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Kyle Flippo, PhD

Assistant Professor of Internal Medicine-Encodrinology and Metabolism

Current Positions

  • Assistant Professor of Internal Medicine-Encodrinology and Metabolism
  • Assistant Professor of Neuroscience and Pharmacology

Education

  • PhD, Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa
  • Postdoctoral Research Scholar, Neurocience & Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Sullivan, A.I., Potthoff, M.J., Flippo, K.H.# Tany-seq: Metanalysis of the tanycyte transcriptome. Under review. #= corresponding author
  • Flippo, K.H.#, Trammell, S.A.J., Gillum, M.P., Aklan, I., Yavuz, Y., Smith, N.K., Jensen-Cody, S.O., Perez, M.B., Zhou, B., Claflin, K.E., Beierschmitt, A., Fink-Jensen, A., Knop, F.K., Palmour, R.M., Grueter, B.A., Atazoy, D., Potthoff, M.J.# FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metab. 34(2):317-328, 2022. PMID: 35108517. #= co-corresponding author. (Featured Article)
  • Claflin, K.E., Flippo, K.H., Zhou, B., Neff, T., Jensen-Cody, S.O., Naber, M., Potthoff, M.J. Conditional gene targeting using Ucp1-Cre mice directly targets the central system beyond thermogenic adipose tissues. Mol. Metab. 55, 2022. PMID: 34844020
  • Sobreira, D.R., Joslin, A.C., Zhang, Q., Williamson, I., Hansen, G.T., Farris, K.M., Sakabe, N.J., Sinnott-Armstrong, N., Bozek, G., Jensen-Cody, S.O., Flippo, K.H., Ober, C., Bickmore, W.A., Potthoff, M.J., Chen, M., Claussnitzer, M., Aneas, I., Nobrega, M.A. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of Irx3 and Irx5. Science. 372(6546):1085-1091, 2021. PMID: 34083488
  • Flippo, K.H., Potthoff, M.J. Metabolic Messengers: FGF21. Nat. Met. 3(3), 309-317, 2020. PMID: 33758421
  • Flippo K.H., Jensen-Cody S.O., Claflin K.E., Potthoff M.J. FGF21 signaling in glutamatergic neurons is required for weight loss associated with dietary protein dilution. Sci Rep. 10(1):19521, 2020. doi: 10.1038/s41598-020-76593-2. PMID: 33177640
  • Jensen-Cody S.O.*, Flippo K.H.*, Claflin K.E., Yavuz Y., Sapouckey S.A., Walters G.C., Usachev Y.M., Atasoy D., Gillum M,P., Potthoff M.J. FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metab. 32(2):273-286, 2020. PMID: 32640184. *= co-first authors
  • Flippo K.H., Lin Z., Dickey A.S., Zhou X., Dhanesha N., Merrill R.A., Meller R., Simon R.P., Chauhan A.K., Usachev Y.M., Strack S. Deletion of a neuronal Drp1 activator protects against cerebral ischemia. J. Neurosci. 40(15):3119-3129, 2020. PMID: 32144179
  • Flippo K.H., Potthoff, M.J.: Chronicles of an FGF Chimera: The Odyssey Continues. EBioMedicine. 49(2019):15-16, 2019. PMID: 31672336
  • Flippo K.H., Gnanasekaran A., Perkins G.A., Ahmad A., Merrill R.A., Dickey A.S., Taylor S.S., McKnight G.S., Chauhan A.K., Usachev Y.M., Strack S. AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission. J. Neurosci. 38(38):8233-8242, 2018. PMID: 30093535. (Featured Article)