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Janice Staber, MD

Associate Professor of Pediatrics - Hematology/Oncology

Introduction

My research involves the development and application of vector systems for the treatment of inherited disorders. Factor VIII deficiency (also known as Hemophilia A) is a severe bleeding disorder causing disabling joint and muscle hemorrhages in those affected. Our laboratory is investigating the development of integrating vector systems for the treatment of hemostatic disorders. We currently are focuses on transposon mediated gene transfer to hepatocytes for treatment of hemophilia A.

Current Positions

  • Associate Professor of Pediatrics - Hematology/Oncology

Education

  • Resident in Pediatrics, University of Iowa Children's Hospital, Iowa City, Iowa
  • MD in Medicine, University of Iowa, Iowa City, Iowa
  • Fellow in Pediatrics, Hematology/Oncology, University of Iowa Children's Hospital, Iowa City, Iowa
  • BS in Biochemistry, with Honors, University of Iowa, Iowa City, Iowa
  • Fellow in Pediatric Hematology/Oncology, University of Iowa Children's Hospital, Iowa City, Iowa

Center, Program and Institute Affiliations

Licenses & Certifications

  • American Board of Pediatrics
  • Certificate, Diagnosis and Management of Coagulation Disorders, Resident and Fellowship Workshop, Cincinnati, OH
  • Permanent Iowa Medical License
  • American Board of Pediatric Hematology/Oncology
  • Resident Iowa Medical License

Selected Publications

  • Staber, J. M. & Pollpeter, M. J. (2016). Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model. PloS one 11 (5) e0154857. DOI: 10.1371/journal.pone.0154857. PMID: 27144769.
  • Jeffery, U., Staber, J. & LeVine, D. (2016). Using the laboratory to predict thrombosis in dogs: An achievable goal?.
  • Chilman-Blair, K., Quigley, C., deLoache, S., Hart, D., Forsyth, K., Morris, A. & Staber, J. (2015). What’s Up with Shaun? Medikidz Explain Hemophilia. In Hemophilia. Medikidz.
  • Staber, J., Pollpeter, M., Arensdorf, A., Sinn, P., Ruftkowski, D. & McCray, P. (2014). “PiggyBac-mediated Phenotypic Correction of Factor VIII deficiency”. Molecular Therapy- Methods and Clinical Development.
  • Lentz, S., Seremetis, S., Staber, J. & Kulkami, R. (2014). “Turoctocog alfa and drug development for hemophilia A”. Expert Opinion on Orphan Drugs 2 (4) 419-431. DOI: doi:10.1517/21678707.2014.891458.
  • Li, X., Burnright, E. R., Cooney, A. L., Malani, N., Brady, T., Sander, J. D., Staber, J., Wheelan, S., Joung, J., McCray, P. B., Bushman, F. D., Sinn, P. L. & Craig, N. L. (2013). "piggyBac transposase tools for genome engineering:. PNAS 110 (25) E2279-87.
  • Staber, J., Burnright, E. R., Koarsakov, P., Li, X., Brett, B. T., Scheetz, T. E., Craig, N. L. & McCray, P. (2012). “A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon”. (Vols. 1). (50) Molecular Therapy Nucleic Acids.
  • Staber, J., Monick, M., Cameron, K., Powers, L. S., Yarovinsky, T. O., Koland, J. G. & HUNNINGHAKE, G. W. (2005). “Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis”. Journal of Biological Chemistry 280 (3) 2147-58.
  • Staber, J., Thomas, K. W., Monick, M., Yarovinsky, T., Carter, A. & HUNNINGHAKE, G. W. (2002). "Respiratory Syncytial Virus Inhibits Apoptosis and Induces NK-kB Activity through a Phosphatidylinositol 3-kinase-dependent Pathway". Journal of Biological Chemistry 277 492-501.
  • Staber, J., Monick, M., Thomas, K. W. & HUNNINGHAKE, G. W. (2001). "Respiratory Syncytial Virus Infection Results in Activation of Multiple Protein Kinase C Isoforms Leading to Activation of Mitogen-Activated Protein Kinase". The Journal Of Immunology 166 2681-2687.