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Mark Smith, MD

Clinical Professor of Radiation Oncology

Current Positions

  • Clinical Professor of Radiation Oncology
  • Clinical Director, Department of Radiation Oncology

Education

  • BS in Physics, Iowa State University, Ames, Iowa
  • MD in Medicine, University of Iowa, Iowa City, Iowa
  • MA in Medical Education, University of Iowa, Iowa City, Iowa
  • Resident in Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI
  • Computer Science, University of Iowa
  • Biomedical Engineering, University of Iowa

Research Interests

  • Investigator Initiated Clinical Trials (Designated supervising faculty)
  • Invesitgator Initiated Clinical Trials (Co-investigator): Lung
  • Investigator Initiated Clinical Trials (Co-investigator): Central Nervous System
  • Investigator Initiated Clinical Trials (Co-investigator): Genitourinary
  • Research Summary
  • Cooperative Group Trials (Local co-investigator): Central Nervous System
  • Cooperative Group Trials (Local co-investigator): Genitourinary
  • Neoadjuvant Intralesional Injection of Talimogene Laherparepvec with Concurrent Preoperative Radiation in Patients with Locally Advanced Soft Tissue Sarcomas IRB# 201504731

Licenses & Certifications

  • American Board of Radiology (Radiation Oncology)
  • Iowa Medical License, Iowa

Selected Publications

  • Hyer DE, Caster J, Smith B, St-Aubin J, Snyder J, Shepard A, Zhang H, Mullan S, Geoghegan T, George B, Byrne J, Smith M, Buatti JM, Sonka M. A Technique to Enable Efficient Adaptive Radiation Therapy: Automated Contouring of Prostate and Adjacent Organs. Adv Radiat Oncol. 2023 Aug 7;9(1):101336. doi: 10.1016/j.adro.2023.101336. PMID: 38260219; PMCID: PMC10801646.
  • Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM. Clin Cancer Res. 2024 Jan 17;30(2):283-293. doi: 10.1158/1078-0432.CCR-22-3952. PMID: 37773633; PMCID: PMC10841843.
  • Dunkerley DAP, Hyer DE, Snyder JE, St-Aubin JJ, Anderson CM, Caster JM, Smith MC, Buatti JM, Yaddanapudi S. Clinical Implementational and Site-Specific Workflows for a 1.5T MR-Linac. J Clin Med. 2022 Mar 16;11(6):1662. doi: 10.3390/jcm11061662. PMID: 35329988; PMCID: PMC8954784.
  • Seyedin SN, Watkins JM, Mayo Z, Snow AN, Laszewski M, Russo JK, Mott SL, Tracy CR, Smith MC, Buatti JM, Caster JM. A Recursive Partitioning Analysis Demonstrating Risk Subsets for 8-Year Biochemical Relapse After Margin-Positive Radical Prostatectomy Without Adjuvant Hormone or Radiation Therapy. Adv Radiat Oncol. 2021 Aug 14;6(6):100778. doi: 10.1016/j.adro.2021.100778. PMID: 34934861; PMCID: PMC8655410.
  • Park BJ, Seaman SC, Noeller JL, Smith MC, Hasan DM, Yasin H, Hitchon PW. Metastatic Renal Cell Carcinoma to the Spine: Outcomes and Morbidity: Single-Center Experience. World Neurosurg. 2021 Oct;154:e398-e405. doi: 10.1016/j.wneu.2021.07.041. Epub 2021 Jul 17. PMID: 34280537.
  • Seaman, S. C., Bathla, G., Park, B. J., Woodroffe, R. W., Smith, M. C., Menezes, A. H., Noeller, J., Yamaguchi, S. & Hitchon, P. W. (2021). MRI Characteristics and Resectability in Spinal Cord Glioma. Clin Neurol Neurosurg. Clin Neurol Neurosurg 200 (106321). DOI: doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194.
  • Cushing, C. M., Petronek, M. S., Bodeker, K. L., Vollstedt, S., Brown, H. A., Opat, E., Hollenbeck, N. J., Shanks, T., Berg, D. J., Smith, B. J., Smith, M. C., Monga, V., Furqan, M., Howard, M. A., Greenlee, J. D., Mapuskar, K. A., St-Aubin, J., Flynn, R. T., Cullen, J. J., Buettner, G. R., Spitz, D. R., Buatti, J. M., Allen, B. G. & Magnotta, V. A. (2021). Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy. Redox biology 38 101804. DOI: 10.1016/j.redox.2020.101804. PMID: 33260088.
  • Liu, W., Chen, Z., Zhang, H., Wang, D., Smith, B. J., Plichta, K., Smith, M., Sonka, M. & Buatti, J. M. (2020). A Just Enough Interaction Segmentation Tool Improves Consistency and Efficiency for Radiotherapy Contouring of Meningiomas. Applied Radiation Oncology 9 (4) 31-38.
  • Buatti, J. S., Buatti, J. M., Yaddanapudi, S., Pennington, E. C., Wang, D., Gross, B., St-Aubin, J. J., Hyer, D. E., Smith, M. C. & Flynn, R. T. (2020). Stereotactic radiotherapy of appropriately selected meningiomas and metastatic brain tumor beds with gamma knife icon versus volumetric modulated arc therapy. Journal of Applied Clinical Medical Physics. DOI: 10.1002/acm2.13100. PMID: 33207030.
  • Li, L., Seaman, S. C., Bathla, G., Smith, M. C., Dundar, B., Noeller, J. & Hitchon, P. W. (2020). Microvascular Decompression Versus Stereotactic Radiosurgery for Trigeminal Neuralgia: A single institution experience. World Neurosurgery. DOI: 10.1016/j.wneu.2020.07.161. PMID: 32745644.