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Hildegard Janouschek, MD

Portrait
Assistant Professor of Psychiatry

Contact Information

2330 PBDB
(319)-335-3036

Education

MD, Medicine, University of Regensburg
Resident, Department of Psychiatry and Psychotherapy, RWTH Aachen University
Resident, Department of Neurology, RWTH Aachen University
Resident, RWTH Aachen University
Post Graduate, Department of Psychiatry and Psychotherapy, Aachen University
Resident, Department of Neurology, RWTH Aachen University
Fellow, Neuro-Critical Care, RWTH Aachen

Center, Program and Institute Affiliations

Iowa Neuroscience Institute

Research Summary

The Janouschek lab is interested in understanding the development of fear-related behaviors from a developmental perspective. Our current projects focus on acid-sensing ion channels, brain-acidity and the emergence of different fear related behaviors during development. In another project we, investigate the influence of cerebellar manipulations on fear related behaviors and memory. In order to answer our questions we use behavioral testing, genetic manipulations, molecular biology, biochemistry and neuropathology.

Publications

Janouschek, H., Eickhoff, C. R., Mühleisen, T. W., Eickhoff, S. B. & Nickl-Jockschat, T. (2018). Using coordinate-based meta-analyses to explore structural imaging genetics. Brain structure & function. PMID: 29730826.

Veselinovic, T., Vernaleken, I., Janouschek, H., Cumming, P., Paulzen, M., Mottaghy, F. M. & Gründer, G. (2018). The role of striatal dopamine D2/3 receptors in cognitive performance in drug-free patients with schizophrenia. Psychopharmacology. PMID: 29717334.

Nickl-Jockschat, T., Janouschek, H., Eickhoff, S. B. & Eickhoff, C. R. (2015). Lack of meta-analytic evidence for an impact of COMT Val158Met genotype on brain activation during working memory tasks. (Vols. 78). (11), pp. e43-6. Biological psychiatry. PMID: 25861704.

Veselinovic, T., Vernaleken, I., Janouschek, H., Kellermann, T., Paulzen, M., Cumming, P. & Gründer, G. (2015). Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology, 232(9), 1607-17. PMID: 25373869.

Janouschek, H., Nickl-Jockschat, T. (2014). The mechanism of action of ECT. In M. Grozinger , T. Nickl-Jockschat , J. Di Pauli (Eds.) Elektrokonvulsionstherapie kompakt. Germany .

Janouschek, H., Nickl-Jockschat, T., Haeck, M., Gillmann, B. & Grözinger, M. (2013). Comparison of methohexital and etomidate as anesthetic agents for electroconvulsive therapy in affective and psychotic disorders. Journal of psychiatric research, 47(5), 686-93. PMID: 23399487.

Neuner, I., Arrubla, J., Ehlen, C., Janouschek, H., Nordt, C., Fimm, B., Schneider, F., Shah, N. J. & Kawohl, W. (2012). Fine motor skills in adult Tourette patients are task-dependent. BMC neurology, 12, 120. PMID: 23057645.

Kuhn, J., Janouschek, H., Raptis, M., Rex, S., Lenartz, D., Neuner, I., Mottaghy, F. M., Schneider, F., Schaefer, W. M., Sturm, V., Gründer, G. & Vernaleken, I. (2012). In vivo evidence of deep brain stimulation-induced dopaminergic modulation in Tourette's syndrome. (Vols. 71). (5), pp. e11-3. Biological psychiatry. PMID: 22129758.

Haeck, M., Gillmann, B., Janouschek, H. & Grözinger, M. (2011). Electroconvulsive therapy can benefit from controlled hyperventilation using a laryngeal mask. European archives of psychiatry and clinical neuroscience, 261 Suppl 2, S172-6. PMID: 21901267.

Vernaleken, I., Janouschek, H., Raptis, M., Hellmann, S., Veselinovic, T., Bröcheler, A., Boy, C., Cumming, P., Hiemke, C., Rösch, F., Schäfer, W. M. & Gründer, G. (2010). Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas. The international journal of neuropsychopharmacology, 13(7), 951-60. PMID: 20392299.

Vernaleken, I., Kuhn, J., Lenartz, D., Raptis, M., Huff, W., Janouschek, H., Neuner, I., Schaefer, W. M., Gründer, G. & Sturm, V. (2009). Bithalamical deep brain stimulation in tourette syndrome is associated with reduction in dopaminergic transmission. (Vols. 66). (10), pp. e15-7. Biological psychiatry. PMID: 19709645.

Neuner, I., Podoll, K., Janouschek, H., Michel, T. M., Sheldrick, A. J. & Schneider, F. (2009). From psychosurgery to neuromodulation: deep brain stimulation for intractable Tourette syndrome. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 10(4 Pt 2), 366-76. PMID: 19005877.

Vernaleken, I., Fellows, C., Janouschek, H., Bröcheler, A., Veselinovic, T., Landvogt, C., Boy, C., Buchholz, H. G., Spreckelmeyer, K., Bartenstein, P., Cumming, P., Hiemke, C., Rösch, F., Schäfer, W., Wong, D. F. & Gründer, G. (2008). Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone). Journal of clinical psychopharmacology, 28(6), 608-17. PMID: 19011428.

Gründer, G., Fellows, C., Janouschek, H., Veselinovic, T., Boy, C., Bröcheler, A., Kirschbaum, K. M., Hellmann, S., Spreckelmeyer, K. M., Hiemke, C., Rösch, F., Schaefer, W. M. & Vernaleken, I. (2008). Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study. The American journal of psychiatry, 165(8), 988-95. PMID: 18381901.