Joseph Glykys, MD, PhD
Associate Professor of Pediatrics - Neurology
Introduction
Dr. Glykys received his Medical Degree from the Universidad de Carabobo, Valencia, Venezuela (2001), and practiced general medicine in underserved communities in Carabobo, Venezuela. He completed his Ph.D. in Neuroscience (2002-07) at the University of California, Los Angeles (UCLA), followed by post-doctoral research at Massachusetts General Hospital (MGH)/Harvard University (2007-09) and then by a Pediatric Neurology Residency (2009-13) at the Harvard/BWH-MGH. Dr. Glykys was an Assistant Professor at MGH until he relocated to the University of Iowa as an Assistant Professor of Pediatrics-Neurology and Neurology in 2019.
Current Positions
- Associate Professor of Pediatrics - Neurology
- Associate Professor of Neurology
Education
- MD in Medicine, Universidad de Carabobo/ Valencia, Valencia, Venezuela
- PhD in Neuroscience, University of California, Los Angeles (UCLA), Los Angeles, California, United States
- Research Fellow, Massachusetts General Hospital, Boston, Massachusetts, United States
- Internship in Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
- Resident in Neurology Residency, Harvard University/Massachusetts General and Brigham and Women’s Hospitals, Boston, Massachusetts, United States
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- neuronal volume
- GABA A receptors
- Neocortex
- Seizures
- Neonatal seizures
Licenses & Certifications
- Board Certified in Neurology with special qualification in Child Neurology, American Board of Psychiatry and Neurology (ABPN), United States
Selected Publications
- Tong, L., Langton, R., Glykys, J. & Baek, S. (2021). ANMAF: An automated neuronal morphology analysis framework using convolutional neural networks. Scientific Reports 11 (1) 8179.
- Cole, M., Zhorne, L. & Glykys, J. (2020). Atypical Presentation of Primary Stabbing Headache in a Patient With Type 3 Gaucher Disease. Pediatric neurology 116 57-58. DOI: 10.1016/j.pediatrneurol.2020.12.002. PMID: 33486419.
- Rahmati, N., Normloyle, K. P., Glykys, J., Dzhala, V. I., Lillis, K. P., Kahle, K. T., Raiyyani, R., Jacob, T. & Staley, K. J. Unique actions of GABA arising from cytoplasmic chloride microdomains. Journal of Neuroscience.
- Glykys, J., Duquette, E., Rahmati, N., Duquette, K. & Staley, K. J. (2019). Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water. Neurobiology of disease 125 163-175. DOI: 10.1016/j.nbd.2019.01.024. PMID: 30711483.
- Glykys, J., Dzhala, V., Egawa, K., Kahle, K. T., Delpire, E. & Staley, K. (2017). Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends in neurosciences 40 (5) 276-294. DOI: 10.1016/j.tins.2017.03.006. PMID: 28431741. PMCID: PMC5473173.
- Glykys, J. & Sims, K. B. (2017). The Neuronal Ceroid Lipofuscinosis Disorders. In Shevell, M., Pearl, P. L., Gropman, A. L., Finkel, R. S., Schor, N. F., Ferriero, D. M., Ashwal, S. & Swaiman, K. F. (Eds.) Swaiman's Pediatric Neurology. (6th Edition) Elsevier.
- Berdichevsky, Y., Glykys, J., Dzhala, V., Lillis, K. & Staley, K. J. (2017). Organotypic Hippocampal Slice Cultures as a Model of Posttraumatic Epileptogenesis. In Moshe, S. L., Galanopoulou, A., Buckmaster, P. & Pitkanen, A. (Eds.) Models of Seizures and Epilepsy. (2nd Edition) Elsevier.
- Glykys, J. & Staley, K. J. (2016). Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices. PloS one 11 (6) e0158012. DOI: 10.1371/journal.pone.0158012. PMID: 27337272. PMCID: PMC4919081.
- Benowitz, I., Cohen, A. R., Glykys, J. C., Gorstein, S. V., Burns, M. M. & Miller, E. S. (2016). An Altered, Unresponsive Teenager in the Emergency Department. The Journal of emergency medicine 50 (1) 116-20. DOI: 10.1016/j.jemermed.2015.09.023. PMID: 26508698.
- Glykys, J. & Staley, K. J. (2015). Diazepam effect during early neonatal development correlates with neuronal Cl(.). Annals of clinical and translational neurology 2 (12) 1055-70. DOI: 10.1002/acn3.259. PMID: 26734658. PMCID: PMC4693588.