Gen Shinozaki, MD

Associate Professor of Psychiatry

Contact Information

Office: B002F Medical Laboratories
200 Hawkins Dr.
Iowa City, IA 52242


BSc, Physics, University of Tokyo School of Science
MSc, Physics-Quantum Optics, University of Tokyo Graduate School of Science
MD, University of Yamanashi School of Medicine
MSc, University of Iowa Interdisciplinary Graduate Program in Informatics

Internship, Medicine, United States Naval Hospital Okinawa
Resident, Psychiatry, University Hospital, University of Yamanashi
Resident, Psychiatry, Mayo Clinic
Resident, Research Chief, Mayo Clinic
Fellow, Psychosomatic Medicine, Mayo Clinic

Licensure and Certifications

Medical License - State of Iowa Board of Medicine
Board Certified in Psychosomatic Medicine - American Board of Psychiatry and Neurology
Board Certified in Psychiatry - American Board of Psychiatry and Neurology
Japanese Board of Medicine


Shinozaki, G., Hing, B. & Potash, J. B. (2014). Chapter 13: Epigenetics of Bipolar Disorder. In J. Peedicayil , D. R. Grayson & D. Avramopoulos (Eds.) Epigenetics in Psychiatry. pp. 265-278. Waltham, MA: Academic Press.

Shinozaki, G., Kung, S. & Mrazek, D. A. (2014). Does 5HTTLPR long allele prevent hospitalization? Test of Hardy-Weinberg equilibrium. Psychiatr Genet, 24(1), 34-6. PMID: 24300662.

Shinozaki, G., Potash, J. B. (2014). New developments in the genetics of bipolar disorder. Curr Psychiatry Rep, 16(11), 493. PMID: 25194313.

Kumar, Y., Kung, S. & Shinozaki, G. (2014). CYP2C19 Variation, Citalopram dose and QTc Prolongation on Electrocardiogram. J Psychopharmacol, 28(12), 1143-1148. PMID: 25122046.

Mrazek, D. A., Biernacka, J. M., McAlpine, D. E., Benitez, J., Karpyak, V. M., Williams, M. D., Hall-Flavin, D. K., Netzel, P. J., Passov, V., Rohland, B. M., Shinozaki, G., Hoberg, A. A., Snyder, K. A., Drews, M. S., Skime, M. K., Sagen, J. A., Schaid, D. J., Weinshilboum, R. & Katzelnick, D. J. (2014). Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study. J Clin Psychopharmacol, 34(3), 313-7.

Shinozaki, G., Romanowicz, M., Mrazek, D. A. & Kung, S. (2013). HTR2A gene-child abuse interaction and association with a history of suicide attempt among Caucasian depressed psychiatric inpatients. J Affect Disord, 150(3), 1200-3. PMID: 23759279.

Shinozaki, G., Romanowicz, M., Passov, V., Rundell, J., Mrazek, D. & Kung, S. (2013). State dependent gene-environment interaction: serotonin transporter gene-child abuse interaction associated with suicide attempt history among depressed psychiatric inpatients. J Affect Disord, 147(1-3), 373-8. PMID: 23261136.

Shinozaki, G., Kumar, Y., Rosen, B. H., Rundell, J. R., Mrazek, D. A. & Kung, S. (2013). "Diminished" association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample. J Affect Disord, 151(1), 397-400. PMID: 23838390.

Shinozaki, G., Romanowicz, M., Kung, S., Rundell, J. & Mrazek, D. (2012). Investigation of serotonin transporter gene (SLC6A4) by child abuse history interaction with body mass index and diabetes mellitus of White female depressed psychiatric inpatients. Psychiatr Genet, 22(3), 109-14. PMID: 22311265.

Shinozaki, G. (2012). The integrated model of serotonin transporter gene variation (5HTTLPR) and the glial cell transporter in stress vulnerability and depression. Med Hypotheses, 78(3), 410-4. PMID: 22236459.

Romanowicz, M., Ehlers, S., Walker, D., Decker, P., Rundell, J., Shinozaki, G., Litzow, M., Hogan, W., Mrazek, D. & Black, J. L. (2012). Testing a diathesis-stress model: potential genetic risk factors for development of distress in context of acute leukemia diagnosis and transplant. Psychosomatics, 53(5), 456-62. PMID: 22652301.

Shinozaki, G. (2011). Continuous un-SERT-ainty of 5-HTTLPR. Pharmacogenomics, 12(7), 935-8. PMID: 21787187.

Rundell, J. R., Staab, J. P., Shinozaki, G., Saad-Pendergrass, D., Moore, K., McAlpine, D. & Mrazek, D. (2011). Pharmacogenomic testing in a tertiary care outpatient psychosomatic medicine practice. Psychosomatics, 52(2), 141-6. PMID: 21397106.

Das, P., Shinozaki, G. & McAlpine, D. (2011). Post-pump chorea--choreiform movements developing after pulmonary thromboendarterectomy for chronic pulmonary hypertension presenting as "functional" movement disorder. Psychosomatics, 52(5), 459-62. PMID: 21907066.

Rundell, J. R., Staab, J. P., Shinozaki, G. & McAlpine, D. (2011). Serotonin transporter gene promotor polymorphism (5-HTTLPR) associations with number of psychotropic medication trials in a tertiary care outpatient psychiatric consultation practice. Psychosomatics, 52(2), 147-53. PMID: 21397107.

Shinozaki, G., Romanowicz, M., Kung, S. & Mrazek, D. A. (2011). A new interaction between SLC6A4 variation and child abuse is associated with resting heart rate. Depress Anxiety, 28(3), 227-33. PMID: 21394855.

Shinozaki, G., Jowsey, S., Amer, H., Biernacka, J., Colby, C., Walker, D., Black, J., Rundell, J., Stegall, M. & Mrazek, D. A. (2011). Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients. Depress Anxiety, 28(12), 1111-8. PMID: 22134958.

Rundell, J., Shinozaki, G. (2010). Pharmacogenomic considerations in patients with comorbid medical and psychiatric illness. Primary Psychiatry, 17(5), 33-8.

Chen, L. P., Murad, M. H., Paras, M. L., Colbenson, K. M., Sattler, A. L., Goranson, E. N., Elamin, M. B., Seime, R. J., Shinozaki, G., Prokop, L. J. & Zirakzadeh, A. (2010). Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clin Proc, 85(7), 618-29.

Sprangers, M. A., Bartels, M., Veenhoven, R., Baas, F., Martin, N. G., Mosing, M., Movsas, B., Ropka, M. E., Shinozaki, G., Swaab, D. & Consortium, G. (2010). Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states. Qual Life Res, 19(10), 1429-37.

Sprangers, M. A., Sloan, J. A., Veenhoven, R., Cleeland, C. S., Halyard, M. Y., Abertnethy, A. P., Baas, F., Barsevick, A. M., Bartels, N., Boomsma, D. I., Chauhan, C., Dueck, A. C., Frost, M. H., Hall, P., Klepstad, P., Martin, N. G., Miaskowski, C., Mosing, M., Movsas, B., Van Noorden, C. J., Patrick, D. L., Pedersen, N. L., Ropka, M. E., Shi, Q., Shinozaki, G., Singh, J. A., Yang, P. & Zwinderman, A. H. (2009). The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes. Twin Res Hum Genet, 12(3), 301-11.