Frederick E. Domann, PhD

Portrait
Co-director, Free Radical Cancer Biology Program
Co-director, Radiation and Antioxidant Enzyme Core Service
Director, Molecular & Cellular Biology Graduate Program
Professor of Radiation Oncology
Professor of Pathology
Professor of Surgery

Contact Information

Primary Office
B180 ML
Iowa City, IA 52242
319-335-8018

Education

BS, Chemistry, University of Wisconsin, Platteville, Wisconsin
PhD, Human Cancer Biology, University of Wisconsin, Madision, Wisconsin
Postdoctoral Fellow, Department of Radiation Oncology, Arizona Cancer Center, The University of Arizona
Postdoctoral Fellow, Department of Pharmacology & Toxicology,, The University of Arizona, Arizona Cancer Center

Education/Training Program Affiliations

Department of Pathology Graduate Program, Free Radical and Radiation Biology Graduate Program, Interdisciplinary Graduate Program in Human Toxicology, Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cancer and Aging Program, Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Environmental Health Sciences Research Center, Fraternal Order of Eagles Diabetes Research Center, Holden Comprehensive Cancer Center, Institute for Clinical and Translational Science, Iowa Institute of Human Genetics.

Research Summary

My laboratory focuses on the transcriptional regulation of cancer related genes including oncogenes and tumor suppressor genes. Specifically, we are studying the molecular mechanisms by which aberrant cytosine methylation of CpG dinucleotides affects gene expression during the development of cancer. We have focused primarily on the tumor suppressor gene SOD2 that encodes the antioxidant enzyme superoxide dismutase. We have determined that site specific DNA methylation of the SOD2 gene promoter can suppress its transcriptional activation. Thus, cytosine methylation of genetic regulatory elements within this important tumor suppressor gene can mediate its inactivation. We are also studying transcription factor AP-2 and its interactions with the SOD2 promoter. Interestingly, these interactions are affected by DNA methylation. We are also assessing chromatin accessibility in the region of the SOD2 promoter in cells that differentially express the gene. Our future research directions will be aimed at elucidating the role of cytosine methylation as a mechanism for inactivation of other genes involved in protection against oxidative damage as well as other classical tumor suppressor genes, and to elucidate the mechanism(s) by which CpG methylation can bring about these changes in gene expression. We have recently become interested in cancer therapy using the human sodium iodide symporter. When expression of this gene is activated, either by gene transfer of epigenetic reactivation, tumor cells acquire the thyroid-like phenotype of iodide concentration. This activity can be exploited as a tool for imaging gene delivery and expression in humans in clinical translational trials of gene therapy; or as a means to deliver therapy itself depnding on which radioisotope of iodine is used.

Publications

Place, T. L., Domann, F. E. & Case, A. J. (2017). Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research. Free radical biology & medicine, 113, 311-322. PMID: 29032224.

Mapuskar, K. A., Flippo, K. H., Schoenfeld, J. D., Riley, D. P., Strack, S., Hejleh, T. A., Furqan, M., Monga, V., Domann, F. E., Buatti, J. M., Goswami, P. C., Spitz, D. R. & Allen, B. G. (2017). Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy. Cancer research, 77(18), 5054-5067. PMID: 28765155.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Kauffman EPS,, Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer cell, 32(2), 268. PMID: 28810149.

Ekoue, D. N., Bera, S., Ansong, E., Hart, P. C., Zaichick, S., Domann, F. E., Bonini, M. G. & Diamond, A. M. (2017). Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin. Free radical research, 51(6), 582-590. PMID: 28587495.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer cell, 31(4), 487-500.e8. PMID: 28366679.

Gómez-Contreras, P., Ramiro-Díaz, J. M., Sierra, A., Stipp, C., Domann, F. E., Weigel, R. J. & Lal, G. (2017). Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases. Clinical & experimental metastasis, 34(1), 37-49. PMID: 27770373.

Nozik-Grayck, E., Woods, C., Stearman, R. S., Venkataraman, S., Ferguson, B. S., Swain, K., Bowler, R. P., Geraci, M. W., Ihida-Stansbury, K., Stenmark, K. R., McKinsey, T. A. & Domann, F. E. (2016). Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension. American journal of physiology. Lung cellular and molecular physiology, 311(1), L124-34. PMID: 27233998.

Christensen, D. K., Armaiz-Pena, G. N., Ramirez, E., Matsuo, K., Zimmerman, B., Zand, B., Shinn, E., Goodheart, M. J., Bender, D., Thaker, P. H., Ahmed, A., Penedo, F. J., DeGeest, K., Mendez, L., Domann, F., Sood, A. K. & Lutgendorf, S. K. (2016). SSRI use and clinical outcomes in epithelial ovarian cancer. Oncotarget, 7(22), 33179-91. PMID: 27121207.

Xiao, W., Sarsour, E. H., Wagner, B. A., Doskey, C. M., Buettner, G. R., Domann, F. E. & Goswami, P. C. (2016). Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Archives of toxicology, 90(2), 319-32. PMID: 25417049.

Cramer-Morales, K., Heer, C. D., Mapuskar, K. A. & Domann, F. E. (2015). SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD. Free radical biology & medicine, 89, 379-86. PMID: 26208779.

Hrabe, J. E., O'Leary, B. R., Fath, M. A., Rodman, S. N., Button, A. M., Domann, F. E., Spitz, D. R. & Mezhir, J. J. (2015). Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor ß-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox biology, 5, 319-27. PMID: 26114584.

O'Leary, B. R., Fath, M. A., Bellizzi, A. M., Hrabe, J. E., Button, A. M., Allen, B. G., Case, A. J., Altekruse, S., Wagner, B. A., Buettner, G. R., Lynch, C. F., Hernandez, B. Y., Cozen, W., Beardsley, R. A., Keene, J., Henry, M. D., Domann, F. E., Spitz, D. R. & Mezhir, J. J. (2015). Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1741-51. PMID: 25634994.

Xiao, W., Son, J., Vorrink, S. U., Domann, F. E. & Goswami, P. C. (2015). Ligand-independentactivation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaThuman keratinocytes. Toxicol Lett., 233(3), 258-66. PMID: PMID: 25668756.

Duangmano, S., Sae-Lim, P., Suksamrarn, A., Patmasiriwat, P. & Domann, F. E. (2015). Corrigendum to "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest". J Oncol., 2015(2015), 486850. PMID: PMID: 25722721.

Jiménez-Chillarón, J. C., Nijland, M. J., Ascensão, A. A., Sardão, V. A., Magalhães, J., Hitchler, M. J., Domann, F. E. & Oliveira, P. J. (2015). Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling. Epigenetics, 10(4), 259-73. PMID: 25774863.

TenNapel, M. J., Lynch, C. F., Burns, T. L., Wallace, R., Smith, B. J., Button, A. & Domann, F. E. (2014). SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in anAged Cohort. PLoS One, 9(12), e115616. PMID: 25541994.

Shaghnessy, D. T., McAllister, K., Worth, L., Haugen, A. C., Meyter, J. N., Domann, F. E., Van Houten, B., Mostoslavsky, R., Bultman, S. J., Baccarelli, A. A., Begley, T. J., Sobol, R. W., Hirschey, M. D., Santos, J. H., Copeland, W. C., Tice, R. R., Balshaw, D. M. & Tyson, F. L. (2014). Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect., 122(12), 1271-1278. PMID: 25127496.

Hallberg, A. R., Vorrink, S. U., Hudachek, D. R., Cramer-Morales, K., Milhem, M. M., Cornell, R. A. & Domann, F. E. (2014). Aberrant CpG methylation of the TFAP2A gene constitutes a mechanism for loss of TFAP2A expression in human metastatic melanoma. Epigenetics, 9(12), 1641-7. PMID: 25625848.

Xiao, W., Sarsour, E. H., Wagner, B. A., Doskey, C. M., Buettner, G. R., Domann, F. E. & Goswami, P. C. (2014). Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolicoxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol., Epub ahead of print. PMID: 25417049.

Yang, S., Jia, Y., Liu, X., Winters, C., Wang, X., Zhang, Y., Devor, E. J., Hovey, A. M., Reyes, H. D., Xiao, X., Xu, Y., Dai, D., Meng, X., Thiel, K. W., Domann, F. E. & Leslie, K. K. (2014). Systematicdissection of the mechanisms underlying progesterone receptor downregulation inendometrial cancer. Oncotarget, 5(20), 9783-9797. PMID: 25229191.

Vorrink, S. U., Sarsour, E. H., Olivier, A. K., Robertson, L. W., Goswami, P. C. & Domann, F. E. (2014). PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in humanHepG2 cells. Exp Toxicol Pathol., 66(8), 377-382. PMID: 24916446.

Vorrink, S. U., Hudachek, D. R. & Domann, F. E. (2014). Epigenetic determinants of CYP1A1induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). Int J Mol Sci., 15(8), 13916-13931. PMID: 25116688.

Vorrink, S. U., Domann, F. E. (2014). Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1a signaling node. Chemico-Biological Interactions, 218C, 82-88. PMID: 24824450.

Vorrink, S. U., Sarsour, E. H., Olivier, A. K., Robertson, L. W., Goswami, P. C. & Domann, F. E. (2014). PCB 126 perturbs hypoxia-induced HIF-1a activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol., pii: S0940-2993(14), 00071-2. PMID: PMID: 24916446.

Wegman-Points, L. J., Teoh-Fitzgerald, M. L., Mao, G., Zhu, Y., Fath, M. A., Spitz, D. R. & Domann, F. E. (2014). Retroviral-infection increases tumorigenic potential of MDA-MB-231 breastcarcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-celllike population. Redox Biol., 2, 847-854. PMID: 25009786.

Hall, D. D., Wu, Y., Domann, F. E., Spitz, D. R. & Anderson, M. E. (2014). Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. PLoS One. PMID: 24802861.

Kim, Y., Seol, D. R., Mohapatra, S., Sunderland, J. J., Schultz, M. K., Domann, F. E. & Lim, T. H. (2014). Locally targeted delivery of a micron-size radiation therapy source using temperature-sensitive hydrogel. International Journal of Radiation Oncology*Biology*Physics, 88(5), 1142–1147. PMID: 24495593.

Gross, T. J., Kremens, K., Powers, L. S., Brink, B., Knutson, T., Domann, F. E., Philbert, R. A., Milhem, M. M. & Monick, M. M. (2014). Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses. The Journal of Immunology, 192(5), 2326-2338. PMID: 24477906.

Vorrink, S. U., Severson, P. L., Kulak, M. V., Futscher, B. W. & Domann, F. E. (2014). Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicology and Applied Pharmacology, 274(3), 408-16. PMID: PMID: 24355420.

Cyr, A. R., Kulak, M. V., Park, J. M., Bogachek, M. V., Spanheimer, P. M., Woodfield, G. W., White-Baer, L. S., O'Malley, Y. Q., Sugg, S. L., Olivier, A. K., Zhang, W., Domann, F. E. & Weigel, R. J. (2014). TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene. PMID: 24469049.

Case, A. J., Domann, F. E. (2014). Absence of manganese superoxide dismutase delays p53-induced tumor formation. Redox Biology, 2, 220-223. PMID: 24494196.

Woods, C., Venkataraman, S., Stearman, R., Villegas, L., Bowler, R., McKinsey, T., Ferguson, B., Ihida-Stansbury3, K., Geraci, M., Stenmark, K., Domann, F. & Nozik-Grayck, E. (2014). Regulation of aberrant expression of EC-SOD in IPAH by epigenetic mechanisms. Annual Meeting of the American Thoracic Society.

Mezhir, J. J., O'Leary, B. R., Altekruse, S., Beardsley, R. A., Henry, M. D., Spitz, D. R. & Domann, F. E. (2014). The role of antioxidant enzymes in pancreatic cancer biology and therapy. AACR Pancreatic Cancer: Innovations in Research and Treatment meeting.

Place, T. L., Nauseef, J. T., Peterson, M. K., Henry, M. D., Mezhir, J. J. & Domann, F. E. (2013). Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition. PLoS One., 8(12), e83021. PMID: PMID: 24367580.

Lal, G., Contreras, P. G., Kulak, M., Woodfield, G., Bair, T., Domann, F. E. & Weigel, R. J. (2013). Human Melanoma Cells Over-Express Extracellular Matrix 1 (ECM1) Which Is Regulated by TFAP2C. PLoS One., 8(9), e73953. PMID: PMID:24023917.

Dholakiya, P. P., Neff, T., Smith, E., Domann, F. E., Spitz, D., Rubenstein, L., Bender, D. P. & Goodheart, M. J. (2013). Inflammatory Gene Expression and Obesity in Endometrial Carcinoma. Society of Gynecologic Oncology.

Gomez-Contreras, P. C., Domann, F. E., Weigel, R. J. & Lal, G. (2013). Extracellular Matrix 1 (ECM1) knockdown alters cellular characteristics, CD44 expression and other metastasis associated genes in breast cancer cells.

Zhou, B., Gibson-Corley, K. N., Herndon, M. E., Sun, Y., Gustafson-Wagner, E., Teoh-Fitzgerald, M., Domann, F. E., Henry, M. D. & Stipp, C. S. (2013). Integrin a3ß1 Can Function to Promote Spontaneous Metastasis and Lung Colonization of Invasive Breast Carcinoma. Mol Cancer Res.. PMID: PMID:24002891.

Sobhakumari, A., Schickling, B. M., Love-Homan, l., Raeburn, A., Fletcher, E. V., Case, A. J., Domann, F. E., Miller, Jr, F. J. & Simons, A. L. (2013). NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. Toxicol Appl Pharmacol., S0041-008X(13)00322-0. PMID: PMID:23917044.

Jacobus, J. A., Duda, C. G., Coleman, M. C., Martin, S. M., Mapuskar, K., Mao, G., Smith, B. J., Aykin-Burns, N., Guida, P., Gius, D., Domann, F. E., Kundson, C. M. & Spitz, D. R. (2013). Low-Dose Radiation-Induced Enhancement of Thymic Lymphomagenesis in Lck-Bax Mice is Dependent on LET and Gender. Radiat Res., 180(2), 156-165. PMID: PMID:23819597.

Cyr, A. R., Hitchler, M. J. & Domann, F. E. (2013). Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics. Antioxidants & redox signaling, 18(15), 1946-55. PMID: 22946823.

Case, A. J., Madsen, J. M., Motto, D. G., Meyerholz, D. K. & Domann, F. E. (2013). Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells. Free radical biology & medicine, 56, 17-27. PMID: 23219873.

Cyr, A. R., Brown, K. E., McCormick, M. L., Coleman, M. C., Case, A. J., Watts, G. S., Futscher, B. W., Spitz, D. R. & Domann, F. E. (2013). Maintenance of mitochondrial genomic integrity in theabsence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biol., 1(1), 172-7. PMID: PMID: 24024150.

Cyr, A. R., Brown, K. E., McCormick, M. L., Coleman, M. C., Case, A. J., Watts, G. S., Futscher, B. W., Spitz, D. R. & Domann, F. E. (2013). Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biol., 5(1), 172-7. PMID: PMID:24024150.

Khoo, N. K., Hebbar, S., Zhao, W., Moore, S. A., Domann, F. E. & Robbins, M. E. (2013). Differentialactivation of catalase expression and activity by PPAR agonists: Implications forastrocyte protection in anti-glioma therapy. Redox Biol., 1(1), 70-9. PMID: PMID: 24024139.

Khoo, N. K., Hebbar, S., Zhao, W., Moore, S. A., Domann, F. E. & Robbins, M. E. (2013). Differential activation of catalase expression and activity by PPAR agonists: Implications for astrocyte protection in anti-glioma therapy. Redox Biol., 1(1), 70-9. PMID: PMID:24024139.

Domann, F. E. (2013). Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases. International journal of molecular sciences, 14(4), 8491-5. PMID: 23594999.

Teoh-Fitzgerald, M. L., Fitzgerald, M. P., Zhong, W., Askeland, R. W. & Domann, F. E. (2013). Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis. Oncogene. PMID: 23318435.

Place, T. L., Domann, F. E. (2013). Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein. Hypoxia, 13-27.

Hitchler, M. J., Domann, F. E. (2012). Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome. Free radical biology & medicine, 53(11), 2178-87. PMID: 23022407.

Case, A. J., Domann, F. E. (2012). Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary gland. Free radical research, 46(11), 1361-8. PMID: 22834911.

Kulak, M. V., Cyr, A. R., Woodfield, G. W., Bogachek, M., Spanheimer, P. M., Li, T., Price, D. H., Domann, F. E. & Weigel, R. J. (2012). Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene. PMID: 22964634.

Duangmano, S., Sae-Lim, P., Suksamrarn, A., Patmasiriwat, P. & Domann, F. E. (2012). Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest. Journal of oncology, 2012, 601682. PMID: 22690217.

Duangmano, S., Sae-Lim, P., Suksamrarn, A., Domann, F. E. & Patmasiriwat, P. (2012). Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC complementary and alternative medicine, 12, 185. PMID: 23062075.

Teoh-Fitzgerald, M. L., Fitzgerald, M. P., Jensen, T. J., Futscher, B. W. & Domann, F. E. (2012). Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Molecular cancer research : MCR, 10(1), 40-51. PMID: 22064654.

Owens, K. M., Aykin-Burns, N., Dayal, D., Coleman, M. C., Domann, F. E. & Spitz, D. R. (2012). Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free radical biology & medicine, 52(1), 160-6. PMID: 22041456.

Case, A. J., Mezhir, J. J., O'Leary, B. R., Hrabe, J. E. & Domann, F. E. (2012). Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase. Redox report : communications in free radical research, 17(6), 239-45. PMID: 23339859.

Yue, W. Y., Clark, J. J., Fernando, A., Domann, F. & Hansen, M. R. (2011). Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides. Neuro-oncology, 13(9), 961-73. PMID: 21697181.

Cyr, A. R., Domann, F. E. (2011). The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxidants & redox signaling, 15(2), 551-89. PMID: 20919933.

Tang, X., Sun, Z., Runne, C., Madsen, J., Domann, F., Henry, M., Lin, F. & Chen, S. (2011). A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer. The Journal of biological chemistry, 286(15), 13244-54. PMID: 21349837.

Case, A. J., McGill, J. L., Tygrett, L. T., Shirasawa, T., Spitz, D. R., Waldschmidt, T. J., Legge, K. L. & Domann, F. E. (2011). Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free radical biology & medicine, 50(3), 448-58. PMID: 21130157.

Aykin-Burns, N., Slane, B. G., Liu, A. T., Owens, K. M., O'Malley, M. S., Smith, B. J., Domann, F. E. & Spitz, D. R. (2011). Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiation research, 175(2), 150-8. PMID: 21268708.

Place, T. L., Fitzgerald, M. P., Venkataraman, S., Vorrink, S. U., Case, A. J., Teoh, M. L. & Domann, F. E. (2011). Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PloS one, 6(1), e14617. PMID: 21297970.

Fitzgerald, M. P., Gourronc, F., Teoh, M. L., Provenzano, M. J., Case, A. J., Martin, J. A. & Domann, F. E. (2011). Human Chondrosarcoma Cells Acquire an Epithelial-Like Gene Expression Pattern via an Epigenetic Switch: Evidence for Mesenchymal-Epithelial Transition during Sarcomagenesis. Sarcoma, 2011, 598218. PMID: 21559267.

Woodfield, G. W., Chen, Y., Bair, T. B., Domann, F. E. & Weigel, R. J. (2010). Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes, chromosomes & cancer, 49(10), 948-62. PMID: 20629094.

Drake, J. M., Barnes, J. M., Madsen, J. M., Domann, F. E., Stipp, C. S. & Henry, M. D. (2010). ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells. The Journal of biological chemistry, 285(44), 33940-8. PMID: 20729552.

Fitzgerald, M. P., Madsen, J. M., Coleman, M. C., Teoh, M. L., Westphal, S. G., Spitz, D. R., Radi, R. & Domann, F. E. (2010). Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity. Radiation research, 174(3), 290-6. PMID: 20726720.

Dayal, D., Martin, S. M., Owens, K. M., Aykin-Burns, N., Zhu, Y., Boominathan, A., Pain, D., Limoli, C. L., Goswami, P. C., Domann, F. E. & Spitz, D. R. (2009). Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiation research, 172(6), 737-45. PMID: 19929420.

Sinthupibulyakit, C., Grimes, K. R., Domann, F. E., Xu, Y., Fang, F., Ittarat, W., St Clair, D. K. & St Clair, W. (2009). p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose. International journal of oncology, 35(3), 609-15. PMID: 19639181.

Teoh, M. L., Fitzgerald, M. P., Oberley, L. W. & Domann, F. E. (2009). Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer research, 69(15), 6355-63. PMID: 19602586.

Hitchler, M. J., Domann, F. E. (2009). Metabolic defects provide a spark for the epigenetic switch in cancer. Free radical biology & medicine, 47(2), 115-27. PMID: 19362589.

Woodfield, G. W., Hitchler, M. J., Chen, Y., Domann, F. E. & Weigel, R. J. (2009). Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clinical cancer research : an official journal of the American Association for Cancer Research, 15(11), 3672-9. PMID: 19458056.

Case, A. J., Domann, F. E. (2009). Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a. In Redox Signaling and Regulation in Biology and Medicine. pp. 207-227. Wiley Online Library-Wiley-VCH Verlag GmbH & Co. KGaA. DOI: DOI: 10.1002/9783527627585.ch9.

Yu, L., Hitchler, M. J., Sun, W., Sarsour, E. H., Goswami, P. C., Klingelhutz, A. J. & Domann, F. E. (2009). AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of oncology, 2009, 780874. PMID: 20066163.

Zhao, R., Xiang, N., Domann, F. E. & Zhong, W. (2009). Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutrition and cancer, 61(3), 397-407. PMID: 19373614.

Hitchler, M. J., Oberley, L. W. & Domann, F. E. (2008). Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. Free radical biology & medicine, 45(11), 1573-80. PMID: 18845242.

Rahimov, F., Marazita, M. L., Visel, A., Cooper, M. E., Hitchler, M. J., Rubini, M., Domann, F. E., Govil, M., Christensen, K., Bille, C., Melbye, M., Jugessur, A., Lie, R. T., Wilcox, A. J., Fitzpatrick, D. R., Green, E. D., Mossey, P. A., Little, J., Steegers-Theunissen, R. P., Pennacchio, L. A., Schutte, B. C. & Murray, J. C. (2008). Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nature genetics, 40(11), 1341-7. PMID: 18836445.

Lal, G., Padmanabha, L., Provenzano, M., Fitzgerald, M., Weydert, J. & Domann, F. E. (2008). Regulation of 14-3-3sigma expression in human thyroid carcinoma is epigenetically regulated by aberrant cytosine methylation. Cancer letters, 267(1), 165-74. PMID: 18440129.

Dong, L. F., Low, P., Dyason, J. C., Wang, X. F., Prochazka, L., Witting, P. K., Freeman, R., Swettenham, E., Valis, K., Liu, J., Zobalova, R., Turanek, J., Spitz, D. R., Domann, F. E., Scheffler, I. E., Ralph, S. J. & Neuzil, J. (2008). Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene, 27(31), 4324-35. PMID: 18372923.

Ahmad, I. M., Abdalla, M. Y., Aykin-Burns, N., Simons, A. L., Oberley, L. W., Domann, F. E. & Spitz, D. R. (2008). 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free radical biology & medicine, 44(5), 826-34. PMID: 18155176.

Watts, G. S., Futscher, B. W., Holtan, N., Degeest, K., Domann, F. E. & Rose, S. L. (2008). DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage. BMC medical genomics, 1, 47. PMID: 18826610.

Provenzano, M. J., Domann, F. E. (2007). A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns. Hearing research, 233(2-Jan), 13-Jan. PMID: 17723285.

Provenzano, M. J., Fitzgerald, M. P., Krager, K. & Domann, F. E. (2007). Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC). Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 137(5), 722-8. PMID: 17967635.

Hitchler, M. J., Domann, F. E. (2007). An epigenetic perspective on the free radical theory of development. Free radical biology & medicine, 43(7), 1023-36. PMID: 17761298.

Provenzano, M. J., Yu, L., Hitchler, M. J., Fitzgerald, M. P., Robinson, R. A., Wayne, S., Ver Meer, M. & Domann, F. E. (2007). AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma. Experimental and molecular pathology, 83(2), 277-82. PMID: 17651731.

Bock, J. M., Menon, S. G., Goswami, P. C., Sinclair, L. L., Bedford, N. S., Domann, F. E. & Trask, D. K. (2007). Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition. Molecular carcinogenesis, 46(10), 857-64. PMID: 17415779.

Ianzini, F., Domann, F. E., Kosmacek, E. A., Phillips, S. L. & Mackey, M. A. (2007). Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe. Radiation research, 168(2), 183-92. PMID: 17638400.

Menon, S. G., Sarsour, E. H., Kalen, A. L., Venkataraman, S., Hitchler, M. J., Domann, F. E., Oberley, L. W. & Goswami, P. C. (2007). Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer research, 67(13), 6392-9. PMID: 17616699.

Bock, J. M., Menon, S. G., Sinclair, L. L., Bedford, N. S., Goswami, P. C., Domann, F. E. & Trask, D. K. (2007). Celecoxib toxicity is cell cycle phase specific. Cancer research, 67(8), 3801-8. PMID: 17440094.

Tompkins, V. S., Hagen, J., Frazier, A. A., Lushnikova, T., Fitzgerald, M. P., di Tommaso, A., Ladeveze, V., Domann, F. E., Eischen, C. M. & Quelle, D. E. (2007). A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. The Journal of biological chemistry, 282(2), 1322-33. PMID: 17110379.

Zhao, R., Domann, F. E. & Zhong, W. (2006). Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Molecular cancer therapeutics, 5(12), 3275-84. PMID: 17172431.

Hitchler, M. J., Wikainapakul, K., Yu, L., Powers, K., Attatippaholkun, W. & Domann, F. E. (2006). Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells. Epigenetics : official journal of the DNA Methylation Society, 1(4), 163-71. PMID: 17965603.

Li, H., Watts, G. S., Oshiro, M. M., Futscher, B. W. & Domann, F. E. (2006). AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells. Oncogene, 25(39), 5405-5415. PMID: PMID: 16636674.

Li, H., Goswami, P. C. & Domann, F. E. (2006). AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells. Neoplasia, 8(7), 568-577. PMID: PMID: 16867219.

Zhao, R., Domann, F. E. & Zhong, W. (2006). Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol Cancer Ther, 12, 3275-3284. PMID: PMID: 17172431.

Berger, K. L., Barriga, F., Lace, M. J., Turek, L. P., Zamba, G. L., Domann, F. E., Lee, J. h. & Klingelhutz, A. J. (2006). Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras. Virology, 356(1-2), 68-78. PMID: PMID: 16945398.

Niu, G., Anderson, R. D., Madsen, M. T., Graham, M. M., Oberley, L. W. & Domann, F. E. (2006). Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer. Nucl Med Biol, 33(3), 391-398. PMID: PMID: 16631088.

Hitchler, M. J., Wikainapakul, K., Yu, L., Powers, K., Attatippaholkun, W. & Domann, F. E. (2006). Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells. Epigenetics, 1(4), 163-171. PMID: PMID: 17965603.

Rose, S. L., Fitzgerald, M. P., White, N. O., Hitchler, M. J., Futscher, B. W., De Geest, K. & Domann, F. E. (2006). Epigenetic regulation of maspin expression in human ovarian carcinoma cells. Gynecologic Oncology, 102(2), 319-324. PMID: PMID: 16457875.

Zhao, R., Xiang, N., Domann, F. E. & Zhong, W. (2006). Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Res, 66(4), 2296-304. PMID: PMID: 16489034.

Yu, L., Venkataraman, S., Coleman, M. C., Spitz, D. R., Wertz, P. W. & Domann, F. E. (2006). Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes. Biochem Biophys Res Commun, 351(4), 1066-1071. PMID: PMID: 17097614.

Luo, J., Spitz, D. R., Li, L., Sun, W., Buettner, G. R., Oberley, L. W. & Domann, F. E. (2006). Inactivation of Cellular Antioxidants by Photodynamic Action Enhances Radiation and Adriamycin Induced Cytotoxicity in Human Melanoma cells. Antioxid Redox Signal, 8(7-8), 1307-1314. PMID: PMID: 16910778.

Luo, J., Li, L., Zhang, Y., Spitz, D. R., Buettner, G. R., Oberley, L. W. & Domann, F. E. (2006). Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen. Antioxid Redox Signal, 8(7-8), 1307-1314. PMID: PMID: 16910778.

Andringa, K. K., Coleman, M. C., Aykin-Burns, N., Hitchler, M. J., Walsh, S. A., Domann, F. E. & Spitz, D. R. (2006). Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res, 66(3), 1605-1610. PMID: PMID: 16452219.

Moussavi-Harami, F., Mollano, A., Martin, J. A., Ayoob, A., Domann, F. E., Gitelis, S. & Buckwalter, J. A. (2006). Intrinsic radiation resistance in human chondrosarcoma cells. Biochemical and Biophysical Research Communications, 346(2), 379-385. PMID: PMID: 16765318.

Chen, P., Cai, Y., Yang, Z. G., Zhou, R., Zhang, G. S., Domann, F. E. & Fang, X. (2006). Involvement of PKC, p38 MAPK and AP-2 in IL-1beta-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells. Respirology., 11(1), 18-23..

Darbro, C. W., Lee, K. M., Nguyan, N. K., Domann, F. E. & Klingelhutz, A. J. (2006). Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells. Oncogene, 25(56), 7421-7433. PMID: PMID: 16767161.

Slane, B. G., Aykin-Burns, N., Smith, B. J., Kalen, A. L., Goswami, P. C., Domann, F. E. & Spitz, D. R. (2006). Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Research, 66(15), 7615-7620. PMID: PMID: 16885361.

Yu, L., Domann, F. E. (2006). Rapid and direct quantitative RT-PCR method to measure promoter activity. Biotechnol Prog, 22(5), 1461-1463. PMID: PMID: 17022688.

Lal, G., Padmanabha, L., Smith, B. J., Nicholson, R. M., Howe, J. R., O'Dorisio, M. S. & Domann, F. E. (2006). RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma. Cancer, 107(12), 2752-2759. PMID: PMID: 17103461.

Futscher, B. W., Domann, F. E. (2005). Epigenetic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis Cancer Metastasis — Biology and Treatment. In DNA Methylation, Epigenetics and Metastasis. pp. 133-155. Springer Link.

Oshiro, M. M., Futscher, B. W., Lisberg, A., Wozniak, R. J., Klimecki, W. T., Domann, F. E. & Cress, A. E. (2005). Epigenetic regulation of the cell type-specific gene 14-3-3sigma. Neoplasia, 7(9), 799-808. PMID: PMID: 16229802.

Oshiro, M. M., Kim, C. J., Wozniak, R. J., Jucnk, D. J., Muñoz-Rodriguez, J. L., Burr, J. A., Fitzgerald, M., Pawar, S. C., Cress, A. E., Domann, F. E. & Futscher, B. W. (2005). Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast Cancer Research, 7(5), R669-R680. PMID: PMID: 16168112.

Wang, M. V., Zhang, H. J., Kirk, J. S., Weydert, C. J., Domann, F. E., Schafer, F. Q., Buettner, G. W. & Oberley, L. W. (2005). Manganese superoxide dismutase supresses hypoxic induction of hypoxia-inducible factor-1? and vascular endothelial growth factor. Oncogene, 24(55), 8154-66. PMID: PMID: 16170370.

Niu, G., Krager, K. J., Graham, M. M., Hichwa, R. D. & Domann, F. E. (2005). Noninvasive radiological imaging of pulmonary gene transfer and expression using the human sodium iodide symporter. Eur. J. Nucl. Med. Mol Imaging, 32(5), 534-540. PMID: PMID: 15599523.

Devlin, A. M., Bottiglieri, T., Domann, F. E. & Lentz, S. R. (2005). Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J. Biol. Chem, 280(27), 25506-25511. PMID: PMID: 15899898.

Futscher, B. W., O'Meara, M. M., Kim, C. J., Rennels, M. A., Lu, D., Gruman, L. M., Seftor, R. E., Hendrix, M. J. & Domann, F. E. (2004). Aberrant methylation of the maspin promoter is an early event in human breast cancer. Neoplasia, 6(4), 380-9. PMID: PMID: 15256060.

Chaves, A. C., Cherubini, K., Herter, N., Furian, R., Santos, D. S., Squier, C. & Domann, F. E. (2004). Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas. Int. J. Oncol, 24(2), 295-303. PMID: PMID: 14719105.

Domann, F. E., Futscher, B. W. (2004). Flipping the epigenetic switch. Am. J. Pathol, 164(6), 1883-1886. PMID: PMID: 15161624.

Gaut, A. W., Niu, G., Krager, K. J., Graham, M. M., Trask, D. K. & Domann, F. E. (2004). Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS). Head Neck, 26(3), 265-271. PMID: PMID: 14999802.

Niu, G., Gaut, A. W., Ponto, L. L., Hichwa, R. D., Madsen, M. T., Graham, M. M. & Domann, F. E. (2004). Multimodality noninvasive imaging of gene transfer using the human sodium iodide symporter. J Nucl. Med, 45(3), 445-449. PMID: PMID: 15001685.

Watts, G. S., Oshiro, M. M., Junk, D. J., Wozniak, R. J., Watterson, S., Domann, F. E. & Futscher, B. W. (2004). The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells. Neoplasia, 6(3), 187-194. PMID: PMID: 15153330.

Nwankwo, J., Spector, A. & Domann, F. E. (2003). An insertion mutation in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. J. Lipid Res, 44(12), 2311-2319. PMID: PMID: 12951357.

Cullen, J. J., Hinkhouse, M. M., Grady, M., Gaut, A. W., Liu, J., Zhang, Y. P., Weydert, C. J., Domann, F. E. & Oberley, L. W. (2003). Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res, 63(17), 5513-5520. PMID: PMID: 14500388.

Domann, F. E., Futscher, B. W. (2003). Editorial: maspin as a molecular target for cancer therapy. J. Urol., 169(3), 1162-4. PMID: PMID: 12576873.

Fitzgerald, M., Oshiro, M., Holtan, N., Krager, K., Cullen, J. J., Futscher, B. W. & Domann, F. E. (2003). Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia, 5(5), 427-436. PMID: PMID: 14670180.

Duan, H., Shang, H. J., Yang, J. Q., Oberley, L. W., Futscher, B. W. & Domann, F. E. (2003). MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cells. Antioxd. Redox Signal, 5(5), 677-688.

Oshiro, M., Watts, G. S., Wozniak, R. J., Junk, D., Munoz-Rodriguez, J., Domann, F. E. & Futscher, B. W. (2003). Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression. Oncogene, 22(23), 3624-3634. PMID: PMID: 12789271.

He, T., Weintraub, N. L., Goswami, P. C., Chatterjee, P., Domann, F. E. & Oberley, L. W. (2003). Redox factor-1 mediates platelet-derived growth factor-BB induced vascular smooth muscle cell proliferation. Am. J. Physiol. Heart Circ. Physiol., 285(2), H804-H812. PMID: PMID: 12730053.

Cullen, J. J., Weydert, C., Hinkhouse, M. M., Ritchie, J., Domann, F. E., Spitz, D. & Oberley, L. W. (2003). The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Res, 63(6), 1297-1303. PMID: PMID: 12649190.

Timmons, S. R., Nwankwo, J. O. & Domann, F. E. (2002). Acetaldehyde activates Jun/AP-1 expression and DNA binding activity in human oral keratinocytes. Oral Oncol, 38(2), 281-290. PMID: PMID: 11978551.

Zhu, C. H., Domann, F. E. (2002). Dominant negative interference of transcription factor AP-2 causes inhibition of erbB-3 expression and suppresses malignant cell growth. Breast Cancer Res. and Treat, 71(1), 47-57. PMID: PMID: 11859873.

Zhang, Y., Zhao, W., Zhang, H. J., Domann, F. E. & Oberley, L. W. (2002). Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Cancer Research, 62, 1205-1212. PMID: PMID: 11861405.

Girnun, G. D., Domann, F. E., Moore, S. A. & Robbins, M. E. (2002). PPAR gamma agonists activate catalase transcription: Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Molecular Endocrinology, 16(12), 2793-2801. PMID: PMID: 12456800.

Zhang, H. J., Drake, V. J., Xu, L., Domann, F. E., Oberley, L. W. & Kregel, K. C. (2002). Redox Regulation of adenovirus-induced AP-1 activation by MnSOD overexpression. J. Virol., 76(1), 355-363. PMID: PMID: 11739700.

Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H. & Domann, F. E. (2002). Role for DNA methylation in the control of cell type specific maspin expression. Nature Genetic, 31(2), 175-179. PMID: PMID: 12021783.

Yang, J. Q., Buettner, G. R., Domann, F. E., Li, Q., Engelhardt, J. F., Weydert, C. D. & Oberley, L. W. (2002). v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species. Molecular Carcinogenesis, 33(4), 206-218. PMID: PMID: 11933074.

Zhu, C. H., Huang, Y., Oberley, L. W. & Domann, F. E. (2001). A family of AP-2 proteins down-regulates manganese superoxide dismutase gene expression. Journal of Biol. Chem, 276(17), 14407-14413. PMID: PMID: 11278550.

Zhu, C., Huang, Y., Weydert, C. J., Oberley, L. W. & Domann, F. E. (2001). Constitutive Activation of Transcription Factor AP-2 is Associated with Decreased MnSOD Expression in Transformed Human Lung Fibroblasts. Antioxidants & Redox Signaling, 3(3), 387-396. PMID: PMID: 11491651.

Zhu, C. H., Huang, Y., Broman, M. & Domann, F. E. (2001). Expression of AP-2 ? in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2? promoter. Biochem. Biophys. Acta, 1519(1-2), 85-91. PMID: PMID: 11406275.

Wang, H. P., Qian, S. Y., Schafer, F. Q., Domann, F. E., Oberley, L. W. & Buettner, G. R. (2001). Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy. Free Radic. Biol. Med, 30(8), 825-835. PMID: PMID: 11295525.

Yang, J. Q., Zhao, W., Duan, H., Robbins, M. E., Buettner, G. R., Oberley, L. W. & Domann, F. E. (2001). v-Ha-ras oncogene up-regulates the 92 kDa typeIV collagenase gene by increasing cellular superoxide production and activating NF-?B. Free Radical Biol Med, 31(4), 520-529. PMID: PMID: 11498285.

Yang, J. Q., Li, S., Huang, Y., Zhang, H., Domann, F. E., Buettner, G. R. & Oberley, L. W. (2001). v-Ha-Ras overexpression induces superoxide production and alters levels of primary antioxidant enzymes. Antioxidants & Redox Signaling, 3(4), 697-709. PMID: PMID: 11554455.

Domann, F. E., Rice, J. C., Hendrix, M. J. & Futscher, B. W. (2000). Epigenetic silencing of maspin gene expression in human breast cancers. International Journal of Cancer, 85, 805-810. PMID: PMID: 10709100.

Sekhar, K. R., Soltaninassab, S. R., Borelli, M. J., Xu, Z. Q., Meredith, M. J., Domann, F. E. & Freeman, M. L. (2000). Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for ?-glutamylcysteine synthetase. Biochem Biophys Res Comm, 270, 311-217. PMID: PMID: 10733945.

Huang, Y., He, T. & Domann, F. E. (1999). Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene. DNA & Cell Biology, 18(8), 643-652. PMID: PMID: 10463060.

Cody, D. T., Huang, Y., Darby, C. J., Johnson, G. K. & Domann, F. E. (1999). Differential DNA methylation of the p16 (INK4a)/CDKN2a promoter in human oral cancer cells and normal human oral keratinocytes. Oral Oncology, 35, 516-522. PMID: PMID: 10694953.

Yang, J., S, L., Domann, F. E., Buettner, G. R. & Oberley, L. W. (1999). Superoxide generation in v-Ha-ras transduced human keratinocyte HaCaT cells. Molecular Carcinogenesis, 26, 180-188. PMID: PMID: 10559793.

Huang, Y., Domann, F. E. (1999). Transcription factor AP-2 mRNA and DNA binding activity are constitutively expressed in SV40 immortalized but not normal human lung fibroblasts. Archives Bichem. Biphys, 364(2), 241-246. PMID: PMID: 10190980.

Huang, Y., Domann, F. E. (1998). Redox modulation of AP-2 DNA binding activity in vitro. Bichem. Biophys. Res. Comm, 249(307-312). PMID: PMID: 9712692.

Peng, J. X., Bowden, G. T. & Domann, F. E. (1997). Activation of AP-1 by okadaic acid in mouse keratinocytes associated with hyperphosphorylation of c-jun. Molecular Carcinogenesis, 18, 37-43. PMID: PMID: 9022811.

Lam, E. N., Zwacka, R., Englehart, J. F., Davidson, B. L., Domann, F. E. & Oberley, L. W. (1997). Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheeck pouch carcinoma cells. Cancer Research, 24, 5550-5556. PMID: PMID: 9407966.

Lam, E., Zwacka, R., Englehart, J. F., Davidson, B. L., Domann, F. E. & Oberley, L. W. (1997). Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheeck pouch carcinoma cells. Cancer Research, 57(24), 5550-5556. PMID: 9407966.

Kelley, E. E., Domann, F. E., Buettner, G. R., Burns, C. P. & Oberley, L. W. (1997). Increased efficacy of photofrin photosensitization of oral squamous cell carcioma by the pro-oxidants iron and ascorbate. Eur. J. Photochem. Photobiol. B:Biology, 40, 273-277. PMID: PMID: 9372616.

Kelley, E. E., Domann, F. E., Buettner, G. R., Burns, C. P. & Oberley, L. W. (1997). Increased efficacy of photofrin photosensitization of oral squamous cell carcioma by the pro-oxidants iron and ascorbate. Eur. J. Photochem. Photobiol. B:Biology, 40, 273-277. PMID: PMID: 9372616.

Kelley, E. E., Domann, F. E., Buettner, G. R., Burns, C. P. & Oberley, L. W. (1997). Increased efficacy of photofrin photosensitization of oral squamous cell carcioma by the pro-oxidants iron and ascorbate. Eur. J. Photochem. Photobiol. B:Biology, 40, 273-277. PMID: PMID: 9372616.

Huang, Y., Peng, J., Oberley, L. W. & Domann, F. E. (1997). Transcriptional inhibition of manganese superoxide dismutase (SOD2) gene expression by DNA methylation of the 5' CpG island. Free Radic Biol Med, 23(2), 314-320. PMID: PMID:9199894.

Peng, J., Bowden, G. T. & Domann, F. E. (1997). Transcriptional regulation of the c-jun proto-oncogene in mouse keratinocytes by the skin tumor promoter okadaic acid. Molecular Carcinogenesis, 18, 37-43.

Peng, J., Bowden, G. T. & Domann, F. E. (1997). Transcriptional regulation of the c-jun proto-oncogene in mouse keratinocytes by the skin tumor promoter okadaic acid. Molecular Carcinogenesis, 18, 37-43.

Zhong, W., Oberley, L. W., Oberley, T. D., Domann, F. E. & St.Clair, D. K. (1996). Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth and Differentiation, 7, 1175-1186. PMID: PMID: 8877099.

Powell, W. C., Domann, F. E., Mitchen, J. M., Matrisian, L. M., Nagle, R. B. & Bowden, G. T. (1996). Matrilysin expression in the involuting rat ventral prostate. Prostate, 29(3), 159-168. PMID: PMID: 8827084.

Domann, F. E., Martinez, M. (1995). An alternative to cloning cylinders for isolation of adherent cell colonies. BioTechniques, 18, 594.

Liu, J., Domann, F. E. & Oberley, L. W. (1995). The use of RT-PCR to distinguish between plasmid MnSOD transcripts and endogenous MnSOD mRNA. Biochem. Biophys. Res. Commun, 216(2), 610-618.

Futscher, B. W., Abbaszadegan, M., Domann, F. E. & Dalton, W. S. (1994). Analysis of MRP mRNA in mitaxantrone-selected, multidrug resistant human tumor cells. Biochem. Pharmacol, 47(9), 1601-1606.

Domann, F. E., Levy, J. P., Finch, J. S. & Bowden, G. T. (1994). Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells. Molecular Carcinogenesis, 9(2), 61-66. PMID: PMID: 8142009.

Bowden, G. T., Schneider, B. L., Domann, F. E. & Kulesz-Martin, M. F. (1994). Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis. Cancer Research, 54(7), 1882s-1885s.

Domann, F. E., Freitas, M., Gould, M. N. & Clifton, K. H. (1994). Quantifying the frequency of radiogenic cancer initiation per clonogenic rat thyroid epithelial cell in vivo. Radiation Res, 137(3), 330-337. PMID: PMID: 8146276.

Domann, F. E., Levy, J. P., Brown, P. H., Birrer, M. J. & Bowden, G. T. (1994). Stable expression of a dominant negative c-jun gene in malignant mouse epidermal cells blocks cellular AP-1 activity and tumor formation. Cell Growth and Differentiation, 5(1), 9-16. PMID: PMID: 8123597.

Nelson, M. A., Domann, F. E., Bowden, G. T., Hooser, S. B., Fernando, Q. & Carter, D. E. (1993). Effects of acute and sub-chronic exposure of topically applied fullerene extracts on the mouse skin. Toxicol. Ind. Health, 9(4), 623-630. PMID: PMID: 8296315.

Clifton, K. H., Domann, F. E. & Groch, K. M. (1991). On the cells of origin of radiogenic thyroid cancer: New studies based on an old idea. J. Radiat. Res, 32, 143-155. PMID: PMID: 1840428.

Clifton, K. H., Groch, K. M. & Domann, F. E. (1991). Thyroid clonogen biology and carcinogenesis. Prog. Clin. Biol. Res, 369, 173-183. PMID: PMID: 1946516.

Domann, F. E., Mitchen, J. M. & Clifton, K. H. (1990). Restoration of thyroid function following total thyroidectomy and quantitative thyroid cell transplantation. Endocrinology, 127(6), 2673-2678. PMID: PMID: 2249620.

Seed, T. M., Kaspar, L. V., Domann, F. E., Niiro, G. K. & LeBuis, D. A. (1988). Developmental and radiobiologic characteristics of canine multinucleated, osteoclast-like cells generated in vitro from canine bone marrow. Scanning Microsc, 2(3), 1599-1611.

Watanabe, H., Tanner, M. A., Domann, F. E., Gould, M. N. & Clifton, K. H. (1988). Inhibition of carcinoma formation and of vascular invasion in grafts of radiation-initiated thyroid clonogens by unirradiated thyroid cells. Carcinogenesis, 9(8), 1329-1335. PMID: PMID: 3402028.