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Kailin Yang, MD, PhD

Assistant Professor

Current Positions

  • Assistant Professor - Radiation Oncology

Education

  • BS, Biological Sciences, Tsinghua University, Beijing, China
  • PhD, Biological Chemistry and Molecular Pharmacology, Harvard University, Cambridge, MA
  • MD, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Center, Program and Institute Affiliations

Research Interests

  • Characterizing intratumoral heterogeneity in head and neck cancer.

Licenses & Certifications

  • Board Certified in Radiation Oncology through the American Board of Radiology (ABR)

Selected Publications

  • Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN. Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2. Cell Metab. 2024 Nov 5;36(11):2419-2436.e8. doi: 10.1016/j.cmet.2024.09.014. Epub 2024 Oct 24. PMID: 39454581.
  • Li F, Yang K, Gao X, Zhang M, Gu D, Wu X, Lu C, Wu Q, Dixit D, Gimple RC, You Y, Mack SC, Shi Y, Kang T, Agnihotri SA, Taylor MD, Rich JN, Zhang N, Wang X. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. Sci Transl Med. 2024 Oct 2;16(767):eadk9524. doi: 10.1126/scitranslmed.adk9524. Epub 2024 Oct 2. PMID: 39356747.
  • Murphy ES, Yang K, Suh JH, Yu JS, Stevens G, Angelov L, Vogelbaum MA, Barnett GH, Ahluwalia MS, Neyman G, Mohammadi AM, Chao ST. Phase I trial of dose escalation for preoperative stereotactic radiosurgery for patients with large brain metastases. Neuro Oncol. 2024 Sep 5;26(9):1651-1659. doi: 10.1093/neuonc/noae076. PMID: 38656347; PMCID: PMC11376451.
  • Hu M, Yang K, Wang J, Qiu RLJ, Roper J, Kahn S, Shu HK, Yang X. MGMT promoter methylation prediction based on multiparametric MRI via vision graph neural network. J Med Imaging (Bellingham). 2024 Jan;11(1):014503. doi: 10.1117/1.JMI.11.1.014503. Epub 2024 Feb 16. PMID: 38370421; PMCID: PMC10869845.
  • Zhao L, Qiu Z, Yang Z, Xu L, Pearce TM, Wu Q, Yang K, Li F, Saulnier O, Fei F, Yu H, Gimple RC, Varadharajan V, Liu J, Hendrikse LD, Fong V, Wang W, Zhang J, Lv D, Lee D, Lehrich BM, Jin C, Ouyang L, Dixit D, Wu H, Wang X, Sloan AE, Wang X, Huan T, Mark Brown J, Goldman SA, Taylor MD, Zhou S, Rich JN. Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nat Cancer. 2024 Jan;5(1):147-166. doi: 10.1038/s43018-023-00658-0. Epub 2024 Jan 3. PMID: 38172338.
  • Asha W, Al-Hilli Z, Djohan R, Budd GT, Obi E, Fleming-Hall E, Yang K, Grobmyer S, Cherian S, Tendulkar R, Shah C. Neoadjuvant Reirradiation for Radiation Therapy-Associated Angiosarcoma of the Breast. Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1082-1085. doi: 10.1016/j.ijrobp.2023.12.050. Epub 2024 Jan 6. PMID: 38191096.
  • Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Mol Cell. 2023 Dec 7;83(23):4334-4351.e7. doi: 10.1016/j.molcel.2023.10.025. Epub 2023 Nov 17. PMID: 37979586; PMCID: PMC10842222.
  • Yuan W, Zhang Q, Gu D, Lu C, Dixit D, Gimple RC, Gao Y, Gao J, Li D, Shan D, Hu L, Li L, Li Y, Ci S, You H, Yan L, Chen K, Zhao N, Xu C, Lan J, Liu D, Zhang J, Shi Z, Wu Q, Yang K, Zhao L, Qiu Z, Lv D, Gao W, Yang H, Lin F, Wang Q, Man J, Li C, Tao W, Agnihotri S, Qian X, Mack SC, Zhang N, You Y, Rich JN, Sun G, Wang X. Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages. Clin Cancer Res. 2023 Sep 15;29(18):3779-3792. doi: 10.1158/1078-0432.CCR-22-3273. PMID: 37439870.
  • Duan Y, Zhou H, Liu X, Iketani S, Lin M, Zhang X, Bian Q, Wang H, Sun H, Hong SJ, Culbertson B, Mohri H, Luck MI, Zhu Y, Liu X, Lu Y, Yang X, Yang K, Sabo Y, Chavez A, Goff SP, Rao Z, Ho DD, Yang H. Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature. 2023 Oct;622(7982):376-382. doi: 10.1038/s41586-023-06609-0. Epub 2023 Sep 11. PMID: 37696289.
  • Jin Z, Zhao Y, Sun Y, Zhang B, Wang H, Wu Y, Zhu Y, Zhu C, Hu T, Du X, Duan Y, Yu J, Yang X, Yang X, Yang K, Liu X, Guddat LW, Xiao G, Zhang L, Yang H, Rao Z. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 Jun;27(6):529-532. doi: 10.1038/s41594-020-0440-6. Epub 2020 May 7. PMID: 32382072.