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Yi Luo, MD, MS, PhD

Portrait
Professor of Urology

Contact Information

Office
240D EMRB
Iowa City, IA 52242
319-335-9835

Education

MD, Nanjing Medical University
MS, Immunobiochemistry, Nanjing Medical University
PhD, Molecular Biology, University of New Brunswick
Fellow, Roswell Park Cancer Institute, Molecular Immunology
Postdoctoral Fellow, Harvard Medical School, Urology

Research Summary

Dr Luo's research focuses on urinary bladder inflammation and cancer, specifically the interplay between the bladder and the immune system. This field is challenging due to a lack of proper animal models. In the early of the 2000s, Dr. Luo’s team used genetic engineering technology to develop a novel transgenic murine model that expresses the membrane form of the well-defined model antigen ovalbumin (OVA) as a self-antigen on the urothelium. This model can develop autoimmune-based bladder inflammation upon introduction of OVA-specific T and/or B cells. This model system facilitates the immune mechanistic studies pertaining to immune cell tolerance, activation, and autoimmune responses. Using this model system, Dr. Luo and his colleagues have demonstrated the ability of the bladder urothelium to present self-antigen to the immune system. This work has led to a panel of novel animal models with experimental autoimmune cystitis (EAC) that have been used in interstitial cystitis (IC) research over 15 years. The recent work of Dr. Luo’s team focuses on identification of the role of regulatory T cells in controlling autoimmune cystitis, characterization of the functional outcomes of the animal models, and development of new treatments for chronic cystitis pain. In addition, Dr. Luo's projects include the development of recombinant BCGs for bladder cancer immunotherapy, identification of biological pathways and genes responsible for bladder cancer resistance to chemotherapy, and establishment of new animal models for bladder cancer research.

Publications

Akiyama, Y., Luo, Y., Hanno, P. M., Maeda, D. & Homma, Y. (2020). Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives. International Journal of Urology. DOI: 10.1111/iju.14229.

Cui, X., Jing, X., Lutgendorf, S. K., Bradley, C. S., Schrepf, A., Erickson, B. A., Magnotta, V. A., Ness, T. J., Kreder, K. J., O'Donnell, M. A. & Luo, Y. (2019). Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: a MAPP Research Network animal study. American journal of physiology. Renal physiology, 317(1), F90-F98. PMID: 31091120.

Woodworth, D. C., Dagher, A., Curatolo, A., Sachdev, M., Ashe-McNalley, C., Ashe-McNalley, C. P., Naliboff, B. D., Labus, J. S., Landis, J. R., Kutch, J. J., Kutch, J., Mayer, E. A., Lee, R. S., Moses, M. A., Ellingson, B. M., Ellingson, B., Clemens, J. Q., Hanno, P., Kirkali, Z., Kusek, J. W., Lucia, M. S., Mullins, C., Pontari, M. A., Klumpp, D. J., Schaeffer, A. J., Apkarian, A. V., Cella, D., Farmer, M. A., Fitzgerald, C., Gershon, R., Griffith, J. W., Heckman, C. J., Jiang, M., Keefer, L., Marko, D. S., Michniewicz, J., Parrish, T., Tu, F., Rodriguez, L. V., Alger, J., Heendeniya, N., Kilpatrick, L. A., Randal, F., Smith, S. R., Kreder, K. J., Bradley, C. S., Eno, M., Greiner, K., Luo, Y., Lutgendorf, S. K., O’Donnell, M. A., Ziegler, B., Clauw, D. J., As-Sanie, S., Berry, S., Halvorson, M. E., Harris, R., Harte, S., Ichesco, E., Oldendorf, A., Scott, K. A., Williams, D. A., Buchwald, D., Afari, N., Krieger, J., Miller, J., Richey, S., Ross, S. O., Spiro, R., Sundsvold, T. J., Strachan, E. & Yang, C. C. (2018). Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP network study. PLoS ONE, 13(12). DOI: 10.1371/journal.pone.0206807.

Kogan, P., Xu, S., Wang, Y., O'Donnell, M. A., Lutgendorf, S. K., Bradley, C. S., Schrepf, A., Kreder, K. J. & Luo, Y. (2018). Sub-noxious Intravesical Lipopolysaccharide Triggers Bladder Inflammation and Symptom Onset in A Transgenic Autoimmune Cystitis Model: A MAPP Network Animal Study. Scientific Reports, 8(1). DOI: 10.1038/s41598-018-24833-x.

Schrepf, A., Naliboff, B., Williams, D. A., Stephens-Shields, A. J., Landis, J. R., Gupta, A., Mayer, E., Rodriguez, L. V., Lai, H., Luo, Y., Bradley, C., Kreder, K. & Lutgendorf, S. K. (2018). Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: A multidisciplinary approach to the study of chronic pelvic pain research network study. Annals of Behavioral Medicine, 52(10), 865-877. DOI: 10.1093/abm/kax060.

Sweeney, S. K., Luo, Y., O'Donnell, M. A. & Assouline, J. G. (2017). Peptide-mediated targeting mesoporous silica nanoparticles: A novel tool for fighting bladder cancer. Journal of Biomedical Nanotechnology, 13(2), 232-242. DOI: 10.1166/jbn.2017.2339.

Wang, X., Liu, W., O'Donnell, M., Lutgendorf, S., Bradley, C., Schrepf, A., Liu, L., Kreder, K. & Luo, Y. (2016). Evidence for the role of mast cells in cystitis-associated lower urinary tract dysfunction: A multidisciplinary approach to the study of chronic pelvic pain research network animal model study. PLoS ONE, 11(12). DOI: 10.1371/journal.pone.0168772.

Stephens-Shields, A. J., Clemens, J. Q., Jemielita, T., Farrar, J., Sutcliffe, S., Hou, X., Landis, J. R., Hanno, P., Kirkali, Z., Kusek, J. W., Lucia, M. S., Moldwin, R. M., Mullins, C., Pontari, M. A., Klumpp, D. J., Schaeffer, A. J., Apkarian, A. (., Cella, D., Farmer, M. A., Fitzgerald, C., Gershon, R., Griffith, J. W., Heckman, C. J., Jiang, M., Keefer, L., Marko, D. S., Michniewicz, J., Parrish, T., Tu, F., Mayer, E. A., Rodríguez, L. V., Alger, J., Ashe-McNalley, C. P., Ellingson, B., Heendeniya, N., Kilpatrick, L., Kulbacki, C., Kutch, J., Labus, J. S., Naliboff, B. D., Randal, F., Smith, S. R., Kreder, K. J., Bradley, C. S., Eno, M., Greiner, K., Luo, Y., Lutgendorf, S. K., O'Donnell, M. A., Ziegler, B., Clauw, D. J., As-Sanie, S., Berry, S., Grayhack, C., Halvorson, M. E., Harris, R., Harte, S., Ichesco, E., Oldendorf, A., Scott, K. A., Williams, D. A., Buchwald, D., Afari, N., Krieger, J., Miller, J., Richey, S., Robertson, K., Ross, S. O., Spiro, R., Sundsvold, T. J., Strachan, E., Yang, C. C., Andriole, G. L., Lai, H. H., Bristol, R. L., Colditz, G., Deutsch, G., Gardner, V. C., Gereau, R. W., Henderson, J. P., Hong, B. A., Hooton, T. M., Ness, T. J., North, C. S., Spitznagle, T. M., Anger, J., Freeman, M., Kim, J., Eilber, K., Van Eyk, J., Yang, W., Funari, V., Cha, J., Barrell, T., Doe, R. P., Gallagher, L., Howard, T., Robinson, N., Smith, S. & Stephens, A. (2016). Symptom Variability and Early Symptom Regression in the MAPP Study: A Prospective Study of Urological Chronic Pelvic Pain Syndrome. Journal of Urology, 196(5), 1450-1455. DOI: 10.1016/j.juro.2016.04.070.

Xu, S., Wang, X., Wang, Y., Lutgendorf, S., Bradley, C., Schrepf, A., Kreder, K., O'Donnell, M. & Luo, Y. (2016). Transgenic mice expressing MCP-1 by the urothelium demonstrate bladder hypersensitivity, pelvic pain and voiding dysfunction: A multidisciplinary approach to the study of chronic pelvic pain research network animal model study. PLoS ONE, 11(9). DOI: 10.1371/journal.pone.0163829.

Schrepf, A., O'Donnell, M. A., Luo, Y., Bradley, C. S., Kreder, K. J. & Lutgendorf, S. K. (2016). Inflammation and Symptom Change in Interstitial Cystitis or Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Urology, 90, 56-61. DOI: 10.1016/j.urology.2015.12.040.

Sweeney, S. K., Luo, Y., O’Donnell, M. A. & Assouline, J. (2016). Nanotechnology and cancer: Improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles. Cancer Nanotechnology, 7(1). DOI: 10.1186/s12645-016-0015-8.

Lai, H., Gereau, R. W., Luo, Y., O'Donnell, M., Rudick, C. N., Pontari, M., Mullins, C. & Klumpp, D. J. (2015). Animal models of urologic chronic pelvic pain syndromes: Findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Urology, 85(6), 1454-1465. DOI: 10.1016/j.urology.2015.03.007.

Schrepf, A., Bradley, C. S., O'Donnell, M., Luo, Y., Harte, S. E., Kreder, K. & Lutgendorf, S. (2015). Toll-like Receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain research network study. Brain, Behavior, and Immunity, 49, 66-74. DOI: 10.1016/j.bbi.2015.03.003.

Clemens, J. Q., Mullins, C., Kusek, J. W., Kirkali, Z., Mayer, E. A., Rodríguez, L. V., Klumpp, D. J., Schaeffer, A. J., Kreder, K. J., Buchwald, D., Andriole, G. L., Lucia, M. S., Landis, J. R., Clauw, D. J., Hanno, P., Pontari, M. A., Apkarian, A. (., Cella, D., Farmer, M. A., Fitzgerald, C., Gershon, R., Griffith, J. W., Heckman, C. J., Jiang, M., Keefer, L., Marko, D. S., Michniewicz, J., Parrish, T., Tu, F., Alger, J., Ashe-McNalley, C. P., Ellingson, B., Heendeniya, N., Kilpatrick, L., Kutch, J., Labus, J. S., Naliboff, B. D., Randal, F., Smith, S. R., Bradley, C. S., Eno, M., Greiner, K., Luo, Y., Lutgendorf, S. K., O'Donnell, M. A., Ziegler, B., As-Sanie, S., Berry, S., Halvorson, M. E., Harris, R., Harte, S., Ichesco, E., Oldendorf, A., Scott, K. A., Williams, D. A., Krieger, J., Miller, J., Richey, S., Ross, S. O., Spiro, R., Sundsvold, T. J., Strachan, E., Yang, C. C., Lai, H. H., Bristol, R. L., Colditz, G., Deutsch, G., Gardner, V. C., Gereau, R. W., Henderson, J. P., Hong, B. A., Hooton, T. M., Ness, T. J., North, C. S., Spitznagle, T. M., Sutcliffe, S., Barrell, T., Hanno, P., Hou, X. & Howard, T. (2014). The MAPP research network: A novel study of urologic chronic pelvic pain syndromes. (Vols. 14). (1) BMC Urology. DOI: 10.1186/1471-2490-14-57.

Newton, M. R., Askeland, E. J., Andresen, E. D., Chehval, V. A., Wang, X., Askeland, R. W., O'Donnell, M. A. & Luo, Y. (2014). Anti-interleukin-10R1 monoclonal antibody in combination with bacillus Calmette-Guérin is protective against bladder cancer metastasis in a murine orthotopic tumour model and demonstrates systemic specific anti-tumour immunity. Clinical and Experimental Immunology, 177(1), 261-268. DOI: 10.1111/cei.12315.

Schrepf, A., O'Donnell, M., Luo, Y., Bradley, C. S., Kreder, K. & Lutgendorf, S. (2014). Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Pain, 155(9), 1755-1761. DOI: 10.1016/j.pain.2014.05.029.

Landis, J. R., Williams, D. A., Lucia, M. S., Clauw, D. J., Naliboff, B. D., Robinson, N. A., Van Bokhoven, A., van Bokhoven, A., Sutcliffe, S., Schaeffer, A. J., Rodriguez, L. V., Rodríguez, L. V., Mayer, E. A., Lai, H. H., Krieger, J. N., Kreder, K. J., Griffith, J. W., Afari, N., Andriole, G. L., Bradley, C. S., Griffith, J. W., Klumpp, D. J., Hong, B. A., Lutgendorf, S. K., Buchwald, D., Yang, C. C., Mackey, S., Pontari, M. A., Hanno, P., Kusek, J. W., Mullins, C., Clemens, J. Q., Kirkali, Z., Farmer, M. A., Fitzgerald, C., Apkarian, A. (., Gershon, R., Cella, D., Heckman, C. J., Jiang, M., Keefer, L., Marko, D. S., Michniewicz, J., Parrish, T., Tu, F., Alger, J., Ashe-McNalley, C. P., Ellingson, B., Heendeniya, N., Kilpatrick, L., Kutch, J., Labus, J. S., Randal, F., Smith, S. R., Eno, M., Greiner, K., Luo, Y., O'Donnell, M. A., Ziegler, B., As-Sanie, S., Berry, S., Halvorson, M. E., Harris, R., Harte, S., Ichesco, E., Oldendorf, A., Scott, K. A., Krieger, J., Miller, J., Richey, S., Ross, S. O. & Spiro, R. (2014). The MAPP research network: Design, patient characterization and operations. BMC Urology, 14(1). DOI: 10.1186/1471-2490-14-58.

Bockholt, N. A., Knudson, M. J., Henning, J. R., Maymi, J. L., Weady, P., Smith, III, G. J., Eisenbraun, M. D., Fraser, J. D., O'Donnell, M. A. & Luo, Y. (2012). Anti-interleukin-10R1 monoclonal antibody enhances bacillus Calmette-Guérin induced T-helper type 1 immune responses and antitumor immunity in a mouse orthotopic model of bladder cancer. J Urol, 187, 2228-35.

Askeland, E. J., Newton, M. R., O'Donnell, M. A. & Luo, Y. (2012). Bladder cancer immunotherapy: BCG and beyond. Adv Urol. PMID: PMC3388311.

Luo, Y., Askeland, E. J., Newton, M. R. & O'Donnell, M. A. (2012). Role of IL-10 in urinary bladder carcinoma and bacillus Calmette-Guerin immunotherapy. Am J Immunol, 8, 1-9.

Kim, R., Liu, W., Chen, X., Kreder, K. & Luo, Y. (2011). Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. J Biomed Biotechnol. PMID: PMC2989383.

Luo, Y., Henning, J. & O'Donnell, M. A. (2011). Th1 cytokine-secreting recombinant Mycobacterium bovis bacillus Calmette-Guérin and prospective use in immunotherapy of bladder cancer. Clin Dev Immunol. PMID: PMC3173967.

Liu, W., Chen, X., Evanoff, D. P. & Luo, Y. (2011). Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells. Mucosal Immunol, 4, 428-37. PMID: PMC3118865.

Luo, Y., Han, R., Evanoff, D. P. & Chen, X. (2010). Interleukin-10 inhibits Mycobacterium bovis bacillus Calmette-Guérin (BCG)-induced macrophage cytotoxicity against bladder cancer cells. Clin Exp Immunol, 160, 359-68. PMID: PMC2883106.

Luo, Y., Knudson, M. J. (2010). Mycobacterium bovis bacillus Calmette-Guérin-induced macrophage cytotoxicity against bladder cancer cells. Clin Dev Immunol. PMID: PMC2939389.

Liu, W., O'Donnell, M. A., Chen, X., Han, R. & Luo, Y. (2009). Recombinant bacillus Calmette-Guérin (BCG) expressing interferon-alpha 2B enhances human mononuclear cell cytotoxicity against bladder cancer cell lines in vitro. Cancer Immunol Immunother, 58, 1647-55.

Liu, W., Deyoung, B., Chen, X., Evanoff, D. P. & Luo, Y. (2008). RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model. J Autoimmun, 30, 267-75.

Chen, X., O'Donnell, M. A. & Luo, Y. (2007). Dose-dependent synergy of Th1-stimulating cytokines on bacille Calmette-Guérin-induced interferon-? production by human mononuclear cells. Clin Exp Immunol, 149, 178-85.

Luo, Y., Chen, X. & O'Donnell, M. A. (2007). Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces human CC- and CXC-chemokines in vitro and in vivo. Clin Exp Immunol, 147, 370-8.

Luo, Y., Yamada, H., Evanoff, D. P. & Chen, X. (2007). Role of Th1-stimulating cytokines in bacillus Calmette-Guérin (BCG)-induced macrophage cytotoxicity against mouse bladder cancer MBT-2 cells. Clin Exp Immunol, 147, 370-8.

Liu, W., Evanoff, D. P., Chen, X. & Luo, Y. (2007). Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation and autoimmune response. J Immunol, 178, 539-546.

Yamada, H., Luo, Y., Matsumoto, T. & O'Donnell, M. A. (2005). A novel expression of macrophage-derived chemokine (MDC) in human urinary bladder cancer. J Urol, 179, 1119-23.

Yamada, H., O'Donnell, M. A., Matsumoto, T. & Luo, Y. (2005). Interferon-? up-regulates Toll-like receptor 4 and cooperates with LPS to produce macrophage-derived chemokine (MDC) and interferon-? inducible protein-10 (IP-10) in human urinary bladder cancer cell line RT4. J Urol, 174, 1119-23.

Luo, Y., Yamada, H., Chen, X., Ryan, A. A., Evanoff, D. P., Triccas, J. A. & O'Donnell, M. A. (2004). Recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clin Exp Immunol, 137, 24-34.

Ludwig, A. T., Moore, J. M., Luo, Y., Chen, X., Saltsgaver, N. A., O'Donnell, M. A. & Griffith, T. (2004). TNF-related apoptosis inducing ligand (TRAIL/Apo-2L): a novel mechanism for BCG-induced anti-tumor activity. Cancer Res, 64, 3386-90.

Luo, Y., Chen, X. & O'Donnell, M. A. (2004). Use of prostate specific antigen (PSA) to measure bladder tumor growth in a mouse orthotopic model. J Urol, 172, 2414-20.