disease. Neurodegenerative Disease Management.

Lee, J. K., Ding, Y., Conrad, A. L., Cattaneo, E., Epping, E., Mathews, K., Gonzalez-Alegre, P., Cahill, L., Magnotta, V., Schlaggar, B. L., Perlmutter, J. S., Kim, R. E., Dawson, J. D. & Nopoulos, P. (2017). Sex-specific effects of the Huntington gene on normal neurodevelopment. J Neurosci Res, 95(1-2), 398-408.

Epping, E. A., Kim, J. I., Craufurd, D., Brashers-Krug, T. M., Anderson, K. E., McCusker, E., Luther, J., Long, J. D. & Paulsen, J. S. (2016). Longitudinal Psychiatric Symptoms in Prodromal Huntington's Disease: A Decade of Data. The American journal of psychiatry, 173(2), 184-92. PMID: 26472629.

Rudd, D., Axelsen, M., Epping, E. A., Andreasen, N. & Wassink, T. (2015). Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28. Clinical case reports, 3(4), 201-7. PMID: 25914809.

Bijanki, K. R., Matsui, J. T., Mayberg, H. S., Magnotta, V. A., Arndt, S., Johnson, H. J., Nopoulos, P., Paradiso, S., McCormick, L. M., Fiedorowicz, J. G., Epping, E. A. & Moser, D. J. (2015). Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease. Frontiers in human neuroscience, 9, 408. PMID: 26236221.

Epping, E., Kim, J., Craufurd, D., Brashers-Krug, T., Andersen, K., Long, J. D. & Paulsen, J. S. (2014). Longitudinal Psychiatric Symptoms Progress in Premanifest HD: a Decade of Data.

Rudd, D., Axelson, M., Epping, E. A., Andreasen, N. C. & Wassink, T. H. (2014). A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet. PMID: 25228354.

Epping, E., Black, D. (2014). Schizophrenia Epidemiology. In Schizophrenia and Related Disorders Primer. Oxford University Press.

Long, J. D., Paulsen, J. S., Marder, K., Zhang, Y., Kim, J. I., Mills, J. A. & Researchers of the Predict HD Study Group (2013). Tracking motor impairments in the progression of Huntington's disease.

Onwuameze, O. E., Nam, K. W., Epping, E. A., Wassink, T. H., Ziebell, S., Andreasen, N. C. & Ho, B. C. (2013). MAPK14 and CNR1 gene variant interactions: Effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychological Medicine, 43(3), 619-31. PMID: 22850347.

HORIZON Investigators of the Huntington Study Group and European Huntington's Disease Network (2013). A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease. JAMA Neurology, 70(1), 25-33. PMID: 23108692.

Biglan, K. M., Zhang, Y., Long, J. D., Geschwind, M., Kang, G. A., Killoran, A., Lu, W., McCusker, E., Mills, J. A., Raymond, L. A., Testa, C., Wojcieszek, J., Paulsen, J. S. & REDICT-HD Investigators of the Huntington Study Group (2013). Refining the diagnosis of Huntington disease: the PREDICT-HD study. Frontiers in Aging Neuroscience, 5(12).

Aylward, E. H., Harrington, D. L., Mills, J. A., Nopoulos, P. C., Ross, C. A., Long, J. D., Liu, D., Westervelt, H. K., Paulsen, J. S. & PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013). Regional atrophy associated with cognitive and motor function in prodromal Huntington disease. J Huntingtons Dis, 2(4), 477-489. DOI: 10.3233/JHD-130076.

Bonner- Jackson, A., Long, J. D., Westervelt, H., Tremont, G., Alyward, E., Paulsen, J. S. & The PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013). Cognitive Reserve and Brain Reserve in Prodromal Huntington's Disease. Journal of the International Neuropsychological Society, 1-12. PMID: 23702309.

Epping, E. A., Mills, J. A., Beglinger, L. J., Fiedorowicz, J. G., Craufurd, D., Smith, M. M., Groves, M., Rowe, K. C., Downing, N., Williams, J. K., Long, J. D., Paulsen, J. S. & PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013). Characterization of depression in prodromal Huntington Disease in the Neurobiological Predictors of HD (PREDICT-HD) Study. Journal of Psychiatry Research, 47(10), 1423-1431.

McCusker, E., Gunn, D., Epping, E. A., Loy, C., Radford, K., Griffith, J., Mills, J. A., Long, J. & Paulsen, J. (2013). Unawareness of motor phenoconversion in Huntington Disease. Neurology, 81(13), 1141-1147.

Lee, J. K., Mathews, K., Schlaggar, B., Perlmutter, J., Paulsen, J. S., Epping, E., Burmeister, L. & Nopoulos, P. (2012). Measures of growth in children at risk for Huntington disease. Neurology, 79(7), 668-74. PMID: 22815549.

Wassink, T. H., Epping, E. A., Rudd, D., Axelsen, M., Ziebell, S., Fleming, F. W., Monson, E., Ho, B. C. & Andreasen, N. C. (2012). Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Archives of General Psychiatry, 69(9), 885-92. PMID: 22945618.

Smith, M. M., Mills, J. A., Epping, E. A., Westervelt, H. J. & Paulsen, J. S. (2012). Depressive symptom severity is related to poorer cognitive performance in prodromal Huntington disease. Neuropsychology, 26(5), 664-9.

Andreasen, N. C., Wilcox, M. A., Ho, B. C., Epping, E., Ziebell, S., Zeien, E., Weiss, B. & Wassink, T. (2012). Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Molecular Psychiatry, 17(11), 1093-102. PMID: 21876540.

Brossman, B., Williams, J. K., Downing, N., Mills, J. A., Paulsen, J. S. & PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2012). Development of the Huntington disease work function scale. Journal of Occupational and Environmental Medicine, 54(10), 1300-8. PMID: 22995807.

Lee, J. M., Ramos, E. M., Lee, J. H., Gillis, T., Mysore, J. S., Hayden, M. R., Warby, S. C., Morrison, P., Nance, M., Ross, C. A., Margolis, R. L., Squitieri, F., Orobello, S., Di Donato, S., Gomez- Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R. J., McCusker, E., Novelletto, A., Frontali, M., Jones, R., Ashizawa, T., Frank, S., Saint- Hilaire, M. H., Hersch, S. M., Rosas, H. D., Lucente, D., Harrison, M. B., Zanko, A., Abramson, R. K., Marder, K., Sequeiros, J., Paulsen, J. S., PREDICT-HD study of the Huntington Study Group (HSG), Landwehrmeyer, G. B., REGISTRY study of the European Huntington's Disease Network, Myers, R. H., HD-MAPS Study Group, MacDonald, M. E., Guesella, J. F. & COHORT study of the HSG (2012). CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology Mar, 78(10), 690-5.

Long, J. S., Matson, W. R., Juhl, A. R., Leavitt, B. R., Paulsen, J. S. & PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2012). 8OHdG as a marker for Huntington disease progression. Neurobiology of Disease, 46(3), 625-34.

Downing, N., Smith, M. M., Beglinger, L. J., Mills, J., Duff, K., Rowe, K. C., Epping, E., Paulsen, J. S. & Predict-Hd Investigators of Huntington Study Group (2012). Perceived stress in prodromal Huntington disease. Psychology and Health, 27(2), 196-209. PMID: 21623544.

Rowe, K. C., Paulsen, J. S., Langbehn, D. R., Wang, C., Mills, J., Beglinger, L. J., Smith, M. M., Epping, E. A., Fiedorowicz, J. G., Duff, K., Ruggle, A. & Moser, D. J. (2012). Patterns of serotonergic antidepressant usage in prodromal Huntington disease. Psychiatry Research, 196(2-3), 309-14.

Harrington, D. L., Smith, M. M., Zhang, Y., Carlozzi, N. E., Paulsen, J. S. & PREDICT-HD Investigators of the Huntington Study Group (2012). Cognitive domains that predict time to diagnosis in prodromal Huntington disease. The Journal of Neurology, Neurosurgery, and Psychiatry, 83(6), 612-9.

Alyward, E. H., Liu, D., Nopoulos, P. C., Ross, C. A., Pierson, R. K., Mills, J. A., Long, J. D., Paulsen, J. S. & PREDICT-HD Investigators of the Huntington Study Group (2012). Striatal volume contributes to the prediction of onset of Huntington disease in incident cases. Biological Psychiatry, 71(9), 822-8.

Nopoulos, P., Epping, E. A., Wassink, T., Schlaggar, B. L. & Perlmutter, J. (2011). Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: Evidence for assortative mating. Behavioral and Brain Functions, 7, 45. PMID: 22008211.

Williams, J., Downing, N., Vaccarino, A. L., Guttman, M., Paulsen, J. S. & PREDICT-HD Investigators of the HSG (2011). Self Reports of Day-to-Day Function in a Small Cohort of People with Prodromal and Early HD. PLoS Currents: Huntington Disease,(18). PMID: 21901173.

Epping, E. A., Paulsen, J. (2011). Depression in the early stages of Huntington disease.

Zhang, Y., Long, J. D., Mills, J. A., Warner, J. H., Lu, W., Paulsen, J. S. & PREDICT-HD Investigators of the Huntington Study Group (2011). Indexing disease progression at study entry with individuals at-risk for Huntington disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156(7), 751-763. PMID: 21858921.

Carlozzi, N. E., Stout, J. C., Mills, J. A., Duff, K., Beglinger, L. J., Alyward, E. H., Whitlock, K. B., Solomon, A. C., Queller, S., Langbehn, D. R., Johnson, S. A., Paulsen, J. S. & PREDICT-HD Investigators of the Huntington Study Group (2011). Estimating Premorbid IQ in the Prodromal Phase of a Neurodegenerative Disease. The Clinical Neuropsychologist, 25, 757-777. PMID: 21660882.

Hartz, S. M., Ho, B. C., Andreasen, N. C., Librant, A., Rudd, D., Epping, E. A. & Wassink, T. H. (2010). G72 influences longitudinal change in frontal lobe volume in schizophrenia. American Journal of Medical Genetics, 153B(2), 640-7. PMID: 19760675.

Nopoulos, P., Aylward, E., Ross, C., Johnson, H., Magnotta, V., Juhl, A., Pierson, R., Mills, J., Langbehn, D., Paulsen, J. & PREDICT-HD Investigators Coordinators of Huntington Study Group (HSG) (2010). Cerebral cortex structure in prodromal Huntington disease. Neurobiology of Disease, 40(3), 544-54. PMID: 20688164.

Duff, K., Paulsen, J., Mills, J., Beglinger, L. J., Moser, D. J., Smith, M. M., Langbehn, D., Stout, J., Queller, S., Harrington, D. L. & PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2010). Mild cognitive impairment in prediagnosed Huntington disease. Neurology, 75(6), 500-7. PMID: 20610833.

Soneson, C., Fontes, M., Zhou, Y., Denisov, V., Paulsen, J. S., Kirik, D., Petersen, A. & Huntington Study Group PREDICT-HD investigators (2010). Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis. Neurobiology of Disease, 40(3), 531-43. PMID: 20682340.

Davis, L. K., Meyer, K. J., Rudd, D. S., Librant, A. L., Epping, E. A., Sheffield, V. C. & Wassink, T. H. (2009). Novel copy number variants in children with autism and additional developmental anomalies. Journal of Neurodevelopmental Disorders, 1(4), 292-301. PMID: 21547721.

Fiedorowicz, J. G., Epping, E. A. & Flaum, M. (2008). Toward defining schizophrenia as a more useful clinical concept. Current Psychiatry Reports, 10(4), 344-51. PMID: 18627674.

Davis, L. K., Meyer, K. J., Rudd, D. S., Librant, A. L., Epping, E. A., Sheffield, V. C. & Wassink, T. H. (2008). Pax6 3' deletion results in aniridia, autism and mental retardation. Human Genetics, 123(4), 371-8. PMID: 18322702.

Ho, B. C., Epping, E., Wang, K., Andreasen, N. C., Librant, A. & Wassink, T. H. (2008). Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities. Schizophrenia Research, 106(2-3), 192-9. PMID: 18799289.

Wassink, T. H., Hazlett, H. C., Epping, E. A., Arndt, S., Dager, S. R., Schellenberg, G. D., Dawson, G. & Piven, J. (2007). Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Archives of General Psychiatry, 64(6), 709-17. PMID: 17548752.

Epping, E. A., Moye-Rowley, W. S. (2002). Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. The Journal of Biological Chemistry, 277(38), 34860-9. PMID: 12107161.

Katzmann, D. J., Epping, E. A. & Moye-Rowley, W. S. (1999). Mutational disruption of plasma membrane trafficking of Saccharomyces cerevisiae Yor1p, a homologue of mammalian multidrug resistance protein. Molecular and Cellular Biology, 19(4), 2998-3009. PMID: 10082567.

Coleman, S. T., Epping, E. A., Steggerda, S. M. & Moye-Rowley, W. S. (1999). Yap1p activates gene transcription in an oxidant-specific fashion. Molecular and Cellular Biology, 19(12), 8302-13. PMID: 10567555.

Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E. A., Moye-Rowley, W. S., Balzi, E. & Goffeau, A. (1995). Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. The Journal of Biological Chemistry, 270(30), 18150-7. PMID: 7629127.