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John Buatti, MD

Professor of Radiation Oncology

Introduction

The focus of my research is the use of imaging to improve outcomes for patients undergoing cancer therapy, radiation therapy in particular.

Grants that I am a part of that support this focus are:

R21 CA130281 Imaging Thymidine Uptake During Treatment for Head and Neck Cancer Other areas of interest are in treating cancers of the Head and Neck and Brain, especially in the pediatric population.

Current Positions

  • Professor of Radiation Oncology
  • Professor of Neurosurgery
  • Professor of Otolaryngology

Education

  • BS in Biology/Theology, Georgetown University, Washington, D.C.
  • MD in Medicine, Georgetown University, Washington, D.C.
  • Internship in Internal Medicine, Georgetown University, Washington DC, District of Columbia, United States
  • Resident in Radiation Oncology, University of Arizona

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Prolifeprosan 20 with Carmustine 3.85% Implant in Patients Undergoing Initial Surgery for Newly Diagnosed Malignant Glioma [University of Florida, 1998-2000]
  • Comprehensive Pediatric Neuro-Oncology Tumor Database [IRB 200008066, O’Dorisio PI]
  • ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients [IRB 201011795, El-Sheikh PI]
  • AHOD03P1: Treatment of Children with Newly-Diagnosed Low Stage Lymphocyte Predominant Hodgkin Disease (LPHD: A Group-wide Pilot Study [IRB 200812743, El-Sheikh PI]
  • A phase II trial of the HIV protease inhibitor Nelfinavir in patients with recurrent symptomatic adenoid cystic cancers of the head and neck [IRB 200905704]
  • Phase II Treatment of Adults With Newly Diagnosed Supratentorial Glioblastoma Multiforme Treated With Gliadel Wafers, Surgery And Limited Field Radiation Plus Concomitant Temozolomide Followed by Temozolomide [IRB 200408035, Ryken PI]
  • Prospective observational study in human subjects undergoing radiation oncology evaluation or treatment [IRB 201109821]
  • ACNS0334: A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate [IRB 200903733, El-Sheikh PI]
  • A phase I trial of a ketogenic diet with concurrent chemoradiation for pancreatic cancer
  • Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Mucositis Pain and Function [IRB 201009732, Lee PI]

Licenses & Certifications

  • Iowa Board of Medical Examiners, Iowa
  • American Board of Radiology (Therapeutic)
  • American Board of Internal Medicine
  • Florida Board of Medicine, Florida

Selected Publications

  • Kozak MM, Mahase S, Traughber B, Machtay M, Buatti JM. (March 2024). MR-Guided Radiotherapy in the Pediatric and Adolescent Patient. In: Das, I.J., Alongi, F., Yadav, P., Mittal, B.B. (eds) A Practical Guide to MR-Linac. Springer, Cham. 2024. https://doi.org/10.1007/978-3-031-48165-9_19   Chapter 19, pp. 355-373.
  • Tamplin MR, Wang JK, Binkley EM, Garvin MK, Hyer DE, Buatti JM, Boldt HC, Grumbach IM, Kardon RH. Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment. Sci Rep. 2024 Feb 9;14(1):3380. doi: 10.1038/s41598-024-53830-6. PMID: 38336828; PMCID: PMC10858219.
  • Kritikos M, Vivanco-Suarez J, Teferi N, Lee S, Kato K, Eschbacher KL, Bathla G, Buatti JM, Hitchon PW. Survival and neurological outcomes following management of intramedullary spinal metastasis patients: a case series with comprehensive review of the literature. Neurosurg Rev. 2024 Feb 6;47(1):75. doi: 10.1007/s10143-024-02308-0. PMID: 38319484.
  • Pascual TNB, Paez D, Iagaru A, Gnanasegaran G, Lee ST, Sathekge M, Buatti JM, Giammarile F, Al-Ibraheem A, Pardo MA, Baum RP, De Bari B, Ben-Haim S, Blay JY, Brink A, Estrada-Lobato E, Fanti S, Golubic AT, Hatazawa J, Israel O, Kiess A, Knoll P, Louw L, Mariani G, Mirzaei S, Orellana P, Prior JO, Urbain JL, Vichare S, Vinjamuri S, Virgolini I, Scott AM. Guiding principles on the education and practice of theranostics. Eur J Nucl Med Mol Imaging. 2024 Jul;51(8):2320-2331. doi: 10.1007/s00259-024-06657-2. Epub 2024 Mar 8. PMID: 38453729; PMCID: PMC11178594.
  • Chowdhury, A.; Teferi, N.; Lee, S. J.; Vivanco-Suarez, J.; Chenoweth, D.; Littlefield, C. P.; Petronek, M.; Buatti, J. M.; Noeller, J.; Hitchon, P. W. Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience. Preprints 2024, 2024020069. https://doi.org/10.20944/preprints202402.0069.v1
  • Petronek MS, Bodeker KL, Lee CY, Teferi N, Eschbacher KL, Jones KA, Loeffler BT, Smith BJ, Buatti JM, Magnotta VA, Allen BG. Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: insights from a phase 2 clinical trial. J Neurooncol. 2024 Feb;166(3):493-501. doi: 10.1007/s11060-024-04571-z. Epub 2024 Jan 29. PMID: 38285244.
  • Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM. Clin Cancer Res. 2024 Jan 17;30(2):283-293. doi: 10.1158/1078-0432.CCR-22-3952. PMID: 37773633; PMCID: PMC10841843.
  • Xie H, Xu W, Xing Wang Y, Buatti JM, Wu X. gcDLSeg: Integrating Graph-cut into Deep Learning for Binary Semantic Segmentation. IEEE Transactions On Pattern Analysis And Machine Intelligence. December 2023. https://doi.org/10.48550/arXiv.2312.04713
  • Chowdhury A, Vivanco-Suarez J, Teferi N, Belzer A, Al-Kaylani H, Challa M, Lee S, Buatti JM, Hitchon P. Surgical management of craniospinal axis malignant peripheral nerve sheath tumors: a single-institution experience and literature review. World J Surg Oncol. 2023 Oct 26;21(1):338. doi: 10.1186/s12957-023-03227-y. PMID: 37880773; PMCID: PMC10601280.
  • Piscopo AJ, Chowdhury AJ, Teferi N, Lee S, Challa M, Petronek M, Eschbacher K, Bathla G, Buatti JM, Hitchon P. Surgical Management of Craniospinal Axis Solitary Fibrous Tumors: A Single-Institution Case Series and Comprehensive Review of the Literature. Neurosurgery. 2024 Feb 1;94(2):358-368. doi: 10.1227/neu.0000000000002692. Epub 2023 Sep 25. PMID: 37747216.