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David K. Meyerholz, DVM, PhD

Professor of Pathology

Introduction

Research Summary

Dr. Meyerholz studies lung diseases and the goals of his research are to define disease pathogenesis, identify new biomarkers and evaluate novel treatments. He has research interests in cystic fibrosis and viral diseases of the lung (e.g. SARS-CoV2, MERS-CoV, SARS-CoV). Dr. Meyerholz is well-published and has served in editorial and reviewer roles at several scientific journals. For more detailed and current information, please see my profile at Researchgate (https://www.researchgate.net/profile/David_Meyerholz).

Current Positions

  • Professor of Pathology
  • Member, Institute for Clinical and Translational Science
  • Director, Division of Comparative Pathology

Education

  • DVM, Iowa State University, Ames, Iowa
  • MS in Veterinary Microbiology, Iowa State University, Ames, Iowa
  • PhD in Veterinary Pathology, Iowa State University

Center, Program and Institute Affiliations

Research Interests

  • Cystic fibrosis – pathogenesis investigations through studies of human animal model tissues
  • Comparative pathology – applications and pathology of animal models of human disease
  • Lung diseases – Viral, bacterial and other models of lung infection

Licenses & Certifications

  • Diplomate, American College of Veterinary Microbiologists (Virology)
  • Diplomate, American College of Veterinary Pathologists
  • Veterinary Medicine License, Iowa Board of Veterinary Medicine, Iowa

Selected Publications

  • Wong L-YR, Odle A, Luhmann E, Wu DC, Wang Y, Teo QW, Ptak C, Sariol A, Lowery S, Mack M, Meyerholz DK, Wu NC, Radoshevich L, Perlman S. (2023) Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice. mBio. Oct 26; 14(6):e0247623. DOI: 10.1128/mbio.02476-23. PMID: 37882568. PMCID: PMC10746224.
  • Pan R, Meyerholz DK, Perlman S. (2023) Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract. J Clin Invest. Nov 15; 133(22):e172659. DOI: 10.1172/JCI172659. PMID: 37966119. PMCID: PMC10645383.
  • Li K, Verma A, Li P, Ortiz ME, Hawkins GM, Schnicker NJ, Szachowicz, Pezzulo AA, Wohlford-Lenane CL, Kicmal T, Meyerholz DK, Gallagher T, Perlman S, McCray Jr PB. (2024) Adaptation of SARS-CoV-2 to ACE2H353K mice reveals new spike residues that drive mouse infection. J Virol. Jan 23; 98(1):e0151023. DOI: 10.1128/jvi.01510-23. PMID: 38168680. PCMID: PMC10804960.
  • Bae H, Kim BR, Jung S, Le J, van der Heide DM, Yu W, Park SH, Hilkin BM, Gansemer ND, Powers LS, Kang T, Meyerholz DK, Schuster VL, Jang C, Welsh MJ. (2024) Arteriovenous metabolomics in pigs reveal CFTR regulation of metabolism in multiple organs. J Clin Invest. May; 14:e174500. DOI: 10.1172/JCI174500. PMID: 38743489.
  • Gangadharan Nambiar G, Gonzalez Szachowicz S, Zirbes CF, Hill JJ, Powers LS, Meyerholz DK, Thornell IM, Stoltz DA, Fischer AJ. (2024) Pancreatic enzymes digest obstructive meconium from cystic fibrosis pig intestines. Front Pediatr. Apr 11; 12:1387171. DOI: 10.3389/fped.2024.1387171. PMID: 38665380. PMCID: PMC11043547.
  • Evans IA, Sun X, Liang B, Vegter AR, Guo L, Lynch TJ, Zhang Y, Zhang Y, Yi Y, Yang Y, Feng Z, Park SY, Shonka A, McCumber H, Qi L, Wu P, Liu G, Lacina A, Wang K, Gibson-Corley KN, Meyerholz DK, Limoli DH, Rosen BH, Yan Z, Bartels J, Engelhardt JF. (2024) In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets. JCI Insight. Apr 22; 9(8):e157229. DOI: 10.1172/jci.inight.157229. PMID: 38646935. PMCID: PMC11141870.
  • Gabriel V, Lincoln A, Zdyrski C, Ralston a, Wickham H, Honold S, Ahmed BH, Paukner K, Feauto R, Merodio MM, Pineyro P, Meyerholz D, Allenspach K, Mochel JP. (2024) Evaluation of different media compositions promoting hepatocyte differentiation in the canine liver organoid model. Heliyon. Mar 25; 10(7):e284220. DOI: 10.1016/j.heliyon.2024.e28420. PMID: 38590903. PMCID: PMC10999936.
  • Tan TJC, Verma AK, Odle A, Lei R, Meyerholz DK, Matreyek KA, Perlman S, Wong L-Y R, Wu NC. (2024) Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike. Pro Natl Acad Sci U S A. Apr 9; 121(15):e2317222121. DOI: 10.1073/pnas.2317222121. PMID: 38557175. PMCID: PMC11009667.
  • Zdyrski C, Gabriel V, Gessler TB, Ralston A, Sifuentes-Romero I, Kundu D, Honold S, Wickham H, Topping NE, Sahoo DK, Bistra B, Tamplin J, Ospina O, Pineyro P, Arriaga M, Galan JA, Meyerholz DK, Allenspach K, Mochel JP, Valenzuela N. (2024) Establishment and characterization of turtle liver organoids provides a potential model to de code their unique adaptations. Commun Biol. Feb 22; 7(1):218. DOI: 10.1038/s42003-024-05818-1. PMID: 38388772. PMCID: PMC10883927.
  • Gabriel V, Zdyrski C, Sahoo DK, Ralston A, Wickham H, Bourgois-Mochel A, Ahmed B, Merodio MM, Paukner K, Pineyro P, Kopper J, Rowe EW, Smith JD, Meyerholz D, Kol A, Viall A, Elbadawy M, Mochel JP, Allenspach K. (2024) Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm. Int J Mol Sci. Jan 5; 25(2):701. DOI: 10.3390/ijms25020701. PMID: 38255775. PMCID: PMC10815683.