David K. Meyerholz, DVM, PhD

Portrait
Director, Division of Comparative Pathology
Professor of Pathology

Contact Information

Primary Office: 1165 Medical Laboratories
Iowa City, IA 52242
--

Education

DVM, Iowa State University
MS, Iowa State University
PhD, Iowa State University

Licensure and Certifications

Diplomate - American College of Veterinary Microbiologists (Virology)
Diplomate - American College of Veterinary Pathologists

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Center for Immunology and Immune-based Diseases, Cystic Fibrosis Research Center, Institute for Clinical and Translational Science

Research Summary

Dr. Meyerholz studies cystic fibrosis (CF), a genetic condition cause by mutations in CFTR gene. Goals of his research are to define the molecular origins of CF disease, identify new biomarkers and evaluate novel treatments. He also has research interests in diseases of the lung (e.g. influenza, MERS-CoV, RSV, SARS-CoV) as well as comparative pathology, cardiovascular disease, cancer and neurofibromatosis-1. Dr. Meyerholz has published >160 peer-reviewed papers in scientific journals.

Publications

Wheeler, D. L., Athmer, J., Meyerholz, D. K. & Perlman, S. (2017). Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus. Journal of virology. PMID: 28835503.

Vijay, R., Fehr, A. R., Janowski, A. M., Athmer, J., Wheeler, D. L., Grunewald, M., Sompallae, R., Kurup, S. P., Meyerholz, D. K., Sutterwala, F. S., Narumiya, S. & Perlman, S. (2017). Virus-induced inflammasome activation is suppressed by prostaglandin D<inf>2</inf>/DP1 signaling. Proceedings of the National Academy of Sciences of the United States of America, 114(27), E5444-E54413. DOI: 10.1073/pnas.1704099114.

Beraldi, R., Meyerholz, D. K., Savinov, A., Kovács, A. D., Weimer, J. M., Dykstra, J. A., Geraets, R. D. & Pearce, D. A. (2017). Genetic Ataxia Telangiectasia porcine model phenocopies the multisystemic features of the human disease. Biochimica et biophysica acta. PMID: 28746835.

Meyerholz, D. K., Ofori-Amanfo, G. K., Leidinger, M. R., Goeken, J. A., Khanna, R., Sieren, J. C., Darbro, B. W., Quelle, D. E. & Weimer, J. M. (2017). Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 22155417729357. PMID: 28846462.

Meyerholz, D. K., Flaherty, H. A. (2017). The Evolving Significance and Future Relevance of the Impact Factor. (Vols. 54). (4), pp. 721-722. Veterinary Pathology. DOI: 10.1177/0300985817690209.

Meyerholz, D. K., Reznikov, L. R. (2017). Simple and reproducible approaches for the collection of select porcine ganglia. Journal of neuroscience methods. PMID: 28602889.

Meyerholz, D. K., Sieren, J. C., Beck, A. P. & Flaherty, H. A. (2017). Approaches to Evaluate Lung Inflammation in Translational Research. Veterinary pathology, 300985817726117. PMID: 28812529.

Ostedgaard, L. S., Moninger, T. O., McMenimen, J. D., Sawin, N. M., Parker, C. P., Thornell, I. M., Powers, L. S., Gansemer, N. D., Bouzek, D. C., Cook, D. P., Meyerholz, D. K., Alaiwa, M. H., Stoltz, D. A. & Welsh, M. J. (2017). Gel-forming mucins form distinct morphologic structures in airways. Proceedings of the National Academy of Sciences of the United States of America, 114(26), 6842-6847. DOI: 10.1073/pnas.1703228114.

Channappanavar, R., Fett, C., Mack, M., Ten Eyck, P. P., Meyerholz, D. K. & Perlman, S. (2017). Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. Journal of immunology (Baltimore, Md. : 1950). PMID: 28373583.

Barr, J. Y., Wang, X., Meyerholz, D. K. & Lieberman, S. M. (2017). CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjögren syndrome. Immunology and cell biology. PMID: 28465508.

Singh, M. V., Cicha, M. Z., Kumar, S., Meyerholz, D. K., Irani, K., Chapleau, M. W. & Abboud, F. M. (2017). Abnormal CD161<sup>+</sup> immune cells and retinoic acid receptor-related orphan receptor ?t-mediate enhanced IL-17F expression in the setting of genetic hypertension. The Journal of allergy and clinical immunology. PMID: 28093217.

Adam, R. J., Abou Alaiwa, M. H., Bouzek, D. C., Cook, D. P., Gansemer, N. D., Taft, P. J., Powers, L. S., Stroik, M. R., Hoegger, M. J., McMenimen, J. D., Hoffman, E. A., Zabner, J., Welsh, M. J., Meyerholz, D. K. & Stoltz, D. A. (2017). Postnatal airway growth in cystic fibrosis piglets. Journal of applied physiology (Bethesda, Md. : 1985), 123(3), 526-533. PMID: 28620056.

Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J. E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S. & McCray, Jr, P. B. (2017). Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proceedings of the National Academy of Sciences of the United States of America, 114(15), E3119-E3128. PMID: 28348219.

Cook, D. P., Adam, R. J., Zarei, K., Deonovic, B., Stroik, M. R., Gansemer, N. D., Meyerholz, D. K., Au, K. F. & Stoltz, D. A. (2017). CF airway smooth muscle transcriptome reveals a role for PYK2. JCI insight, 2(17). PMID: 28878137.

Kohl, K. D., Oakeson, K. F., Dunn, D., Meyerholz, D. K., Dale, C., Weiss, R. B. & Dearing, M. D. (2017). Patterns of host gene expression associated with harboring a foregut microbial community. BMC genomics, 18(1), 697. PMID: 28874116.

Piersigilli, A., Meyerholz, D. K. (2016). The "Naked Truth": Naked Mole-Rats Do Get Cancer. (Vols. 53). (3), pp. 519-20. Veterinary pathology. PMID: 27000397.

Meyerholz, D. K. (2016). Modeling Emergent Diseases: Lessons From Middle East Respiratory Syndrome. (Vols. 53). (3), pp. 517-8. Veterinary pathology. PMID: 27000399.

Cooney, A. L., Abou Alaiwa, M. H., Shah, V. S., Bouzek, D. C., Stroik, M. R., Powers, L. S., Gansemer, N. D., Meyerholz, D. K., Welsh, M. J., Stoltz, D. A., Sinn, P. L. & McCray, Jr, P. B. (2016). Lentiviral-mediated phenotypic correction of cystic fibrosis pigs. JCI insight, 1(14). PMID: 27656681.

Li, X., Tang, X. X., Vargas Buonfiglio, L. G., Comellas, A. P., Thornell, I. M., Ramachandran, S., Karp, P. H., Taft, P. J., Sheets, K., Abou Alaiwa, M. H., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & Zabner, J. (2016). Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense. American journal of physiology. Lung cellular and molecular physiology, 310(7), L670-9. PMID: 26801568.

Meyerholz, D. K., Lambertz, A. M. & McCray, Jr, P. B. (2016). Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome. The American journal of pathology, 186(1), 78-86. PMID: 26597880.

Cook, D. P., Rector, M. V., Bouzek, D. C., Michalski, A. S., Gansemer, N. D., Reznikov, L. R., Li, X., Stroik, M. R., Ostedgaard, L. S., Abou Alaiwa, M. H., Thompson, M. A., Prakash, Y. S., Krishnan, R., Meyerholz, D. K., Seow, C. Y. & Stoltz, D. A. (2016). CFTR in Sarcoplasmic Reticulum of Airway Smooth Muscle: Implications for Airway Contractility. American journal of respiratory and critical care medicine, 193(4), 417-26. PMID: 26488271.

Meyerholz, D. K. (2016). Lessons learned from the cystic fibrosis pig. Theriogenology, 86(1), 427-32. PMID: 27142487.

Meyerholz, D. K., Lambertz, A. M., Reznikov, L. R., Ofori-Amanfo, G. K., Karp, P. H., McCray, Jr, P. B., Welsh, M. J. & Stoltz, D. A. (2016). Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicologic pathology, 44(3), 434-41. PMID: 26511846.

Boi, S. K., Buchta, C. M., Pearson, N. A., Francis, M. B., Meyerholz, D. K., Grobe, J. L. & Norian, L. A. (2016). Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet. Obesity, 24(10), 2140-9. PMID: 27515998.

Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K. & Perlman, S. (2016). Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell host & microbe, 19(2), 181-93. PMID: 26867177.

Zhao, J., Zhao, J., Mangalam, A. K., Channappanavar, R., Fett, C., Meyerholz, D. K., Agnihothram, S., Baric, R. S., David, C. S. & Perlman, S. (2016). Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity, 44(6), 1379-91. PMID: 27287409.

Paharik, A. E., Salgado-Pabon, W., Meyerholz, D. K., White, M. J., Schlievert, P. M. & Horswill, A. R. (2016). The Spl Serine Proteases Modulate <i>Staphylococcus aureus</i> Protein Production and Virulence in a Rabbit Model of Pneumonia. mSphere, 1(5). PMID: 27747296.

Shah, V. S., Meyerholz, D. K., Tang, X. X., Reznikov, L., Abou Alaiwa, M., Ernst, S. E., Karp, P. H., Wohlford-Lenane, C. L., Heilmann, K. P., Leidinger, M. R., Allen, P. D., Zabner, J., McCray, Jr, P. B., Ostedgaard, L. S., Stoltz, D. A., Randak, C. O. & Welsh, M. J. (2016). Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science (New York, N.Y.), 351(6272), 503-7. PMID: 26823428.

Fehr, A. R., Channappanavar, R., Jankevicius, G., Fett, C., Zhao, J., Athmer, J., Meyerholz, D. K., Ahel, I. & Perlman, S. (2016). The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. mBio, 7(6). PMID: 27965448.

Bartlett, J. A., Ramachandran, S., Wohlford-Lenane, C. L., Barker, C. K., Pezzulo, A. A., Zabner, J., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & McCray, Jr, P. B. (2016). Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus. American journal of respiratory and critical care medicine, 194(7), 845-854. PMID: 27027566.

Reznikov, L. R., Meyerholz, D. K., Adam, R. J., Abou Alaiwa, M., Jaffer, O., Michalski, A. S., Powers, L. S., Price, M. P., Stoltz, D. A. & Welsh, M. J. (2016). Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. PloS one, 11(11), e0166089. PMID: 27820848.

Harwani, S. C., Ratcliff, J., Sutterwala, F. S., Ballas, Z. K., Meyerholz, D. K., Chapleau, M. W. & Abboud, F. M. (2016). Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat. Circulation research, 119(10), 1101-1115. PMID: 27660287.

Channappanavar, R., Lu, L., Xia, S., Du, L., Meyerholz, D. K., Perlman, S. & Jiang, S. (2015). Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection. The Journal of infectious diseases. PMID: 26164863.

Diwakar, A., Adam, R. J., Michalski, A. S., Tamegnon, M. M., Fischer, A. J., Launspach, J. L., Horan, R. A., Kao, S. C., Chaloner, K., Meyerholz, D. K. & Stoltz, D. A. (2015). Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis. The Laryngoscope. PMID: 25827636.

Bartlett, J. A., Meyerholz, D. K., Wohlford-Lenane, C. L., Naumann, P. W., Salzman, N. H. & McCray, P. B. (2015). Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Disease models & mechanisms, [Epub ahead of print]. PMID: 25765466.

Olivier, A. K., Gibson-Corley, K. N. & Meyerholz, D. K. (2015). Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology. American journal of physiology. Gastrointestinal and liver physiology, 308(6), G459-71. PMID: 25591863.

Knudson, C. J., Hartwig, S. M., Meyerholz, D. K. & Varga, S. M. (2015). RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets. PLoS pathogens, 11(3), e1004757. PMID: 25769044.

Zhao, J., Perera, R. A., Kayali, G., Meyerholz, D., Perlman, S. & Peiris, M. (2015). Passive Immunotherapy With Dromedary Immune Serum In An Experimental Animal Model For MERS Coronavirus Infection. Journal of virology, 89(11), 6117-20. PMID: 25787284.

Singh, M. V., Cicha, M. Z., Meyerholz, D. K., Chapleau, M. W. & Abboud, F. M. (2015). Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression. Hypertension, 66(3), 647-56. PMID: 26195481.

Meyerholz, D. K., Lambertz, A. M., Reznikov, L. R., Ofori-Amanfo, G. K., Karp, P. H., McCray, Jr, P. B., Welsh, M. J. & Stoltz, D. A. (2015). Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Toxicologic pathology. PMID: 26511846.

Beraldi, R., Chan, C. H., Rogers, C. S., Kovács, A. D., Meyerholz, D. K., Trantzas, C., Lambertz, A. M., Darbro, B. W., Weber, K. L., White, K. A., Rheeden, R. V., Kruer, M. C., Dacken, B. A., Wang, X. J., Davis, B. T., Rohret, J. A., Struzynski, J. T., Rohret, F. A., Weimer, J. M. & Pearce, D. A. (2015). A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease. Human molecular genetics, 24(22), 6473-84. PMID: 26374845.

Ebert, S. M., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Murry, D. J., Fox, D. K., Bongers, K. S., Lira, V. A., Meyerholz, D. K., Talley, J. J. & Adams, C. M. (2015). Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. The Journal of biological chemistry. PMID: 26338703.

Stoltz, D. A., Meyerholz, D. K. & Welsh, M. J. (2015). Origins of Cystic Fibrosis Lung Disease. The New England Journal of Medicine, 372(4), 351-362. PMID: 25607428.

Li, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K. & McCray, Jr, P. B. (2015). Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. The Journal of infectious diseases. PMID: 26486634.

Gibson-Corley, K. N., Meyerholz, D. K. & Engelhardt, J. F. (2015). Pancreatic Pathophysiology in Cystic Fibrosis. The Journal of pathology. PMID: 26365583.

Vijay, R., Hua, X., Meyerholz, D. K., Miki, Y., Yamamoto, K., Gelb, M., Murakami, M. & Perlman, S. (2015). Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. The Journal of experimental medicine, 212(11), 1851-68. PMID: 26392224.

Sun, X., Olivier, A. K., Yi, Y., Pope, C. E., Hayden, H. S., Liang, B., Sui, H., Zhou, W., Hager, K. R., Zhang, Y., Liu, X., Yan, Z., Fisher, J. T., Keiser, N. W., Song, Y., Tyler, S. R., Goeken, J. A., Kinyon, J. M., Radey, M. C., Fligg, D., Wang, X., Xie, W., Lynch, T. J., Kaminsky, P. M., Brittnacher, M. J., Miller, S. I., Parekh, K., Meyerholz, D. K., Hoffman, L. R., Frana, T., Stewart, Z. A. & Engelhardt, J. F. (2014). Gastrointestinal Pathology in Juvenile and Adult CFTR-Knockout Ferrets. The American journal of pathology [Epub ahead of print]. PMID: 24637292.

Uc, A., Olivier, A. K., Griffin, M. A., Meyerholz, D. K., Yao, J., Abu-El-Haija, M., Buchanan, K., Vanegas Calderón, O. G., Abu-El-Haija, M., Pezzulo, A. A., Reznikov, L. R., Hoegger, M. J., Rector, M. V., Ostedgaard, L. S., Taft, P. J., Gansemer, N. D., Ludwig, P. S., Hornick, E. E., Stoltz, D. A., Ode, K. L., Welsh, M. J., Engelhardt, J. F. & Norris, A. W. (2014). Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clinical science, 128(2), 131-42. PMID: 25142104.

Sun, X., Olivier, A. K., Liang, B., Yi, Y., Sui, H., Evans, T. I., Zhang, Y., Zhou, W., Tyler, S. R., Fisher, J. T., Keiser, N. W., Liu, X., Yan, Z., Song, Y., Goeken, J. A., Kinyon, J. M., Fligg, D., Wang, X., Xie, W., Lynch, T. J., Kaminsky, P. M., Stewart, Z. A., Pope, R. M., Frana, T., Meyerholz, D. K., Parekh, K. & Engelhardt, J. F. (2014). Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. American journal of respiratory cell and molecular biology, 50(3), 502-512. PMID: 24074402.

Reed, S. M., Hagen, J., Muniz, V. P., Rosean, T. R., Borcherding, N., Sciegienka, S., Goeken, J. A., Naumann, P. W., Zhang, W., Tompkins, V. S., Janz, S., Meyerholz, D. K. & Quelle, D. E. (2014). NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas. PLoS One, 9(11), e112126. PMID: 25393878.

Rasmussen, J. A., Post, D. M., Gibson, B. W., Lindemann, S. R., Apicella, M. A., Meyerholz, D. K. & Jones, B. D. (2014). Francisella tularensis Schu S4 LPS Core Sugar and O-antigen Mutants are Attenuated in a Mouse Model of Tularemia. Infection and immunity [Epub ahead of print]. PMID: 24452684.

Channappanavar, R., Fett, C., Zhao, J., Meyerholz, D. & Perlman, S. (2014). Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. Journal of virology, 88(19), 11034-44. PMID: 25056892.

Sieren, J. C., Meyerholz, D. K., Wang, X. J., Davis, B. T., Newell Jr, J. D., Hammond, E., Rohret, J. A., Rohret, F. A., Struzynski, J. T., Goeken, J. A., Naumann, P. W., Leidinger, M. R., Taghiyev, A., Van Rheeden, R., Hagan, J., Darbro, B. W., Quelle, D. E. & Rogers, C. S. (2014). Development and translational imaging of a TP53 porcine tumorigenesis model. Journal of clinical investigation, 124(9), 4052-66. PMID: 25105366.

Gibson-Corley, K. N., Rogers, L. M., Goeken, A., Dupuy, A. J. & Meyerholz, D. K. (2014). Keratoacanthoma Pathobiology in Mouse Models. Diseases, 2(2), 106-119. PMID: 25309748.

Dassie, J. P., Hernandez, L. I., Thomas, G. S., Long, M. E., Rockey, W. M., Howell, C. A., Chen, Y., Hernandez, F. J., Liu, X. Y., Wilson, M. E., Allen, L. A., Vaena, D. A., Meyerholz, D. K. & Giangrande, P. H. (2014). Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate specific membrane antigen (PSMA). Molecular therapy [Epub ahead of print]. PMID: 24954476.

Fehr, A. R., Athmer, J., Channappanavar, R., Phillips, J. M., Meyerholz, D. K. & Perlman, S. (2014). The NSP3 Macrodomain Promotes Virulence in Mice With Coronavirus-induced Encephalitis. Journal of virology, [Epub ahead of print]. PMID: 25428866.

Hernandez, F. J., Huang, L., Olson, M. E., Powers, K. M., Hernandez, L. I., Meyerholz, D. K., Thedens, D. R., Behlke, M. A., Horswill, A. R. & McNamara, J. O. (2014). Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe. Nature medicine, 20(3), 301-306. PMID: 24487433.

Kempuraj, D., Twait, E. C., Williard, D. E., Yuan, Z., Meyerholz, D. & Samuel, I. (2013). The Novel Cytokine Interleukin-33 Activates Acinar Cell Proinflammatory Pathways and Induces Acute Pancreatic Inflammation in Mice. PLoS One, 8(2), e56866. PMID: 23418608.

Simons, A. L., Lu, P., Gibson-Corley, K. N., Robinson, R. A., Meyerholz, D. & Colgan, J. D. (2013). The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Laboratory Investigation, 93(6), 711-719. PMID: 23608756.

Stoltz, D. A., Rokhlina, T., Ernst, S. E., Pezzulo, A. A., Ostedgaard, L. S., Karp, P. H., Samuel, M. S., Reznikov, L. R., Rector, M. V., Gansemer, N. D., Bouzek, D. C., Alaiwa, M. H., Hoegger, M. J., Ludwig, P. S., Taft, P. J., Wallen, T. J., Wohlford-Lenane, C., McMenimen, J. D., Chen, J. H., Bogen, K. L., Adam, R. J., Hornick, E. E., Nelson, G. A., Hoffman, E. A., Chang, E. H., Zabner, J., McCray, P. B., Prather, R. S., Meyerholz, D. K. & Welsh, M. J. (2013). Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. Journal of Clinical Investigation, 123(6), 2685-93. PMID: 23676501.

Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., Hayden, P. J., Luczak, E. D., Dickey, D. D., Allamargot, C., Olivier, A. K., Meyerholz, D., Robison, A. J., Winder, D. G., Blackwell, T. S., Dworski, R., Sammut, D., Wagner, B. A., Buettner, G. R., Pope, R. M., Miller, F. J., Dibbern, M. E., Haitchi, H. M., Mohler, P. J., Howarth, P. H., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E. (2013). CaMKII Is Essential for the Proasthmatic Effects of Oxidation. Science translational medicine, 5(195), 195-97. PMID: 23884469.

Scroggins, S. M., Olivier, A. K., Meyerholz, D. K. & Schlueter, A. J. (2013). Characterization of Regulatory Dendritic Cells That Mitigate Acute Graft-versus-Host Disease in Older Mice Following Allogeneic Bone Marrow Transplantation. PLoS One, 8(9), e75158. PMID: 24040397.

Gibson-Corley, K. N., Olivier, A. K. & Meyerholz, D. K. (2013). Principles for valid histopathologic scoring in research. Veterinary pathology, 50(6), 1007-1015. PMID: 23558974.

Adam, R. J., Michalski, A. S., Bauer, C., Abou Alaiwa, M. H., Gross, T. J., Awadalla, M. S., Bouzek, D. C., Gansemer, N. D., Taft, P. J., Hoegger, M. J., Diwakar, A., Ochs, M., Reinhardt, J. M., Hoffman, E. A., Beichel, R. R., Meyerholz, D. K. & Stoltz, D. A. (2013). Air trapping and airflow obstruction in newborn cystic fibrosis piglets. American journal of respiratory and critical care medicine, 188(12), 1434-41. PMID: 24168209.

Chang, E. H., Pezzulo, A. A., Meyerholz, D., Potash, A. E., Wallen, T. J., Reznikov, L. R., Sieren, J. C., Karp, P. H., Ernst, S., Moninger, T. O., Gansemer, N. D., McCray, P. B., Stoltz, D. A., Welsh, M. J. & Zabner, J. (2012). Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. The Laryngoscope, 122(9), 1898-905. PMID: 22711071.

Gibson-Corley, K. N., Hochstedler, C., Sturm, M., Rogers, J., Olivier, A. K. & Meyerholz, D. (2012). Successful Integration of the Histology Core Laboratory in Translational Research. Journal of histotechnology, 35(1), 17-21. PMID: 22904581.

Shelton, D. N., Fornalik, H., Neff, T., Park, S. Y., Bender, D., DeGeest, K., Liu, X., Xie, W., Meyerholz, D., Engelhardt, J. F. & Goodheart, M. J. (2012). The role of LEF1 in endometrial gland formation and carcinogenesis. PloS one, 7(7), e40312. PMID: 22792274.

Curtiss, M. L., Gorman, J. V., Businga, T. R., Traver, G., Singh, M., Meyerholz, D., Kline, J. N., Murphy, A. J., Valenzuela, D. M., Colgan, J. D., Rothman, P. B. & Cassel, S. L. (2012). Tim-1 regulates Th2 responses in an airway hypersensitivity model. European journal of immunology, 42(3), 651-61. PMID: 22144095.

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M. (2012). Transepithelial migration of neutrophils into the lung requires TREM-1. Journal of Clinical Investigation, 123, 138-149. PMID: 23241959.

Abu-El-Haija, M., Ramachandran, S., Meyerholz, D., Abu-El-Haija, M., Griffin, M., Giriyappa, R. L., Stoltz, D. A., Welsh, M. J., McCray, P. B. & Uc, A. (2012). Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. The American journal of pathology, 181(2), 499-507. PMID: 22683312.

Rollins, K. E., Meyerholz, D., Johnson, G. D., Capparella, A. P. & Loew, S. S. (2012). A forensic investigation into the etiology of bat mortality at a wind farm: barotrauma or traumatic injury?. Veterinary pathology, 49(2), 362-71. PMID: 22291071.

Uc, A., Giriyappa, R., Meyerholz, D., Griffin, M., Ostedgaard, L. S., Tang, X., Abu-El-Haija, M., Stoltz, D. A., Ludwig, P., Pezzulo, A. A., Abu-El-Haija, M., Taft, P. J. & Welsh, M. J. (2012). Pancreatic and biliary secretion are both altered in cystic fibrosis pigs. American journal of physiology. Gastrointestinal and liver physiology, 303(8), G961-8. PMID: 22936270.

Yu, S., Zhou, X., Steinke, F. C., Liu, C., Chen, S. C., Zagorodna, O., Jing, X., Yokota, Y., Meyerholz, D., Mullighan, C. G., Knudson, C. M., Zhao, D. M. & Xue, H. H. (2012). The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity, 37(5), 813-26. PMID: 23103132.

Olivier, A. K., Yi, Y., Sun, X., Sui, H., Liang, B., Hu, S., Xie, W., Fisher, J. T., Keiser, N. W., Lei, D., Zhou, W., Yan, Z., Li, G., Evans, T. I., Meyerholz, D., Wang, K., Stewart, Z. A., Norris, A. W. & Engelhardt, J. F. (2012). Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. The Journal of clinical investigation, 122(10), 3755-68. PMID: 22996690.

Olivier, A. K., Naumann, P., Goeken, A., Hochstedler, C., Sturm, M., Rodgers, J. R., Gibson-Corley, K. N. & Meyerholz, D. (2012). Genetically modified species in research: Opportunities and challenges for the histology core laboratory. Journal of histotechnology, 35(2), 63-67. PMID: 22904582.

Capparella, A., Loew, S. & Meyerholz, D. (2012). Ecology: Bat deaths from wind turbine blades. Nature, 488(7409), 32. PMID: 22859192.

Bolon, B., Altrock, B., Barthold, S. W., Baumgarth, N., Besselsen, D., Boivin, G., Boyd, K. L., Brayton, C., Cardiff, R. D., Couto, S., Eaton, K. A., Foreman, O., Griffey, S. M., La Perle, K., Lairmore, M. D., Liu, C., Meyerholz, D., Nikitin, A. Y., Schoeb, T. R., Schwahn, D., Sellers, R. S., Sundberg, J. P., Tolwani, R., Valli, V. E. & Zink, M. C. (2011). Advancing translational research. Science, 331(6024), 1516-7. PMID: 21436422.

Abu-El-Haija, M., Sinkora, M., Meyerholz, D., Welsh, M. J., McCray, P. B., Butler, J. & Uc, A. (2011). An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis. Pancreatology, 11(5), 506-15. PMID: 22057257.

Haverkamp, J. M., Charbonneau, B., Crist, S. A., Meyerholz, D., Cohen, M. B., Snyder, P. W., Svensson, R. U., Henry, M. D., Wang, H. H. & Ratliff, T. L. (2011). An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate. The Prostate, 71(11), 1139-50. PMID: 21656824.

Yuan, Z., Meyerholz, D., Twait, E. C., Kempuraj, D., Williard, D. E. & Samuel, I. (2011). Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis. Journal of gastrointestinal surgery, 15(10), 1670-8. PMID: 21800226.

Kondratowicz, A. S., Lennemann, N. J., Sinn, P. L., Davey, R. A., Hunt, C. L., Moller-Tank, S., Meyerholz, D., Rennert, P., Mullins, R. F., Brindley, M., Sandersfeld, L. M., Quinn, K., Weller, M., McCray, P. B., Chiorini, J. & Maury, W. (2011). T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proceedings of the National Academy of Sciences of the United States of America, 108(20), 8426-31. PMID: 21536871.

Muniz, V. P., Barnes, J. M., Paliwal, S., Zhang, X., Tang, X., Chen, S., Zamba, K. D., Cullen, J. J., Meyerholz, D., Meyers, S., Davis, J. N., Grossman, S. R., Henry, M. D. & Quelle, D. E. (2011). The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. Molecular cancer research, 9(7), 867-77. PMID: 21636682.

Ostedgaard, L. S., Meyerholz, D., Chen, J. H., Pezzulo, A. A., Karp, P. H., Rokhlina, T., Ernst, S. E., Hanfland, R. A., Reznikov, L. R., Ludwig, P. S., Rogan, M. P., Davis, G. J., Dohrn, C. L., Wohlford-Lenane, C., Taft, P. J., Rector, M. V., Hornick, E., Nassar, B. S., Samuel, M., Zhang, Y., Richter, S. S., Uc, A., Shilyansky, J., Prather, R. S., McCray, P. B., Zabner, J., Welsh, M. J. & Stoltz, D. A. (2011). The ?F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Science translational medicine, 3(74), 74ra24. PMID: 21411740.

Berquam-Vrieze, K. E., Nannapaneni, K., Brett, B. T., Holmfeldt, L., Ma, J., Zagorodna, O., Jenkins, N. A., Copeland, N. G., Meyerholz, D., Knudson, C. M., Mullighan, C. G., Scheetz, T. E. & Dupuy, A. J. (2011). Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood, 118(17), 4646-56. PMID: 21828136.

Bolon, B., Altrock, B., Barthold, S., Baumgarth, N., Besselsen, D., Boivin, G., Boyd, K., Brayton, C., Cardiff, R., Couto, S., Eaton, K., Foreman, O., Griffey, S., La Perle, K., Lairmore, M., Liu, C., Meyerholz, D., Nikitin, A., Schoeb, T., Schwahn, D., Sellers, R., Sundberg, J., Tolwani, R., Valli, V. & Zink, M. (2011). NIH plan will hinder translational studies. Nature, 471, 7336.

Ostedgaard, L. S., Meyerholz, D., Vermeer, D. W., Karp, P. H., Schneider, L., Sigmund, C. D. & Welsh, M. J. (2011). Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 2921-6. PMID: 21285372.

Lazic, T., Sow, F. B., Van Geelen, A., Meyerholz, D., Gallup, J. M. & Ackermann, M. R. (2011). Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of the fetal lung. Alcohol, 45(7), 673-80. PMID: 21163613.

Weiss, K. A., Christiaansen, A. F., Fulton, R. B., Meyerholz, D. & Varga, S. M. (2011). Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. Journal of immunology, 187(6), 3145-54. PMID: 21844390.

Hunninghake, G. W., Doerschug, K. C., Nymon, A. B., Schmidt, G. A., Meyerholz, D. & Ashare, A. (2010). Insulin-like growth factor-1 levels contribute to the development of bacterial translocation in sepsis. American journal of respiratory and critical care medicine, 182(4), 517-25. PMID: 20413631.

Peters, A. L., Stunz, L. L., Meyerholz, D., Mohan, C. & Bishop, G. A. (2010). Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice. Journal of immunology, 185(7), 4053-62. PMID: 20810985.

Meyerholz, D., Stoltz, D. A., Namati, E., Ramachandran, S., Pezzulo, A. A., Smith, A. R., Rector, M. V., Suter, M. J., Kao, S., McLennan, G., Tearney, G. J., Zabner, J., McCray, Jr., P. B. & Welsh, M. J. (2010). Loss of CFTR function produces abnormalities in tracheal development in neonatal pigs and young children. American Journal of Respiratory and Critical Care Medicine, 182(10), 1251-61. PMID: 20622026.

Radi, Z. A., Meyerholz, D. & Ackermann, M. R. (2010). Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. Viral immunology, 23(1), 43-8. PMID: 20121401.

Langlois, R. A., Meyerholz, D., Coleman, R. A., Cook, R. T., Waldschmidt, T. J. & Legge, K. L. (2010). Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice. Alcoholism, clinical and experimental research, 34(8), 1425-31. PMID: 20497135.

Fulton, R. B., Meyerholz, D. & Varga, S. M. (2010). Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. Journal of immunology, 185(4), 2382-92. PMID: 20639494.

Lu, P., Hankel, I. L., Knisz, J., Marquardt, A., Chiang, M. Y., Grosse, J., Constien, R., Meyer, T., Schroeder, A., Zeitlmann, L., Al-Alem, U., Friedman, A. D., Elliott, E. I., Meyerholz, D., Waldschmidt, T. J., Rothman, P. B. & Colgan, J. D. (2010). The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. The Journal of experimental medicine, 207(7), 1359-67. PMID: 20530203.

Meyerholz, D., Stoltz, D. A., Pezzulo, A. A. & Welsh, M. J. (2010). Pathology of gastrointestinal organs in a porcine model of cystic fibrosis. The American journal of pathology, 176(3), 1377-89. PMID: 20110417.

Samuel, I., Yuan, Z., Meyerholz, D., Twait, E., Williard, D. E. & Kempuraj, D. (2010). A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality. Pancreatology, 10(5), 536-44. PMID: 20975317.

McNamara, A. R., Zamba, K. D., Sokolich, J. C., Jaskille, A. D., Light, T. D., Griffin, M. A. & Meyerholz, D. (2010). Apoptosis is differentially regulated by burn severity and dermal location. The Journal of surgical research, 162(2), 258-63. PMID: 19439323.

Gookin, J. L., Stone, M. R., Yaeger, M. J., Meyerholz, D. & Moisan, P. (2010). Fluorescence in situ hybridization for identification of Tritrichomonas foetus in formalin-fixed and paraffin-embedded histological specimens of intestinal trichomoniasis. Veterinary parasitology, 172(2-Jan), 139-43. PMID: 20447769.

O'Keefe, B. R., Giomarelli, B., Barnard, D. L., Shenoy, S. R., Chan, P. K., McMahon, J. B., Palmer, K. E., Barnett, B. W., Meyerholz, D., Wohlford-Lenane, C. L. & McCray, P. B. (2010). Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. Journal of virology, 84(5), 2511-21. PMID: 20032190.

Sun, X., Sui, H., Fisher, J. T., Yan, Z., Liu, X., Cho, H. J., Joo, N. S., Zhang, Y., Zhou, W., Yi, Y., Kinyon, J. M., Lei-Butters, D. C., Griffin, M. A., Naumann, P., Luo, M., Ascher, J., Wang, K., Frana, T., Wine, J. J., Meyerholz, D. & Engelhardt, J. F. (2010). Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. The Journal of clinical investigation, 120(9), 3149-60. PMID: 20739752.

Ulland, T. K., Buchan, B. W., Ketterer, M. R., Fernandes-Alnemri, T., Meyerholz, D., Apicella, M. A., Alnemri, E. S., Jones, B. D., Nauseef, W. M. & Sutterwala, F. S. (2010). Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. Journal of immunology, 185(5), 2670-4. PMID: 20679532.

Lazic, T., Matic, M., Gallup, J. M., Van Geelen, A., Meyerholz, D., Grubor, B., Imerman, P. M., de-Macedo, M. M. & Ackermann, M. R. (2010). Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia. Pediatric pulmonology, 45(3), 255-62. PMID: 20131324.

Stoltz, D. A., Meyerholz, D., Pezzulo, A. A., Ramachandran, S., Rogan, M. P., Davis, G. J., Hanfland, R. A., Wohlford-Lenane, C., Dohrn, C. L., Bartlett, J. A., Nelson, G. A., Chang, E. H., Taft, P. J., Ludwig, P. S., Estin, M., Hornick, E. E., Launspach, J. L., Samuel, M., Rokhlina, T., Karp, P. H., Ostedgaard, L. S., Uc, A., Starner, T. D., Horswill, A. R., Brogden, K. A., Prather, R. S., Richter, S. S., Shilyansky, J., McCray, P. B., Zabner, J. & Welsh, M. J. (2010). Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Science translational medicine, 2(29), 29ra31. PMID: 20427821.

Khanolkar, A., Hartwig, S. M., Haag, B. A., Meyerholz, D., Epping, L. L., Haring, J. S., Varga, S. M. & Harty, J. T. (2009). Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome. Journal of virology, 83(18), 9258-72. PMID: 19570864.

Wohlford-Lenane, C. L., Meyerholz, D., Perlman, S., Zhou, H., Tran, D., Selsted, M. E. & McCray, P. B. (2009). Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. Journal of virology, 83(21), 11385-90. PMID: 19710146.

Bouley, D., Meyerholz, D., Sellers, R., Boyd, K. & La Perle, K. (2009). Where's the mouse pathology training?. Veterinary pathology, 46(6), 1245-7. PMID: 19890103.

Dassie, J. P., Liu, X. Y., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., Meyerholz, D., McCaffrey, A. P., McNamara, J. O. & Giangrande, P. H. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nature biotechnology, 27(9), 839-49. PMID: 19701187.

Meyerholz, D., Piester, T. L., McNamara, A. R., Sokolich, J. C., Jaskille, A. D., Orion, K. C., Zamba, K. D. & Light, T. D. (2009). Pharmacologic modification to resuscitation fluid after thermal injury--is drotrecogin alfa the answer to arrest burn depth progression?. The Journal of trauma, 67(5), 996-1003. PMID: 19901660.

Khanolkar, A., Hartwig, S. M., Haag, B. A., Meyerholz, D., Harty, J. T. & Varga, S. M. (2009). Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice. Journal of virology, 83(17), 8946-56. PMID: 19553337.

Murthy, S., Adamcakova-Dodd, A., Perry, S. S., Tephly, L. A., Keller, R. M., Metwali, N., Meyerholz, D., Wang, Y., Glogauer, M., Thorne, P. S. & Carter, A. B. (2009). Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology, 297(5), L846-55. PMID: 19684199.

Meyerholz, D., Rodgers, J., Castilow, E. M. & Varga, S. M. (2009). Alcian Blue and Pyronine Y histochemical stains permit assessment of multiple parameters in pulmonary disease models. Veterinary pathology, 46(2), 325-8. PMID: 19261646.

Meyerholz, D., Piester, T. L., Sokolich, J. C., Zamba, G. K. & Light, T. D. (2009). Morphological parameters for assessment of burn severity in an acute burn injury rat model. International journal of experimental pathology, 90(1), 26-33. PMID: 19200248.

Meyerholz, D., Griffin, M. A., Castilow, E. M. & Varga, S. M. (2009). Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model. Toxicologic pathology, 37(2), 249-55. PMID: 19181630.

Welsh, M. J., Rogers, C. S., Stoltz, D. A., Meyerholz, D. & Prather, R. S. (2009). Development of a porcine model of cystic fibrosis. Transactions of the American Clinical and Climatological Association, 120, 149-62. PMID: 19768173.

Sow, F. B., Gallup, J. M., Meyerholz, D. & Ackermann, M. R. (2009). Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response. Developmental and comparative immunology, 33(6), 761-71. PMID: 19189846.

McGill, J., Meyerholz, D., Edsen-Moore, M., Young, B., Coleman, R. A., Schlueter, A. J., Waldschmidt, T. J., Cook, R. T. & Legge, K. L. (2009). Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. Journal of immunology, 182(12), 7803-8. PMID: 19494304.

Netland, J., Meyerholz, D., Moore, S., Cassell, M. & Perlman, S. (2008). Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. Journal of virology, 82(15), 7264-75. PMID: 18495771.

Rogers, C. S., Abraham, W. M., Brogden, K. A., Engelhardt, J. F., Fisher, J. T., McCray, P. B., McLennan, G., Meyerholz, D., Namati, E., Ostedgaard, L. S., Prather, R. S., Sabater, J. R., Stoltz, D. A., Zabner, J. & Welsh, M. J. (2008). The porcine lung as a potential model for cystic fibrosis. American journal of physiology. Lung cellular and molecular physiology, 295(2), L240-63. PMID: 18487356.

Meyerholz, D., Edsen-Moore, M., McGill, J., Coleman, R. A., Cook, R. T. & Legge, K. L. (2008). Response to Comment on "Chronic alcohol consumption increases the severity of murine influenza virus infections". Journal of immunology, 181(9), 5813; author reply 5813-4. PMID: 18941167.

George, C. L., Goss, K. L., Meyerholz, D., Lamb, F. S. & Snyder, J. M. (2008). Surfactant-associated protein A provides critical immunoprotection in neonatal mice. Infection and immunity, 76(1), 380-90. PMID: 17967856.

Rogers, C. S., Stoltz, D. A., Meyerholz, D., Ostedgaard, L. S., Rokhlina, T., Taft, P. J., Rogan, M. P., Pezzulo, A. A., Karp, P. H., Itani, O. A., Kabel, A. C., Wohlford-Lenane, C. L., Davis, G. J., Hanfland, R. A., Smith, T. L., Samuel, M., Wax, D., Murphy, C. N., Rieke, A., Whitworth, K., Uc, A., Starner, T. D., Brogden, K. A., Shilyansky, J., McCray, P. B., Zabner, J., Prather, R. S. & Welsh, M. J. (2008). Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science, 321(5897), 1837-41. PMID: 18818360.

Meyerholz, D., Edsen-Moore, M., McGill, J., Coleman, R. A., Cook, R. T. & Legge, K. L. (2008). Chronic alcohol consumption increases the severity of murine influenza virus infections. Journal of immunology, 181(1), 641-8. PMID: 18566431.

Meyerholz, D., Williard, D. E., Grittmann, A. M. & Samuel, I. (2008). Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury. American journal of surgery, 196(5), 675-82. PMID: 18789417.

Castilow, E. M., Olson, M. R., Meyerholz, D. & Varga, S. M. (2008). Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. Journal of virology, 82(5), 2196-207. PMID: 18094193.

Castilow, E. M., Meyerholz, D. & Varga, S. M. (2008). IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease. Journal of immunology, 180(4), 2376-84. PMID: 18250447.

Meyerholz, D., Gallup, J. M., Lazic, T., de Macedo, M. M., Lehmkuhl, H. D. & Ackermann, M. R. (2007). Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection. Viral immunology, 20(1), 188-96. PMID: 17425433.

Fach, S. J., Meyerholz, D., Gallup, J. M., Ackermann, M. R., Lehmkuhl, H. D. & Sacco, R. E. (2007). Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts. Viral immunology, 20(1), 119-30. PMID: 17425426.

Dee, F. R., Meyerholz, D. (2007). Teaching medical pathology in the twenty-first century: virtual microscopy applications. Journal of veterinary medical education, 34(4), 431-6. PMID: 18287469.

Meyerholz, D., Samuel, I. (2007). Morphologic characterization of early ligation-induced acute pancreatitis in rats. American journal of surgery, 194(5), 652-8. PMID: 17936429.

Itoh, T., Iwashita, S., Cohen, M. B., Meyerholz, D. & Linn, S. (2007). Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. Human molecular genetics, 16(13), 1578-86. PMID: 17468495.

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., Meyerholz, D., Kirby, P., Look, D. C. & Perlman, S. (2007). Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. Journal of virology, 81(2), 813-21. PMID: 17079315.

Lazic, T., Wyatt, T. A., Matic, M., Meyerholz, D., Grubor, B., Gallup, J. M., Kersting, K. W., Imerman, P. M., Almeida-De-Macedo, M. & Ackermann, M. R. (2007). Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia. Alcohol, 41(5), 347-55. PMID: 17889311.

Grubor, B., Meyerholz, D., Lazic, T., DeMacedo, M. M., Derscheid, R. J., Hostetter, J. M., Gallup, J. M., DeMartini, J. C. & Ackermann, M. R. (2006). Regulation of surfactant protein and defensin mRNA expression in cultured ovine type II pneumocytes by all-trans retinoic acid and VEGF. International journal of experimental pathology, 87(5), 393-403. PMID: 16965567.

Meyerholz, D., Grubor, B., Lazic, T., Gallup, J. M., de Macedo, M. M., McCray, P. B. & Ackermann, M. R. (2006). Monocytic/macrophagic pneumonitis after intrabronchial deposition of vascular endothelial growth factor in neonatal lambs. Veterinary pathology, 43(5), 689-94. PMID: 16966446.

Meyerholz, D., Kawashima, K., Gallup, J. M., Grubor, B. & Ackermann, M. R. (2006). Expression of select immune genes (surfactant proteins A and D, sheep beta defensin 1, and toll-like receptor 4) by respiratory epithelia is developmentally regulated in the preterm neonatal lamb. Developmental and comparative immunology, 30(11), 1060-9. PMID: 16510184.

Kawashima, K., Meyerholz, D., Gallup, J. M., Grubor, B., Lazic, T., Lehmkuhl, H. D. & Ackermann, M. R. (2006). Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus. Viral immunology, 19(2), 316-23. PMID: 16817774.

Grubor, B., Meyerholz, D. & Ackermann, M. R. (2006). Collectins and cationic antimicrobial peptides of the respiratory epithelia. Veterinary pathology, 43(5), 595-612. PMID: 16966437.

Meyerholz, D., DeGraaff, J. A., Gallup, J. M., Olivier, A. K. & Ackermann, M. R. (2006). Depletion of alveolar glycogen corresponds with immunohistochemical development of CD208 antigen expression in perinatal lamb lung. The journal of histochemistry and cytochemistry, 54(11), 1247-53. PMID: 16899762.

Meyerholz, D., Hostetter, S. J. (2005). Unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse. Veterinary pathology, 42(4), 496-8. PMID: 16006610.

Meyerholz, D., Vanloubbeeck, Y. E., Hostetter, S. J., Jordan, D. M. & Fales-Williams, A. J. (2005). Surveillance of amyloidosis and other diseases at necropsy in captive trumpeter swans (Cygnus buccinator). Journal of veterinary diagnostic investigation, 17(3), 295-8. PMID: 15945393.

Meyerholz, D., Haynes, J. S. (2005). Actinobacillus capsulatus septicemia in a domestic rabbit (Oryctolagus cuniculus). Journal of veterinary diagnostic investigation, 17(1), 83-5. PMID: 15690960.

Meyerholz, D., Ackermann, M. R. (2005). Antimicrobial peptides and surfactant proteins in ruminant respiratory tract infection. Veterinary Immunology and Immunopathology, 108, 91-96.

Meyerholz, D., Ackermann, M. R. (2005). Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease. Veterinary immunology and immunopathology, 108, 91-6. PMID: 16140392.

Meyerholz, D. (2004). Invited book review of the Textbook of Respiratory Disease in Dogs and Cats, by Lesley G. King. Journal of the American Veterinary Medical Association, 224, 1926-1927.

Grubor, B., Gallup, J. M., Meyerholz, D., Crouch, E. C., Evans, R. B., Brogden, K. A., Lehmkuhl, H. D. & Ackermann, M. R. (2004). Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clinical and diagnostic laboratory immunology, 11(3), 599-607. PMID: 15138188.

Meyerholz, D., Haynes, J. S. (2004). Solitary retinal astrocytoma in a dog. Veterinary pathology, 41(2), 177-8. PMID: 15017032.

Meyerholz, D., Grubor, B., Fach, S. J., Sacco, R. E., Lehmkuhl, H. D., Gallup, J. M. & Ackermann, M. R. (2004). Reduced clearance of respiratory syncytial virus infection in a preterm lamb model. Microbes and infection, 6(14), 1312-9. PMID: 15555538.

Ackermann, M. R., Gallup, J. M., Zabner, J., Evans, R. B., Brockus, C. W., Meyerholz, D., Grubor, B. & Brogden, K. A. (2004). Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microbial pathogenesis, 37(1), 21-7. PMID: 15194156.

Meyerholz, D., Grubor, B., Gallup, J. M., Lehmkuhl, H. D., Anderson, R. D., Lazic, T. & Ackermann, M. R. (2004). Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. Journal of clinical microbiology, 42(10), 4780-7. PMID: 15472341.

Meyerholz, D., Caston, S. S. & Haynes, J. S. (2004). Congenital fetal rhabdomyoma in a foal. Veterinary pathology, 41(5), 518-20. PMID: 15347826.

Meyerholz, D., Gallup, J. M., Grubor, B. M., Evans, R. B., Tack, B. F., McCray, P. B. & Ackermann, M. R. (2004). Developmental expression and distribution of sheep beta-defensin-2. Developmental and comparative immunology, 28(2), 171-8. PMID: 12969802.

Meyerholz, D., Stabel, T. J. (2003). Comparison of early ileal invasion by Salmonella enterica serovars Choleraesuis and Typhimurium. Veterinary pathology, 40(4), 371-5. PMID: 12824508.

Meyerholz, D., Stabel, T. J. & Cheville, N. F. (2002). Segmented filamentous bacteria interact with intraepithelial mononuclear cells. Infection and immunity, 70(6), 3277-80. PMID: 12011024.

Wu, M. T., Carlson, S. A. & Meyerholz, D. (2002). Cytopathic effects observed upon expression of a repressed collagenase gene present in Salmonella and related pathogens: mimicry of a cytotoxin from multiple antibiotic-resistant Salmonella enterica serotype Typhimurium phagetype DT104. Microbial pathogenesis, 33(6), 279-87. PMID: 12495674.

Meyerholz, D., Stabel, T. J., Ackermann, M. R., Carlson, S. A., Jones, B. D. & Pohlenz, J. (2002). Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileum. Veterinary pathology, 39(6), 712-20. PMID: 12450202.

Carlson, S. A., Meyerholz, D., Stabel, T. J. & Jones, B. D. (2001). Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104. Microbial pathogenesis, 31(4), 201-4. PMID: 11562173.