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Kenneth G. Nepple, MD

Clinical Professor of Urology

Current Positions

  • Clinical Professor of Urology

Education

  • BS in Psychology, Iowa State University, Ames, Iowa, United States
  • MD in Medicine, University of Iowa, Iowa City, Iowa, United States
  • Resident in Urology, University of Iowa, Iowa City, Iowa, United States
  • Fellow in Urologic Oncology, Washington Unversity, St. Louis, Missouri, United States

Research Interests

  • Clinical Informatics/Electronic Medical Records
  • Impact of Outreach Activities on Quality of Bladder Cancer Care
  • Impact of Malnutrition and Frailty in Cancer Patients
  • Urologic Oncology

Selected Publications

  • Lakritz S, Nicklawsky A, Alami V, Kohli M, Moskaluk C, Riedlinger G, Salhia B, Singer EA, Naqash AR, Nepple K, Edge S, Myint Z, Kolesar J, Adra N, Flaig T, Graham LS. Activity of Platinum Chemotherapy in Men With Prostate Cancer With and Without DNA Damage Repair Mutations. Clin Genitourin Cancer. 2025 Feb;23(1):102293. doi: 10.1016/j.clgc.2024.102293. Epub 2024 Dec 12. PMID: 39793235.
  • Finnerty MC, Leach FE 3rd, Zakharia Y, Nepple KG, Bartlett MG, Henry MD, Cummings BS. Identification of blood lipid markers of docetaxel treatment in prostate cancer patients. Sci Rep. 2024 Sep 27;14(1):22069. doi: 10.1038/s41598-024-73074-8. PMID: 39333185; PMCID: PMC11436995.
  • Davis HA, Hoberg AA, Jacobus LS, Nepple K, Seaman AT, Sorensen J, Weiner GJ, Gilbertson-White S. Leveraging oncology collaborative networks and biomedical informatics data resources to rapidly recruit and enroll rural residents into oncology quality of life clinical trials. J Clin Transl Sci. 2024 Sep 23;8(1):e135. doi: 10.1017/cts.2024.576. PMID: 39345703; PMCID: PMC11428118.
  • Dutta D, Guo X, Winter TD, Jahagirdar O; Renal Cancer Genetics Consortium; Ha E, Susztak K, Machiela MJ, Chanock SJ, Purdue MP. Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma. Am J Hum Genet. 2024 Aug 12:S0002-9297(24)00256-8. doi: 10.1016/j.ajhg.2024.07.012. Epub ahead of print. PMID: 39137781.
  • Kohlmann W, Nix DA, Pauley K, Greenberg S, Atkinson A, Boucher KM, Kolesar J, Singer EA, Edge SB, Churchman ML, Graham L, Salhia B, Sanchez A, Zakharia Y, Nepple KG, Schneider BP, Byrne L, Jain RK, Chahoud J, Feng BJ, Gupta S. Inherited Germline Variants in Urinary Tract Cancer: A Multicenter Whole-Exome Sequencing Analysis and Correlation With Clinical Features and Tumor Genomics. JCO Precis Oncol. 2024 Jun;8:e2300697. doi: 10.1200/PO.23.00697. PMID: 38976819.
  • Purdue MP, Dutta D, Machiela MJ, Gorman BR, Winter T, Okuhara D, Cleland S, Ferreiro-Iglesias A, Scheet P, Liu A, Wu C, Antwi SO, Larkin J, Zequi SC, Sun M, Hikino K, Hajiran A, Lawson KA, Cárcano F, Blanchet O, Shuch B, Nepple KG, Margue G, Sundi D, Diver WR, Folgueira MAAK, van Bokhoven A, Neffa F, Brown KM, Hofmann JN, Rhee J, Yeager M, Cole NR, Hicks BD, Manning MR, Hutchinson AA, Rothman N, Huang WY, Linehan WM, Lori A, Ferragu M, Zidane-Marinnes M, Serrano SV, Magnabosco WJ; BioBank Japan Project; Vilas A, Decia R, Carusso F, Graham LS, Anderson K, Bilen MA, Arciero C, Pellegrin I, Ricard S; FinnGen; Scelo G, Banks RE, Vasudev NS, Soomro N, Stewart GD, Adeyoju A, Bromage S, Hrouda D, Gibbons N, Patel P, Sullivan M, Protheroe A, Nugent FI, Fournier MJ, Zhang X, Martin LJ, Komisarenko M, Eisen T, Cunningham SA, Connolly DC, Uzzo RG, Zaridze D, Mukeria A, Holcatova I, Hornakova A, Foretova L, Janout V, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Gaborieau V, Abedi-Ardekani B, McKay J, Johansson M, Phouthavongsy L, Hayman L, Li J, Lungu I, Bezerra SM, Souza AG, Sares CTG, Reis RB, Gallucci FP, Cordeiro MD, Pomerantz M, Lee GM, Freedman ML, Jeong A, Greenberg SE, Sanchez A, Thompson RH, Sharma V, Thiel DD, Ball CT, Abreu D, Lam ET, Nahas WC, Master VA, Patel AV, Bernhard JC, Freedman ND, Bigot P, Reis RM, Colli LM, Finelli A, Manley BJ, Terao C, Choueiri TK, Carraro DM, Houlston R, Eckel-Passow JE, Abbosh PH, Ganna A, Brennan P, Gu J, Chanock SJ. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024 May;56(5):809-818. doi: 10.1038/s41588-024-01725-7. Epub 2024 Apr 26. PMID: 38671320.
  • Leyderman M, McElree IM, Nepple KG, Zakharia Y, Ghodoussipour S, Packiam VT. Management of Renal Cell Carcinoma With Supradiaphragmatic Inferior Vena Cava Thrombus Diagnosed During Acute COVID-19 Infection. Cureus. 2024 Mar 5;16(3):e55565. doi: 10.7759/cureus.55565. PMID: 38576641; PMCID: PMC10993925.
  • Gore JL, Follmer K, Reynolds J, Nash M, Anderson CB, Catto JWF, Chamie K, Daneshmand S, Dickstein R, Garg T, Gilbert SM, Guzzo TJ, Kamat AM, Kates MR, Lane BR, Lotan Y, Mansour AM, Master VA, Montgomery JS, Morris DS, Nepple KG, O'Neil BB, Patel S, Pohar K, Porten SP, Riggs SB, Sankin A, Scarpato KR, Shore ND, Steinberg GD, Strope SA, Taylor JM, Comstock BA, Kessler LG, Wolff EM, Smith AB. Interruptions in bladder cancer care during the COVID-19 public health emergency. Urol Oncol. 2024 Apr;42(4):116.e17-116.e21. doi: 10.1016/j.urolonc.2023.11.010. Epub 2023 Dec 11. PMID: 38087711.
  • Chua KJ, Kronstedt S, Kaldany A, Srivastava A, Doppalapudi SK, Liu H, Tarhini AA, Gatti-Mays M, Gaughan E, Hu-Lieskovan S, Aljumaily R, Nepple K, Schneider B, Sterling J, Singer EA. Comparing the rate of immunotherapy treatment change due to toxicity by sex. Cancer Rep (Hoboken). 2024 Feb;7(2):e1932. doi: 10.1002/cnr2.1932. Epub 2024 Jan 8. PMID: 38189893. PMCID: PMC10849926.
  • Khan Q, Myers B, Bowar B, Khan M, Mullaney H, Gainey J, Schneider R, Dahmoush L, Nepple KG, Byrne JD. Case report: Robotically visualized and biopsy-confirmed peritoneal carcinomatosis as initial identification of metastatic prostate adenocarcinoma in a patient with a history of prostatic urethral lift. Front Oncol. 2024 Jan 19;13:1284688. doi: 10.3389/fonc.2023.1284688. PMID: 38313211; PMCID: PMC10834618.