Contact Information
Phone: 335-8982
Office: 4235 MERF
Faculty Profile
Brief description of current research:
Work in my laboratory led to the identification and characterization of G-protein coupled estrogen receptor which has importance in metabolic regulation and advanced cancer. Current efforts are focused on: i) understanding its molecular mechanism of action and its biological role in the progression of female reproductive cancers, ii) developing cancer therapeutics that target this receptor and iii) evaluating the toxicological potency of environmental estrogens that act through GPER and their relevance for metabolic disorder and cancer.
3 most influential diabetes/obesity/metabolism publications:
- Filardo EJ. A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis. J Steroid Biochem Mol Biol. 2018 Feb;176:38-48. PMID: 28595943.
- Cheng SB, Dong J, Pang Y, LaRocca J, Hixon M, Thomas P, Filardo EJ. Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 2014 Feb;382(2):950-959. PMID: 24239983.
- Waters EM, Thompson LI, Patel P, Gonzales AD, Ye HZ, Filardo EJ, Clegg DJ, Gorecka J, Akama KT, McEwen BS, Milner TA. G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus. Journal of Neurosci. 2015; 35, 2384-97. PMID: 25673833.
Quote:
“It is a privilege to work among colleagues dedicated to improving the quality of life for all”