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Mitchell Coleman, PhD

Assistant Professor of Radiation Oncology

Introduction

Dr. Mitchell Coleman is a cell biologist with specific research interests in the redox biology and biochemistry of articular chondrocytes. He obtained his undergraduate degree in biomedical engineering as well as his PhD in free radical and radiation biology from the University of Iowa. He then joined the Department of Orthopedics and Rehabilitation for his post-doctoral work characterizing intracellular pathology in vivo following intraarticular fracture, meniscal destabilization and articular impact injuries. Additional research interests include aging- and diabetes-associated changes in articular cartilage as well as development of sarcoma therapies built around musculoskeletal cell biological concepts. He is currently an active member of the Orthopedic Research Society and the Society for Free Radical Biology and Medicine.

Current Positions

  • Assistant Professor of Radiation Oncology
  • Assistant Professor of Orthopedics and Rehabilitation

Education

  • MA in Religious Studies, University of Iowa, Iowa City, Iowa
  • BSE in Biomedical Engineering, University of Iowa, Iowa City, Iowa
  • BA in Religious Studies, University of Iowa, Iowa City, Iowa
  • PhD in Free Radical and Radiation Biology, University of Iowa, Iowa City, Iowa
  • Postdoctoral Scholar in Orthopaedics, University of Iowa Carver College of Medicine, Iowa City, Iowa

Graduate Program Affiliations

Research Interests

  • Cartilage Degeneration and Repair
  • Cartilage Mechanobiology
  • Intracellular Oxidant Signaling
  • Oxidative Stress
  • Mitochondrial Metabolism
  • Radiosensitization and Radioprotection
  • Sarcoma Biology and Treatment
  • Thiol Biochemistry
  • Traumatic Joint Injury

Selected Publications

  • Hines, M.R., Liman, S., Fredericks, D.C., Van Remmen, H., Coleman, M.C. GPx4 overexpression alters bone remodeling in response to overloading and injury. Submitted to the Society for Redox Biology and Medicine September 2024
  • Dobson, C., Coleman, M.C., Cyndari, K., Elkins, J.M. Inflammation in Posterior Cruciate Ligaments of Bariatric Arthroplasty Patients. Submitted to the Orthopedic Research Society August 2024.
  • Fisher, J.S., Dobson, C.B., Liman, S., Hines, M.R., Fredericks, D.C., Olinger, C.R., Coleman, M.C. Development of Histological Measures of Metallosis in a Novel Model of Spinal Fusion. Presented at the CCOM Medical Student Research Conference (September 18-19 2024), Iowa City, IA.
  • 1.      Dobson, C., Coleman, M.C., Cyndari, K., Elkins, J.M. Oxidative Stress and Inflammation in Posterior Cruciate Ligaments of Bariatric Arthroplasty Patients. Presented at the CCOM Medical Student Research Conference (September 18-19 2024), Iowa City, IA.
  • Lu, K.J., Liman, S., Hines, M.R., Fisher, J.S., Peplinski, J.R., McNally, L.D., Witt, E., Byrne, J.D., Coleman, M.C. Manipulation of Thiol Metabolism During Carbon Monoxide Treatment for Cartilage Injury Reveals Zone-Specific Responses. Presented at the University of Iowa Biomedical Scholars Undergraduate Research Program (July 2024), Iowa City, IA.
  • Peplinski, J.R., Hines, M.R., Liman, S., Fisher, J., Lu, K., McNally, L., Witt, E., Byrne, J., Coleman, M.C.  Synovia Treated with Carbon Monoxide Demonstrate Decreased Indications of Protein Oxidation. Presented at the University of Iowa Biomedical Scholars Undergraduate Research Program Symposium (July 2024), Iowa City, IA
  • McNally, L.D., Liman, S., Hines, M.R., Byrne, J.D., Coleman, M.C. Carbon Monoxide Improves Mitochondrial Morphology After Tert-Butyl Hydroperoxide Injury in Human Chondrocytes. Presented at the University of Iowa Spring Undergraduate Research Festival 2024, Iowa City, IA.
  • Liman S., Kluz P.N., Gomez-Contreras P.C., Hines M.R., Femino E.L., Sakyi M.Y., Byrne J.D., Goetz J.E., Coleman M.C. Targeting Hemoproteins with Carbon Monoxide to Protect Articular Cartilage From Injury at the 2024 SfRBM Regional Symposium, Birmingham, Alabama, March 7, 2024.
  • Hines, M. R., Gomez-Contreras, P. C., Liman, S., Saunders G. K., Wilson, A. M., Fredericks, D. C., Goetz, J. E., Van Remmen, H., Coleman, M. C. (2023) Lipid Peroxidation is a Critical Feedback Regulator of Mitochondria in Articular Chondrocytes. Abstract published from the Society for Redox Biology and Medicine (SfRBM) meeting, Punta Del Este, Uruguay, November 15-18, 2023.
  • Hines, M. R., Gomez-Contreras, P. C., Rodman, S. N. III, Liman, S., Fredericks, D. C., Van Remmen, H., Goetz, J. E., Coleman, M. C. (2023) Chondrocyte Mitochondrial Biogenesis is Regulated by Lipid Peroxidation via Activation of Peroxisome Proliferating Activator Receptor- Gamma. Abstract published from the 2023 University of Iowa Orthopedics Senior Residents Day, Iowa City, Iowa, June 9-10, 2023