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Bryan G. Allen, MD, PHD

Portrait
Assistant Professor, Department of Radiation Oncology
Assistant Professor of Radiation Oncology

Contact Information

Primary Office: Pomerantz Family Pavilion
Iowa City, 52242
Phone: --

Office:
Phone: 319-353-8836

Education

BS, Major in Biology; Minor in Chemistry, University of Utah
PhD, Biochemistry, University of Iowa
MD, Medicine, University of Iowa

Internship, University of Iowa
Resident, University of Iowa

Licensure and Certifications

American Board of Radiology Board - Oral - American Board of Radiology
American Board of Radiology Board-Clinical - American Board of Radiology

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program

Publications

Verma, V., Simone, C. B., Allen, P. K., Gajjar, S. R., Shah, C., Zhen, W., Harkenrider, M. M., Hallemeier, C. L., Jabbour, S. K., Matthiesen, C. L., Braunstein, S. E., Lee, P., Dilling, T. J., Allen, B. G., Nichols, E. M., Attia, A., Zeng, J., Biswas, T., Paximadis, P., Wang, F., Walker, J. M., Stahl, J. M., Daly, M. E., Decker, R. H., Hales, R. K., Willers, H., Videtic, G. M., Mehta, M. P. & Lin, S. H. (2017). Multi-Institutional Experience of Stereotactic Ablative Radiation Therapy for Stage I Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys, 97(2), 362-371.
[PubMed]

Mapuskar, K. A., Flippo, K. H., Schoenfeld, J. D., Riley, D., Strack, S., Abu Hejleh, T., Furqan, M., Buatti, J. M., Goswami, P. C., Spitz, D. R. & Allen, B. G. (In Press). Mitochondrial superoxide mediates donor age-associated increases in susceptibility of dermal fibroblasts to radiation and chemotherapy.. Cancer Research.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan,, Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2•- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell, S1535-6108(17)30062-4.
[PubMed]

Zahra, A., Fath, M. A., Opat, E., Bhatia, S. K., Ma, D. C., Rodman, S. N., Snyders, T. P., Chenard, C. A., Eichenberger-Gilmore, J. M., Bodeker, K. L., Ahmann, L., Smith, B. J., Vollstedt, S. A., Brown, H. A., Abu Hejleh, T., Clamon, G. H., Berg, D. J., Spitz, D. R., Buatti, J. M. & Allen, B. G. (2017). Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung and Pancreatic Cancer: The University of Iowa Experience of Two Phase I Clinical Trials.. Radiat. Res.
[PubMed]

Allen, B. G., Spitz, D. R. (2016). Physiologic and Pathologic Functions of Mitochondrial. Springer: Springer.

Allen, B. G., Spitz, D. (2016). Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment. In Redox Active Theapeutics. Springer Book Series.

Rodman, S. N., Spence, J. M., Ronnfeldt, T. J., Zhu, Y., Solst, S. R., O'Neill, R. A., Allen, B. G., Guan, X., Spitz, D. R. & Fath, M. A. (2016). Enhancement of radiation response in breast cancer stem cells by inhibition of thioredoxin- and glutathione-dependent metabolism. Radiat Res, 186(4), 385-395.
[PubMed]

Houwen, F. K., O'Leary, B. R., Johnson, C. L., Allen, B. G., Buettner, G., Cullen, J. J., Spitz, D. R. & Mezhir, J. (In Press). Pharmacologic Ascorbate is a Potential Novel Therapy for Treatment of Gastric Adenocarcinoma. Academic Surgical Congress 11th Annual, Jacksonville, FL.

Zahra, A., Chang, T., Hejleh, T. A., Furgan, M., Clamon, G. H., Bhatia, S. K., Watkins, J. M., Mott, S. L., Ahmann, L. L., Bodeker, K. L., Spitz, D. R., Buatti, J. M. & Allen, B. G. (2016). Once Daily High-Dose Radiation (>60 Gy) Treatment in Limited Stage Small Cell Lung Cancer.. J Oncol Transl Res, 2(1), 108.
[PubMed]

Rodman, S. N., Spence, J. M., Ronnfeldt, T. J., Zhu, Y., Solst, S. R., O'Neill, R. A., Allen, B. G., Guan, X., Spitz, D. R., Fath, M. A. (2016). Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin and Glutathione Dependent Metabolism. Radiation Research, 186(4), 385-395.
[PubMed]

O'Leary, B. R., Fath, M. A., Bellizzi, A. M., Hrabe, J. E., Button, A. M., Allen, B. G., Case, A. J., Altekruse, S. F., Wagner, B., Buettner, G. R., Lynch, C. G., Hernandez, B. Y., Cozen, W., Beardsley, R. A., Keene, J., Henry, M. D., Domann, F. E., Spitz, D. R. & Mezhir, J. J. (2015). Loss of SOD3 (EcSOD) expression promotes an aggressive phenotype in human pancreatic ductal adenocarcinoma. Clin Cancer Res, 21(7), 1741-51.
[PubMed]

Houwen, F. K., O'Leary, B. R., Allen, B. G., Beardsley, R. A., Spitz, D. R. & Mezhir, J. J. (2015). SOD mimics inhibit cell growth and invasion in human gastric adenocarcinoma (GAC) cells,. American College of Surgeons Clinical Congress.

Ma, D. C., Rodman, S. N., Buatti, J. M., Anderson, C., Allen, B. G., Spitz, D. R. & Fath, M. A. (2015). Abstract 1177: Ketogenic diet sensitizes FaDu human head and neck cancer xenografts to cisplatin as well as ionizing radiation combined with cetuximab. Philadelphia, PA: Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015;.

, Cieslak III, J., Welsh, J., Sibenaller, Z., Allen, B., Wagner, B., Kalen, A., Doskey, C., Strother, R., Button, A., Mott, S., Smith, B., Tsai, S., Mezhir, J., Goswami, P., Spitz, D., Buettner, G. & Cullen, J. (2015). Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research, 75(16), 3314-26.
[PubMed]

Mapuskar, K. A., Schoenfeld, J. D., Sibenaller, Z., Buettner, G. R., Domann, F. E., Spitz, D. R. & Allen, B. G. (In Press). Superoxide mediates alterations in Complex I activity seen in adult versus neonatal fibroblasts . SFRBM November 2014. Seattle WA.

Allen, B. G., Bhatia, S. K., Anderson, C. M., Eichenberger Gilmore, J. M., Sibenaller, Z. A., Mapuskar, K. A., Schoenfeld, J. D., Buatti, J. M., Spitz, D. A. & Fath, M. A. (2014). Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biol, 2C, 963-70.
[PubMed]

Allen, B. G. (2013). Radiogenomics: The Future of Personalized Radiation Therapy?. In Informatics in Radiation Oncology. pp. 115. Boca Raton; Taylor & Francis.

Allen, B. G., Spitz, D. R., Szweda, L. I., Buatti, J. M., Bhatia, S. K., Brandt, K. E., Lindholm, K. E., Button, A. M., Smith, B. J. & Fath, M. A. (2013). Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts. Clin Cancer Res, 19(14), 3905-13.
[PubMed]

Allen, B., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L., Smith, M., Walsh, S., Bayouth, J. & Spitz, D. R. (2012). High dose ascorbate enhances chemo-radio-sensitization in GBM and lung cancer. 2012 American Society of Radiation Oncology, Boston MA.

Allen, B., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L., Smith, M., Walsh, S., Bayouth, J. & Spitz, D. R. (2012). Ascorbate is a radiosensitizer in pancreatic cancer. 2012 Society of Free Radical Biology and Medicine, San Diego CA.

Li, Y. E., Allen, B. G. & Weeks, D. L. (2012). Using FC31 integrase to mediate insertion of DNA in Xenopus embryos. Methods Mol Bio,(917), 219-30.
[PubMed]

Allen, B. G., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L. & Spitz, D. R. (2012). High Dose Ascorbate Enhances Chemo-Radio-Sensitization in GBM. Int J Radiat Oncol Biol Phys, 84(3), S702.

Allen, B., Szweda, L. I., Buatti, J. M., Bhatia, S., Spitz, D. R. & Fath, M. A. (2011). Ketogenic Diets enhance lung cancer responses to therapy. 2011 Society of Free Radical Biology and Medicine, Atlanta GA.

Allen, B., Fath, M. A., Simons, A. L., Bhatia, S., Buatti, J. M. & Spitz, D. R. (2010). Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response. 2010 American Society of Therapeutic Radiation Oncology, San Diego, CA.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Environmental Exposure Alters Expression Of Cardiac Genes Required For Normal Early Heart Development. NICHD Child Health Research Centers Annual Retreat.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Mitochondrial Respiratory Chain Complex I Activity Is Essential for Early Heart Formation. University of Iowa Carver College of Medicine Research Week.

Allen, B. G., Weeks, D. L. (2009). Bacteriophage phic31 integrase medicated transgenesis in Xenopus laevis for protein expression in endogenous levels. Methods Mol Bio, 518, 113-22.
[PubMed]

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Early Heart Formation Requires MRC Complex I Activity. Midwest Regional Developmental Biology, Iowa City, IA.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Mitochondrial Respiratory Chain Complex I Activity Is Essential for Early Heart Formation. Weinstein Cardiovascular Development Conference, San Francisco CA.

Allen, B., Weeks, D. L. (2006). Reduction of XNk2-10 expression leads to malformation of the embryonic heart.

Allen, B., Weeks, D. L. (2006). Using phiC31 integrase to make transgenic Xenopus Laevis embryos. Nat Protocols, 1(3), 1248-1257.
[PubMed]

Allen, B., Weeks, D. L. (2006). Transgenic rescue of induced heart defects in Xenopus laevis. 2006 National Graduate Student Research Festival, Bethesda MD.

Allen, B., Weeks, D. L. (2006). Utilization of Phage phiC31 integrase to generate single insertion transgenes into the Xenopus genome. 11th International Xenopus Confeence, Kazuza, Japan.

Allen, B. G., Allen-Brady, K. & Weeks, D. L. (2006). Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev, 123(10), 719-29.
[PubMed]

Allen, B. G., Weeks, D. L. (2006). Using FC31 integrase to make transgenic Xenopus laevis embryos. In Laboratory handbook for The X-omics Transgenesis Workshop.

Allen, B. G., Johnson, M., Marsh, A. E. & Dornfield, K. J. (2006). Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation induced radiosensitization. Int J Radiat Oncol Biol Phys, 65(5), 1544-52.
[PubMed]

Allen, B., Weeks, D. L. (2005). PhiC31 mediated transgenesis in Xenopus laevis. 3rd Annual International Conference on transposition and Animal Biotechnology, Minneapolis MN.

Allen, B., Weeks, D. L. (2005). Utilization of a phage integrase to make transgenic Xenopus embryos. Weinstein Meeting on Cardiovascular Development, Tucson AZ.

Allen, B., Weeks, D. (2005). Transgenic Xenopus laevis embryos can be generated using phiC31 integrase. Nat Methods, 2(12), 975-9.
[PubMed]

Allen, B., Weeks, D. L. (2004). Phage phiC31 integrase mediated insertion into the genome of developing Xenopus Laevis. 10th International Xenopus Meeting, Woods Hole, MA.