Bryan G. Allen, MD, PhD

Portrait
Assistant Professor, Department of Radiation Oncology
Assistant Professor of Radiation Oncology

Contact Information

Primary Office
Iowa City, IA 52242
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Office
319-353-8836

Education

BS, Major in Biology; Minor in Chemistry, University of Utah
PhD, Biochemistry, University of Iowa
MD, Medicine, University of Iowa
Internship, University of Iowa
Resident, University of Iowa

Licensure and Certifications

American Board of Radiology Board - Oral - American Board of Radiology
American Board of Radiology Board-Clinical - American Board of Radiology

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program

Publications

Hansen, M., Robinett, Z. N., Allen, B., Wu, A. Y., Bathla, G., Wilson, T. C., Kirby, P., Sibenaller, Z. & Clark, J. (2018). Persistent oxidative stress in vestibular schwannomas after stereotactic radiation therapy?. Otology & Neurotology. PMID: 30106845.

Brandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman, 3rd, S. N., Gu, Z., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., Berg, D. J., Spitz, D. R. & Fath, M. A. (2018). Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87]. Redox biology. PMID: 29891355.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Monga, V., Milhem, M. M., Spitz, D. R. & Allen, B. (2018). Redox Active Metals and H2O2 Mediate the Increased Efficacy of Pharmacological Ascorbate in Combination with Gemcitabine or Radiation in Pre-Clinical Sarcoma Models. Redox Biology, 14, 417-422. PMID: 29069637.

O'Leary, B. R., Houwen, F. K., Johnson, C. L., Allen, B. G., Mezhir, J. J., Berg, D. J., Cullen, J. J. & Spitz, D. R. (2018). Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. (Vols. 189). (5), pp. 456-465. Radiat Res. PMID: 29547353.

Heer, C. D., Davis, A. B., Riffe, D. B., Wagner, B. A., Falls, K. C., Allen, B. G., Buettner, G. R., Beardsley, R. A., Riley, D. P. & Spitz, D. R. (2018). Superoxide dismutase mimetic GC4419 enhances the oxidation of pharmacological ascorbate and its anticancer effects in an H2O2-dependent manner. Antioxidante. PMID: 29351198.

Mohiuddin, I. H., Furqan, M., Clamon, G., Keech, J., Anderson, C., Smith, M. C., Buatti, J. M. & Allen, B. G. (2017). A Single-Institution Analysis of Thymic Carcinoma Treatedwith Multi-Modality Therapy. Annals of Radiation Therapy and Oncology, 1(3), Article 1011 (1-5).

Anderson, C. M., Sonis, S. T., Lee, C. M., Adkins, D., Allen, B. G., Sun, W., Agarwala, S. S., Venigalla, M. L., Chen, Y., Zhen, W., Mould, D. R., Holmlund, J. T., Brill, J. M. & Buatti, J. M. (2017). Phase 1b/2a Trial of the Superoxide Dismutase Mimetic GC4419 to Reduce Chemoradiotherapy-Induced Oral Mucositis in Patients With Oral Cavity or Oropharyngeal Carcinoma. Int J Radiat Oncol Biol Phys, S0360-3016(17), 34024-5. PMID: 29174131.

Brandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman III, S. N., Gu, h., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., Berg, D. J., Spitz, D. R. & Fath, M. A. (2017). Augmentation of intracellular iron using ironsucrose enhances the toxicity of pharmacologicalascorbate in colon cancer cells. Redox Biology, 14, 82-87. PMID: 28886484.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan,, Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2•- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell, 32(2), 268. PMID: 28810149.

Plichta, K., Camden, N., Furqan, M., Abu Hejleh, T., Clamon, G. H., Zhang, J., Flynn, R. T., Bhatia, S. K., Smith, M. C., Buatti, J. M. & Allen, B. G. (2017). SBRT to Adrenal Metastases Provides High Local Control with Minimal Toxicity Advances in Radiation Oncology. Advances in Radiation Oncology, 2(4), 581-587. PMID: 29204525.

Mapuskar, K. A., Flippo, K. H., Schoenfeld, J. D., Riley, D., Strack, S., Abu Hejleh, T., Furqan, M., Buatti, J. M., Goswami, P. C., Spitz, D. R. & Allen, B. G. (2017). Mitochondrial superoxide mediates donor age-associated increases in susceptibility of dermal fibroblasts to radiation and chemotherapy. Cancer Research, 77(18), 5054-5067. PMID: 28765155.

Wears, B., Mohiuddin, I., Flynn, R., Yusung Kim,, Waldron, T., Allen, B. & Junyi Xia, (2017). Design of a compact collimator and 3D imaging system for a scanning beam low-energy intraoperative radiation therapy system for pancreatic cancer. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2017, 4325-4328. PMID: 29060854.

Zahra, A., Fath, M. A., Opat, E., Bhatia, S. K., Ma, D. C., Rodman, S. N., Snyders, T. P., Chenard, C. A., Eichenberger-Gilmore, J. M., Bodeker, K. L., Ahmann, L., Smith, B. J., Vollstedt, S. A., Brown, H. A., Abu Hejleh, T., Clamon, G. H., Berg, D. J., Spitz, D. R., Buatti, J. M. & Allen, B. G. (2017). Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung and Pancreatic Cancer: The University of Iowa Experience of Two Phase I Clinical Trials. Radiat. Res, 187(6), 743-754. PMID: 28437190.

Verma, V., Simone, C. B., Allen, P. K., Gajjar, S. R., Shah, C., Zhen, W., Harkenrider, M. M., Hallemeier, C. L., Jabbour, S. K., Matthiesen, C. L., Braunstein, S. E., Lee, P., Dilling, T. J., Allen, B. G., Nichols, E. M., Attia, A., Zeng, J., Biswas, T., Paximadis, P., Wang, F., Walker, J. M., Stahl, J. M., Daly, M. E., Decker, R. H., Hales, R. K., Willers, H., Videtic, G. M., Mehta, M. P. & Lin, S. H. (2017). Multi-Institutional Experience of Stereotactic Ablative Radiation Therapy for Stage I Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys, 97(2), 362-371. PMID: 28011047.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). Ox and H2O2 mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell, 31(4), 487-500. PMID: 28366679.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Monga, V., Milhem, M., Spitz, D. R. & Allen, B. G. (2017). Pharmacological ascorbate in combination with gemcitabine or radiation therapy increases local tumor control in an orthotopic sarcoma model. Redox Biology, 14, 417-422. PMID: 29069637.

Zahra, A., Chang, T., Hejleh, T. A., Furgan, M., Clamon, G. H., Bhatia, S. K., Watkins, J. M., Mott, S. L., Ahmann, L. L., Bodeker, K. L., Spitz, D. R., Buatti, J. M. & Allen, B. G. (2016). Once Daily High-Dose Radiation (>60 Gy) Treatment in Limited Stage Small Cell Lung Cancer. J Oncol Transl Res, 2(1), 108. PMID: 27981260.

Rodman, S. N., Spence, J. M., Ronnfeldt, T. J., Zhu, Y., Solst, S. R., O'Neill, R. A., Allen, B. G., Guan, X., Spitz, D. R., Fath, M. A. (2016). Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin and Glutathione Dependent Metabolism. Radiation Research, 186(4), 385-395. PMID: 27643875.

Houwen, F. K., O'Leary, B. R., Johnson, C. L., Allen, B. G., Buettner, G., Cullen, J. J., Spitz, D. R. & Mezhir, J. (In Press). Pharmacologic Ascorbate is a Potential Novel Therapy for Treatment of Gastric Adenocarcinoma. Academic Surgical Congress 11th Annual, Jacksonville, FL.

Allen, B. G., Spitz, D. (2016). Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment. In , Batinic-Haberle , Reboucas , Spasojevic (Eds.) Redox Active Theapeutics. Springer Book Series.

Allen, B. G., Spitz, D. R. (2016). Physiologic and Pathologic Functions of Mitochondrial., D. Hockenbery (Eds.) Springer: Springer.

Rodman, S. N., Spence, J. M., Ronnfeldt, T. J., Zhu, Y., Solst, S. R., O'Neill, R. A., Allen, B. G., Guan, X., Spitz, D. R. & Fath, M. A. (2016). Enhancement of radiation response in breast cancer stem cells by inhibition of thioredoxin- and glutathione-dependent metabolism. Radiat Res, 186(4), 385-395. PMID: 27643875.

, Cieslak III, J., Welsh, J., Sibenaller, Z., Allen, B., Wagner, B., Kalen, A., Doskey, C., Strother, R., Button, A., Mott, S., Smith, B., Tsai, S., Mezhir, J., Goswami, P., Spitz, D., Buettner, G. & Cullen, J. (2015). Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research, 75(16), 3314-26. PMID: 26081808.

Ma, D. C., Rodman, S. N., Buatti, J. M., Anderson, C., Allen, B. G., Spitz, D. R. & Fath, M. A. (2015). Abstract 1177: Ketogenic diet sensitizes FaDu human head and neck cancer xenografts to cisplatin as well as ionizing radiation combined with cetuximab. Philadelphia, PA: Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015;.

O'Leary, B. R., Fath, M. A., Bellizzi, A. M., Hrabe, J. E., Button, A. M., Allen, B. G., Case, A. J., Altekruse, S. F., Wagner, B., Buettner, G. R., Lynch, C. G., Hernandez, B. Y., Cozen, W., Beardsley, R. A., Keene, J., Henry, M. D., Domann, F. E., Spitz, D. R. & Mezhir, J. J. (2015). Loss of SOD3 (EcSOD) expression promotes an aggressive phenotype in human pancreatic ductal adenocarcinoma. Clin Cancer Res, 21(7), 1741-51. PMID: 25634994.

Houwen, F. K., O'Leary, B. R., Allen, B. G., Beardsley, R. A., Spitz, D. R. & Mezhir, J. J. (2015). SOD mimics inhibit cell growth and invasion in human gastric adenocarcinoma (GAC) cells,. American College of Surgeons Clinical Congress.

Mapuskar, K. A., Schoenfeld, J. D., Sibenaller, Z., Buettner, G. R., Domann, F. E., Spitz, D. R. & Allen, B. G. (In Press). Superoxide mediates alterations in Complex I activity seen in adult versus neonatal fibroblasts. SFRBM November 2014. Seattle WA.

Allen, B. G., Bhatia, S. K., Anderson, C. M., Eichenberger Gilmore, J. M., Sibenaller, Z. A., Mapuskar, K. A., Schoenfeld, J. D., Buatti, J. M., Spitz, D. A. & Fath, M. A. (2014). Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biol, 2C, 963-70. PMID: 25460731.

Allen, B. G., Spitz, D. R., Szweda, L. I., Buatti, J. M., Bhatia, S. K., Brandt, K. E., Lindholm, K. E., Button, A. M., Smith, B. J. & Fath, M. A. (2013). Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts. Clin Cancer Res, 19(14), 3905-13. PMID: 23743570.

Allen, B. G. (2013). Radiogenomics: The Future of Personalized Radiation Therapy?. In , G. Starkschall , R. C. Siochi (Eds.) Informatics in Radiation Oncology. pp. 115. Boca Raton; Taylor & Francis.

Allen, B., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L., Smith, M., Walsh, S., Bayouth, J. & Spitz, D. R. (2012). Ascorbate is a radiosensitizer in pancreatic cancer. 2012 Society of Free Radical Biology and Medicine, San Diego CA.

Allen, B. G., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L. & Spitz, D. R. (2012). High Dose Ascorbate Enhances Chemo-Radio-Sensitization in GBM. Int J Radiat Oncol Biol Phys, 84(3), S702.

Allen, B., Sibenaller, Z., Cullen, J., Wagner, B. A., Buettner, G. R., Van't Erve, J., Welsh, J. L., Buatti, J. M., Carlisle, T. L., Smith, M., Walsh, S., Bayouth, J. & Spitz, D. R. (2012). High dose ascorbate enhances chemo-radio-sensitization in GBM and lung cancer. 2012 American Society of Radiation Oncology, Boston MA.

Li, Y. E., Allen, B. G. & Weeks, D. L. (2012). Using FC31 integrase to mediate insertion of DNA in Xenopus embryos. Methods Mol Bio,(917), 219-30. PMID: 22956091.

Allen, B., Szweda, L. I., Buatti, J. M., Bhatia, S., Spitz, D. R. & Fath, M. A. (2011). Ketogenic Diets enhance lung cancer responses to therapy. 2011 Society of Free Radical Biology and Medicine, Atlanta GA.

Allen, B., Fath, M. A., Simons, A. L., Bhatia, S., Buatti, J. M. & Spitz, D. R. (2010). Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response. 2010 American Society of Therapeutic Radiation Oncology, San Diego, CA.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Environmental Exposure Alters Expression Of Cardiac Genes Required For Normal Early Heart Development. NICHD Child Health Research Centers Annual Retreat.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Early Heart Formation Requires MRC Complex I Activity. Midwest Regional Developmental Biology, Iowa City, IA.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Mitochondrial Respiratory Chain Complex I Activity Is Essential for Early Heart Formation. Weinstein Cardiovascular Development Conference, San Francisco CA.

Bartlett, H. L., Struck-Marcell, A., Schultz, M., Wedemeyer, E. W., Allen, B. & Weeks, D. L. (2009). Mitochondrial Respiratory Chain Complex I Activity Is Essential for Early Heart Formation. University of Iowa Carver College of Medicine Research Week.

Allen, B. G., Weeks, D. L. (2009). Bacteriophage phic31 integrase medicated transgenesis in Xenopus laevis for protein expression in endogenous levels. Methods Mol Bio, 518, 113-22. PMID: 19085128.

Allen, B., Weeks, D. L. (2006). Transgenic rescue of induced heart defects in Xenopus laevis. 2006 National Graduate Student Research Festival, Bethesda MD.

Allen, B. G., Allen-Brady, K. & Weeks, D. L. (2006). Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev, 123(10), 719-29. PMID: 16949797.

Allen, B., Weeks, D. L. (2006). Utilization of Phage phiC31 integrase to generate single insertion transgenes into the Xenopus genome. 11th International Xenopus Confeence, Kazuza, Japan.

Allen, B., Weeks, D. L. (2006). Using phiC31 integrase to make transgenic Xenopus Laevis embryos. Nat Protocols, 1(3), 1248-1257. PMID: 17406408.

Allen, B. G., Johnson, M., Marsh, A. E. & Dornfield, K. J. (2006). Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation induced radiosensitization. Int J Radiat Oncol Biol Phys, 65(5), 1544-52. PMID: 16863931.

Allen, B. G., Weeks, D. L. (2006). Using FC31 integrase to make transgenic Xenopus laevis embryos. In Laboratory handbook for The X-omics Transgenesis Workshop.

Allen, B., Weeks, D. L. (2006). Reduction of XNk2-10 expression leads to malformation of the embryonic heart.

Allen, B., Weeks, D. (2005). Transgenic Xenopus laevis embryos can be generated using phiC31 integrase. Nat Methods, 2(12), 975-9. PMID: 16299484.

Allen, B., Weeks, D. L. (2005). PhiC31 mediated transgenesis in Xenopus laevis. 3rd Annual International Conference on transposition and Animal Biotechnology, Minneapolis MN.

Allen, B., Weeks, D. L. (2005). Utilization of a phage integrase to make transgenic Xenopus embryos. Weinstein Meeting on Cardiovascular Development, Tucson AZ.

Allen, B., Weeks, D. L. (2004). Phage phiC31 integrase mediated insertion into the genome of developing Xenopus Laevis. 10th International Xenopus Meeting, Woods Hole, MA.