Bryan Allen, MBA, MD, PhD
Professor, Chair and DEO of Radiation Oncology
Current Positions
- Chair and DEO of Radiation Oncology
- Professor of Radiation Oncology
- Chair of Translational Research, Department of Radiation Oncology
Education
- BS in Major in Biology; Minor in Chemistry, University of Utah, Salt Lake City, Utah, United States
- PhD in Biochemistry, University of Iowa, Iowa City, Iowa
- MD in Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, United States
- Internship in Internal Medicine, University of Iowa, Iowa City, Iowa, United States
- Resident in Radiation Oncology, University of Iowa, Iowa City, Iowa, United States
- MBA, University of Iowa, Iowa City, Iowa, United States
Graduate Program Affiliations
Research Interests
- Research Interest
Licenses & Certifications
- American Board of Radiology Board - Oral, American Board of Radiology
- American Board of Radiology Board-Clinical, American Board of Radiology
Selected Publications
- Zaher A, Petronek MS, Allen BG, Mapuskar KA. Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues. Int J Mol Sci. 2024 Aug 15;25(16):8885. doi: 10.3390/ijms25168885. PMID: 39201571; PMCID: PMC11354297.
- Lee CY, Thedens DR, Lullmann O, Steinbach EJ, Tamplin MR, Petronek MS, Grumbach IM, Allen BG, Harshman LA, Magnotta VA. An Improved Postprocessing Method to Mitigate the Macroscopic Cross-Slice B0 Field Effect on R2* Measurements in the Mouse Brain at 7T. Tomography. 2024 Jul 11;10(7):1074-1088. doi: 10.3390/tomography10070081. PMID: 39058053; PMCID: PMC11280969.
- Zaher A, Mapuskar KA, Petronek MS, Tanas MR, Isaacson AL, Dodd RD, Milhem M, Furqan M, Spitz DR, Miller BJ, Beardsley RA, Allen BG. Superoxide Dismutase Mimetic Avasopasem Manganese Enhances Radiation Therapy Effectiveness in Soft Tissue Sarcomas and Accelerates Wound Healing. Antioxidants (Basel). 2024 May 10;13(5):587. doi: 10.3390/antiox13050587. PMID: 38790692; PMCID: PMC11117842.
- Singhania M, Zaher A, Pulliam CF, Bayanbold K, Searby CC, Schoenfeld JD, Mapuskar KA, Fath MA, Allen BG, Spitz DR, Petronek MS. Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer. Int J Mol Sci. 2024 Feb 18;25(4):2398. doi: 10.3390/ijms25042398. PMID: 38397073; PMCID: PMC10889593.
- Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG. The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury. Redox Biol. 2024 Apr;70:103022. doi: 10.1016/j.redox.2023.103022. Epub 2024 Jan 1. PMID: 38215546; PMCID: PMC10821164.
- Petronek MS, Bodeker KL, Lee CY, Teferi N, Eschbacher KL, Jones KA, Loeffler BT, Smith BJ, Buatti JM, Magnotta VA, Allen BG. Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: insights from a phase 2 clinical trial. J Neurooncol. 2024 Feb;166(3):493-501. doi: 10.1007/s11060-024-04571-z. Epub 2024 Jan 29. PMID: 38285244.
- Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM. Clin Cancer Res. 2024 Jan 17;30(2):283-293. doi: 10.1158/1078-0432.CCR-22-3952. PMID: 37773633; PMCID: PMC10841843.
- Mapuskar KA, Pulliam CF, Zepeda-Orozco D, Griffin BR, Furqan M, Spitz DR, Allen BG. Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. Antioxidants (Basel). 2023 Sep 6;12(9):1728. doi: 10.3390/antiox12091728. PMID: 37760031; PMCID: PMC10525889.
- Solst SR, Mapuskar KA, Graham CH, King SA, Rheem R, Current K, Allen BG, Caster JM, Spitz DR, Howard ME. Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate. Radiat Res. 2023 Nov 1;200(5):456-461. doi: 10.1667/RADE-23-00006.1. PMID: 37758035; PMCID: PMC10759934.
- Bayanbold K, Singhania M, Fath MA, Searby CC, Stolwijk JM, Henrich JB, Pulliam CF, Schoenfeld JD, Mapuskar KA, Sho S, Caster JM, Allen BG, Buettner GR, Spies M, Goswami PC, Petronek MS, Spitz DR. Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer. Antioxidants (Basel). 2023 Nov 15;12(11):2005. doi: 10.3390/antiox12112005. PMID: 38001858; PMCID: PMC10669787.