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Corinne Griguer, PhD

Professor of Radiation Oncology

Current Positions

  • Professor of Radiation Oncology

Graduate Program Affiliations

Research Interests

  • Novel mechanism of chemoresistance in malignant gliomas
  • Novel prognostic marker in glioma
  • Bioenergetics in malignant gliomas

Selected Publications

  • Won, W. J., Deshane, J. S., Leavenworth, J. W., Oliva, C. R. & Griguer, C. E. (2019). Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma. Cell stress 3 (2) 47-65. DOI: 10.15698/cst2019.02.176. PMID: 31225500. PMCID: PMC6551710.
  • Bernal Rubio, Y. L., González-Reymúndez, A., Wu, K. H., Griguer, C. E., Steibel, J. P., de Los Campos, G., Doseff, A., Gallo, K. & Vazquez, A. I. (2018). Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme. G3 (Bethesda, Md.) 8 (11) 3627-3636. DOI: 10.1534/g3.118.200391. PMID: 30228192. PMCID: PMC6222579.
  • Oliva, C. R., Halloran, B., Hjelmeland, A. B., Vazquez, A., Bailey, S. M., Sarkaria, J. N. & Griguer, C. E. (2018). IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling. Cell communication and signaling : CCS 16 (1) 61. DOI: 10.1186/s12964-018-0273-7. PMID: 30231881. PMCID: PMC6148802.
  • Gandhirajan, R. K., Rödder, K., Bodnar, Y., Pasqual-Melo, G., Emmert, S., Griguer, C. E., Weltmann, K. D. & Bekeschus, S. (2018). Cytochrome C oxidase Inhibition and Cold Plasma-derived Oxidants Synergize in Melanoma Cell Death Induction. Scientific reports 8 (1) 12734. DOI: 10.1038/s41598-018-31031-2. PMID: 30143716. PMCID: PMC6109085.
  • Oliva, C. R., Zhang, W., Langford, C., Suto, M. J. & Griguer, C. E. (2017). Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit. Oncotarget 8 (23) 37568-37583. DOI: 10.18632/oncotarget.17247. PMID: 28455961. PMCID: PMC5514931.
  • Oliva, C. R., Markert, T., Ross, L. J., White, E. L., Rasmussen, L., Zhang, W., Everts, M., Moellering, D. R., Bailey, S. M., Suto, M. J. & Griguer, C. E. (2016). Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells. The Journal of biological chemistry 291 (46) 24188-24199. DOI: 10.1074/jbc.M116.749978. PMID: 27679486. PMCID: PMC5104942.
  • King, A. L., Mantena, S. K., Andringa, K. K., Millender-Swain, T., Dunham-Snary, K. J., Oliva, C. R., Griguer, C. E. & Bailey, S. M. (2016). The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease. Redox biology 9 188-197. DOI: 10.1016/j.redox.2016.08.005. PMID: 27566282. PMCID: PMC5007436.
  • Oliva, C. R., Markert, T., Gillespie, G. Y. & Griguer, C. E. (2015). Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas. Oncotarget 6 (6) 4330-44. DOI: 10.18632/oncotarget.3015. PMID: 25726526. PMCID: PMC4414193.
  • King, A. L., Swain, T. M., Mao, Z., Udoh, U. S., Oliva, C. R., Betancourt, A. M., Griguer, C. E., Crowe, D. R., Lesort, M. & Bailey, S. M. (2014). Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. American journal of physiology. Gastrointestinal and liver physiology 306 (4) G265-77. DOI: 10.1152/ajpgi.00278.2013. PMID: 24356880. PMCID: PMC3920122.
  • Oliva, C. R., Moellering, D. R., Gillespie, G. Y. & Griguer, C. E. (2011). Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PloS one 6 (9) e24665. DOI: 10.1371/journal.pone.0024665. PMID: 21931801. PMCID: PMC3170372.