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James A. Brown, MD

Professor of Biomedical Engineering (BME)
Professor of Urology

Contact Information

3251 Carver Pavilion (RCP)
Iowa City, IA 52242


BS, Engineering Science, Colorado State University
MD, Baylor College of Medicine
Fellow, Henry Ford Hospital, Urologic Oncology
Fellow, Indiana University School of Medicine, Urologic Laparoscopy
Fellow, Massachusetts General Hospital, Urologic Oncology
Fellow, Thomas Jefferson University Hospital, Urologic Oncology
Resident, Mayo Graduate School of Medicine, Urology

Licensure and Certifications

Diplomate - American Board of Urology

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Development of translational biomedical engineering devices related to and benefitting urologic medical care and surgery.


Boi, S. K., Orlandella, R. M., Gibson, J. T., Turbitt, W. J., Wald, G., Thomas, L., Buchta Rosean, C., Norris, K. E., Bing, M., Bertrand, L., Gross, B. P., Makkouk, A., Starenki, D., Farag, K. I., Sorge, R. E., Brown, J. A., Gordetsky, J., Yasin, H., Garje, R., Nandagopal, L., Weiner, G. J., Lubaroff, D. M., Arend, R. C., Li, P., Zakharia, Y., Yang, E., Salem, A. K., Nepple, K., Marquez-Lago, T. T. & Norian, L. A. (2020). Obesity diminishes response to PD-1-based immunotherapies in renal cancer. Journal for immunotherapy of cancer, 8(2). PMID: 33427691.

Yong, C., Moose, D. L., Bannick, N., Gutierrez, W. R., Vanneste, M., Svensson, R., Breheny, P., Brown, J. A., Dodd, R. D., Cohen, M. B. & Henry, M. D. (2020). Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PloS one, 15(9), e0232807. PMID: 32986721.

Yong, C., Brown, J. A. & Takacs, E. B. (2020). Performing Medical Education Research in Urology: Challenges and Opportunities. Current urology reports, 21(11), 45. PMID: 32889609.

Gibson, J. T., Norris, K. E., Wald, G., Buchta Rosean, C. M., Thomas, L. J., Boi, S. K., Bertrand, L. A., Bing, M., Gordetsky, J. B., Deshane, J., Li, P., Brown, J. A., Nepple, K. G. & Norian, L. A. (2020). Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma. PloS one, 15(5), e0233795. PMID: 32469992.

West, J. M., Ma, D., Mott, S. L. & Brown, J. A. (2020). Cell cycle progression score has potential prognostic value for stage T1 renal cell carcinomas. Urologic oncology, 38(5), 545-552. PMID: 32081562.

Oberle, A. D., Brown, J. A. (2020). Small Renal Mass with Sarcomatoid Features. (Vols. 14). (1), pp. 54-56. Current urology. PMID: 32398998.

Alzubaidi, A. N., Nepple, K. G., Vollstedt, A., Dahmoush, L., Ma, D., Henry, M. D. & Brown, J. A. (In Press). a-Dystroglycan staining pattern and mortality in patients undergoing radical prostatectomy with lymph node positive prostate cancer. Canadian Journal of Urology.

Garje, R., Chennamadhavuni, A., Mott, S. L., Chambers, I. M., Gellhaus, P., Zakharia, Y. & Brown, J. A. (2019). Utilization and Outcomes of Surgical Castration in Comparison to Medical Castration in Metastatic Prostate Cancer. Clinical Genitourinary Cancer. DOI: https://doi.org/10.1016/j.clgc.2019.09.020.

West, J. M., Goates, A. J. & Brown, J. A. (2018). A 26-Year-Old Male with a 14-Year History of Left Intermittent Testicular Torsion Treated with Self-Manual Reduction. Current Urology, 11(3), 166-168. DOI: 10.1159/000447213.

Bertrand, L. A., Thomas, L. J., Li, P., Buchta, C. M., Boi, S. K., Orlandella, R. M., Brown, J. A., Nepple, K. G. & Norian, L. A. (2017). Obesity as defined by waist circumference but not body mass index is associated with higher renal mass complexity. Urologic Oncology: Seminars and Original Investigations, 35(11), 661.e1-661.e6. DOI: 10.1016/j.urolonc.2017.06.058.

Varzavand, A., Hacker, W., Ma, D., Gibson-Corley, K., Hawayek, M., Tayh, O. J., Brown, J. A., Henry, M. D. & Stipp, C. S. (2016). a3ß1 integrin suppresses prostate cancer metastasis via regulation of the Hippo pathway. Cancer Research, 76(22), 6577-6587. DOI: 10.1158/0008-5472.CAN-16-1483.

Ghareeb, G. M., Kenleigh, D. A. & Brown, J. A. (2016). Left Hand-assisted Laparoscopic Nephrectomy With Renal Vein Thrombectomy for Stage T3b Renal Cell Carcinoma. Urology, 90, e3-4. PMID: 26777747.

Miller, M. R., Ma, D., Schappet, J., Breheny, P., Mott, S. L., Bannick, N., Askeland, E., Brown, J. & Henry, M. D. (2015). Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma. Molecular Cancer, 14(1). DOI: 10.1186/s12943-015-0416-z.

Moriarty, M. A., Uhlman, M. A., Bing, M. T., O'Donnell, M. A., Brown, J. A., Tracy, C. R., Deorah, S., Nepple, K. G. & Gupta, A. (2015). Evaluating the safety of intraoperative instillation of intravesical chemotherapy at the time of nephroureterectomy. BMC urology, 15, 45. PMID: 26018765.

Askeland, E. J., Chehval, V. A., Askeland, R. W., Fosso, P. G., Sangale, Z., Xu, N., Rajamani, S., Stone, S. & Brown, J. A. (2015). Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection. Cancer biomarkers : section A of Disease markers, 15(6), 861-7. PMID: 26406412.

Lubaroff, D. M., Vaena, D., Brown, J. A., Zehr, P., Griffith, K. C., Brown, E., Eastman, J., Nepple, K., Kattula, A. & Williams, R. D. (2014). Vaccine immunotherapy for prostate cancer: from mice to men. Immunologic research, 59(1-3), 229-35. PMID: 24847764.

Wald, G., Barnes, K. T., Bing, M. T., Kresowik, T. P., Tomanek-Chalkley, A., Kucaba, T. A., Griffith, T. S., Brown, J. A. & Norian, L. A. (2014). Minimal changes in the systemic immune response after nephrectomy of localized renal masses. Urologic oncology, 32(5), 589-600. PMID: 24768357.

Brown, J. A. (2014). Minimally invasive partial nephrectomy feasible in morbidly obese?. (Vols. 21). (1), pp. 7150-7150. Canadian Journal of Urology.

Strigenz, M. E., Uhlman, M. A. & Brown, J. A. (2014). Use of blunt right angles to aid in intussusception of a Bricker ileal conduit. Canadian Journal of Urology, 21(1), 7171-7174.

Brown, J. A. (2014). Minimally invasive partial nephrectomy feasible in morbidly obese?. The Canadian journal of urology, 21(1), 7150. PMID: 24529019.

Strigenz, M. E., Uhlman, M. A. & Brown, J. A. (2014). Use of blunt right angles to aid in intussusception of a Bricker ileal conduit. The Canadian journal of urology, 21(1), 7171-4. PMID: 24529026.

Hadj-Moussa, M., Nepple, K. G. & Brown, J. A. (2014). Comparison of a single center, academic surgeon real-world experience with three percutaneous nephrolithotomy lithotripters. Canadian Journal of Urology, 21(5), 7470-7474.

Bockholt, N. A., DeRoo, E. M., Nepple, K. G., Modrick, J. M., Smith, M. C., Fallon, B., Hass, A. C., Tracy, C. R. & Brown, J. A. (2013). First 100 cases at a low volume prostate brachytherapy institution: learning curve and the importance of continuous quality improvement. The Canadian journal of urology, 20(5), 6907-12. PMID: 24128827.

Hadj-Moussa, M., Brown, J. A. (2013). Effect of high shock number on acute complication development after extracorporeal shockwave lithotripsy. Journal of endourology / Endourological Society, 27(8), 1015-9. PMID: 23537270.

Berneking, A. D., Rosevear, H. M., Askeland, E. J., Newton, M. R., O'Donnell, M. A. & Brown, J. A. (2013). Morbidity and mortality of octogenarians following open radical cystectomy using a standardized reporting system. The Canadian journal of urology, 20(4), 6826-31. PMID: 23930606.

Brown, R. J., Uhlman, M. A., Fernandez, J. D., Collins, T. & Brown, J. A. (2013). Novel Use of AngioVac System to Prevent Pulmonary Embolism during Radical Nephrectomy with Inferior Vena Cava Thrombectomy. Current urology, 7(1), 34-6. PMID: 24917754.

Bream, M. J., Dahmoush, L. & Brown, J. A. (2013). pT0 Prostate Cancer: Predictive Clinicopathologic Features in an American Population. Current urology, 7(1), 14-8. PMID: 24917750.

Calcaterra, D., Collins, T. E., Turek, J. W., Parekh, K. R., Bashir, M., Ueda, K., Hanada, S. & Brown, J. A. (2013). Normothermic cardiopulmonary bypass with beating heart for management of renal cell carcinoma with atrial tumor thrombus. Innovations (Philadelphia, Pa.), 8(4), 316-9. PMID: 24145979.

Uhlman, M. A., Pate, S. C. & Brown, J. A. (2013). Explosive growth of a renal tumor during active surveillance. The Canadian journal of urology, 20(2), 6739-41. PMID: 23587518.

Schurtz, E. A., Markes, J., Newton, M. R. & Brown, J. A. (2013). Novel use of the capio urethral anastomotic suturing device: a 50-case assessment. Current urology, 7(3), 145-8. PMID: 24917776.

Uhlman, M. A., Brown, J. A. (2012). Partial nephrectomy: novel closure technique using bovine pericardium. The Canadian journal of urology, 19(5), 6485-8. PMID: 23040634.

Cheng, M., Looney, S. W. & Brown, J. A. (2011). Ureteroileal anastomotic strictures after a Bricker ileal conduit: 50 case assessment of the impact of conversion from a slit incision to a "shield shaped" ileotomy. Can J Urol, 18(2), 5644-9. PMID: 21504654.

Calhoun, J. B., Merchen, T. D. & Brown, J. A. (2011). Radical nephrectomy and inferior vena caval thrombectomy: outcomes in a lower volume practice. Can J Urol, 18(1), 5537-41. PMID: 21333047.

Brown, J. A., Siddiqi, K. (2011). Bilateral hand-assisted laparoscopic renal surgery in the supine position: the spleen at risk. JSLS, 15(1), 27-31. PMID: 21902938.

Hadj-Moussa, M., Brown, J. A. (2010). Use of surgical clips prevents suture slippage when ligating folded vas deferens during vasectomy. Can J Urol, 17(3), 5213-5. PMID: 20566017.

Brown, J. A., Sajadi, K. P. & Wynn, J. J. (2010). Ureteral clipping simplifies hand-assisted laparoscopic donor nephrectomy. JSLS, 14(4), 531-3. PMID: 21605517.

Bittner, J. G., Sajadi, K. & Brown, J. A. (2009). Comparison of renal artery occlusion techniques in hand-assisted laparoscopic living donor nephrectomy. J Endourol, 23(6), 933-7. PMID: 19473062.

Brown, J. A., Rodin, D. M., Harisinghani, M. & Dahl, D. M. (2009). Impact of preoperative endorectal MRI stage classification on neurovascular bundle sparing aggressiveness and the radical prostatectomy positive margin rate. Urol Oncol, 27(2), 174-9. PMID: 18640062.

Brown, J. A., Sajadi, K. P. (2009). Laparoscopic radical prostatectomy: six months of fellowship training doesn't prevent the learning curve when incorporating into a lower volume practice. Urol Oncol, 27(2), 144-8. PMID: 18367119.

Brown, J. A., Inocencio, M. D. & Sundaram, C. P. (2008). Use of a warming bath to prevent lens fogging during laparoscopy. J Endourol, 22(11), 2413-4. PMID: 19046081.

Goel, M. C., Mohammadi, Y., Sethi, A. S., Brown, J. A. & Sundaram, C. P. (2008). Pathologic upstaging after laparoscopic radical nephrectomy. J Endourol, 22(10), 2257-61. PMID: 18937590.

Brown, J. A., Bihrle, R. & Foster, R. S. (2008). Delayed orchiectomy at postchemotherapy retroperitoneal lymph node dissection due to laterality of retroperitoneal metastatic pattern consistent with testicular primary: assessment of pathologic findings. Urology, 71(5), 911-4. PMID: 18342916.

Brown, J. A., Chenven, E., Looney, S. W., Miller, K. M., Strup, S. E., Bagley, D. H. & Gomella, L. G. (2008). Hand-assisted laparoscopic nephroureterectomy (HALNU): an assessment of the impact of obesity in 50 procedures. J Laparoendosc Adv Surg Tech A, 18(1), 61-8. PMID: 18266577.

Sajadi, K. P., Kim, T., Terris, M. K., Brown, J. A. & Lewis, R. W. (2007). High yield of saturation prostate biopsy for patients with previous negative biopsies and small prostates. Urology, 70(4), 691-5. PMID: 17991539.

Sajadi, K. P., Wynn, J. J. & Brown, J. A. (2007). Impact of fellowship training in initiating a laparoscopic donor nephrectomy program. J Laparoendosc Adv Surg Tech A, 17(4), 425-8. PMID: 17705720.

Brown, J. A., Shah, S., Siddiqi, K. & Boyd, B. (2007). Incorporation of hand-assisted laparoscopic nephrectomy into an academic training program: an assessment of the utility of a 3-month minifellowship. J Laparoendosc Adv Surg Tech A, 17(4), 435-9. PMID: 17705722.

Brown, J. A., Lewis, R. W. (2006). A multi-institution, minimally invasive urological oncology fellowship: a critical assessment of the clinical training and academic benefits. J Urol, 176(6 Pt 1), 2619-23; discussion 2623. PMID: 17085174.

Brown, J. A., Garlitz, C. J., Hubosky, S. G. & Gomella, L. G. (2006). Hand-assisted laparoscopic ureterolysis to treat ureteral obstruction secondary to idiopathic retroperitoneal fibrosis: assessment of a novel technique and initial series. Urology, 68(1), 46-9. PMID: 16806417.

Brown, J. A., Strup, S. E., Chenven, E., Bagley, D. & Gomella, L. G. (2005). Hand-assisted laparoscopic nephroureterectomy: analysis of distal ureterectomy technique, margin status, and surgical outcomes. Urology, 66(6), 1192-6. PMID: 16360439.

Brown, J. A., Canal, D. & Sundaram, C. P. (2005). Optical-access visual obturator trocar entry into desufflated abdomen during laparoscopy: assessment after 96 cases. J Endourol, 19(7), 853-5. PMID: 16190843.

Brown, J. A., Rodin, D. M., Lee, B. & Dahl, D. M. (2005). Laparoscopic radical prostatectomy and body mass index: an assessment of 151 sequential cases. J Urol, 173(2), 442-5. PMID: 15643198.

Brown, J. A., Rodin, D., Lee, B. & Dahl, D. M. (2005). Transperitoneal versus extraperitoneal approach to laparoscopic radical prostatectomy: an assessment of 156 cases. Urology, 65(2), 320-4. PMID: 15708046.

Brown, J. A., Garlitz, C., Strup, S. E., Hubosky, S. G. & Gomella, L. (2004). Laparoscopic radical prostatectomy after neoadjuvant hormonal therapy: an apparently safe and effective procedure. J Laparoendosc Adv Surg Tech A, 14(6), 335-8. PMID: 15684777.

Brown, J. A., Medlock, M. D. & Dahl, D. M. (2004). Ventriculoperitoneal shunt externalization during laparoscopic prostatectomy. Urology, 63(6), 1183-5. PMID: 15183985.

Brown, J. A., Hubosky, S. G., Gomella, L. G. & Strup, S. E. (2004). Hand assisted laparoscopic partial nephrectomy for peripheral and central lesions: a review of 30 consecutive cases. J Urol, 171(4), 1443-6. PMID: 15017194.

Brown, J. A., Dahl, D. M. (2004). Transperitoneal laparoscopic radical prostatectomy in patients after laparoscopic prosthetic mesh inguinal herniorrhaphy. Urology, 63(2), 380-2. PMID: 14972502.

Brown, J. A., Garlitz, C., Gomella, L. G., McGinnis, D. E., Diamond, S. M. & Strup, S. E. (2004). Perioperative morbidity of laparoscopic radical prostatectomy compared with open radical retropubic prostatectomy. Urol Oncol, 22(2), 102-6. PMID: 15082005.

Brown, J. A., Garlitz, C., Gomella, L. G., Hubosky, S. G., Diamond, S. M., McGinnis, D. & Strup, S. E. (2003). Pathologic comparison of laparoscopic versus open radical retropubic prostatectomy specimens. Urology, 62(3), 481-6. PMID: 12946751.

Brown, J. A. (2003). Lateral gluteal myonecrosis in a patient undergoing partial nephrectomy in the modified flank position. Urology, 61(2), 462. PMID: 12597972.