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Marco Hefti, MD

Assistant Professor of Pathology

Introduction

I am a neuropathologist with a particular interest in pediatric and fetal neuropathology. I graduated from the Mount Sinai School of Medicine in 2008. I completed two years of general surgery residency at Beth Israel Deaconess Medical Center in Boston before doing a two-year postdoctoral fellowship at Harvard Medical School. I then did a residency in anatomic pathology at Beth Israel before moving to Mount Sinai to do my neuropathology fellowship.

Current Positions

  • Assistant Professor of Pathology

Education

  • BA in Psychology, Cornell University, Ithaca, New York, United States
  • Postbaccalaureate in Pre-medical, Columbia University, New York
  • MD in Medicine, Mount Sinai School of Medicine, New York City
  • Resident in Surgery, Beth Israel Deaconess, Boston, Massachusetts
  • Postdoctoral Fellow in Surgery/Pathology, Harvard Medical School, Boston, Massachusetts
  • Resident in Anatomic Pathology, Beth Israel Deaconess, Boston, Massachusetts
  • Chief Resident in Anatomic Pathology, Beth Israel Deaconess, Boston, Massachusetts
  • Fellow in Neuropathology, Mount Sinai School of Medicine, New York

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Microtubule-associated proteins in neonatal hypoxic-ischemic injury.
  • Role of the tau protein in human brain development
  • Aberrant tau splicing in the pathogenesis of cognitive dysfunction in myotonic dystrophy

Licenses & Certifications

  • Diplomate in Neuropathology, American Board of Pathology
  • Iowa Board of Medicine, Iowa, United States
  • Diplomate in Anatomic Pathology, American Board of Pathology

Selected Publications

  • Tish MM, Voss NA, Bertolli AX, Klimara MJ, Smith RJ, Thedens DR, Allamargot C, Hefti MM, Howard MA, Aldridge GM, Geerling JC. (2024) Normal pressure hydrocephalus in adult mice causes gait impairment, cognitive deficits, and urinary frequency with incontinence. eNeuro. doi: 10.1523/ENEURO.0412-24.2024.
  • Gasparini S, Peltekian L, McDonough M, Mitchell C.J., Hefti MM, Resch J.M., Geerlin J.C. (2024) Aldosterone-induced salt appetite requires HSD2 Neurons. JDI Insight Oct 24: PMID: 39446486. DOI: 10.1172/jci.insight.175087
  • Fiock KL, Hook JN, Hefti MM. (2023) Determinants of astrocytic pathology in stem cell models of primary tauopathies. Acta Neuropathol Commun. Oct 6; 11(1):161. DOI: 10.1186/s40478-023-01655-1. PMID: 37803326. PMCID: PMC10557325.
  • Piel S, Janowska JI, Ward JL, McManus MJ, Aronowitz DI, Janowski PK, Starr J, Hook JN, Hefti MM, Clayman CL, Elmér E, Hansson MJ, Jang DH, Karlsson M, Ehinger JK, Kilbaugh TJ. (2023) Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat. Mol Cell Biochem. 2023 Jun; 478(6):1231-1244. DOI: 10.1007/s11010-022-04589-9.  PMID: 36282352. Epub 2022 Oct 25.
  • Khan KM, Balasubramanian N, Gaudencio G, Wang R, Selvakumar GP, Kolling L, Pierson S, Taadinada SM, Abel T, Hefti M, Marcinkiewz CA. (2023) Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease. Acta Neuropathol Commun. 2023 Apr 3; 11(1):57. DOI: 10.1186/s40478-023-01546-5. PMID: 37009893. PMCID: PMC10069039.
  • Fiock KL, Betters RK, Hefti MM. (2023) Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. J Histochem Cytochem. 2023 Feb; 71(2):73-86. DOI: 10.1369/00221554231158428. PMID:36861683. PMCID: PMC10071402. Epub 2023 Mar 2.
  • Slovis JC, Volk L, Mavroudis C, Hefti M, Landis WP, Roberts AL, Delso N, Hallowell T, Graham K, Starr J, Lin Y, Melchior R, Nadkarni V, Sutton RM, Berg RA, Piel S, Morgan RW, Kilbaugh TJ. (2023) Pediatric Extracorporeal Cardiopulmonary Resuscitation: Development of a Porcine Model and the Influence of Cardiopulmonary Resuscitation Duration on Brain Injury. J Am Heart Assoc. 2023 Feb 21; 12(4):e026479. DOI: 10.1161/JAHA.122.026479. PMID: 36789866. PMCID: PMC10111482. Epub 2023 Feb 15.
  • Daneshgar N, Leidinger MR, Le S, Hefti M, Prigione A, Dai DF. (2023) Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome. Front Neurosci. 2023 Jan 18; 16:1068498. DOI: 10.3389/fnins.2022.1068498. PMID:36741056. PMCID: PMC9889986.
  • Agostinelli LJ, Seaman SC, Saper CB, Fykstra DP, Hefti MM, Koscik TR, Dlouhy BJ, Bassuk AG. (2023) Human Brainstem and Cerebellum Atlas: Chemoarchitecture and Cytoarchitecture Paired to MRI. J Neurosci. 2023 Jan 11; 43(2):221-239. DOI: 10.1523/JNEUROSCI.0587-22.2022. PMID:36442999. PMCID: PMC9838717. Epub 2022 Nov 28.
  • Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP, Santi M, Fernandes IL, Nirschl J, Dahiya S, Neill S, Solomon D, Perez E, Capper D, Mani H, Caccamo D, Ball M, Badruddoja M, Chkheidze R, Camelo-Piragua S, Fullmer J, Alexandrescu S, Yeaney G, Eberhart C, Martinez-Lage M, Chen J, Zach L, Kleinschmidt-DeMasters BK, Hefti M, Lopes MB, Nuechterlein N, Horbinski C, Rodriguez FJ, Quezado M, Pratt D, Aldape K. Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1. (2023) Acta Neuropathol. 2023 Jan 1; 145(1):71-82. DOI: 10.1007/s00401-022-02513-5. PMID:36271929. PMCID: PMC9844520. Epub 2022 Oct 22.