Janice Staber, MD

Portrait
Assistant Professor of Pediatrics - Hematology Oncology

Contact Information

Primary Office
3080J ML
Iowa City, IA 52242
319-335-6688

Education

BS, Biochemistry, with Honors, University of Iowa, Iowa City, Iowa
MD, Medicine, University of Iowa, Iowa City, Iowa
Resident, Pediatrics, University of Iowa Children's Hospital, Iowa City, Iowa
Fellow, Pediatric Hematology/Oncology, University of Iowa Children's Hospital, Iowa City, Iowa

Licensure and Certifications

American Board of Pediatric Hematology/Oncology
American Board of Pediatrics
Certificate, Diagnosis and Management of Coagulation Disorders, Resident and Fellowship Workshop, Cincinnati, OH
Permanent Iowa Medical License

Research Summary

My research involves the development and application of vector systems for the treatment of inherited disorders. Factor VIII deficiency (also known as Hemophilia A) is a severe bleeding disorder causing disabling joint and muscle hemorrhages in those affected. Our laboratory is investigating the development of integrating vector systems for the treatment of hemostatic disorders. We currently are focuses on transposon mediated gene transfer to hepatocytes for treatment of hemophilia A.

Publications

Staber, J. M., Pollpeter, M. J. (2016). Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model. PloS one, 11(5), e0154857. PMID: 27144769.

Jeffery, U., Staber, J. & LeVine, D. (2016). Using the laboratory to predict thrombosis in dogs: An achievable goal?.

Chilman-Blair, K., Quigley, C., deLoache, S., Hart, D., Forsyth, K., Morris, A. & Staber, J. (2015). What’s Up with Shaun? Medikidz Explain Hemophilia. In Hemophilia. Medikidz.

Staber, J., Pollpeter, M., Arensdorf, A., Sinn, P., Ruftkowski, D. & McCray, P. (2014). “PiggyBac-mediated Phenotypic Correction of Factor VIII deficiency”. Molecular Therapy- Methods and Clinical Development.

Lentz, S., Seremetis, S., Staber, J. & Kulkami, R. (2014). “Turoctocog alfa and drug development for hemophilia A”. Expert Opinion on Orphan Drugs, 2(4), 419-431. DOI: doi:10.1517/21678707.2014.891458.

Li, X., Burnright, E. R., Cooney, A. L., Malani, N., Brady, T., Sander, J. D., Staber, J., Wheelan, S., Joung, J., McCray, P. B., Bushman, F. D., Sinn, P. L. & Craig, N. L. (2013). "piggyBac transposase tools for genome engineering:. PNAS, 110(25), E2279-87.

Staber, J., Burnright, E. R., Koarsakov, P., Li, X., Brett, B. T., Scheetz, T. E., Craig, N. L. & McCray, P. (2012). “A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon”. (Vols. 1). (50) Molecular Therapy Nucleic Acids.

Staber, J., Monick, M., Cameron, K., Powers, L. S., Yarovinsky, T. O., Koland, J. G. & HUNNINGHAKE, G. W. (2005). “Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis”. Journal of Biological Chemistry, 280(3), 2147-58.

Staber, J., Thomas, K. W., Monick, M., Yarovinsky, T., Carter, A. & HUNNINGHAKE, G. W. (2002). "Respiratory Syncytial Virus Inhibits Apoptosis and Induces NK-kB Activity through a Phosphatidylinositol 3-kinase-dependent Pathway". Journal of Biological Chemistry, 277, 492-501.

Staber, J., Monick, M., Thomas, K. W. & HUNNINGHAKE, G. W. (2001). "Respiratory Syncytial Virus Infection Results in Activation of Multiple Protein Kinase C Isoforms Leading to Activation of Mitogen-Activated Protein Kinase". The Journal Of Immunology, 166, 2681-2687.