Virginia Willour, PhD

Portrait
Associate Professor of Psychiatry

Contact Information

Office: B002J Medical Laboratories
Iowa City, IA 52242
319-335-7140

Education

BS, Biology, German, University of Michigan, Ann Arbor, MI
PhD, Genetics, Stanford University, Palo Alto, CA

Post Doctoral Fellow, Psychiatric Genetics, Johns Hopkins University, Baltimore, MD

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Neuroscience, Medical Scientist Training Program

Publications

Monson, E. T., Pirooznia, M., Parla, J., Kramer, M., Goes, F. S., Gaine, M. E., Gaynor, S. C., de Klerk, K., Jancic, D., Karchin, R., McCombie, W. R., Zandi, P. P., Potash, J. B. & Willour, V. L. (2017). Assessment of whole-exome sequence data in attempted suicide within a bipolar disorder cohort. Mol Neuropsychiatry, 3(1), 1-11.

Monson, E. T., de Klerk, K., Gaynor, S. C., Wagner, A. H., Breen, M. E., Parsons, M., Casavant, T. L., Zandi, P. P., Potash, J. B. & Willour, V. L. (2016). Whole-gene sequencing investigation of SAT1 in attempted suicide. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. PMID: 27229768.

Gaynor, S. C., Breen, M. E., Monson, E. T., de Klerk, K., Parsons, M., DeLuca, A. P., Scheetz, T. E., Zandi, P. P., Potash, J. B. & Willour, V. L. (2016). A targeted sequencing study of glutamatergic candidate genes insuicide attempters with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet.

Breen, M. E., Seifuddin, F., Zandi, P. P., Potash, J. B. & Willour, V. L. (2015). Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder. Psychiatr Genet. PMID: 25714448.

Willour, V. L., Seifuddin, F., Mahon, P. B., Jancic, D., Pirooznia, M., Steele, J., Schweizer, B., Goes, F. S., Mondimore, F. M., Mackinnon, D. F., Perlis, R. H., Lee, P. H., Huang, J., Kelsoe, J. R., Shilling, P. D., Rietschel, M., Nothen, M., Cichon, S., Gurling, H., Purcell, S., Smoller, J. W., Craddock, N., DePaulo JR, J. R., Schulze, T. G., McMahon, F. J., Zandi, P. P. & Potash, J. B. (2012). A genome-wide association study of attempted suicide. Mol psychiatry, 17(4), 433-444. PMID: 21423239.

Jancic, D., Seifuddin, F., Zandi, P. P., Potash, J. B. & Willour, V. L. (2012). Association study of X chromosome SNPs in attempted suicide. Psychiatry Res,(2-3), 1044-1046. PMID: 22766010.

Reti, I. M., Xu, J. Z., Yanofski, J., McKibben, J., Uhart, M., Cheng, Y. J., Zandi, P., Bienvenu, O. J., Samuels, J., Willour, V., Kasch-Semenza, L., Costa, P., Bandeen-Roche, K., Eaton, W. W. & Nestadt, G. (2011). Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse. Compr Psychiatry, 52(2), 188-94. PMID: 21295226.

Mahon, P. B., Stütz, A. M., Seifuddin, F., Huo, Y., Goes, F. S., Jancic, D., Judy, J. T., Depaulo, J. R., Gershon, E. S., McMahon, F. J., Zandi, P. P., Potash, J. B. & Willour, V. (2010). Case-control association study of TGOLN2 in attempted suicide. Am J Med Genet B Neuropsychiatr Genet, 153B(5), 1016-23. PMID: 20468057.

Perlis, R. H., Huang, J., Purcell, S., Fava, M., Rush, A. J., Sullivan, P. F., Hamilton, S. P., McMahon, F. J., Schulze, T. G., Schulze, T., Potash, J. B., Zandi, P. P., Willour, V., Penninx, B. W., Boomsma, D. I., Vogelzangs, N., Middeldorp, C. M., Rietschel, M., Nöthen, M., Cichon, S., Gurling, H., Bass, N., McQuillin, A., Hamshere, M., Craddock, N., Sklar, P. & Smoller, J. W. (2010). Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry, 167(12), 1499-507. PMID: 21041247.

Bruce, H. A., Sachs, N., Rudnicki, D. D., Lin, S. G., Willour, V., Cowell, J. K., Conroy, J., McQuaid, D. E., Rossi, M., Gaile, D. P., Nowak, N. J., Holmes, S. E., Sklar, P., Ross, C. A., Delisi, L. E. & Margolis, R. L. (2009). Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations. Psychiatr Genet, 19(2), 64-71. PMID: 19672138.

Cullen, B., Samuels, J. F., Pinto, A., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Greenberg, B. D., Knowles, J. A., Piacentini, J., Bienvenu, O. J., Grados, M. A., Riddle, M. A., Rasmussen, S. A., Pauls, D. L., Willour, V., Shugart, Y. Y., Liang, K. Y., Hoehn-Saric, R. & Nestadt, G. (2008). Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder. Depress Anxiety, 25(3), 218-24. PMID: 17345603.

Pinto, A., Greenberg, B. D., Grados, M. A., Bienvenu, O. J., Samuels, J. F., Murphy, D. L., Hasler, G., Stout, R. L., Rauch, S. L., Shugart, Y. Y., Pauls, D. L., Knowles, J. A., Fyer, A. J., McCracken, J. T., Piacentini, J., Wang, Y., Willour, V., Cullen, B., Liang, K. Y., Hoehn-Saric, R., Riddle, M. A., Rasmussen, S. A. & Nestadt, G. (2008). Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories. Psychiatry Res, 160(1), 83-93. PMID: 18514325.

Samuels, J. F., Bienvenu, O. J., Pinto, A., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Grados, M. A., Greenberg, B. D., Knowles, J. A., Piacentini, J., Cannistraro, P. A., Cullen, B., Riddle, M. A., Rasmussen, S. A., Pauls, D. L., Willour, V., Shugart, Y. Y., Liang, K. Y., Hoehn-Saric, R. & Nestadt, G. (2007). Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther, 45(4), 673-86. PMID: 16824483.

Samuels, J., Shugart, Y. Y., Grados, M. A., Willour, V., Bienvenu, O. J., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Rauch, S. L., Murphy, D. L., Wang, Y., Pinto, A., Fyer, A. J., Piacentini, J., Pauls, D. L., Cullen, B., Rasmussen, S. A., Hoehn-Saric, R., Valle, D., Liang, K. Y., Riddle, M. A. & Nestadt, G. (2007). Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry, 164(3), 493-9. PMID: 17329475.

Hasler, G., Pinto, A., Greenberg, B. D., Samuels, J., Fyer, A. J., Pauls, D., Knowles, J. A., McCracken, J. T., Piacentini, J., Riddle, M. A., Rauch, S. L., Rasmussen, S. A., Willour, V., Grados, M. A., Cullen, B., Bienvenu, O. J., Shugart, Y. Y., Liang, K. Y., Hoehn-Saric, R., Wang, Y., Ronquillo, J., Nestadt, G. & Murphy, D. L. (2007). Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry, 61(5), 617-25. PMID: 17027929.

Lin, P. I., McInnis, M. G., Potash, J. B., Willour, V., MacKinnon, D. F., DePaulo, J. R. & Zandi, P. P. (2006). Clinical correlates and familial aggregation of age at onset in bipolar disorder. Am J Psychiatry, 163(2), 240-6. PMID: 16449477.

Samuels, J. F., Riddle, M. A., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Grados, M. A., Pinto, A., Knowles, J. A., Piacentini, J., Cannistraro, P. A., Cullen, B., Bienvenu, O. J., Rasmussen, S. A., Pauls, D. L., Willour, V., Shugart, Y. Y., Liang, K. Y., Hoehn-Saric, R. & Nestadt, G. (2006). The OCD collaborative genetics study: methods and sample description. Am J Med Genet B Neuropsychiatr Genet, 141B(3), 201-7. PMID: 16511842.

Lin, P. I., McInnis, M. G., Potash, J. B., Willour, V., Mackinnon, D. F., Miao, K., Depaulo, J. R. & Zandi, P. P. (2005). Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. Am J Hum Genet, 77(4), 545-55. PMID: 16175501.

Willour, V., Yao Shugart, Y., Samuels, J., Grados, M., Cullen, B., Bienvenu, O. J., Wang, Y., Liang, K. Y., Valle, D., Hoehn-Saric, R., Riddle, M. & Nestadt, G. (2004). Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. Am J Hum Genet, 75(3), 508-13. PMID: 15272418.

McGinnis, M. G., Dick, D. M., Willour, V., Avramopoulos, D., MacKinnon, D. F., Simpson, S. G., Potash, J. B., Edenberg, H. J., Bowman, E. S., McMahon, F. J., Smiley, C., Chellis, J. L., Huo, Y., Diggs, T., Meyer, E. T., Miller, M., Matteini, A. T., Rau, N. L., DePaulo, J. R., Gershon, E. S., Badner, J. A., Rice, J. P. (2003). Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biol Psychiatry, 54(11), 1265-73. PMID: 14643094.

Segurado, R., Detera-Wadleigh, S. D., Levinson, D. F., Lewis, C. M., Gill, M., Nurnberger, J. I., Craddock, N., DePaulo, J. R., Baron, M., Gershon, E. S., Ekholm, J., Cichon, S., Turecki, G., Claes, S., Kelsoe, J. R., Schofield, P. R., Badenhop, R. F., Morissette, J., Coon, H., Blackwood, D., McInnes, L. A., Foroud, T., Edenberg, H. J., Reich, T., Rice, J. P., Goate, A., McInnis, M. G., McMahon, F. J., Badner, J. A., Goldin, L. R., Bennett, P., Willour, V., Zandi, P. P., Liu, J., Gilliam, C., Juo, S. H., Berrettini, W. H., Yoshikawa, T., Peltonen, L., Lönnqvist, J., Nöthen, M. M., Schumacher, J., Windemuth, C., Rietschel, M., Propping, P., Maier, W., Alda, M., Grof, P., Rouleau, G. A., Del-Favero, J., Van Broeckhoven, C., Mendlewicz, J., Adolfsson, R., Spence, M. A., Luebbert, H., Adams, L. J., Donald, J. A., Mitchell, P. B., Barden, N., Shink, E., Byerley, W., Muir, W., Visscher, P. M., Macgregor, S., Gurling, H., Kalsi, G., McQuillin, A., Escamilla, M. A., Reus, V. I., Leon, P., Freimer, N. B., Ewald, H., Kruse, T. A., Mors, O., Radhakrishna, U., Blouin, J. L., Antonarakis, S. E. & Akarsu, N. (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet, 73(1), 49-62. PMID: 12802785.

Potash, J. B., Willour, V., Chiu, Y. F., Simpson, S. G., MacKinnon, D. F., Pearlson, G. D., DePaulo, J. R. & McInnis, M. G. (2001). The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. Am J Psychiatry, 158(8), 1258-64. PMID: 11481160.

Margolis, R. L., O'Hearn, E., Rosenblatt, A., Willour, V., Holmes, S. E., Franz, M. L., Callahan, C., Hwang, H. S., Troncoso, J. C. & Ross, C. A. (2001). A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion. Ann Neurol, 50(3), 373-80. PMID: 11558794.

Margolis, R. L., O'Hearn, E., Rosenblatt, A., Willour, V., Holmes, S. E., Franz, M. L., Callahan, C., Hwang, H. S., Troncoso, J. C. & Ross, C. A. (2001). A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion. Ann Neurol, 50(6), 373-80. PMID: 11761463.

Stone, N. E., Fan, J. B., Willour, V., Pennacchio, L. A., Warrington, J. A., Hu, A., de la Chapelle, A., Lehesjoki, A. E., Cox, D. R. & Myers, R. M. (1996). Construction of a 750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene. Genome Res, 6(3), 218-25. PMID: 8963899.

Pennacchio, L. A., Lehesjoki, A. E., Stone, N. E., Willour, V., Virtaneva, K., Miao, J., D'Amato, E., Ramirez, L., Faham, M., Koskiniemi, M., Warrington, J. A., Norio, R., de la Chapelle, A., Cox, D. R. & Myers, R. M. (1996). Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1). Science, 271(5256), 1731-4. PMID: 8596935.