Stanley Perlman, MD, PhD

Portrait
Professor of Microbiology and Immunology
Professor of Pediatrics

Contact Information

Office
3-712 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-8549

Lab
3-730 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-7576

Education

AB, Physics, University of Rochester
PhD, Biophysics, Massachusetts Institute of Technology
MD, Medicine, University of Miami School of Medicine
Fellow, Massachusetts Institute of Technology
Fellow, Harvard University
Fellow, University of Edinburgh
Fellow, Brandeis University
Resident, Children's Hospital Medical Center
Fellow, Infectious Diseases, Children's Hospital Medical Center

Licensure and Certifications

American Board of Pediatrics
Medical License, Iowa
Medical License, Massachusetts

Education/Training Program Affiliations

Biomedical Science Program, Department of Microbiology Graduate Program, Interdisciplinary Graduate Program in Immunology, Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases, Helen C. Levitt Center for Viral Pathogenesis, Holden Comprehensive Cancer Center, Institute for Clinical and Translational Science, NIH Vaccine Treatment and Evaluation Unit

Research Summary

My laboratory has been interested in the pathogenesis of murine coronavirus infections for several years. Now, we also study three respiratory human coronavirus infections: SARS (Severe Acute Respiratory Syndrome)-coronavirus, Middle East Respiratory syndrome (MERS)-coronavirus, human coronavirus-OC43 and human coronavirus-NL63.

Mice infected with mouse hepatitis virus develop a demyelinating disease with many similarities to the human disease, multiple sclerosis. Research in my laboratory is aimed at determining the immunological and viral factors involved in the demyelinating process. Previously, we determined the CD4 and CD8 T cell epitopes recognized in the central nervous system (CNS) of infected mice. We showed that in mice infected chronically with the virus, cytotoxic T cell escape mutants arise. These mutations completely abrogate recognition by CD8 T cells and thereby facilitate persistence.

We have developed reverse genetics system for introducing mutations into the murine coronavirus, SARS-CoV and MERS-CoV genomes. We also study the anti-inflammatory components that are needed to diminish immunopathological disease, with specific focus on regulatory CD4 T cells and IL-10. The ultimate goal of our work is to understand the interplay of pro and anti-inflammatory factors that result in myelin and lung destruction.

SARS-CoV and MERS-CoV causes the most significant diseases of any of the human coronaviruses. The disease is especially severe in aged populations. We are using mice infected with murine adapted strains of SARS-CoV to understand the basis of this severe disease. We have begun studies of the coronavirus that causes the Middle East Respiratory Syndrome (MERS-CoV). We have developed mouse models for studying MERS and begun to evaluate several MERS-CoV specific vaccines and therapies. We also study immune responses in patients who survived MERS, in collaboration with investigators from the Kingdom of Saudi Arabia.

Publications

Grunewald, M. E., Fehr, A. R., Athmer, J. & Perlman, S. (2017). The coronavirus nucleocapsid protein is ADP-ribosylated. Virology, Epub ahead of print. PMID: 29199039.

Zheng, J., Perlman, S. (2017). Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host. Curr Opin Virol, 28, 43-52. PMID: 29172107.

Zhao, J., Alshukairi, A. N., Baharoon, S. A., Ahmed, W. A., Bokhari, A. A., Nehdi, A. M., Layqah, L. A., Alghamdi, M. G., Al Gethamy, M. M., Dada, A. M., Khalid, I., Boujelal, M., Al Johani, S. M., Vogel, L., Subbarao, K., Mangalam, A., Wu, C., Ten Eyck, P., Perlman, S. & Zhao, J. (2017). Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol, 2(14), eaan5393. PMID: 28778905.

Wheeler, D. L., Athmer, J., Meyerholz, D. K. & Perlman, S. (2017). Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus. J Virol, Epub ahead of print. PMID: 28835503.

Earnest, J. T., Hantak, M. P., Li, K., McCray, P. B., Perlman, S. & Gallagher, T. (2017). The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog, 13(7), e1006546. PMID: 28759649.

Vijay, R., Fehr, A. R., Janowski, A. M., Athmer, J., Wheeler, D. L., Grunewald, M., Sompallae, R., Kurup, S. P., Meyerholz, D. K., Sutterwala, F. S., Narumiya, S. & Perlman, S. (2017). Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proc Natl Acad Sci U S A, 114(27), E5444-E5453. PMID: 28630327.

Channappanavar, R., Perlman, S. (2017). Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol, 39(5), 529-539. PMID: 28466096.

Channappanavar, R., Fett, C., Mack, M., Ten Eyck, P., Meyerholz, D. K. & Perlman, S. (2017). Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. J Immunol, 198(10), 4046-4053. PMID: 28373583.

Chi, H., Zheng, X., Wang, X., Wang, C., Wang, H., Gai, W., Perlman, S., Yang, S., Zhao, J. & Xia, X. (2017). DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice. Vaccine, 35(16), 2069-75. PMID: 28314561.

Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J. E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S. & McCray, P. B. (2017). Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A, 114(15), E3119-E3128. PMID: 28348219.

Athmer, J., Fehr, A. R., Grunewald, M., Smith, E. C., Denison, M. R. & Perlman, S. (2017). In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins. MBio, 8(1), e02320-16. PMID: 28143984.

de Wilde, A. H., Falzarano, D., Zevenhoven-Dobbe, J. C., Beugeling, C., Fett, C., Martellaro, C., Posthuma, C. C., Feldmann, H., Perlman, S. & Snijder, E. J. (2017). Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Res, 228, 7-13. PMID: 27840112.

Fehr, A. R., Channappanavar, R. & Perlman, S. (2017). Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus. Annu Rev Med, 68, 387-399. PMID: 27576010.

Wang, Y., Sun, J., Channappanavar, R., Zhao, J., Perlman, S. & Zhao, J. (2017). Simultaneous Intranasal/Intravascular Antibody Labeling of CD4+ T Cells in Mouse Lungs. Bio Protoc, 7(1), e2099. PMID: 28516121.

Perlman, S., Zhao, J. (2017). Roles of regulatory T cells and IL-10 in virus-induced demyelination. J Neuroimmunol, 308, 6-11. PMID: 28065579.

Zhao, Y., Wang, C., Qiu, B., Li, C., Wang, H., Jin, H., Gai, W., Zheng, X., Wang, T., Sun, W., Yan, F., Gao, Y., Wang, Q., Yan, J., Chen, L., Perlman, S., Zhong, N., Zhao, J., Yang, S. & Xia, X. (2017). Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model. Antiviral Res, 137, 125-130. PMID: 27890674.

Fehr, A., Jankevicius, G., Ahel, I. & Perlman, S. (In Press). Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis. Trends Microbiol, in press.

Cui, J., Zhao, Y., Wang, H., Qiu, B., Cao, Z., Li, Q., Zhang, Y., Yan, F., Jin, H., Wang, T., Sun, W., Feng, N., Gao, Y., Sun, J., Wang, Y., Perlman, S., Zhao, J., Yang, S. & Xia, X. (2016). Equine Immunoglobulin and Equine Neutralizing F(ab')2 Protect Mice from West Nile Virus Infection. Viruses, 8(12), pii: E332. PMID: 27999340.

Tai, W., Wang, Y., Fett, C. A., Zhao, G., Li, F., Perlman, S., Jiang, S., Zhou, Y. & Du, L. (2016). Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants. J Virol, 91(1), pii: e01651-16. PMID: 27795425.

Fehr, A. R., Channappanavar, R., Jankevicius, G., Fett, C., Zhao, J., Athmer, J., Meyerholz, D. K., Ahel, I. & Perlman, S. (2016). The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. mBio, 7(6), pii: e01721-16. PMID: 27965448.

Du, L., Tai, W., Yang, Y., Zhao, G., Zhu, Q., Sun, S., Liu, C., Tao, X., Tseng, C. K., Perlman, S., Jiang, S., Zhou, Y. & Li, F. (2016). Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines. Nat Commun, 7, 13473. PMID: 27874853.

Park, J. E., Li, K., Barlan, A., Fehr, A. R., Perlman, S., McCray, Jr, P. B. & Gallagher, T. (2016). Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism. Proc Natl Acad Sci U S A, 113(43), 12262-12267. PMID: 27791014.

Zhao, J., Vijay, R., Zhao, J., Gale Jr, M., Diamond, M. S. & Perlman, S. (2016). MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis. J Virol, 90(16), 7098-108. PMID: 27226371.

Zhao, J., Zhao, J., Mangalam, A. K., Channappanavar, R., Fett, C., Meyerholz, D. K., Agnihothram, S., Baric, R. S., David, C. S. & Perlman, S. (2016). Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity, 44(6), 1379-91. PMID: 27287409.

Alshukairi, A. N., Khalid, I., Ahmed, W. A., Dada, A. M., Bayumi, D. T., Malic, L. S., Althawadi, S., Ignacio, K., Alsalmi, H. S., Al-Abdely, H. M., Wali, G. Y., Qushmaq, I. A., Alraddadi, B. M. & Perlman, S. (2016). Antibody Response and Disease Severity in Healthcare Worker MERS Survivors. Emerg Infect Dis, 22(6). PMID: 27192543.

Perlman, S., Vijay, R. (2016). Middle East respiratory syndrome vaccines. Int J Infect Dis, 47, 23-8. PMID: 27062985.

Bedell, K., Buchaklian, A. H. & Perlman, S. (2016). Efficacy of an Automated Multiple Emitter Whole-Room Ultraviolet-C Disinfection System Against Coronaviruses MHV and MERS-CoV. Infect Control Hosp Epidemiol, 37(5), 598-9. PMID: 26818469.

Zhang, N., Channappanavar, R., Ma, C., Wang, L., Tang, J., Garron, T., Tao, X., Tasneem, S., Lu, L., Tseng, C. T., Zhou, Y., Perlman, S., Jiang, S. & Du, L. (2016). Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus. Cell Mol Immunology, 13(2), 180-90. PMID: 25640653.

Li, K., Wohlford-Lenane, C., Perlman, S., Zhao, J., Jewell, A. K., Reznikov, L. R., Gibson-Corley, K. N., Meyerholz, D. K. & McCray Jr, P. B. (2016). Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. J Infect Dis, 213(5), 7122-22. PMID: 26486634.

Luke, T., Wu, H., Zhao, J., Channappanavar, R., Coleman, C. M., Jiao, J. A., Matsushita, H., Liu, Y., Postnikova, E. N., Ork, B. L., Glenn, G., Flyer, D., Defang, G., Raviprakash, K., Kochel, T., Wang, J., Nie, W., Smith, G., Hensley, L. E., Olinger, G. G., Kuhn, J. H., Holbrook, M. R., Johnson, R. F., Perlman, S., Sullivan, E. & Frieman, M. B. (2016). Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med, 8(326), 326ra21. PMID: 26888429.

Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K. & Perlman, S. (2016). Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe, 19(2), 181-93. PMID: 26867177.

Vijay, R., Perlman, S. (2016). Middle East respiratory syndrome and severe acute respiratory syndrome. Curr Opin Virol, 16, 70-6. PMID: 26855039.

Channappanavar, R., Lu, L., Xia, S., Du, L., Meyerholz, D. K., Perlman, S. & Jiang, S. (2015). Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection. J Infect Dis, 212(12), 1894-903. PMID: 26164863.

Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Zhang, B., Yuen, K. Y., Perlman, S., Gao, G. F. & Yan, J. (2015). A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Cell Res, 25(11), 1237-49. PMID: 26391698.

Jimenez-Guardeño, J. M., Regla-Nava, J. A., Nieto-Torres, J. L., DeDiego, M. L., Castaño-Rodriguez, C., Fernandez-Delgado, R., Perlman, S. & Enjuanes, L. (2015). Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine. PLoS Pathog, 11(10), e1005215. PMID: 26513244.

Vijay, R., Hua, X., Meyerholz, D. K., Miki, Y., Yamamoto, K., Gelb, M., Murakami, M. & Perlman, S. (2015). Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med, 212(11), 1851-68. PMID: 26392224.

Zumla, A., Hui, D. S. & Perlman, S. (2015). Middle East respiratory syndrome. Lancet, 386(9997), 995-1007. PMID: 26049252.

Corti, D., Zhao, J., Pedotti, M., Simonelli, L., Agnihothram, S., Fett, C., Fernandez-Rodriguez, B., Foglierini, M., Agatic, G., Vanzetta, F., Gopal, R., Langrish, C. J., Barrett, N. A., Sallusto, F., Baric, R. S., Varani, L., Zambon, M., Perlman, S. & Lanzavecchia, A. (2015). Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci U S A, 112(33), 10473-8. PMID: 26216974.

Perlman, S. (2015). Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. PLoS Pathog, 11(7), e1005023. PMID: 26172373.

Petersen, E., Hui, D. S., Perlman, S. & Zumla, A. (2015). Middle East Respiratory Syndrome - advancing the public health and research agenda on MERS - lessons from the South Korea outbreak. Int J Infect Dis, 36, 54-5. PMID: 26072036.

Hui, D. S., Perlman, S. & Zumla, A. (2015). Spread of MERS to South Korea and China. Lancet Respir Med, 3(7), 509-10. PMID: 26050550.

Zhao, J., Perera, R. A., Kayali, G., Meyerholz, D., Perlman, S. & Peiris, M. (2015). Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection. J Virol, 89(11), 6117-20. PMID: 25787284.

Mielech, A. M., Deng, X., Chen, Y., Kindler, E., Wheeler, D. L., Mesecar, A. D., Thiel, V., Perlman, S. & Baker, S. C. (2015). Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis. J Virol, 89(9), 4907-17. PMID: 25694594.

Regla-Nava, J. A., Nieto-Torres, J. L., Jimenez-Guardeño, J. M., Fernandez-Delgado, R., Fett, C., Castaño-Rodriguez, C., Perlman, S., Enjuanes, L. & DeDiego, M. L. (2015). Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates. J Virol, 89(7), 3870-87. PMID: 25609816.

Zumla, A., Perlman, S., McNabb, S. J., Shaikh, A., Heymann, D. L., McCloskey, B. & Hui, D. S. (2015). Middle East respiratory syndrome in the shadow of Ebola. Lancet Respir Med, 3(2), 100-2. PMID: 25592990.

Fehr, A. R., Athmer, J., Channappanavar, R., Phillips, J. M., Meyerholz, D. K. & Perlman, S. (2015). The NSP3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. J Virol, 89(3), 1523-36. PMID: 25428866.

Fehr, A. R., Perlman, S. (2015). Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol, 1282, 1-23. PMID: 25720466.

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. T., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W. (2014). The cellular redox environment alters antigen presentation. J Biol Chem, 289(40), 27979-91. PMID: 25135637.

Channappanavar, R., Fett, C., Zhao, J., Meyerholz, D. K. & Perlman, S. (2014). Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. J Virol, 88(19), 11034-44. PMID: 25056892.

Zhao, J., Zhao, J. & Perlman, S. (2014). Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages. PLoS Pathog, 10(8), e1004279. PMID: 25102154.

Channappanavar, R., Zhao, J. & Perlman, S. (2014). T cell-mediated immune response to respiratory coronaviruses. Immunol Res, 59(1-3), 118-28. PMID: 24845462.

Hemida, M., Perera, R., Al Jassim, R., Kayali, G., Siu, L., Wang, P., Chu, K., Perlman, S., Ali, M., Alnaeem, A., Guan, Y., Poon, L., Saif, L. & Peiris, M. (2014). Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Euro Surveill, 19(23), pii: 20828. PMID: 24957744.

Trujillo, J. A., Gras, S., Twist, K. A., Croft, N. P., Channappanavar, R., Rossjohn, J., Purcell, A. W. & Perlman, S. (2014). Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes. J Immunol, 192(11), 5245-56. PMID: 24795457.

Barlan, A., Zhao, J., Sarkar, M. K., Li, K., McCray, P. B., Perlman, S. & Gallagher, T. (2014). Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol, 88(9), 4953-61. PMID: 24554656.

Zhao, J., Li, K., Wohlford-Lenane, C., Agnihothram, S. S., Fett, C., Zhao, J., Gale, M. J., Baric, R. S., Enjuanes, L., Gallagher, T., McCray, P. B. & Perlman, S. (2014). Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A, 111(13), 4970-5. PMID: 24599590.

Lin, S. Y., Liu, C. L., Chang, Y. M., Zhao, J., Perlman, S. & Hou, M. H. (2014). Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target. J Med Chem, 57(6), 2247-57. PMID: 24564608.

McIntosh, K., Perlman, S. (2014). Coronaviridae.

DeDiego, M. L., Nieto-Torres, J. L., Regla-Nava, J. A., Jimenez-Guardeño, J. M., Fernandez-Delgado, R., Fett, C., Castaño-Rodriguez, C., Perlman, S. & Enjuanes, L. (2014). Inhibition of NF-?B-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival. J Virol, 88(2), 913-24. PMID: 24198408.

Zhao, J., Fett, C., Pewe, L., Zhao, J. & Perlman, S. (2013). Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor. J Immunol Methods, 396(1-2), 56-64. PMID: 23928495.

Perlman, S. (2013). The middle East respiratory syndrome--how worried should we be?. MBio, 4(4), e00531-13. PMID: 23963179.

Perlman, S., McCray, P. B. (2013). Person-to-person spread of the MERS coronavirus--an evolving picture. (Vols. 369). (5), pp. 466-7. N Engl J Med. PMID: 23902487.

de Groot, R. J., Baker, S. C., Baric, R. S., Brown, C. S., Drosten, C., Enjuanes, L., Fouchier, R. A., Galiano, M., Gorbalenya, A. E., Memish, Z. A., Perlman, S., Poon, L. L., Sinjder, E. J., Stephens, G. M., Woo, P. C., Zaki, A. M., Zambon, M. & Ziebuhr, J. (2013). Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. (Vols. 87). (14), pp. 7790-2. J Virol. PMID: 23678167.

Fett, C., DeDiego, M. L., Regla-Nava, J. A., Enjuanes, L. & Perlman, S. (2013). Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein. J Virol, 87(12), 6551-9. PMID: 23576515.

Chen, I. J., Yuann, J. M., Chang, Y. M., Lin, S. Y., Zhao, J., Perlman, S., Shen, Y. Y., Huang, T. H. & Hou, M. H. (2013). Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein. Biochim Biophys Acta, 1834(6), 1054-62. PMID: 23501675.

Gallagher, T., Perlman, S. (2013). Public health: Broad reception for coronavirus. (Vols. 495). (7440), pp. 176-7. Nature. PMID: 23486053.

Trujillo, J. A., Fleming, E. L. & Perlman, S. (2013). Transgenic CCL2 Expression in the Central Nervous System Results in a Dysregulated Immune Response and Enhanced Lethality after Coronavirus Infection. J Virol, 87(5), 2376-89. PMID: 23269787.

Perlman, S., Zhao, J. (2013). Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus. (Vols. 4). (1), pp. e00002-13. MBio. PMID: 23322635.

Masters, P., Perlman, S. (2013). Coronaviridae. In D. M. Knipe (Eds.) Fields Virology. pp. 825-58.

Zhao, J., Wohlford-Lenane, C., Zhao, J., Fleming, E., Lane, T. E., McCray, P. B. & Perlman, S. (2012). Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol, 86(21), 11416-24. PMID: 22915814.

Zhao, J., Zhao, J. & Perlman, S. (2012). Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-?, IL-2 and IL-2R. PLoS One, 7(9), e46241. PMID: 23029447.

Zhao, J., Zhao, J., Legge, K. & Perlman, S. (2011). Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest, 121(12), 4921-30. PMID: 22105170.

DeDiego, M. L., Nieto-Torres, J. L., Jiménez-Guardeño, J. M., Regla-Nava, J. A., Alvarez, E., Oliveros, J. C., Zhao, J., Fett, C., Perlman, S. & Enjuanes, L. (2011). Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. PLoS Pathog, 7(10), e1002315. PMID: 22028656.

Zhao, J., Zhao, J., Fett, C., Trandem, K., Fleming, E. & Perlman, S. (2011). IFN-?- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med, 208(8), 1571-7. PMID: 21746812.

Trandem, K., Jin, Q., Weiss, K. A., James, B. R., Zhao, J. & Perlman, S. (2011). Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice. J Virol, 85(14), 6822-31. PMID: 21593179.

Trandem, K., Zhao, J., Fleming, E. & Perlman, S. (2011). Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol, 186(6), 3642-52. PMID: 21317392.

Shulla, A., Heald-Sargent, T., Subramanya, G., Zhao, J., Perlman, S. & Gallagher, T. (2011). A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. J Virol, 85(2), 873-82. PMID: 21068237.

de Groot, R. J., Baker, S. C., Baric, R., Enjuanes, L., Gorbalenya, A. E., Holmes, K. V., Perlman, S., Poon, L., Rottier, P. J., Talbot, P. J., Woo, P. C. & Ziebuhr, J. (2011). Coronaviridae. In A. M. King , M. J. Adams , E. B. Carstens , E. J. Lefkowitz (Eds.) Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. pp. 774-96. Elsevier Academic Press, San Diego.

Zhou, H., Zhao, J. & Perlman, S. (2010). Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection. MBio, 1(4), e00219-10. PMID: 20978536.

Zhao, J., Zhao, J. & Perlman, S. (2010). T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J Virol, 84(18), 9318-25. PMID: 20610717.

Trandem, K., Anghelina, D., Zhao, J. & Perlman, S. (2010). Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol, 184(8), 4391-400. PMID: 20208000.

Zhou, H., Ferraro, D., Zhao, J., Hussain, S., Shao, J., Trujillo, J., Netland, J., Gallagher, T. & Perlman, S. (2010). The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication. J Virol, 84(7), 3542-51. PMID: 20106914.

Netland, J., DeDiego, M. L., Zhao, J., Fett, C., Alvarez, E., Nieto-Torres, J. L., Enjuanes, L. & Perlman, S. (2010). Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease. Virology, 399(1), 120-8. PMID: 20110095.

Wohlford-Lenane, C. L., Meyerholz, D., Perlman, S., Zhou, H., Tran, D., Selsted, M. E. & McCray, P. (2009). Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol, 83(21), 11385-90. PMID: 19710146.

Zhao, J., Zhao, J. & Perlman, S. (2009). De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J Immunol, 183(8), 5163-70. PMID: 19786545.

Zhao, J., Zhao, J., Van Rooijen, N. & Perlman, S. (2009). Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog, 5(10), e1000636. PMID: 19851468.

Perlman, S., Netland, J. (2009). Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol, 7(6), 439-50. PMID: 19430490.

Enquist, L. W., Editors of the Journal of Virology, & Perlman, S. (2009). Virology in the 21st century. J Virol, 83(11), 5296-308. PMID: 19297504.

Anghelina, D., Zhao, J., Trandem, K. & Perlman, S. (2009). Role of regulatory T cells in coronavirus-induced acute encephalitis. Virology, 385(2), 358-67. PMID: 19141357.

Zhao, J., Falcón, A., Zhou, H., Netland, J., Enjuanes, L., Pérez Breña, P. & Perlman, S. (2009). Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication. J Virol, 83(5), 2368-73. PMID: 19091867.

Whitman, L., Zhou, H., Perlman, S. & Lane, T. E. (2009). IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells. Virology, 384(1), 209-15. PMID: 19059617.

McIntosh, K., Perlman, S. (2009). Coronaviridae.

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. PLoS Pathog, 4(10), e1000186. PMID: 18949029.

Netland, J., Meyerholz, D., Moore, S., Cassell, M. & Perlman, S. (2008). Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol, 82(15), 7264-75. PMID: 18495771.

Dediego, M. L., Pewe, L., Alvarez, E., Rejas, M. T., Perlman, S. & Enjuanes, L. (2008). Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice. Virology, 376(2), 379-89. PMID: 18452964.

Hussain, S., Perlman, S. & Gallagher, T. M. (2008). Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. J Virol, 82(14), 7212-22. PMID: 18448520.

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol, 180(6), 3926-37. PMID: 18322201.

Templeton, S. P., Perlman, S. (2008). Role of IFN-gamma responsiveness in CD8 T-cell-mediated viral clearance and demyelination in coronavirus-infected mice. J Neuroimmunol, 194(1-2), 18-26. PMID: 18082272.

Templeton, S. P., Kim, T. S., O'Malley, K. & Perlman, S. (2008). Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus. Brain Pathol, 18(1), 40-51. PMID: 17935605.

Perlman, S. (2008). Nidoviruses. S. Perlman , T. Gallagher , E. Snijder (Eds.) ASM Press, Washington, DC.

Nicholls, J., Peiris, M. & Perlman, S. (2008). Severe Acute Respiratory Syndrome: Epidemiology, pathogenesis and animal models. In S. Perlman , T. Gallagher & E. J. Snijder (Eds.) Nidoviruses. ASM Press, Washington, DC.

Butler, N. S., Dandekar, A. A. & Perlman, S. (2007). Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus. J Virol, 81(24), 13291-8. PMID: 17913802.

Bonthius, D., Perlman, S. (2007). Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. PLoS Pathog, 3(11), e149. PMID: 18052527.

Netland, J., Ferraro, D., Pewe, L., Olivares, H., Gallagher, T. & Perlman, S. (2007). Enhancement of murine coronavirus replication by severe acute respiratory syndrome coronavirus protein 6 requires the N-terminal hydrophobic region but not C-terminal sorting motifs. J Virol, 81(20), 11520-5. PMID: 17670827.

Tangudu, C., Olivares, H., Netland, J., Perlman, S. & Gallagher, T. (2007). Severe acute respiratory syndrome coronavirus protein 6 accelerates murine coronavirus infections. J Virol, 81(3), 1220-9. PMID: 17108045.

Lai, M. M., Perlman, S. & Anderson, L. J. (2007). Chapter 36. Coronaviridae.

McCray, P., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., Meyerholz, D., Kirby, P. A., Look, D. C. & Perlman, S. (2007). Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol, 81(2), 813-21. PMID: 17079315.

Zhou, H., Perlman, S. (2007). Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA. J Virol, 81(2), 568-74. PMID: 17079305.

Templeton, S. P., Perlman, S. (2007). Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM. Immunol Res, 39(1-3), 160-72. PMID: 17917063.

Kedzierska, K., Day, E. B., Pi, J., Heard, S. B., Doherty, T. C., Turner, S. J. & Perlman, S. (2006). Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J Immunol, 177(10), 6705-12. PMID: 17082583.

Anghelina, D., Pewe, L. & Perlman, S. (2006). Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis. Am J Pathol, 169(1), 209-22. PMID: 16816374.

Butler, N., Pewe, L., Trandem, K. & Perlman, S. (2006). Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology, 347(2), 410-21. PMID: 16413043.

Zhou, H., Perlman, S. (2006). Preferential infection of mature dendritic cells by mouse hepatitis virus strain JHM. J Virol, 80(5), 2506-14. PMID: 16474157.

Pewe, L., Zhou, H., Netland, J., Tangadu, C., Olivares, H., Shi, L., Look, D. C., Gallagher, T. & Perlman, S. (2006). A SARS-CoV-specific protein enhances virulence of an attenuated strain of mouse hepatitis virus. Adv Exp Med Biol, 581, 493-8. PMID: 17037583.

Butler, N., Pewe, L., Trandem, K. & Perlman, S. (2006). HCoV-OC43-induced encephalitis is in part immune-mediated. Adv Exp Med Biol, 581, 531-4. PMID: 17037592.

Jia, H. P., Look, D. C., Hickey, M., Shi, L., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S. & McCray, P. (2006). Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. Adv Exp Med Biol, 581, 479-84. PMID: 17037581.

Zhou, H., Perlman, S. (2006). Preferential infection of mature dendritic cells by the JHM strain of mouse hepatitis virus. Adv Exp Med Biol, 581, 411-4. PMID: 17037570.

Dandekar, A., Perlman, S. (2006). Severe Acute Respiratory Syndrome (SARS). In Encyclopedia of Life Sciences. Nature Publishing Group, London.

Perlman, S. (2006). The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases. In S. Perlman , K. V. Holmes (Eds.) Advances in Experimental Medicine and Biology. (Vols. 581). Springer, New York.

Jia, H. P., LOOK, D. C., Shi, L., Hickey, M., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S. & McCray, P. (2005). ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol, 79(23), 14614-21. PMID: 16282461.

Perlman, S., Dandekar, A. A. (2005). Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol, 5(12), 917-27. PMID: 16322745.

Pewe, L., Zhou, H., Netland, J., Tangudu, C., Olivares, H., Shi, L., Look, D. C., Gallagher, T. & Perlman, S. (2005). A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol, 79(17), 11335-42. PMID: 16103185.

Dandekar, A. A., O'Malley, K. & Perlman, S. (2005). Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol, 79(15), 9388-96. PMID: 16014902.

Kim, T. S., Perlman, S. (2005). Viral expression of CCL2 is sufficient to induce demyelination in RAG1-/- mice infected with a neurotropic coronavirus. J Virol, 79(11), 7113-20. PMID: 15890951.

Kim, T. S., Perlman, S. (2005). Virus-specific antibody, in the absence of T cells, mediates demyelination in mice infected with a neurotropic coronavirus. Am J Pathol, 166(3), 801-9. PMID: 15743792.

Butler, N., Pewe, L. & Perlman, S. (2005). A murine model of human coronavirus infection. Xth International Nidovirus Symposium, Colorado Springs, CO.

Pewe, L., Zhou, H., Netland, J., Tangadu, C., Shi, L., Look, D., Gallagher, T. & Perlman, S. (2005). A SARS-CoV-specific protein enhances virulence of an attenuated murine coronavirus. Xth International Nidovirus Symposium, Colorado Springs, CO.

Dandekar, A., Perlman, S. (2005). Axons and neurons in coronavirus-induced demyelination. In E. Lavi , C. S. Constantinescu (Eds.) Experimental Models of Multiple Sclerosis. pp. 737-45. Springer.

Zhou, H., Perlman, S. (2005). In vitro and in vivo infection of dendritic cells by mouse hepatitis virus strain JHM. Xth International Nidovirus Symposium, Colorado Springs, CO.

Kim, T., Perlman, S. (2005). The role of T cell epitopes in coronavirus infection. In E. Lavi , C. S. Constantinescu (Eds.) Experimental Models of Multiple Sclerosis. pp. 771-9. Springer.

Bergmann, C., Perlman, S. & Stohlman, S. (2005). The role of T cells in coronavirus induced demyelination. In E. Lavi , C. S. Constantinescu (Eds.) Experimental Models of Multiple Sclerosis. pp. 747-57. Springer.

Pewe, L. L., Netland, J. M., Heard, S. B. & Perlman, S. (2004). Very diverse CD8 T cell clonotypic responses after virus infections. J Immunol, 172(5), 3151-6. PMID: 14978121.

Dandekar, A. A., Anghelina, D. & Perlman, S. (2004). Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am J Pathol, 164(2), 363-9. PMID: 14742242.

Dandekar, A., Anghelina, D. & Perlman, S. (2004). Interferon-g mediated bystander demyelination in a coronavirus model of multiple sclerosis. (Vols. 18). pp. A457 (335.4). FASEB J.

Kim, T., Perlman, S. (2004). Interplay of complement and Fc receptors in antibody-induced demyelinating disease in mice infected with a neurotropic coronavirus. (Vols. 18). pp. A1163 (778.3). FASEB J.

Dandekar, A. A., Jacobsen, G., Waldschmidt, T. J. & Perlman, S. (2003). Antibody-mediated protection against cytotoxic T-cell escape in coronavirus-induced demyelination. J Virol, 77(22), 11867-74. PMID: 14581523.

Ontiveros, E., Kim, T. S., Gallagher, T. M. & Perlman, S. (2003). Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein. J Virol, 77(19), 10260-9. PMID: 12970410.

Kim, T. S., Perlman, S. (2003). Protection against CTL escape and clinical disease in a murine model of virus persistence. J Immunol, 171(4), 2006-13. PMID: 12902505.

Haring, J. S., Perlman, S. (2003). Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus. J Neuroimmunol, 137(1-2), 42-50. PMID: 12667646.

Dandekar, A., Jacobsen, G., Waldschmidt, T. & Perlman, S. (2003). Antibody suppression of CTL escape in mice chronically infected with mouse hepatitis virus, strain JHM. IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.

Ontiveros, E., Kim, T., Gallagher, T. & Perlman, S. (2003). Enhanced neurovirulence mediated by mouse hepatitis virus-JHM is associated with a S310G change in the spike glycoprotein. IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.

Kim, T., Perlman, S. (2003). Selection of CTL escape variants in mice infected with recombinant MHV. IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.

Dandekar, A. A., Perlman, S. (2002). Virus-induced demyelination in nude mice is mediated by gamma delta T cells. Am J Pathol, 161(4), 1255-63. PMID: 12368199.

Haring, J. S., Pewe, L. L. & Perlman, S. (2002). Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system. J Immunol, 169(3), 1550-5. PMID: 12133983.

Pewe, L., Haring, J. & Perlman, S. (2002). CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus. J Virol, 76(14), 7329-33. PMID: 12072531.

Pewe, L., Perlman, S. (2002). Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus. J Immunol, 168(4), 1547-51. PMID: 11823480.

Dandekar, A., Perlman, S. (2002). Demyelination is mediated by gamma-delta T cells in mice infected with a neurotropic coronavirus. 4th International Symposium of NeuroVirology, Dusseldorf, Germany.

Ontiveros, E., Kuo, L., Masters, P. S. & Perlman, S. (2001). Inactivation of expression of gene 4 of mouse hepatitis virus strain JHM does not affect virulence in the murine CNS. Virology, 289(2), 230-8. PMID: 11689046.

Haring, J., Perlman, S. (2001). Mouse hepatitis virus. Curr Opin Microbiol, 4(4), 462-6. PMID: 11495812.

Dandekar, A. A., Wu, G. F., Pewe, L. & Perlman, S. (2001). Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus. J Virol, 75(13), 6115-20. PMID: 11390613.

Haring, J. S., Pewe, L. L. & Perlman, S. (2001). High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice. J Virol, 75(6), 3043-7. PMID: 11222733.

Kolb, A. F., Pewe, L., Webster, J., Perlman, S., Whitelaw, C. B. & Siddell, S. G. (2001). Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis. J Virol, 75(6), 2803-9. PMID: 11222704.

Ontiveros, E., Kuo, L., Masters, P. & Perlman, S. (2001). Analysis of MHV-JHM gene 4 KO and CD4 T cell epitope escape recombinants. 20th Ann Meeting of the Amer Soc Virol, Madison, WI.

Ontiveros, E., Kuo, L., Masters, P. & Perlman, S. (2001). Analysis of nonessential gene function in recombinant MHV-JHM. Coronavirus meeting, Pennsylvania.

Ontiveros, E., Kuo, L., Masters, P. & Perlman, S. (2001). Analysis of nonessential gene function in recombinant MHV-JHM. Gene 4 knockout recombinant virus. Adv Exp Med Biol, 494, 83-9. PMID: 11774550.

Haring, J., Pewe, L. & Perlman, S. (2001). Characterization of the CD4 T cell response following CNS infection with MHV-JHM. 20th Ann Meeting of the Amer Soc Virol, Madison, WI.

Perlman, S., Pewe, L. (2001). Demyelination in RAG1 KO mice infected with mouse hepatitis virus. (Vols. 118). pp. 8. J Neuroimmunol.

Perlman, S., Wu, G. F. (2001). Selection of and evasion from cytotoxic T cell responses in the central nervous system. Adv Virus Res, 56, 219-42. PMID: 11450301.

Dandekar, A., Wu, G., Pewe, L. & Perlman, S. (2001). T cell mediated axonal damage in a coronavirus-induced demyelinating disease. 20th Ann Meeting of the Amer Soc Virol, Madison, WI.

Wu, G. F., Dandekar, A. A., Pewe, L. & Perlman, S. (2001). The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination. Adv Exp Med Biol, 494, 341-7. PMID: 11774490.

Wu, G., Dandekar, A., Pewe, L. & Perlman, S. (2001). The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination. Coronavirus meeting, Pennsylvania.

Wang, G., Deering, C., Macke, M., Shao, J., Burns, R., Blau, D. M., Holmes, K. V., Davidson, B. L., Perlman, S. & McCray, P. (2000). Human coronavirus 229E infects polarized airway epithelia from the apical surface. J Virol, 74(19), 9234-9. PMID: 10982370.

Wu, G. F., Dandekar, A. A., Pewe, L. & Perlman, S. (2000). CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J Immunol, 165(4), 2278-86. PMID: 10925317.

Wu, G. F., Pewe, L. & Perlman, S. (2000). Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase. J Virol, 74(16), 7683-6. PMID: 10906226.

Pewe, L., Heard, S. B., Bergmann, C., Dailey, M. O. & Perlman, S. (1999). Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system. J Immunol, 163(11), 6106-13. PMID: 10570300.

Rakasz, E., Mueller, A., Perlman, S. & Lynch, R. G. (1999). Gammadelta T cell response induced by vaginal Herpes simplex 2 infection. Immunol Lett, 70(2), 89-93. PMID: 10569697.

Wu, G. F., Perlman, S. (1999). Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus. J Virol, 73(10), 8771-80. PMID: 10482631.

Xue, S., Sun, N., Van Rooijen, N. & Perlman, S. (1999). Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus. J Virol, 73(8), 6327-34. PMID: 10400724.

Pewe, L., Perlman, S. (1999). Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice. Virology, 255(1), 106-16. PMID: 10049826.

Perlman, S., Lane, T. L. & Buchmeier, M. J. (1999). Coronaviruses: Hepatitis, Peritonitis and Central Nervous System Disease. In M. Cunningham , R. S. Fujinami (Eds.) Effects of Microbes on the Immune System. pp. 331-48. Lippincott-Raven.

Perlman, S., Pewe, L. (1999). CTL escape mutants are selected in the presence of a polyclonal T cells response in MHV-infected mice: Demonstration with MHC classI/peptide tetramers. 18th Annual Meeting of the Amer Soc Virol, Amherst, MA.

Wu, G., Perlman, S. (1999). Immune-mediated mechanisms of demyelination following MHV-JHM infection of the murine CNS. 18th Annual Meeting of the Amer Soc Virol, Amherst, MA.

Stohlman, S. A., Bergmann, C. C. & Perlman, S. (1999). Persistent infection by mouse hepatitis virus. In R. Ahmed , I. Chen (Eds.) Persistent Viral Infections. pp. 537-57. John Wiley & Sons.

Pewe, L., Xue, S. & Perlman, S. (1998). Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus. J Virol, 72(7), 5912-8. PMID: 9621053.

LaBrecque, F. D., LaBrecque, D. R., Klinzman, D., Perlman, S., Cederna, J. B., Winokur, P. L., Han, J. Q. & Stapleton, J. T. (1998). Recombinant hepatitis A virus antigen: improved production and utility in diagnostic immunoassays. J Clin Microbiol, 36(7), 2014-8. PMID: 9650953.

Wu, G., Perlman, S. (1998). Apoptosis in MHV-infected mice. International Meeting for Neuroimmunology, Montreal, Canada.

Perlman, S., Pewe, L. (1998). CTL escape mutants cause increased mortality and morbidity in mice infected with mouse hepatitis virus, strain JHM. Keystone Symposium: Molecular Aspects of Viral Immunity, Tamarron, CO.

Perlman, S. (1998). Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects. Adv Exp Med Biol, 440, 503-13. PMID: 9782322.

Xue, S., Pewe, L. & Perlman, S. (1998). Recognition of additional CTL epitopes and TCR usage in mice infected MHV CTL escape mutants. 17th Meeting of Amer Soc Virol, Vancouver, BC.

Perlman, S., Pewe, L. (1998). Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM. Adv Exp Med Biol, 440, 515-9. PMID: 9782323.

Xue, S., Perlman, S. (1997). Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus. Virology, 238(1), 68-78. PMID: 9375010.

Pewe, L., Xue, S. & Perlman, S. (1997). Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus. J Virol, 71(10), 7640-7. PMID: 9311846.

Grzybicki, D. M., Kwack, K. B., Perlman, S. & Murphy, S. P. (1997). Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection. J Neuroimmunol, 73(1-2), 15-27. PMID: 9058755.

Xue, S., Perlman, S. (1997). Recognition of M and S proteins by CD4 T cells in the CNS of mice infected with mouse hepatitis virus. 16th Ann Meeting of the Amer Soc Virol, Bozeman, MT.

Pewe, L., Wu, G. F., Barnett, E. M., Castro, R. F. & Perlman, S. (1996). Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity, 5(3), 253-62. PMID: 8808680.

Sun, N., Cassell, M. D. & Perlman, S. (1996). Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system. J Virol, 70(8), 5405-13. PMID: 8764051.

Castro, R. F., Perlman, S. (1996). Differential antigen recognition by T cells from the spleen and central nervous system of coronavirus-infected mice. Virology, 222(1), 247-51. PMID: 8806504.

Perlman, S., Pewe, L. (1996). A high rate of mutation in the dominant CD8+ T cell epitope occurs during the course of the persistent CNS infection caused by mouse hepatitis virus. Abstr 15th Annu Meet Am Soc Virol.

Xue, S., Perlman, S. (1996). Identification of CD4+ T cell epitopes within the S glycoprotein of mouse hepatitis virus. Abstr 15th Annu Meet Am Soc Virol, London, Ontario.

Castro, R. F., Perlman, S. (1995). CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J Virol, 69(12), 8127-31. PMID: 7494335.

Sun, N., Grzybicki, D., Castro, R. F., Murphy, S. & Perlman, S. (1995). Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virology, 213(2), 482-93. PMID: 7491773.

Barnett, E. M., Evans, G. D., Sun, N., Perlman, S. & Cassell, M. D. (1995). Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1. J Neurosci, 15(4), 2972-84. PMID: 7536824.

Xue, S., Jaszewski, A. & Perlman, S. (1995). Identification of a CD4+ T cell epitope within the M protein of a neurotropic coronavirus. Virology, 208(1), 173-9. PMID: 11831697.

Sun, N., Perlman, S. (1995). Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes. J Virol, 69(2), 633-41. PMID: 7815526.

Loihl, A., Grzybicki, D., Kardos, S., Perlman, S. & Murphy, S. (1995). Expression of nitric oxide synthase Type II in the CNS during acute and persistent hepatitis virus infection. Society for Neuroscience.

Castro, R. F., Perlman, S. (1995). Identification of CTL epitopes within the surface (S) glycoprotein of a mouse neurotropic coronavirus and their possible role in viral demyelinating disease. (Vols. Supple). pp. 306, abstr J2-245. J Cell Biochem.

Smith, E. M., Johnson, S. R., Cripe, T., Perlman, S., McGuinness, G., Jiang, D., Cripe, L. & Turek, L. P. (1995). Perinatal transmission and maternal risks of human papillomavirus infection. Cancer Detect Prev, 19(2), 196-205. PMID: 7750107.

Perlman, S., Castro, R. F. & Sun, N. (1995). Role of astrocytes and cytotoxic T cells in mice with chronic demyelination caused by MHV-JHM. Abstr 14th Annu Meet Am Soc Virol.

Perlman, S., Sun, N. & Barnett, E. M. (1995). Spread of MHV-JHM from nasal cavity to white matter of spinal cord. Transneuronal movement and involvement of astrocytes. Adv Exp Med Biol, 380, 73-8. PMID: 8830549.

Pettit, D. L., Perlman, S. & Malinow, R. (1994). Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Science, 266(5192), 1881-5. PMID: 7997883.

Chung, S., Gorczynski, R., Cruz, B., Fingerote, R., Skamene, E., Perlman, S., Leibowitz, J., Fung, L., Flowers, M. & Levy, G. (1994). A Th1 cell line (3E9.1) from resistant A/J mice inhibits induction of macrophage procoagulant activity in vitro and protects against MHV-3 mortality in vivo. Immunology, 83(3), 353-61. PMID: 7835959.

Castro, R. F., Evans, G. D., Jaszewski, A. & Perlman, S. (1994). Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology, 200(2), 733-43. PMID: 8178457.

Barnett, E. M., Jacobsen, G., Evans, G., Cassell, M. & Perlman, S. (1994). Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation. J Infect Dis, 169(4), 782-6. PMID: 8133092.

Barnett, E. M., Evans, G. D., Cassell, M. D. & Perlman, S. (1994). Anterograde viral tracing of trigeminal pain pathways from the tooth pulp to cortex using herpes simplex virus. (Vols. 35). (4), pp. 378A. Pediatr Res.

Evans, G. D., Barnett, E. M., Jacobsen, G. L., Cassell, M. & Perlman, S. (1994). Trigeminal herpes infection via murine pulp models human herpetic encephalitis. (Vols. 73). (IADR Abstracts), pp. 299. J Dent Res.

Barnett, E. M., Cassell, M. D. & Perlman, S. (1993). Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb. Neuroscience, 57(4), 1007-25. PMID: 8309541.

Barnett, E. M., Perlman, S. (1993). The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM. Virology, 194(1), 185-91. PMID: 8386871.

Barnett, E. M., Evans, G. D., Cassell, M. D. & Perlman, S. (1993). Anterograde transneuronal spread of herpes simplex virus from the murine pulp to two cortical areas associated with jaw movement. (Vols. 19). (2), pp. 1210. Society for Neuroscience Abstracts.

Gallagher, T. M., Buchmeier, M. J. & Perlman, S. (1993). Dissemination of MHV4 (strain JHM) infection does not require specific coronavirus receptors. Adv Exp Med Biol, 342, 279-84. PMID: 8209743.

Barnett, E. M., Perlman, S. (1993). Herpes simplex encephalitis resulting from trigeminal infection via the toot pulp in Balb/c mice. American Society for Virology.

Jacobsen, G., Barnett, E. M., Evans, G., Walton, R. & Perlman, S. (1993). Herpes spread from pulp into CNS extensions of trigenimal nerve. International and American Association for Dental Research.

Oleszak, E. L., Perlman, S., Parr, R., Collisson, E. W. & Leibowitz, J. L. (1993). Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor. Adv Exp Med Biol, 342, 183-8. PMID: 8209728.

Perlman, S., Barnett, E. & Jacobsen, G. (1993). Mouse hepatitis virus and herpes simplex virus move along different CNS pathways. Adv Exp Med Biol, 342, 313-8. PMID: 7516106.

Pettit, D. L., Perlman, S. & Malinow, R. (1993). Postsynaptic expression of constitutively active CaMKII occludes LTP in the hippocampal slice. (Vols. 19). pp. 703.1. Neuroscience Abstracts.

Castro, R. F., Perlman, S. (1993). Primary cytotoxic T lymphocyte activity in mice infected with mouse hepatitis virus strain JHM. pp. A75, abstr 32-8. Abstr 12th Annu Meet Am Soci Virol.

Chung, S., Li, C., Fung, L. S., Crow, A., Gorczynski, R., Cole, E., Perlman, S., Leibowitz, J. & Levy, G. (1993). Role of macrophage procoagulant activity in mouse hepatitis virus (MHV) infection: studies using T cell MHV-3 clones and monoclonal antibody 3D4.3. Adv Exp Med Biol, 342, 377-84. PMID: 8209757.

Gallagher, T. M., Buchmeier, M. J. & Perlman, S. (1992). Cell receptor-independent infection by a neurotropic murine coronavirus. Virology, 191(1), 517-22. PMID: 1413526.

Denison, M. R., Zoltick, P. W., Hughes, S. A., Giangreco, B., Olson, A. L., Perlman, S., Leibowitz, J. L. & Weiss, S. R. (1992). Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology, 189(1), 274-84. PMID: 1318604.

Mobley, J., Evans, G., Dailey, M. O. & Perlman, S. (1992). Immune response to a murine coronavirus: identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins. Virology, 187(2), 443-52. PMID: 1347668.

Page, W. V., Perlman, S., Smith, F. G., Segar, J. L. & Robillard, J. E. (1992). Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. Am J Physiol, 262(3 Pt 2), R459-63. PMID: 1373041.

Jacobsen, G. L., Perlman, S., Evans, G. D., Barnett, E. M. & Walton, R. E. (1992). Herpes spread from pulp to CNS via inferior alveolar nerve. International Association for Dental Research.

Barnett, E., Perlman, S. (1992). MHV and HSV-1 move along different olfactory pathways after intranasal inoculation. American Society for Virology.

Barnett, E., Perlman, S. (1992). MHV and HSV-1 move along different olfactory pathways after intranasal inoculation. Fifth International Coronavirus Symposium, Chantilly, France.

Oleszak, E. L., Perlman, S. & Leibowitz, J. L. (1992). MHV S peplomer protein expressed by a recombinant vaccinia virus vector exhibits IgG Fc-receptor activity. Virology, 186(1), 122-32. PMID: 1309271.

Gallagher, T., Buchmeier, M. & Perlman, S. (1992). Receptor-independent spread of a neurotropic coronavirus infection. Fifth International Coronavirus Symposium, Chantilly, France.

Chao, C., Perlman, S. & Dailey, M. O. (1992). Regulation of gp90MEL-14 (LECAM-1) mRNA by activated T cells. (Vols. 6). pp. 1142. FASEB J.

Robillard, J. E., Page, W. V., Smith, F. G., Segar, J. L. & Perlman, S. (1992). Renal nerves increase renin gene expression and renin secretion at birth. Ninth Congress of the International Pediatric Nephrology Association, Jerusalem, Israel.

Robillard, J. E., Page, W. V., Smith, F. G., Segar, J. L. & Perlman, S. (1992). Renal nerves increase renin gene expression and renin secretion at birth. (Vols. 31). (4, Part 2) Pediatr Res.

Olson, A. L., Robillard, J. E., Kisker, C. T., Smith, B. A. & Perlman, S. (1991). Negative regulation of angiotensinogen gene expression by glucocorticoids in fetal sheep liver. Pediatr Res, 30(3), 256-60. PMID: 1945565.

Oleszak, E. L., Perlman, S. & Leibowitz, J. L. (1991). Molecular mimicry between Fc gamma receptor and mouse hepatitis virus (MHV) S peplomer protein. FASEB.

Kisker, C. T., Bohlken, D., Perlman, S., Olson, A. L., Robillard, J. E. & Clarke, W. (1991). Regulatory mechanisms controlling prothrombin and the development of blood coagulation factors during gestation.

Barnett, E. M., Cassell, M. & Perlman, S. (1991). Tracing olfactory pathways in the mouse with a coronavirus. (Vols. 17). (2), pp. 1511. Society for Neuroscience.

Perlman, S., Evans, G. & Afifi, A. (1990). Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. J Exp Med, 172(4), 1127-32. PMID: 1698910.

Olson, A. L., Perlman, S. & Robillard, J. E. (1990). Developmental regulation of angiotensinogen gene expression in sheep. Pediatr Res, 28(3), 183-5. PMID: 2235111.

Bale Jr, J. F., O'Neil, M. E., Lyon, B. & Perlman, S. (1990). The pathogenesis of murine cytomegalovirus ocular infection. Anterior chamber inoculation. Invest Ophthalmol Vis Sci, 31(8), 1575-81. PMID: 2167300.

Perlman, S., Jacobsen, G., Olson, A. L. & Afifi, A. (1990). Identification of the spinal cord as a major site of persistence during chronic infection with a murine coronavirus. Virology, 175(2), 418-26. PMID: 2158180.

Olson, A. L., Perlman, S. & Robillard, J. E. (1990). Development regulation of angiotensinogen (Ao) gene expression in sheep. (Vols. 27). (4, Part 2), pp. 235A. Pediatr Res.

Robillard, J. E., Kirby, R. F., Page, W. V., Olson, A. L. & Perlman, S. (1990). Effect of dietary salt manipulation on kidney renin gene expression in artificially-reared newborn WKY rats. (Vols. 1). (4), pp. 425. JASN.

Robillard, J. E., Kirby, R. F., Page, W. V., Olson, A. L. & Perlman, S. (1990). Effect of dietary salt manipulation on kidney renin gene expression in artificially-reared newborn WKY rats. (Vols. 27). (4, Part 2), pp. 337A. Pediatr Res.

Jacobsen, G., Perlman, S. (1990). Localization of virus and antibody response in mice infected persistently with MHV-JHM. Adv Exp Med Biol, 276, 573-8. PMID: 1966451.

Van Dyke, D. C., Alexander, R. C., Perlman, S., Smith, W. J. & Dekowski, S. A. (1989). Fusiform bacterial sepsis. Metastases with osteomyelitis and hepatic abscess occurring in a chaotic family. Clin Pediatr (Phila), 28(9), 423-5. PMID: 2766646.

Perlman, S., Jacobsen, G. & Afifi, A. (1989). Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves. Virology, 170(2), 556-60. PMID: 2543129.

Olson, A. L., Perlman, S. & Kisker, C. T. (1989). Cortisol-stimulated prothrombin gene expression during gestation. (Vols. 74). pp. 290a. Blood.

Jacobsen, G., Perlman, S. (1989). Localization of virus in mice infected persistently with MHV-JHM. Fourth International Coronavirus Symposium, Cambridge, England.

Olson, A. L., Perlman, S. & Kisker, C. T. (1989). Prothrombin gene transcription rate during gestation: Fetal lamb model. (Vols. 25). (4), pp. 271A. Pediatr Res.

Kisker, C. T., Olson, A. L. & Perlman, S. (1989). Prothrombin gene transcription rate during gestation: Fetal lamb model. (Vols. 62). pp. 300. Thromb Haemost.

Kisker, C. T., Perlman, S., Bohlken, D. & Wicklund, B. (1988). Measurement of prothrombin mRNA during gestation and early neonatal development. J Lab Clin Med, 112(4), 407-12. PMID: 2459278.

Perlman, S., Jacobsen, G. & Moore, S. (1988). Regional localization of virus in the central nervous system of mice persistently infected with murine coronavirus JHM. Virology, 166(2), 328-38. PMID: 2845647.

Denison, M., Perlman, S. & Andersen, R. D. (1988). Misidentification of Neisseria species in a neonate with conjunctivitis. Pediatrics, 81(6), 877-8. PMID: 3285316.

Leibowitz, J. L., Perlman, S., Weinstock, G., DeVries, J. R., Budzilowicz, C., Weissemann, J. M. & Weiss, S. R. (1988). Detection of a murine coronavirus nonstructural protein encoded in a downstream open reading frame. Virology, 164(1), 156-64. PMID: 2834866.

Kisker, C. T., Perlman, S., Bohlken, D. P. & Wicklund, B. (1988). Prothrombin messenger RNA during fetal and neonatal development. APS/SBR.

Kisker, C. T., Perlman, S., Bohlken, D. P. & Wicklund, B. (1988). Prothrombin messenger RNA during fetal and neonatal development. (Vols. 23). (4) Pediatr Res.

Perlman, S., Ries, D. (1987). The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM. Microb Pathog, 3(4), 309-14. PMID: 2849022.

Denison, M., Perlman, S. (1987). Identification of putative polymerase gene product in cells infected with murine coronavirus A59. Virology, 157(2), 565-8. PMID: 3029990.

Perlman, S., Schelper, R., Bolger, E. & Ries, D. (1987). Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody. Microb Pathog, 2(3), 185-94. PMID: 2853274.

Bale jr, J. F., O'Neil, M. E., Giller, R., Perlman, S. & Koszinowski, U. (1987). Murine cytomegalovirus genomic material in marrow cells: relation to altered leukocyte counts during sublethal infection of mice. J Infect Dis, 155(2), 207-12. PMID: 3027192.

Perlman, S., Denison, M. (1987). Identification of the N-terminal putative polymerase protein of coronavirus MHV A59. Third International Coronavirus Symposium, Asilomar, CA.

Perlman, S., Schelper, R. & Ries, D. (1987). Maternal antibody modulated infection in C57BL/6 and BALB/c mice. Third International Coronavirus Symposium, Asilomar, CA.

Perlman, S., Schelper, R. & Ries, D. (1987). Maternal antibody-modulated MHV-JHM infection in C57BL/6 and BALB/c mice. Adv Exp Med Biol, 218, 297-305. PMID: 2829543.

Denison, M., Perlman, S. (1987). Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells. Adv Exp Med Biol, 218, 155-6. PMID: 2829524.

Perlman, S., Ries, D., Bolger, E., Chang, L. J. & Stoltzfus, C. M. (1986). MHV nucleocapsid synthesis in the presence of cycloheximide and accumulation of negative strand MHV RNA. Virus Res, 6(3), 261-72. PMID: 3033933.

Denison, M. R., Perlman, S. (1986). Translation and processing of mouse hepatitis virus virion RNA in a cell-free system. J Virol, 60(1), 12-8. PMID: 3018279.

Murph, J., Bale, J. F., Murray, J., Stinski, M. F. & Perlman, S. (1986). Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices. J Pediatr, 109(1), 35-9. PMID: 3014103.

Perlman, S., Schelper, R., Bolger, E. & Ries, D. (1986). Development of subacute demyelinating encephalomyelitis in mice infected with mouse hepatitis virus, strain JHM. (Vols. 20). pp. 318A. Pediatr Res.

Denison, M., Perlman, S. (1986). In vitro translation of virion RNA of mouse hepatitis virus A59, a murine coronavirus. (Vols. 20). pp. 308A. Pediatr Res.

Bale Jr, J. F., Perlman, S. (1986). Slow Virus Infections Due to Unconventional Agents. In A. B. Baker , R. J. Joynt (Eds.) Clinical Neurology. Harper & Row.

Bale Jr, J. F., Perlman, S. (1986). Viral Encephalitis. In A. B. Baker , R. J. Joynt (Eds.) Clinical Neurology. Harper & Row.

Perlman, S., Bell, W. (1986). Viral meningitis/encephalitis. In R. E. Rakel (Eds.) Conn's Current Therapy. (39th edition), pp. 744-6. W.B. Saunders Co., Philadelphia.

Broderick, A., Perlman, S. & Dietz, F. (1985). Pseudomonas bursitis: inoculation from a catfish. Pediatr Infect Dis, 4(6), 693-4. PMID: 4080588.

Denison, M., Perlman, S. (1985). In vitro translation of coronavirus MHV-A59 virion RNA. American Society for Virology, Albuquerque, NM.

Murph, J. R., Bale, Jr, J. F., Perlman, S. & Swack, N. S. (1985). The prevalence of cytomegalovirus infection in a midwest day care center. (Vols. 19). pp. 205A. Pediatr Res.

Denison, M., Perlman, S. (1985). Translation of murine coronavirus virion RNA. Pediatr Res.

Perlman, S., Bell, W. (1985). Viral meningitis/encephalitis. In R. E. Rakel (Eds.) Conn's Current Therapy. (38th edition), pp. 730-2. W.B. Saunders Co., Philadelphia.

Perlman, S., Carr, S. A. (1984). Citramalic acid in cerebrospinal fluid of patients with bacterial meningitis. Clin Chem, 30(7), 1209-12. PMID: 6145530.

Piccoli, D. A., Perlman, S. & Ephros, M. (1983). Transfusion-acquired Plasmodium malariae infection in two premature infants. Pediatrics, 72(4), 560-2. PMID: 6351009.

Perlman, S., Rosbash, M. (1978). Analysis of Xenopus laevis ovary and somatic cell polyadenylated RNA by molecular hybridization. Dev Biol, 63(1), 197-212. PMID: 564793.

Perlman, S., Ford, P. J. & Rosbash, M. M. (1977). Prescence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis. Proc Natl Acad Sci U S A, 74(9), 3835-9. PMID: 269434.

Perlman, S., Phillips, C. & Bishop, J. O. (1976). A study of foldback DNA. Cell, 8(1), 33-42. PMID: 986250.

Bishop, J. O., Beckmann, J. S., Campo, M. S., Hastie, N. D., Izquierdo, M. & Perlman, S. (1975). DNA-RNA hybridization. Philos Trans R Soc Lond B Biol Sci, 272(915), 147-57. PMID: 1811.

Perlman, S. (1975). Effect of cycloheximide on replication and transcription in cells infected with vesicular stomatitiis virus. In Negative Strand Viruses. pp. 379-85. Academic Press.

Palma, E. L., Perlman, S. & Huang, A. S. (1974). Ribonucleic acid synthesis of vesicular stomatitis virus. VI. Correlation of defective particle RNA synthesis with standard RNA replication. J Mol Biol, 85(1), 127-36. PMID: 4365257.

Perlman, S., Huang, A. S. (1973). RNA synthesis of vesicular stomatitis virus. V. Interactions between transcription and replication. J Virol, 12(6), 1395-400. PMID: 4357512.

Penman, S., Abelson, H., Hirsch, M. & Perlman, S. (1973). The poly (A)-containing RNA in mitochondria. International Conference Biogenesis of Mitochondria, Bari, Italy.

Perlman, S., Abelson, H. T. & Penman, S. (1973). Mitochondrial protein synthesis: RNA with the properties of Eukaryotic messenger RNA. Proc Natl Acad Sci U S A, 70(2), 350-3. PMID: 4510280.

Price, R., Singer, R., Perlman, S., Hirsch, M. & Penman, S. (1973). RNA synthesis and processing in the mammalian cell nucleus. (Vols. 5). pp. 117-32. Proc Australian Biochem Soc.

Perlman, S., Huang, A. S. (1973). Transcription and replication of vesicular stomatitis virus RNA. In Virus Research 2nd ICN-UCLA Symp of Mol Bio. pp. 97-103. Academic Press, New York.

Perlman, S., Huang, A. S. (1973). Virus-Specific RNA Specified by the Group I and IV Temperature-Sensitive Mutants of Vesicular Stomatitis Virus. Intervirology, 2(5-6), 312-25.

Perlman, S., Hirsch, M. & Penman, S. (1972). Utilization of messenger in adenovirus-2-infected cells at normal and elevated temperatures. Nat New Biol, 238(83), 143-4. PMID: 4506191.

Zylber, E. A., Perlman, S. & Penman, S. (1971). Mitochondrial RNA turnover in the presence of cordycepin. Biochim Biophys Acta, 240(4), 588-93. PMID: 5315931.

Perlman, S., Penman, S. (1970). Mitochondrial protein synthesis: Resistance to emetine and response to RNA synthesis inhibitors. Biochem Biophys Res Commun, 40(4), 941-8. PMID: 5495740.

Perlman, S., Penman, S. (1970). Protein-synthesizing structures associated with mitochondria. Nature, 227(5254), 133-7. PMID: 4316951.

Penman, S., Fan, H., Perlman, S., Rosbash, M., Weinberg, R. & Zylber, E. (1970). Distinct RNA Synthesis Systems of the HeLa Cell. (Vols. 35). pp. 561-75. Cold Spring Harb Symp Quant Biol.

Jobin, W., Ginsburg, E. & Perlman, S. (1969). Rat control: A strategy for Boston. (Vols. Technical Note No. 14). MIT Department of Civil Engineering, Hydrodynamics Laboratory.