Kathleen A. Sluka, PT, PhD, FAPTA

Portrait
Professor of Physical Therapy and Rehabilitation Science

Contact Information

Primary Office
1-248 Medical Education Building
Iowa City, IA 52242
319-335-9791

Education

BS, Physical Therapy, Georgia State University
PhD, Anatomy, University of Texas Medical Branch

Licensure and Certifications

Physical Therapy - State Board of Iowa

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Dr. Sluka's laboratory studies the peripheral and central mechanisms of chronic musculoskeletal pain, and non-pharmacological treatment for chronic pain. These studies involve the use of animal models of muscle pain developed and characterized in Dr. Sluka's laboratory, as well as projects in human subjects. We use a variety of techniques to address these questions including cell culture, molecular biology, genetic manipulations, behavioral pharmacology, and standard clinical trial methodology. Our overall goals are to improve the management of pain for people with a variety of musculoskeletal pain conditions by discovering the underlying mechanisms that lead to the development of chronic pain, discovering new therapies for pain management, and improving the use of currently available treatment for pain.

Publications

Resende, L., Merriwether, E., Rampazo, É. P., Dailey, D., Embree, J., Deberg, J., Liebano, R. E. & Sluka, K. A. (2017). Meta-analysis of transcutaneous electrical nerve stimulation for relief of spinal pain. European journal of pain (London, England). PMID: 29282846.

Bobinski, F., Teixeira, J. M., Sluka, K. A. & Santos, A. (2017). Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain. Pain. PMID: 29140923 [Epub ahead of print].

Hadlandsmyth, K., Dailey, D. L., Rakel, B. A., Zimmerman, M. B., Vance, C. G., Merriwether, E. N., Chimenti, R. L., Geasland, K. M., Crofford, L. J. & Sluka, K. A. (2017). Somatic symptom presentations in women with fibromyalgia are differentially associated with elevated depression and anxiety. Journal of health psychology, 1359105317736577. PMID: 29076404 [Epub ahead of print].

Lima, L. V., DeSantana, J. M., Rasmussen, L. A. & Sluka, K. A. (2017). Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms. Pain, 158(9), 1697-1710. PMID: 28621702 [Epub 2017 Jun 8].

Brito, R. G., Rasmussen, L. A. & Sluka, K. A. (2017). Regular physical activity prevents development of chronic muscle pain through modulation of supraspinal opioid and serotonergic mechanisms. Pain reports, 2(5), e618. PMID: 29392233.

Merriwether, E. N., Rakel, B. A., Zimmerman, M. B., Dailey, D. L., Vance CGT,, Darghosian, L., Golchha, M., Geasland, K. M., Chimenti, R., Crofford, L. J. & Sluka, K. A. (2017). Reliability and Construct Validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Instruments in Women with Fibromyalgia. Pain medicine (Malden, Mass.), 18(8), 1485-1495. PMID: 27561310.

Hadlandsmyth, K., Zimmerman, M. B., Wajid, R., Sluka, K. A., Herr, K., Clark, C. R., Noiseux, N. O., Callaghan, J. J. & Rakel, B. A. (2017). Longitudinal Postoperative Course of Pain and Dysfunction Following Total Knee Arthroplasty. The Clinical journal of pain. PMID: 28731957.

Lima, L. V., Abner TSS, & Sluka, K. A. (2017). Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena. The Journal of physiology, 595(13), 4141-4150. PMID: 28369946.

Hadlandsmyth, K., Sabic, E., Zimmerman, M. B., Sluka, K. A., Herr, K. A., Clark, C. R., Noiseux, N. O., Callaghan, J. J., Geasland, K. M., Embree, J. L. & Rakel, B. A. (2017). Relationships among pain intensity, pain-related distress, and psychological distress in pre-surgical total knee arthroplasty patients: a secondary analysis. Psychology, health & medicine, 22(5), 552-563. PMID: 27216314.

Cooper, N. A., Rakel, B. A., Zimmerman, B., Tonelli, S. M., Herr, K. A., Clark, C. R., Noiseux, N. O., Callaghan, J. J. & Sluka, K. A. (2017). Predictors of multidimensional functional outcomes after total knee arthroplasty. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. PMID: 28471509.

Inoue, S., Johanek, L. M. & Sluka, K. A. (2017). Lack of Analgesic Synergy of the Cholecystokinin Receptor Antagonist Proglumide and Spinal Cord Stimulation for the Treatment of Neuropathic Pain in Rats. Neuromodulation : journal of the International Neuromodulation Society. PMID: 28393429.

Frey Law, L., Sluka, K. A. (2017). How does physical activity modulate pain?. Pain, 158(3), 369-370. PMID: 28135214.

Quintans-Júnior, L. J., Brito, R. G., Quintans, J. S., Santos, P. L., Camargo, Z. T., Barreto, P. A., Arrigoni-Blank, M. F., Lucca-Júnior, W., Scotti, L., Scotti, M. T., Kolker, S. J. & Sluka, K. A. (2017). Nanoemulsion Thermoreversible Pluronic F127-Based Hydrogel Containing Hyptis pectinata (Lamiaceae) Leaf Essential Oil Produced a Lasting Anti-hyperalgesic Effect in Chronic Noninflammatory Widespread Pain in Mice. Molecular neurobiology. PMID: 28194646.

Sluka, K. A., Clauw, D. J. (2016). Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience, 3(338), 114-129. PMID: 27291641 Epub 2016 Jun 9.

Corrêa, J. B., Costa, L. O., Oliveira, N. T., Lima, W. P., Sluka, K. A. & Liebano, R. E. (2016). Effects of the carrier frequency of interferential current on pain modulation and central hypersensitivity in people with chronic nonspecific low back pain: A randomized placebo-controlled trial. European journal of pain (London, England), 20(10), 1653-1666. PMID: 27150263.

Teixeira, J. M., Bobinski, F., Parada, C. A., Sluka, K. A. & Tambeli, C. H. (2016). P2X3 and P2X2/3 Receptors Play a Crucial Role in Articular Hyperalgesia Development Through Inflammatory Mechanisms in the Knee Joint Experimental Synovitis. Molecular neurobiology. PMID: 27709491.

Gong, W. Y., Abdelhamid, R. E., Carvalho, C. S. & Sluka, K. A. (2016). Resident Macrophages in Muscle Contribute to Development of Hyperalgesia in a Mouse Model of Noninflammatory Muscle Pain. The journal of pain : official journal of the American Pain Society, 17(10), 1081-94. PMID: 27377621 Epub Jul 1, 2016.

Noehren, B., Shuping, L., Jones, A., Akers, D. A., Bush, H. M. & Sluka, K. A. (2016). Somatosensory and Biomechanical Abnormalities in Females With Patellofemoral Pain. The Clinical journal of pain, 32(10), 915-9. PMID: 26626291.

Frey-Law, L. A., Bohr, N. L., Sluka, K. A., Herr, K., Clark, C. R., Noiseux, N. O., Callaghan, J. J., Zimmerman, M. B. & Rakel, B. A. (2016). Pain sensitivity profiles in patients with advanced knee osteoarthritis. Pain, 157(9), 1988-99. PMID: 27152688.

Hadlandsmyth, K., Sabic, E., Zimmerman, M. B., Sluka, K. A., Herr, K. A., Clark, C. R., Noiseux, N. O., Callaghan, J. J., Geasland, K. M., Embree, J. L. & Rakel, B. A. (2016). Relationships among pain intensity, pain-related distress, and psychological distress in pre-surgical total knee arthroplasty patients: a secondary analysis. Psychology, health & medicine, 1-12. PMID: 27216314.

Corrêa, J. B., Costa, L. O., Oliveira, N. T., Lima, W. P., Sluka, K. A. & Liebano, R. E. (2016). Effects of the carrier frequency of interferential current on pain modulation and central hypersensitivity in people with chronic nonspecific low back pain: A randomized placebo-controlled trial. European journal of pain (London, England). PMID: 27150263.

Merriwether, E., Rakel, B., Dailey, D., Alemo Munters, L., Darghosian, L., Abdelhamid, R., Vance, C. G., Frey Law, L. A., Allen, L., Crofford, L. & Sluka, K. A. (2016). Monocyte phenotype is associated with physical activity and pain outcomes in women with fibromyalgia. Journal of Pain, 17(4), S95. DOI: org/10.1016/j.jpain.2016.01.289.

Bohr, N., Rakel, B., Sluka, K. A. & Gardner, S. (2016). Cytokine expression in wound fluid: a pilot study. The Journal of Pain, 17(4), S39.

Cooper, N. A., Scavo, K. M., Strickland, K. J., Tipayamongkol, N., Nicholson, J. D., Bewyer, D. C. & Sluka, K. A. (2016). Prevalence of gluteus medius weakness in people with chronic low back pain compared to healthy controls. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 25(4), 1258-65. PMID: 26006705 Epub 2015 May 26.

Lima, L. V., DeSantana, J. M. & Sluka, K. A. (2016). Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms. The Journal of Pain, 17(4), S95.

Inoue, C., Sluka, K. A. (2016). Testosterone protect against development of chronic widespread fatigue induced muscle pain. The Journal of Pain, 17(4), S68.

Quintans-Júnior, L. J., Araújo, A. A., Brito, R. G., Santos, P. L., Quintans, J. S., Menezes, P. P., Serafini, M. R., Silva, G. F., Carvalho, F. M., Brogden, N. K. & Sluka, K. A. (2016). ß-caryophyllene, a dietary cannabinoid, complexed with ß-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn. Life sciences, 149, 34-41. PMID: 26883973.

Gong, W. Y., Johanek, L. M. & Sluka, K. A. (2016). A Comparison of the Effects of Burst and Tonic Spinal Cord Stimulation on Hyperalgesia and Physical Activity in an Animal Model of Neuropathic Pain. Anesthesia and analgesia. PMID: 26859873.

Subharwal, R., Rasmussen, L., Sluka, K. A. & Chapleau, M. W. (2016). Exercise Prevents Development of Autonomic Dysregulation and Hyperalgesia in a Mouse Model of Chronic Muscle Pain. Pain, 157(2), 387-98. PMID: 26313406.

Gordon, D. B., de Leon-Casasola, O. A., Wu, C. L., Sluka, K. A., Brennan, T. J. & Chou, R. (2016). Research Gaps in Practice Guidelines for Acute Postoperative Pain Management in Adults: Findings From a Review of the Evidence for an American Pain Society Clinical Practice Guideline. The journal of pain : official journal of the American Pain Society, 17(2), 158-66. PMID: 26719073.

Leung, A., Gregory, N. S., Allen, L. H. & Sluka, K. A. (2016). Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing IL-10 in mice. Pain, 157(1), 70-9. PMID: 26230740 Epub 2015 July 30.

Sluka, K. A. (2016). Mechanisms and Management of Pain for the Physical Therapist. K. A. Sluka (Eds.) (2nd Edition) Wolters Kluwer.

Johnson, M. I., Paley, C. A., Howe, T. E. & Sluka, K. A. (2015). Transcutaneous electrical nerve stimulation for acute pain. The Cochrane database of systematic reviews, 6, CD006142. PMID: 26075732.

Corrêa, J. B., Costa, L. O., de Oliveira, N. T., Sluka, K. A. & Liebano, R. E. (2015). Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case-control study. Experimental brain research, 233(8), 2391-9. PMID: 25963754 Epub 2015 May 12.

Vance, C. G., Dailey, D. L., Rakel, B. A., Geasland, K. M., Darghosian, L., Alemo Munters, L., Merriwether, E. N., Crofford, L. J. & Sluka, K. A. (2015). Skin Impedance is not a factor in transcutaneous electrical nerve stimulation effectiveness. Palm Springs, CA: American Pain Society 34th Annual Scientific Meeting.

Abdelhamid, R., Merriwether, E. N., Kolker, S., Allen, L. & Sluka, K. A. (2015). Exercise attenuates LPS-induced musculoskeletal hyperalgesia in mice by preventing excessive macrophage activation. Palm Springs, CA: American Pain Society 34th Annual Scientific Meeting.

Rakel, B., Vance, C., Zimmerman, M. B., Petsas-Blodgett, N., Amendola, A. & Sluka, K. A. (2015). Mechanical Hyperalgesia and Reduced Quality of Life Occur in People with Mild Knee Osteoarthritis Pain. Clin J Pain, 31(4), 315-22. PMID: 24866856.

da Silva, M. D., Bobinski, F., Sato, K. L., Kolker, S. J., Sluka, K. A. & Santos, A. R. (2015). IL-10 Cytokine Released from M2 Macrophages Is Crucial for Analgesic and Anti-inflammatory Effects of Acupuncture in a Model of Inflammatory Muscle Pain. Mol Neurobiol, 51(1), 19-31. PMID: 24961568 Epub ahead of print.

Bjordal, J. M., Ronzio, O., Baxter, G. D. & Sluka, K. A. (2015). On "The American Physical Therapy Association's top five Choosing Wisely recommendations." White NT, Delitto A, Manal TJ, Miller S. Phys Ther. doi: 10.2522/ptj.20140287. (Vols. 95). (2), pp. 275-8. Physical therapy. PMID: 25639528.

Hoeger Bement, M. K., Sluka, K. A. (2015). The current state of physical therapy pain curricula in the United States: a faculty survey. The journal of pain : official journal of the American Pain Society, 16(2), 144-52. PMID: 25463698.

Gregory, N. S., Brito, R. G., Fusaro, M. C. & Sluka, K. A. (2015). ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia. Molecular neurobiology. PMID: 25577172.

Abdelhamid, R. E., Sluka, K. A. (2015). ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases. Physiology (Bethesda), 30(6), 449-59. PMID: 26525344.

Gregory, N. S., Whitley, P. E. & Sluka, K. A. (2015). Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats. PLoS One, 10(9), e0138576. PMID: 26378796.

Noehren, B., Dailey, D. L., Rakel, B. A., Vance, C. G., Zimmerman, M. B., Crofford, L. J. & Sluka, K. A. (2015). Effect of transcutaneous electrical nerve stimulation on pain, function, and quality of life in fibromyalgia: a double-blind randomized clinical trial. Phys Ther, 95(1), 129-40. PMID: 25212518 Epub 2014 Sep 11.

Brito, R. G., Araujo, A. A., Quintans, J. S., Sluka, K. A. & Quintans-Junior, L. J. (2015). Enhanced analgesic activity by cyclodextrins - a systematic review and meta-analysis. Expert Opin Drug Deliv, 12(10), 1677-88. PMID: 26159048.

Walsh, D. M., Howe, T. E., Johnson, M. I. & Sluka, K. A. (2015). Review: Transcutaneous electrical nerve stimulation for acute pain. (Vols. 6). pp. CD006142. Cochrane Database of Systematic Reviews. PMID: 19370629.

Bobinski, F., Ferreira, T. A., Cordova, M. M., Dombrowski, P. A., da Cunha, C., Santo, C. C., Poli, A., Pires, R. G., Martins-Silva, C., Sluka, K. A. & Santos, A. R. (2015). Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice. Pain, 156(12), 2595-606. PMID: 26447701.

Sluka, K. A., Gregory, N. S. (2015). The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation. Neuropharmacology, 94, 58-63. PMID: 25582293.

Gereau 4th, R. W., Sluka, K. A., Maixner, W., Savage, S. R., Price, T. J., Murinson, B. B., Sullivan, M. D. & Fillingim, R. B. (2014). A Pain Research Agenda for the 21st Century. J Pain, 15(12), 1203-14. PMID: 25419990 Epub ahead of print.

Sato, K. L., Johanek, L. M., Sanada, L. S. & Sluka, K. A. (2014). Spinal cord stimulation (SCS) improves decreased physical activity induced by nerve injury. Behav Neurosci, 128(5), 625-32. PMID: 24911318 Epub 2014 Jun 9.

Rakel, B., Zimmerman, M. B., Geasland, K., Embree, J., Clark, C. R., Noiseux, N. O., Callaghan, J. J., Herr, K., Walsh, D. & Sluka, K. A. (2014). Transcutaneous Electrical Nerve Stimulation (TENS) for the Control of Pain during Rehabilitation after Total Knee Arthroplasty (TKA): A Randomized, Blinded, Placebo-Controlled Trial. Pain, 155(12), 2599-611. PMID: 25270585 Epub ahead of print.

Glass, N., Segal, N. A., Sluka, K. A., Torner, J. C., Nevitt, M. C., Felson, D. T., Bradley, L. A., Neogi, T., Lewis, C. E. & Frey-Law, L. A. (2014). Examining sex differences in knee pain: the Multicenter Osteoarthritis Study. Osteoarthritis Cartliage, 22(8), 1100-6. PMID: 24999111 Epub 2014 Jul 4.

Dailey, D. L., Keffala, V. J. & Sluka, K. A. (2014). Do cognitive and physical fatigue tasks enhance pain, cognitive fatigue and physical fatigue in people with fibromyalgia?. Arthritis Care Res (Hoboken), 67(2), 288-96. PMID: 25074583 Epub ahead of print.

Noiseux, N. O., Callaghan, J. J., Clark, C. R., Zimmerman, M. B., Sluka, K. A. & Rakel, B. A. (2014). Preoperative predictors of pain following total knee arthroplasty. J Arthroplasty, 29(7), 1383-7. PMID: 24630598.

Gong, W., Johanek, L. M. & Sluka, K. A. (2014). Spinal cord stimulation reduces mechanical hyperalgesia and restores physical activity levels in animals with noninflammatory muscle pain in a frequency-dependent manner. Anesth Analg, 119(1), 186-95. PMID: 24797123.

Gong, W., Kolker, S. J., Usachev, Y., Walder, R. Y., Boyle, D. L., Firestein, G. S. & Sluka, K. A. (2014). Acid-Sensing Ion Channel 3 decreases phosphorylation of ERK and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther, 16(3), R121. PMID: 24923411.

Sanada, L. S., Sato, K. L., Machado, N. L., Carmo Ede, C., Sluka, K. A. & Fazan, V. P. (2014). Cortex glial cells activation, associated with lowered mechanical thresholds and motor dysfunction, persists into adulthood after neonatal pain. Int J Dev Neurosci, 35, 55-63. PMID: 24667146 Epub 2014 Mar 22.

Hoeger Bement, M. K., St Marie, B. J., Nordstrom, T. M., Christensen, N., Mongoven, J. M., Koebner, I. J., Fishman, S. M. & Sluka, K. A. (2014). An interprofessional consensus of core competencies for prelicensure education in pain management: curriculum application for physical therapy. Phys Ther, 94(4), 451-65. PMID: 24309615.

Sato, K. L., Johanek, L. M., Sanada, L. S. & Sluka, K. A. (2014). Spinal cord stimulation reduces mechanical hyperalgesia and glial cell activation in animals with neuropathic pain. Anesth Analg, 118(2), 464-72. PMID: 24361846.

Gregory, N. S., Sluka, K. A. (2014). Anatomical and Physiological Factors Contributing to Chronic Muscle Pain. In B. K. Taylor , D. Finn (Eds.) Behavioral Neurobiology of Chronic Pain. pp. 327-348. New York, New York: Springer.

Vance, C. G., Dailey, D. L., Rakel, B. A. & Sluka, K. A. (2014). Using TENS for pain control: the state of the evidence. Pain Manag, 4(3), 197-209. PMID: 24953072.

Dailey, D. L., Rakel, B. A., Vance, C. G., Liebano, R. E., Amrit, A. S., Bush, H. M., Lee, K. S., Lee, J. E. & Sluka, K. A. (2013). Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain, 154(11), 2554-62. PMID: 23900134.

Sluka, K. A., Mense, S. (2013). Animal Models of Muscle Pain. In H. O. Handwerker , L. Arendt-Nielsen (Eds.) Pain Models: Translational Relevance and Applications. Washington, DC: IASP Press.

Alves, I. G., da Cruz, K. M., Mota, C. N., de Santana, D. S., Gaujac, D. P., de Carvalho, V. C., Reis, L. C., Sluka, K. A., Quintans-Junior, L. J., Antoniolli, A. R., Desantana, J. M., Badauê-Passos, D. & de Santana-Filho, V. J. (2013). Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats. (Vols. 17). (9), pp. 1291-8. Eur J Pain. PMID: 23536325 Epub 2013 Mar 27.

Sluka, K. A., Bjordal, J. M., Marchand, S. & Rakel, B. A. (2013). What Makes Transcutaneous Electrical Nerve Stimulation Work? Making Sense of the Mixed Results in the Clinical Literature. Phys Ther, 93(10), 1397-402. PMID: 23641031 Epub 2013 May 2.

Gregory, N. S., Harris, A. L., Robinson, C. R., Dougherty, P. M., Fuchs, P. N. & Sluka, K. A. (2013). An Overview of Animal Models of Pain: Disease Models and Outcome Measures. J Pain. PMID: 24035349.

Pratt, D., Fuchs, P. N. & Sluka, K. A. (2013). Assessment of avoidance behaviors in mouse models of muscle pain. Neuroscience, 248, 54-60. PMID: 23747349 Epub 2013 Jun 7.

Gardner, S. E., Blodgett, N. P., Hillis, S. L., Borhart, E., Mallory, L., Abbott, L., Pezzella, P., Jensen, M., Sommer, T., Sluka, K. A. & Rakel, B. A. (2013). HI-TENS Reduces Moderate-to-Severe Pain Associated with Wound Care Procedures: A Pilot Study. Biol Res Nurs. PMID: 23956353.

Gregory, N. S., Gibson-Corley, K., Frey Law, L. & Sluka, K. A. (2013). Fatigue-enhanced hyperalgesia in response to muscle insult: induction and development occur in a sex-dependent manner. Pain, 154(12), 2668-76. PMID: 23906552.

Santos, C. M., Francischi, J. N., Lima-Paiva, P., Sluka, K. A. & Resende, M. A. (2013). Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin. Int J Neurosci, 123(7), 507-515. PMID: 23336713.

Sluka, K. A. (2013). Effects of physical activity on laboratory pain: Studies on animals. In P. Ekkekakis (Eds.) The Routledge Handbook of Physical Activity and Mental Health. New York, New York: Taylor and Francis.

Correa, J. B., Costa, L. O., De Oliveira, N. T., Sluka, K. A. & Liebano, R. E. (2013). Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial. BMC Musculoskelet Disord, 14(1), 195. PMID: 23802771.

Sluka, K. A., Rasmussen, L. A., Edgar, M. M., O'Donnell, J. M., Walder, R. Y., Kolker, S. J., Boyle, D. L. & Firestein, G. S. (2013). Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum, 65(5), 1194-1202. PMID: 23335302.

Liebano, R. E., Vance, C. G., Rakel, B. A., Lee, J. E., Cooper, N. A., Marchand, S., Walsh, D. M. & Sluka, K. A. (2013). Transcutaneous electrical nerve stimulation and conditioned pain modulation influence the perception of pain in humans. Eur J Pain. PMID: 23650092.

Fishman, S. M., Young, H. M., Chou, R. & Sluka, K. A. (2013). Core Competencies for Pain Management: Results of an Interprofessional Consensus Summit. Pain Med. PMID: 23577878.

Sato, K. L., King, E. W., Johanek, L. M. & Sluka, K. A. (2013). Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner. Eur J Pain, 17(4), 551-561. PMID: 23065849.

Alves, I. G., Sluka, K. A. (2013). Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats. Eur J Pain.

Sluka, K. A. (2013). Peripheral and central mechanisms of chronic musculoskeletal pain. Pain Manag, 3(2), 103-107. PMID: 24504260.

Sluka, K. A., O'Donnell, J. M., Danielson, J. & Rasmussen, L. A. (2013). Regular physical activity prevents development of chronic pain and activation of central neurons. J Appl Physiol, 114(6), 725-733. PMID: 23271699.

Boyan, B. D., Tosi, L. L., Coutts, R. D., Enoka, R. M. & Sluka, K. A. (2013). Addressing the gaps: sex differences in osteoarthritis of the knee. Biol Sex Differ, 4(1), 4. PMID: 23374401.

Boyan, B. D., Hart, D. A., Enoka, R. M. & Sluka, K. A. (2013). Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee. Biol Sex Differ, 4(1), 3. PMID: 23374322.

DeSantana, J. M., da Cruz, K. M. & Sluka, K. A. (2013). Animal models of fibromyalgia. Arthritis Res Ther, 15(6), 222. PMID: 24314231.

Sluka, K. A., Arendt-Nielsen, L. (2013). Widespread Chronic Pain: Underlying Mechanisms and Clinical Implications. In B. Taylor , D. Finn (Eds.) Behavioral Neurobiology of Chronic Pain. New York, New York: Springer.

Sluka, K. A., Berkley, K. J. & O'Connor, M. I. (2012). Neural and psychosocial contributions to sex differences in knee osteoarthritic pain. Biol Sex Differ, 3(1), 26. PMID: 23244577.

Lu, Y., Whiteis, C., Sluka, K. A., Chapleau, M. W. & Abboud, F. M. (2012). Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction). J Physiol. PMID: 23165770.

Rakel, B. A., Blodgett, N. P., Zimmerman, M. B., Logsden-Sackett, N., Clark, C., Noiseaux, N., Callaghan, J., Herr, K., Geaslan, K., Yang, X. & Sluka, K. A. (2012). Predictors of Postoperative Movement Pain following Total Knee Replacement. Pain, 153(11), 2192-2203. PMID: 22840570.

Lu, Y., Whiteis, C., Sluka, K. A., Chapleau, M. W. & Abboud, F. M. (2012). Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction). J Physiol. PMID: 23165770.

Sato, K. A., Salada, L., Rakel, B. A. & Sluka, K. A. (2012). Increasing intensity of TENS daily prevents development of analgesic tolerance in rats. J Pain, 13(9), 884-890. PMID: 22858165.

Walder, R. Y., Radhakrishnan, R., Loo, L., Rasmussen, L. A., Mohapatra, D. P., Wilson, S. P. & Sluka, K. A. (2012). TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain, 153(8), 1664-1672. PMID: 22694790.

Vance, C. G., Rakel, B. A., Blodgett, N. P., DeSantana, J. M., Amendola, A., Zimmerman, M. B., Walsh, D. M. & Sluka, K. A. (2012). Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial. Phys Ther, 92(7), 898-910. PMID: 22466027.

Oliveira, L. R., De Melo, V. U., Macedo, F. N., Barreto, A. S., Badaue-Passos, D., Viana Dos Santos, M. R., Dias, D. P., Sluka, K. A., DeSantana, J. M. & Santana-Filho, V. J. (2012). Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats. Auton Neurosci, 167(1-2), 45-49. PMID: 22266357.

Sluka, K. A., Danielson, J., Rasmussen, L. & DaSilva, L. F. (2012). Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei. Med Sci Sports Exerc, 44(3), 420-427. PMID: 21795998.

Gautam, M., Benson, C. J., Ranier, J. D., Light, A. R. & Sluka, K. A. (2012). ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections. Pain Res Treat, 2012(817347). PMID: 22191025 Epub 2011 Dec 8.

Tonelli, S. M., Rakel, B. A., Cooper, N. A., Angstom, W. L. & Sluka, K. A. (2011). Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement. Biol Sex Differ, 2, 12. PMID: 22074728.

Walder, R. Y., Gautam, M., Wilson, S. P., Benson, C. J. & Sluka, K. A. (2011). Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation. Pain, 152(10), 2348-2356. PMID: 21843914.

Moran, F., Leonard, T., Hawthorne, S., Hughes, C. M., McCrum-Gardner, E., Johnson, M. I., Rakel, B. A., Sluka, K. A. & Walsh, D. M. (2011). Hypoalgesia in Response to Transcutaneous Electrical Nerve Stimulation (TENS) Depends on Stimulation Intensity. J Pain, 12(8), 929-935. PMID: 21481649 Epub 2011 Apr 9.

Pantaleao, M. A., Laurino, M. F., Gallego, N. L., Cabral, C. M., Rakel, B., Vance, C., Sluka, K. A., Walsh, D. M. & Liebano, R. E. (2011). Adjusting pulse amplitude during transcutaneous electrical nerve stimulation (TENS) application produces greater hypoalgesia. J Pain, 12(5), 581-590. PMID: 21277840 Epub 2011 Feb 1.

Schutte, D., Mukhopadhyay, N., Vance, C., Walder, R., Sluka, K. A., Rakel, B. & Govil, M. (2011). Genetic predictors of knee pain in persons with mild to moderate osteoarthritis. Dearborn MI: Midwest Nursing Research Society Annual Conference,.

Liebano, R. E., Rakel, B., Vance, C. G., Walsh, D. M. & Sluka, K. A. (2011). An investigation of the development of analgesic tolerance to TENS in humans. Pain, 152(2), 335-342. PMID: 21144659.

De Resende, M. A., Da Silva, L. F., Sato, K., Arendt-Nielsen, K. & Sluka, K. A. (2011). Blockade of opioid receptors in the SRD, but not the RVM, prevents analgesia produced by DNIC in rats with muscle inflammation. J Pain. PMID: 21330219.

Dailey, D. L., Rakel, B. A., Anand, A., Lee, J. E. & Sluka, K. A. (2011). Fatigue and Fibromyalgia. Austin, TX: Annual Meeting of the American Pain Society.

Lee, J. E., Dailey, D. L., Vance, C. G., Liebano, R., Rakel, B. A. & Sluka, K. A. (2011). Psychological distress and fatigue influence pain and function in fibromyalgia patients. Austin, TX: American Pain Society Annual Meeting.

Lee, J. E., Rakel, B. A., Sluka, K. A., Logsden-Slockett, N. & Yang, X. (2011). The role of biopsychosocial factors in the level of TENS amplitude achieved after Total Knee Replacement. Austin, TX: American Pain Society Annual Meeting.

Dailey, D. L., Rakel, B. A., Vance, C., Lee, J. E., Liebano, R., Anand, A. & Sluka, K. A. (2011). Transcutaneous Electrical Nerve Stimulation (TENS) reduces pain and improves function in people with Fibromyalgia. Austin, TX: American Pain Society Annual Meeting.

Dannecker, E. A., Sluka, K. A. (2011). Pressure and Activity-Related Allodynia in Delayed-Onset Muscle Pain. Clinical J Pain, 27(1), 42-47. PMID: 20842023.

Lee, J. E., Dailey, D. L., Vance, C. G., Liebano, R., Rakel, B. A. & Sluka, K. A. (2011). Psychological distress and fatigue influence pain and function in fibromyalgia patients. Iowa City, IA: University of Iowa Health Sciences Research Week.

DaSilva, L. F., Walder, R. Y., Davidson, B. L., Wilson, S. P. & Sluka, K. A. (2010). Changes in expression of NMDA-NR1 receptor subunits in the rostral ventromedial medulla modulate pain behaviors. Pain, 151(1), 155-161. PMID: 20688433.

Gautam, M., Benson, C. J. & Sluka, K. A. (2010). Increased response of muscle sensory neurons to decreases in PH after muscle inflammation. Neuroscience, 170(3), 893-900. PMID: 20691768.

Kolker, S. J., Walder, R. Y., Usachev, Y., Hillman, J., Boyle, D. L., Firestein, G. S. & Sluka, K. A. (2010). ASIC3 is expressed in Type B synoviocytes and chondrocytes modulates hyaluronan expression, and release. Annals Rhuem Disease, 69(5), 903-909. PMID: 19933746.

Da Silva, L. F., DeSantana, J. M. & Sluka, K. A. (2010). Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats. Pain, 11(4), 378-387. PMID: 19853525.

Walder, R. Y., Rasmussen, L. A., Rainier, J. D., Light, A. R., Wemmie, J. A. & Sluka, K. A. (2010). ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain, 11(3), 210-218. PMID: 20015600.

Sluka, K. A., Rasmussen, L. A. (2010). Fatiguing exercise enhances hyperalgesia to muscle inflammation. Pain, 148(2), 188-197. PMID: 19632780.

DeSantana, J. M., DaSilva, L. F. & Sluka, K. A. (2010). Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats. Pain, 148(1), 84-93. PMID: 19944533.

Sluka, K. A. (2010). Global Year Against Musculoskeletal Pain – Exercisehttp://www.youtube.com/watch?v=CB9FP-EP_EE&feature=channel.

Sluka, K. A. (2010). Global Year Against Musculoskeletal Pain – Introductionhttp://www.youtube.com/watch?v=VtV8BZFI12g&feature=channel.

Sluka, K. A. (2010). Global Year Against Musculoskeletal Pain – Mythshttp://www.youtube.com/watch?v=nTQQ57P5TxE.

Rakel, B., Cooper, N., Adams, H. J. & Sluka, K. A. (2009). A New Transient Sham TENS Device Allows for Investigator Blinding While Delivering a True Placebo Treatment. J Pain, 11(3), 230-238. PMID: 19945354.

Sluka, K. A. (2009). Is it possible to develop an animal model of fibromyalgia?. Pain, 146(1-2), 3-4. PMID: 19695780.

DeSantana, J. M., DaSilva, L. S., DeResende, M. & Sluka, K. A. (2009). Transcutaneous Electrical Nerve Stimulation (TENS) at both high and low frequencies activates ventrolateral periaqueductal grey to decrease mechanical hyperalgesia in arthritic rats. Neuroscience, 163(4), 1233-1241. PMID: 19576962.

Sluka, K. A., Winter, O. C. & Wemmie, J. A. (2009). Acid-sensing ion channels: A new target for pain and CNS diseases. Curr Opin Drug Discov Devel, 12(5), 693-704. PMID: 19736627.

Cowen, S., McKenna, J., McCrum-Gardner, E., Johnson, M. I., Sluka, K. A. & Walsh, D. M. (2009). An Investigation of the Hypoalgesic Effects of TENS Delivered By a Glove Electrode. J Pain, 10(7), 694-701. PMID: 19398378.

Radhakrishnan, P., Sluka, K. A. (2009). Increased glutamate and decreased glycine release in the RVM during induction of a pre-clinical model of chronic widespread muscle pain. N Lett, 457(3), 141-145. PMID: 19429181.

Sluka, K. A., Turk Dennis, C. (2009). Invited Commentary, Cognitive-Behavioral Therapy for Older Adults with Chronic Pain. Physical Therapy, 89(5), 470-473. PMID: 19411242.

Walsh, D. M., Johnson, M., Howe, T. & Sluka, K. A. (2009). Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database of Systematic Reviews,(2), CD006142. PMID: 19370629.

Ikeuchi, M., Kolker, S. J. & Sluka, K. A. (2009). Acid sensing ion channel 3 expression in mice knee joint afferents and effects of carrageenan-induced arthritis. J Pain, 10(3), 336-342. PMID: 19185546.

Maeda, Y., Lisi, T. L., Vance, C. G. & Sluka, K. A. (2009). Release of GABA and activation of GABAA in the spinal cord mediates the effects of TENS in rats. Br Research, 1136(1), 43-50. PMID: 17234163.

Walder, R. Y., Benson, C. J. & Sluka, K. A. (2009). Acid-Sensing Ion Channels and Pain. In B. E. Cairns (Eds.) Peripheral Receptor Targets for Analgesia. Novel Approaches to Pain Management. pp. 153-174. John Wiley and Sons.

DeSantana, J. M., Sluka, K. A. & Lauretti, G. R. (2009). High and low frequency TENS reduce postoperative pain intensity after laparoscopic sterilization for tubal ligation: a randomized controlled trial. Clinical J Pain, 25(1), 12-19. PMID: 19158541.

Maeda, Y., Ikeuchi, M., Wacnik, P. & Sluka, K. A. (2009). Increased c-fos immunoreactivity in the spinal cord and brain following spinal cord stimulation is frequency-dependent. Brain Res, 1259(9), 40-50. PMID: 19161992.

Sluka, K. A. (2009). Pain Mechanisms and Management for the Physical Therapist. K. A. Sluka (Eds.) Seattle, WA: IASP Press - International Association for the Study of Pain.

DeSantana, J. M., Walsh, D. M., Vance, C., Rakel, B. A. & Sluka, K. A. (2008). Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain. Curr Rheumatol, 10(6), 492-499. PMID: 19007541.

Arendt-Nielsen, L., Sluka, K. A. & Hie, H. L. (2008). Experimental muscle pain impairs descending inhibition. Pain, 140(3), 465-471. PMID: 18977598.

Frey Law, L. A., Sluka, K. A., McMullen, T., Lee, J. E., Arendt-Neilsen, L. & Graven-Nielsen, T. (2008). Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans. Pain, 140(2), 254-264. PMID: 18835099.

de Santana, J. M., Sluka, K. A. (2008). Central mechanisms in the maintenance of chronic widespread non-inflammatory muscle pain. Curr Pain Headache Rep, 12(5), 338-343. PMID: 18765138.

Maeda, Y., Wacnik, P. & Sluka, K. A. (2008). Low frequencies, but not high frequencies of bi-polar spinal cord stimulation reduce cutaneous and muscle hyperalgesia induced by nerve injury. Pain, 138(1), 143-152. PMID: 18207326.

Ikeuchi, M., Kolker, S. J., Burnes, L. A., Walder, R. Y. & Sluka, K. A. (2008). Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain, 137(3), 662-669. PMID: 18343037.

Frey Law, L. A., Evans, S., Knudtson, J., Nus, S., Scholl, K. & Sluka, K. A. (2008). Massage reduces pain perception and hyperalgesia in experimental muscle pain: a randomized, controlled trial. J Pain, 9(8), 714-721. PMID: 18455480.

Burnes, L. A., Kolker, S. J., Danielson, J. F., Walder, R. Y. & Sluka, K. A. (2008). Enhanced muscle fatigue occurs in male but not female ASIC3 -/- mice. Am J Physiol Regul Integr Comp Physiol, 294(4), R1347-R1355. PMID: 18305024.

de Santana, J. M., Santana-Filho, V. J., Guerra, D. R., Sluka, K. A., Gurgel, R. Q. & da Silva Jr., W. M. (2008). Hypoalgesic effect of the transcutaneous electrical nerve stimulation following inguinal herniorrhaphy: A randomized controlled trial. J Pain, 9(7), 623-629. PMID: 18387854.

De Santana, J. M., Santana-Filho, V. J. & Sluka, K. (2008). Modulation between high- and low- frequency transcutaneous electrical nerve stimulation delays the development of analgesic tolerance in arthritic rats. Arch Phys Med Rehabil, 89(4), 754-760. PMID: 18374009.

Walder, R. Y., Sluka, K. A. (2008). Bilateral, long-lasting hyperalgesia due to repeated excitation of muscle nociceptors: a role for ASIC3. In Fundamental of Musculoskeletal Pain. IASP Press.

Walder, R. Y., Sluka, K. A. (2008). Centering on central mechanisms in the development and maintenance of chronic widespread muscle pain. J Musculoskeletal Pain, 16(1-2), 107-113.

Sluka, K. A., Skyba, D. A., Hoeger Bement, M. K., Audette, K. M. & Radhakrishnana, R. (2008). Chapter 17: Second messenger pathways in pain. In Molecular Pain. Springer, China: Higher Education Press.

Sluka, K. A., Westlund, K. N. (2008). Neurological Regulation of Inflammation.

Hingne, P. M., Sluka, K. A. (2007). Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats. J Pain, 9(3), 217-225. PMID: 18061543.

Yokoyama, T., Ushida, T., Yamasaki, F., Inoue, S. & Sluka, K. A. (2007). Epidural puncture can be confirmed by the Queckenstedt-test procedure in patients with cervical spinal canal stenosis. Acta Anaesthesiol Scand, 52(2), 265-261. PMID: 17999711.

Tillu, D. V., Gebhart, G. F. & Sluka, K. A. (2007). Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult. Pain, 136(3), 331-339. PMID: 17764841.

Yokoyama, T., Lisi, T. L., Moore, S. A. & Sluka, K. A. (2007). Muscle fatigue increases the probability of developing hyperalgesia in mice. J Pain, 8(9), 692-699. PMID: 17627895.

Sluka, K. A., Radhakrishnan, R., Benson, C. J. & Price, M. P. (2007). ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain, 129(1-2), 102-112. PMID: 17134831.

Yokoyama, T., Maeda, Y., Audette, K. M. & Sluka, K. A. (2007). Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. J Pain, 8(5), 422-429. PMID: 17293165.

Yokoyama, T., Sadahiro, T., Sluka, K. A., Yamashita, K., Tokoroyama, H. & Manabe, M. (2007). Tethered cord syndrome discovered in preoperative examination. J Anesth, 21(2), 270-272. PMID: 17458659.

Moss, P., Sluka, K. A. & Wright, A. (2007). The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther, 12(2), 109-118. PMID: 16777467 Epub 2006 June 13.

Bement, M. H., Sluka, K. A. (2007). Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model. Neuroscience Letters, 418(1), 22-27. PMID: 17395373.

Hingne, P. M., Sluka, K. A. (2007). Differences in waveform characteristics have no effect on the anti-hyperalgesia produced by transcutaneous electrical nerve stimulation (TENS) in rats with joint inflammation. J Pain, 8(3), 251-255. PMID: 17169615.

Hoeger Bement, M. K., Sluka, K. A. (2007). Pain: Perception and mechanisms. In Magee , Zachazewski , Quillen (Eds.) Scientific Foundations and Principles of Practice in Musculoskeletal Rehabilitation. Saunders-Elsevier Health Sciences.

Sluka, K. A., Skyba, D. A., Hoeger Bement, M. K., Audette, K. M. & Radhakrishnan, R. (2007). Second Messenger Pathways in Pain. In M. Zhuo (Eds.) Molecular Pain. (Part V), pp. pp 219-234. Springer New York. DOI: 10.1007/978-0-387-75269-3_17.

Sluka, K. A. (2007). The Neurobiology of Pain and Foundations for Electrical Stimulation for Pain Control. In Clinical Electrophysiology. AJ Robinson and L Snyder-Mackler.

Vance, C. G., Radhakrishnan, R., Skyba, D. A. & Sluka, K. A. (2007). Transcutaneous electrical nerve stimulation at both high and low frequencies reduces primary hyperalgesia in rats with joint inflammation in a time-dependent manner. Phys Ther, 87(1), 44-51. PMID: 17142641.

Yokoyama, T., Yamashita, K., Manabe, M. & Sluka, K. A. (2006). Tracheobronchomalacia-like lung collapse during three separate trials of general anesthesia. Anesth Analg, 103(4), 1039-1040. PMID: 17000829.

Sluka, K. A., Lisi, T. L. & Westlund, K. N. (2006). Increased release of serotonin in the spinal cord during low, but not high, frequency TENS in rats with joint inflammation. Arch Phys Med Rehab, 87(8), 1137-1140. PMID: 16876561.

Sluka, K. A., Skyba, D. A., Radhakrishnan, R., Leeper, B. J. & Wright, A. (2006). Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats. J Pain, 7(8), 602-607. PMID: 16885017.

Sluka, K. A., Audette, K. M. (2006). Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia. Mol Pain, 2, 13. PMID: 16584564.

Vadakkan, K. I., Wang, H., Ko, S. W., Zastepa, E., Petrovic, M. J., Sluka, K. A. & Zhuo, M. (2006). Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases. Mol Pain, 2, 7. PMID: 16503978.

Lisi, T. L., Sluka, K. A. (2006). A new electrochemical HPLC method for analysis of enkelphalins and endomorphins. J Neurosci Methods, 150(1), 74-79. PMID: 16051372.

Moss, P., Sluka, K. & Wright, A. (2006). Chapter 73: Passive joint movement produces local and widespread hypoalgesic effects in subjects with knee osteoarthritis. In Proceedings of the 11th World Congress on Pain. pp. 843-850. Seattle, WA: IASP Press.

Sluka, K. A., Westlund, K. N. (2006). Nocifensive behaviors (muscle and joint).

Sluka, K. A. (2006). Opioids and muscle pain.

Moss, P., Sluka, K. A. & Wright, A. (2006). Passive joint movement produces local and widespread hypoalgesic effects in subjects with knee osteoarthritis. In Proceedings of the 11th World Congress on Pain. Seattle: IASP Press.

Sluka, K. A., Wu, G. & Chung, J. M. (2006). Recent insights into analgesic mechanisms of acupuncture and TENS. In Proceedings of the 11th World Congress on Pain. pp. 859-866. IASP Press.

Sluka, K. A. (2006). TENS, mechanisms of action.

Sluka, K. A., Vance, C. G. & Lisi, T. L. (2005). High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn. J Neurochem, 95(6), 1794-1801. PMID: 16236028.

Skyba, D. A., Lisi, T. L. & Sluka, K. A. (2005). Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injections of acidic saline. Pain, 119(1-3), 142-149. PMID: 16297556.

Ainsworth, L., Budelier, K., Clinesmith, M., Fiedler, A., Landstrom, R., Leeper, B. J., Moeller, L., Mutch, S., O'Dell, J., Ross, J., Radhakrishnan, R. & Sluka, K. A. (2005). Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation. Pain, 120(1-2), 182-187. PMID: 16360266.

Radhakrishnan, R., Sluka, K. A. (2005). Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-induced antihyperalgesia. J Pain, 6(10), 673-680. PMID: 16202960.

Bement, M. K., Sluka, K. A. (2005). Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. Arch Phys Med Rehabil, 86(9), 1736-1740. PMID: 16181935.

Carlson, E. W., Audette, K., Altman, G. A., Nguyen, H. O., Sluka, K. A. & Fairbanks, C. A. (2005). Transcutaneous electrical nerve stimulation activates peripherally located alpha 2A adrenergic receptors. Pain, 115(3), 364-373. PMID: 15911163.

Radhakrishnan, R., Sluka, K. A. (2005). Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats. J Pharmacol Exp Ther, 313(2), 921-927. PMID: 15743922.

Skyba, D., Radhakrishnan, R. & Sluka, K. A. (2005). Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. J Pain, 6(1), 41-47. PMID: 15629417.

Sluka, K. A., Radhakrishnan, R. (2005). Chronic musculoskeletal pain: Preclinical models and drug discovery. Indian Pharmaceutical Forum Proceedings.

Skyba, D., Radhakrishnan, R., Hoeger Bement, M. K. & Sluka, K. A. (2004). AC-cAMP pathway and pain: Potential targets for drug development. Drug Discovery Today, 1, 115-119.

Radhakrishnan, R., Bement, M., Skyba, D., Kehl, L. & Sluka, K. (2004). Models of muscle pain: Carrageenan model and acidic saline model. In S. J. Enna , M. Williams , J. Ferkany , T. Kenakin & R. Porsolt , J. Sullivan (Eds.) In: Current Protocols in Pharmacology. pp. 25:5.35.1-5.35.28. Hoboken, NJ: John Wiley & Sons. DOI: 10.1002/0471141755.

Sluka, K. A., Price, M. P., Wemmie, J. A. & Welsh, M. J. (2004). The ASIC3, but not the ASIC1 channel is involved in chronic muscle pain. In J. O. Dostrovsky , D. B. Carr , M. Koltzeburt (Eds.) Proceedings of the 10th World Congress on Pain. IASP Press.

Sluka, K. A., Price, M. P., Breese, N. M., Stucky, C. L., Wemmie, J. A. & Welsh, M. J. (2003). Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain, 106(3), 229-239. PMID: 14659506.

Radhakrishnan, R., Sluka, K. A. (2003). Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats. Neuropharmacology, 45(8), 1111-1119. PMID: 14614954.

Skyba, D. A., Radhakrishnan, R., Rohlwing, J. J., Wright, A. & Sluka, K. A. (2003). Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord. Pain, 106(1-2), 159-168. PMID: 14581123.

Radhakrishnan, R., King, E. W., Dickman, J. K., Herold, C. A., Johnston, N. F., Spurgin, M. L. & Sluka, K. A. (2003). Spinal 5-HT2 and 5-HT3 receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats. Pain, 105(1-2), 205-213. PMID: 14499437.

Radhakrishnan, R., Moore, S. A. & Sluka, K. A. (2003). Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain, 104(3), 567-577. PMID: 12927629.

Hoeger Bemet, M. K., Sluka, K. A. (2003). Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections. J Neurosci, 23(13), 5437-5445. PMID: 12843242.

Lisi, T. L., Westlund, K. N. & Sluka, K. A. (2003). Comparison of microdialysis and push-pull perfusion for retrieval of serotonin and norepinephrine in the spinal cord dorsal horn. J Neurosci Meth, 126(2), 187-194. PMID: 12814843.

Saito, F., Moore, S. A., Barresi, R., Henry, M. D., Messing, A., Ross-Barta, S. E., Cohn, R. D., Williamson, R. A., Sluka, K. A., Sherman, D. L., Brophy, P. J., Schmelzer, J. D., Low, P. A., Wrabetz, L., Feltri, M. L. & Campbell, K. P. (2003). Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron, 38(5), 747-758. PMID: 12797959.

Sluka, K. A., Walsh, D. (2003). TENS: basic science mechanisms and clinical effectiveness. J Pain, 4(3), 109-121. PMID: 14622708.

Chandran, P., Sluka, K. A. (2003). Development of opioid tolerance with repeated TENS administration. Pain, 102(1-2), 195-201. PMID: 12620611.

Hoeger Bement, M. K., Skyba, D. A., Radhakrishnan, R. & Sluka, K. A. (2003). Central sensitization and musculoskeletal pain. Seminars in Pain Medicine, 1(3), 139-149.

Sluka, K. A., Chandran, P. (2002). Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS. Pain, 100(1-2), 183-190. PMID: 12435471.

Zahn, P. K., Sluka, K. A. & Brennan, T. J. (2002). Excitatory amino acid release in the spinal cord caused by plantar incision in the rat. Pain, 100(1-2), 65-76. PMID: 12435460.

Sluka, K. A., Rohlwing, J. J., Bussey, R. A., Eikenberry, S. A. & Wilken, J. M. (2002). Chronic muscle pain induced by repeated acid injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J Pharmacol Exp Ther, 302(3), 1146-1150. PMID: 12183674.

Skyba, D. A., King, E. W. & Sluka, K. A. (2002). Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline. Pain, 98(1-2), 69-78. PMID: 12098618.

Sluka, K. A. (2002). Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway. J Neuroscience, 22(13), 5687-5693. PMID: 12097520.

Sluka, K. A., Hoeger, M. K. & Skyba, D. A. (2002). Basic science mechanisms of physical therapy treatments for pain. In M. A. Giamberaridino (Eds.) Pain 2002 An Updated Review: A Refresher Course. Seattle: ASP Press.

Price, M. P., McIlwrath, S. L., Xie, J., Cheng, C., Qioa, J., Tarr, D. E., Sluka, K. A., Brennan, T. J., Lewin, G. R. & Welsh, M. (2001). The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron, 32(6), 1071-1083. PMID: 11754838.

Kalra, A., Urban, M. O. & Sluka, K. A. (2001). Blockade of opioid receptors in the rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exp Ther, 298(1), 257-263. PMID: 11408550.

King, E. W., Sluka, K. A. (2001). The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on the treatment of secondary mechanical hyperalgesia in an animal model of inflammation. J Pain, 2, 128-133. PMID: 14622834.

Wright, A., Sluka, K. A. (2001). Non-pharmacological treatments for musculoskeletal pain. Clin J Pain, 17(1), 33-46. PMID: 11289087.

Ma, Y. T., Sluka, K. A. (2001). Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetized rats. Exp Brain Res, 137(1), 94-102. PMID: 11310176.

Patterson, S. L., Sluka, K. A. & Arnold, M. A. (2001). A novel transverse push-pull micro-probe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn. J Neurochem, 76(1), 234-246. PMID: 11145997.

Sluka, K. A., Wright, A. (2001). Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint. Europ J Pain, 5(1), 81-87. PMID: 11394925.

Sluka, K. A. (2001). The basic science mechanisms of TENS and clinical implications. APS Bulletin, 1, 10-13.

Sluka, K. A., Kalra, A. & Moore, S. M. (2001). Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. Muscle & Nerve, 24(1), 37-46. PMID: 11150964.

Gopalkrishnan, P., Sluka, K. A. (2000). Effect of varying frequency and intensity of TENS on primary hyperalgesia in rats. Arch Phys Med Rehabil, 81(7), 984-990. PMID: 10896017.

Sluka, K. A., Judge, M. A., McColley, M. M., Reveiz, P. M. & Taylor, B. M. (2000). Low frequency TENS is less effective than high frequency TENS at reducing inflammation induced hyperalgesia in morphine tolerant rats. Europ J Pain, 4(2), 185-193. PMID: 10957699.

Sluka, K. A. (2000). Systemic morphine in combination with TENS produces an increased analgesia in rats with acute inflammation. J Pain, 1(3), 204-211. PMID: 14622619.

Sluka, K. A., Deacon, M., Stribal, A., Strissel, S. & Terpstra, A. (1999). Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats. J Pharm Exp Ther, 289(2), 840-846. PMID: 10215661.

Sluka, K. A., Christy, M. R., Peterson, W. L., Rudd, S. L. & Troy, S. M. (1999). Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis. Arch Phys Med Rehabil, 80(3), 313-317. PMID: 10084440.

Sluka, K. A. (1998). Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation. J Pharmacol Exp Ther, 287(1), 232-237. PMID: 9765342.

Rees, H., Sluka, K. A., Urban, L., Walpole, C. J. & Willis, W. D. (1998). The effects of SDZ NKT 343, a potent NK1 receptor antagonist on cutaneous responses of primate spinothalamic tract neurons sensitized by intradermal injection of capsaicin. Brain Res, 121(3), 355-358. PMID: 9746141.

Sluka, K. A., Willis, W. D. (1998). Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor. Brain Res, 798(1-2), 281-286. PMID: 9666148.

Sluka, K. A., Bailey, K., Bogush, J., Olson, R. & Ricketts, A. (1998). Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint. Pain, 77(1), 97-102. PMID: 9755024.

Willis, W. D., Sluka, K. A., Rees, H. & Westlund, K. (1998). Chapter 25: A Contribution of Dorsal Root Reflexes to Peripheral Inflammation. In P. Rudomin , R. Romo , L. M. Mendell (Eds.) In: Presynaptic Inhibition and Neural Control. pp. 424-439. New York: Oxford University Press.

Sluka, K. A. (1997). Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin. Br J Pharm, 122(6), 1165-1173. PMID: 9401762.

Sluka, K. A., Rees, H., Chen, P. S., Tsuruoka, M. & Willis, W. D. (1997). Capsaicin induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor. Brain Res, 772(1-2), 82-86. PMID: 9406958.

Sluka, K. A. (1997). Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats. Pain, 71(2), 157-164. PMID: 9211477.

Sluka, K. A., Rees, H., Chen, P. S., Tsuruoka, M. & Willis, W. D. (1997). Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation & the desensitization to heat of spinothalamic tract neurons to induced intradermal injection of capsaicin in the primate. Exp Brain Res, 115(1), 15-24. PMID: 9224830.

Sluka, K. A., Willis, W. D. (1997). The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin. Pain, 71(2), 165-178. PMID: 9211478.

Sluka, K. A., Milton, M. A., Westlund, K. N. & Willis, W. D. (1997). Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation. Br J Pharm, 120(7), 1263-1273. PMID: 9105701.

Sluka, K. A., Rees, H. (1997). The neuronal response to pain. Physiotherapy Theory and Practice, 13(1), 3-22. DOI: 10.3109/09593989709036445.

Rees, H., Sluka, K. A., Lu, X., Westlund, K. N. & Willis, W. D. (1996). Dorsal root reflexes in articular afferents occur bilaterally in a chronic model of arthritis in rats. J Neurophysiol, 76(6), 4190-4193. PMID: 8985913.

Sluka, K. A. (1996). Pain mechanisms involved in musculoskeletal disorders. J Orthop Sports Phys Ther, 24(4), 240-254. PMID: 8892139.

Chen, P. S., Sluka, K. A., Rees, H. & Willis, W. D. (1996). a-2 noradrenergic receptor antagonist, idazoxan, blocks anterior pretectal nucleus induced antinociception in rats. In 8th World Congress on Pain. International Association for the Study of Pain,.

Willis, W. D., Sluka, K. A., Rees, H. & Westlund, K. N. (1996). Cooperative mechanisms of neurotransmitter action in central nervous sensitization. Prog Brain Res, 110, 151-166. PMID: 9000723.

Willis, W. D., Sluka, K. A., Rees, H. & Westlund, K. N. (1996). Chapter 12: Cooperative mechanisms of neurotransmitter actions in central sensitization. In G. Carli , M. Zimmerman (Eds.) In: Towards the Neurobiology of Chronic Pain, Progress in Brain Research. pp. 151-166. Amsterdam: Elsevier. DOI: org/10.1016/S0079-6123(08)62572-8.

Sluka, K. A., Rees, H., Westlund, K. N. & Willis, W. D. (1995). Fiber types contributing to dorsal root reflexes induced by joint inflammation in cats and monkeys. J Neurophysiol, 74(3), 981-989. PMID: 7500166.

Rees, H., Sluka, K. A., Westlund, K. N. & Willis, W. D. (1995). The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat. J Physiol, 484, 437-445. PMID: 7602536.

Sluka, K. A., Willis, W. D. & Westlund, K. N. (1995). The role of dorsal root reflexes in neurogenic inflammation. Pain Forum, 4, 141-149.

Sluka, K. A., Jordan, H. H., Willis, W. D. & Westlund, K. N. (1994). Differential effects of NMDA and non-NMDA receptor antagonists on release of amino acids after development of acute arthritis. Brain Res, 664(1-2), 77-84. PMID: 7895049.

Sluka, K. A., Willis, W. D. & Westlund, K. N. (1994). Arthritis induced release of excitatory amino acids is prevented by spinal administration of a GABAA and not by a GABAB receptor antagonist in rats. J Pharm Exp Ther, 271(1), 76-82. PMID: 7965759.

Sluka, K. A., Jordan, H. H. & Westlund, K. N. (1994). Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist. Pain, 59(1), 95-100. PMID: 7854809.

Sluka, K. A., Lawand, N. B. & Westlund, K. N. (1994). Joint inflammation is reduced by dorsal rhizotomy and not by sympathectomy or spinal cord transection. Annals Rheum Dis, 53(5), 309-314. PMID: 8017984.

Rees, H., Sluka, K. A., Westlund, K. N. & Willis, W. D. (1994). Dorsal root reflexes augment peripheral inflammation. NeuroReport, 5(7), 821-824. PMID: 8018857.

Sluka, K. A., Willis, W. D. & Westlund, K. N. (1994). Central control of peripheral joint inflammation and heat hyperalgesia. In G. F. Gebhart , D. L. Hammond & T. S. Jensen (Eds.) Proceedings of the 7th World Congress on Pain. pp. 359-371. Seattle: IASP Press.

Sluka, K. A., Westlund, K. N. (1993). Behavioral and immunohistochemical changes in an experimental arthritis model in rats. Pain, 55(3), 367-377. PMID: 7510059.

Sluka, K. A., Westlund, K. N. (1993). Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation. Pain, 55(2), 217-225. PMID: 7906027.

Sluka, K. A., Willis, W. D. & Westlund, K. N. (1993). Joint inflammation and hyperalgesia are reduced by spinal bicuculline. NeuroReport, 5(2), 109-112. PMID: 8110997.

Sluka, K. A., Westlund, K. N. (1993). Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists. Brain Res, 627(1), 89-103. PMID: 7904887.

Sluka, K. A., Westlund, K. N. (1993). An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn. Neurosci Lett, 149(1), 99-102. PMID: 8097022.

Sluka, K. A., Westlund, K. N. (1992). An experimental arthritis in rat: dorsal horn aspartate and glutamate increases. Neurosci Lett, 145(2), 141-144. PMID: 1361220.

Sluka, K. A., Westlund, K. N. (1992). Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat. Brain Res, 579(1), 67-73. PMID: 1623408.

Dougherty, P. M., Sluka, K. A., Sorkin, L. S., Westlund, K. N. & Willis, W. D. (1992). Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids. Brain Res Rev, 17(1), 1-13. PMID: 1638273.

Westlund, K. N., Sun, Y. C., Sluka, K. A., Dougherty, P. M., Sorkin, L. S. & Willis, W. D. (1992). Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve. Brain Res Rev, 17(1), 15-27. PMID: 1353392.

Sluka, K. A., Dougherty, P. M., Sorkin, L. S., Willis, W. D. & Westlund, K. N. (1992). Neural changes in acute arthritis in monkeys. III Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord. Brain Res Rev, 17(1), 29-38. PMID: 1379098.

Sorkin, L. S., Westlund, K. N., Sluka, K. A., Dougherty, P. M. & Willis, W. D. (1992). Neural changes in acute arthritis in monkeys. IV. Time course of amino acid release into the lumbar dorsal horn. Brain Res Rev, 17(1), 39-50. PMID: 1638274.