Karl J. Kreder, MD, MBA
Introduction
Dr. Kreder's clinical research focuses on two main areas of interest: overactive bladder/female incontinence and interstitial cystitis. Within these fields of study, Dr. Kreder acts as principal or co-principal investigator on a number of clinical trials for conventional medications and surgical treatments as well as complementary and alternative therapies. His work in the area of overactive bladder and female urinary incontinence encompasses the entire spectrum of treatments, including behavior and diet modifications and pelvic floor exercises, medications, or one of numerous reconstructive surgical procedures. Dr. Kreder's emphasis of study in interstitial cystitis begins with collaborations in the basic science research labs to help determine the etiology of this disease. His clinical work addresses the reduction of symptoms through conventional therapies and alternative options as well as the psychosocial impact of the condition on the patient.
Current Positions
- Professor of Urology
Education
- BA, Assumption College, Worcester, Massachusetts, United States
- MD, Georgetown University School of Medicine, Washington, District of Columbia, United States
- MBA, University of Iowa, Iowa City, Iowa, United States
- Internship, Tripler Army Medical Center, Honolulu, Hawaii, United States
- Resident, Tripler Army Medical Center, General Surgery, Honolulu, Hawaii, United States
- Resident, Tripler Army Medical Center, Urology, Honolulu, Hawaii, United States
- Fellow, Duke University Medical Center, Urodynamics and Reconstructive Surgery, Durham, North Carolina, United States
Research Interests
- Geriatric Urinary Incontinence: An Epidemiologic Analysis Using the AHEAD Study, Department of Preventive Medicine and Environmental Health
- Markers of Inflammation and Disease in Interstitial Cystitis, Fishbein Family Interstitial Cystitis Research Foundation
- Tissue healing, bowel physiology, urodynamics, incontinence
- Percutaneous Afferent Nerve Stimulator for Treatment of Urinary Urgency and Frequency
- Clinical Continence Center Initiative
- Studies in Geriatric Voiding Dysfunction: Epidemiology, Clinical Outcomes, Neurourology and Urodynamics
- Development of an Animal Model for Urinary Outflow Obstruction
- Fundamentals in Geriatric Urology: Development of Computerized Case-based Learning Materials
Licenses & Certifications
- American Board of Urology
Selected Publications
- Farrar J, Locke K, Clemens J, Griffith J, Harte S, Kirkali Z, Kreder K, Krieger J, Lai HH, Moldwin R, Mullins C, Naliboff B, Pontari M, Rodríguez L, Schaeffer A, Stephens-Shields A, Sutcliffe S, Taple B, Williams D, Landis J. Widespread pain phenotypes impact treatment efficacy results in randomized clinical trials for interstitial cystitis/bladder pain syndrome: A MAPP Network study. Pain. 2024 Nov 5. doi: 10.1097/j.pain.0000000000003455. Online ahead of print. PMID: 39499552.
- Leech KA, Kettlety SA, Mack WJ, Kreder KJ, Schrepf A, Kutch JJ. Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Pain. 2024 Oct 16. doi: 10.1097/j.pain.0000000000003424. Epub ahead of print. PMID: 39432808.
- Owens RG, Tracy CR, Humble RM, Kreder KJ. Unusual Presentation of Ureteral Hunner Lesion: A Case Report. JU Open Plus. 2024;2(11):e00113. doi: 10.1097/JU9.0000000000000219.
- Cameron AP, Yang CC, Bradley CS, Griffith JW, Kirkali Z, Clemens JQ, Kreder KJ, Kenton KS, Andreev VP, Amundsen CL, Jelovsek JE, Helfand BT, Lai HH; LURN Study Group. Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II. Neurourol Urodyn. 2024 Nov;43(8):1800-1808. doi: 10.1002/nau.25566. Epub 2024 Jul 29. PMID: 39075835. PMCID: PMC11498147.
- Ashton L, Nataksuka H, Johnson CM, Kenne K, Kreder KJ, Kruse R, Wendt L, Takacs EB, Vollstedt AJ. A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial. Urology. 2024 Nov;193:63-68. doi: 10.1016/j.urology.2024.06.047. Epub 2024 Jun 26. PMID: 38942391.
- Lai HH, Rutlin J, Smith AR, Helmuth ME, Hokanson JA, Yang CC, Clemens JQ, Magnotta VA, Bretschneider CE, Kenton K, DeLancey JOL, John K, Kirkali Z, Shimony JS; LURN Study Group. Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Magnetic Resonance Imaging: Findings From a Symptoms of Lower Urinary Tract Dysfunction Research Network Cross-Sectional Case-Control Study. J Urol. 2024 Aug;212(2):351-361. doi: 10.1097/JU.0000000000004022. Epub 2024 May 8. PMID: 38717915. PMCID: PMC11233244.
- Clemens JQ, Locke K Jr, Landis JR, Kreder K, Rodriguez LV, Yang CC, Tu FF, Harte SE, Schrepf A, Farrar JT, Sutcliffe S, Naliboff BD, Williams DA, Afari N, Spitznagle T, Taple BJ, Lai HH; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Validation of a simple body map to measure widespread pain in urologic chronic pelvic pain syndrome: A MAPP research network study. Neurourol Urodyn. 2024 Mar;43(3):727-737. doi: 10.1002/nau.25400. Epub 2024 Jan 25. PMID: 38270336.
- Erickson BA, Griffith JW, Wensheng G, Mengying Y, Herman T, Bradley CS, Quentin Clemens J, Farrar JT, Gupta P, Kreder KJ, Henry Lai H, Naliboff BD, Newman DK, Rodriguez LV, Spitznagle T, Sutcliffe S, Sutherland SE, Taple BJ, Landis JR. Ecological momentary assessment of pelvic pain and urinary urgency variability in urologic chronic pelvic pain syndrome and their association with illness impact and quality of life: Findings from the multidisciplinary approach to the study of chronic pelvic pain symptom patterns study. Neurourol Urodyn. 2024 Apr;43(4):893-901. doi: 10.1002/nau.25363. Epub 2024 Jan 22. PMID: 38247366.
- Akiyama Y, Harada K, Miyakawa J, Kreder KJ, O'Donnell MA, Daichi M, Katoh H, Hori M, Owari K, Futami K, Ishikawa S, Ushiku T, Kume H, Homma Y, Luo Y. Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis. iScience. 2023 Oct 21;26(11):108262. doi: 10.1016/j.isci.2023.108262. PMID: 38026177; PMCID: PMC10663743.
- Mawla I, Schrepf A, Kutch JJ, Helmuth ME, Smith AR, Ichesco E, Yang CC, Andreev VP, Kreder KJ, Bradley CS, Magnotta VA, Kirkali Z, Harris RE, Lai HH, Harte SE. Naturalistic bladder filling reveals subtypes in overactive bladder syndrome that differentially engages urinary urgency-related brain circuits: results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). J Urol. 2023 Oct 5:101097JU0000000000003699. doi: 10.1097/JU.0000000000003699. Epub ahead of print. PMID: 37796776.