Curt D. Sigmund, PhD

Portrait
Chair and Department Executive Officer
Roy J Carver Chair in Hypertension Research
Professor of Pharmacology
Professor of Internal Medicine
Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 2-471B-1 BSB
51 Newton Rd.
Iowa City, IA 52242
319-335-7946

Lab: 2-340 BSB
Iowa City, IA 52242
319-335-8926

Education

BA, Biology, State University of New York at Buffalo
MA, Biology, State University of New York at Buffalo
PhD, Molecular Biology, The State University of New York at Buffalo

Fellow, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY

Education/Training Program Affiliations

Department of Pharmacology Graduate Program, Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Informatics, Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

UIHC Center for Hypertension Research

Research Summary

Dr. Sigmund's research interests focus on mechanisms of blood pressure regulation by the renin-angiotensin system and the transcription factor PPAR-gamma. He utilizes a combination of molecular biological, genetic and physiological approaches in his research. Dr. Sigmund addresses many hypotheses with the generation of unique transgenic and knockout models of cardiovascular diseases including hypertension and arteriosclerosis.

Publications

Ferdaus, M. Z., Miller, L. N., Agbor, L. N., Saritas, T., Singer, J. D., Sigmund, C. D. & McCormick, J. A. (2017). Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. JCI insight, 2(24). PMID: 29263298.

Shinohara, K., Nakagawa, P., Gomez, J., Morgan, D. A., Littlejohn, N. K., Folchert, M. D., Weidemann, B. J., Liu, X., Walsh, S. A., Ponto, L. L., Rahmouni, K., Grobe, J. L. & Sigmund, C. D. (2017). Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979), 70(5), 990-997. PMID: 28874461.

Woll, A. W., Quelle, F. W. & Sigmund, C. D. (2017). PPAR? and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium. Physiological genomics, 49(11), 653-658. PMID: 28916634.

Sapouckey, S. A., Deng, G., Sigmund, C. D. & Grobe, J. L. (2017). Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiological genomics, 49(12), 722-732. PMID: 28986397.

De Silva, T. M., Hu, C., Kinzenbaw, D. A., Modrick, M. L., Sigmund, C. D. & Faraci, F. M. (2017). Genetic Interference With Endothelial PPAR-? (Peroxisome Proliferator-Activated Receptor-?) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension (Dallas, Tex. : 1979), 70(3), 559-565. PMID: 28674038.

Nakagawa, P., Sigmund, C. D. (2017). How Is the Brain Renin-Angiotensin System Regulated?. Hypertension (Dallas, Tex. : 1979), 70(1), 10-18. PMID: 28559391.

Keen, H. L., Sigmund, C. D. (2017). Microarray Analysis of Hypertension. Methods in molecular biology (Clifton, N.J.), 1527, 41-52. PMID: 28116705.

Hu, C., Keen, H. L., Lu, K. T., Liu, X., Wu, J., Davis, D. R., Ibeawuchi, S. C., Vogel, S., Quelle, F. W. & Sigmund, C. D. (2017). Retinol-binding protein 7 is an endothelium-specific PPAR<b>?</b> cofactor mediating an antioxidant response through adiponectin. JCI insight, 2(6), e91738. PMID: 28352663.

Sigmund, C. D., Diz, D. I. & Chappell, M. C. (2017). No Brain Renin-Angiotensin System: Déjà vu All Over Again?. (Vols. 69). (6), pp. 1007-1010. Hypertension (Dallas, Tex. : 1979). PMID: 28396531.

Agassandian, K., Grobe, J. L., Liu, X., Agassandian, M., Thompson, A. P., Sigmund, C. D. & Cassell, M. D. (2017). Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. American journal of physiology. Regulatory, integrative and comparative physiology, 312(6), R973-R981. PMID: 28490451.

Mukohda, M., Lu, K. T., Guo, D. F., Wu, J., Keen, H. L., Liu, X., Ketsawatsomkron, P., Stump, M., Rahmouni, K., Quelle, F. W. & Sigmund, C. D. (2017). Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle. Hypertension (Dallas, Tex. : 1979), 70(1), 174-182. PMID: 28507170.

Stump, M., Guo, D. F., Lu, K. T., Mukohda, M., Cassell, M. D., Norris, A. W., Rahmouni, K. & Sigmund, C. D. (2016). Nervous System Expression of PPAR? and Mutant PPAR? Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology, 157(11), 4266-4275. PMID: 27575030.

Lu, K. T., Keen, H. L., Weatherford, E. T., Sequeira-Lopez, M. L., Gomez, R. A. & Sigmund, C. D. (2016). Estrogen Receptor a Is Required for Maintaining Baseline Renin Expression. Hypertension, 67(5), 992-9. PMID: 2698806.

Chu, Y., Lund, D. D., Doshi, H., Keen, H. L., Knudtson, K. L., Funk, N. D., Shao, J. Q., Cheng, J., Hajj, G. P., Zimmerman, K. A., Davis, M. K., Brooks, R. M., Chapleau, M. W., Sigmund, C. D., Weiss, R. M. & Heistad, D. D. (2016). Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. Arterioscler Thromb Vasc Biol, 36(3), 466-74. PMID: 26769049.

Muntner, P., Becker, R. C., Calhoun, D., Chen, D., Cowley, Jr., A. W., Flynn, J. T., Grobe, J. L., Kidambi, S., Kotchen, T. A., Lackland, D. T., Leslie, K. K., Li, Y., Liang, M., Lloyd, A., Mattson, D. L., Mendizabal, B., Mitsnefes, M., Nair, A., Pierce, G. L., Pollock, J. S., Safford, M. M., Santillan, M. K., Sigmund, C. D., Thomas, D. J. & Urbina, E. M. (2016). Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension, 67(4), 674-80. PMID: 26902490.

Muta, K., Morgan, D. A., Grobe, J. L., Sigmund, C. D. & Rahmouni, K. (2016). mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology, 157(8), 3140-8. PMID: 27254006.

Mukohda, M., Stump, M., Ketsawatsomkron, P., Hu, C., Quelle, F. W. & Sigmund, C. D. (2016). Endothelial PPAR-? provides vascular protection from IL-1ß-induced oxidative stress. Am J Physiol Heart Circ Physiol, 310(1), H39-48. PMID: 26566726.

Stump, M., Guo, D. F., Lu, K. T., Mukohda, M., Liu, X., Rahmouni, K. & Sigmund, C. D. (2016). Effect of selective expression of dominant-negative PPAR? in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics, 48(7), 491-501. PMID: 27199455.

Hu, C., Lu, K. T., Mukohda, M., Davis, D. R., Faraci, F. M. & Sigmund, C. D. (2016). Interference with PPARgamma in endothelium accelerates angiotensin II-induced endothelial dysfunction. Physiol Genomics, 48(2), 124-34. DOI: 10.1152/physiolgenomics.00087.2015.

Wu, J., Sigmund, C. D. (2016). Hypertension: A Disease That Strikes Around the Clock. Hypertension, 67(3), 493-5. DOI: 10.1161/hypertensionaha.115.06331.

Agbor, L. N., Ibeawuchi, S. C., Hu, C., Wu, J., Davis, D. R., Keen, H. L., Quelle, F. W. & Sigmund, C. D. (2016). Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight., 1(19), e91015. PMID: 27882355.

Song, K., Stuart, D., Abraham, N., Wang, F., Wang, S., Yang, T., Sigmund, C. D., Kohan, D. E. & Ramkumar, N. (2016). Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. PLoS One, 11(7), e0159872. PMID: 27467376.

Ketsawatsomkron, P., Keen, H. L., Davis, D. R., Lu, K. T., Stump, M., De Silva, T. M., Hilzendeger, A. M., Grobe, J. L., Faraci, F. M. & Sigmund, C. D. (2016). Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-gamma Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension, 67(1), 214-22. DOI: 10.1161/hypertensionaha.115.06391.

Wu, J., Sigmund, C. D. (2016). Hypertension: A Disease That Strikes Around the Clock. Hypertension, 67(3), 493-5. PMID: 26781274.

Prasad, A. M., Ketsawatsomkron, P., Nuno, D. W., Koval, O. M., Dibbem, M. E., Venema, A. N., Sigmund, C. D., Lamping, K. G. & Grumbach, I. M. (2016). Role of CaMKII in Ang-II-dependent small artery remodeling. Vascul Pharmacol, 87, 172-179. PMID: 27658984.

Littlejohn, N. K., Keen, H. L., Weidemann, B. J., Claflin, K. E., Tobin, K. V., Markan, K. R., Park, S., Naber, M. C., Gourronc, F. A., Pearson, N. A., Liu, X., Morgan, D. A., Klingelhutz, A. J., Potthoff, M. J., Rahmouni, K., Sigmund, C. D., Grobe, J. L. (2016). Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep, 16(6), 1548-60. PMID: 27477281.

Ketsawatsomkron, P., Sigmund, C. D. (2015). Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. Curr Opin Nephrol Hypertens, 24(2), 123-30. DOI: 10.1097/mnh.0000000000000103.

Ibeawuchi, S. R., Agbor, L. N., Quelle, F. W. & Sigmund, C. D. (2015). Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem, 290(31), 19208-17. DOI: 10.1074/jbc.M115.645358.

Coble, J. P., Grobe, J. L., Johnson, A. K. & Sigmund, C. D. (2015). Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. Am J Physiol Regul Integr Comp Physiol, 308(4), R238-49. DOI: 10.1152/ajpregu.00486.2014.

Stump, M., Mukohda, M., Hu, C. & Sigmund, C. D. (2015). PPARgamma Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep, 17(12), 89. DOI: 10.1007/s11906-015-0601-x.

Santillan, M. K., Pelham, C. J., Ketsawatsomkron, P., Santillan, D. A., Davis, D. R., Devor, E. J., Gibson-Corley, K. N., Scroggins, S. M., Grobe, J. L., Yang, B., Hunter, S. K. & Sigmund, C. D. (2015). Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep, 3(1). DOI: 10.14814/phy2.12257.

Jin, H., Gebska, M. A., Blokhin, I. O., Wilson, K. M., Ketsawatsomkron, P., Chauhan, A. K., Keen, H. L., Sigmund, C. D. & Lentz, S. R. (2015). Endothelial PPAR-gamma protects against vascular thrombosis by downregulating P-selectin expression. Arterioscler Thromb Vasc Biol, 35(4), 838-44. DOI: 10.1161/atvbaha.115.305378.

Sandgren, J. A., Scroggins, S. M., Santillan, D. A., Devor, E. J., Gibson-Corley, K. N., Pierce, G. L., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin: the missing link for preeclampsia?. Am J Physiol Regul Integr Comp Physiol, 309(9), R1062-4. DOI: 10.1152/ajpregu.00073.2015.

Sequeira-Lopez, M. L., Nagalakshmi, V. K., Li, M., Sigmund, C. D. & Gomez, R. A. (2015). Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol, 309(6), R650-7. DOI: 10.1152/ajpregu.00313.2015.

Sequeira-Lopez, M. L., Lin, E. E., Li, M., Hu, Y., Sigmund, C. D. & Gomez, R. A. (2015). The earliest metanephric arteriolar progenitors and their role in kidney vascular development. Am J Physiol Regul Integr Comp Physiol, 308(2), R138-49. DOI: 10.1152/ajpregu.00428.2014.

Hasan, D. M., Starke, R. M., Gu, H., Wilson, K., Chu, Y., Chalouhi, N., Heistad, D. D., Faraci, F. M. & Sigmund, C. D. (2015). Smooth Muscle Peroxisome Proliferator-Activated Receptor gamma Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension, 66(1), 211-20. DOI: 10.1161/hypertensionaha.115.05332.

De Silva, T. M., Ketsawatsomkron, P., Pelham, C., Sigmund, C. D. & Faraci, F. M. (2015). Genetic interference with peroxisome proliferator-activated receptor gamma in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension, 65(2), 345-51. DOI: 10.1161/hypertensionaha.114.04541.

Prasad, A. M., Morgan, D. A., Nuno, D. W., Ketsawatsomkron, P., Bair, T. B., Venema, A. N., Dibbern, M. E., Kutschke, W. J., Weiss, R. M., Lamping, K. G., Chapleau, M. W., Sigmund, C. D., Rahmouni, K. & Grumbach, I. M. (2015). Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. J Am Heart Assoc, 4(6), e001949. DOI: 10.1161/jaha.115.001949.

Jo, F., Jo, H., Hilzendeger, A. M., Thompson, A. P., Cassell, M. D., Rutkowski, D. T., Davisson, R. L., Grobe, J. L. & Sigmund, C. D. (2015). Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension, 65(6), 1341-8. DOI: 10.1161/hypertensionaha.115.05377.

De Silva, T. M., Modrick, M. L., Ketsawatsomkron, P., Lynch, C., Chu, Y., Pelham, C. J., Sigmund, C. D. & Faraci, F. M. (2014). Role of peroxisome proliferator-activated receptor-gamma in vascular muscle in the cerebral circulation. Hypertension, 64(5), 1088-93. DOI: 10.1161/hypertensionaha.114.03935.

Borges, G. R., Morgan, D. A., Ketsawatsomkron, P., Mickle, A. D., Thompson, A. P., Cassell, M. D., Mohapatra, D. P., Rahmouni, K. & Sigmund, C. D. (2014). Interference with peroxisome proliferator-activated receptor-gamma in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. Hypertension, 64(3), 590-6. DOI: 10.1161/hypertensionaha.114.03553.

Coble, J. P., Cassell, M. D., Davis, D. R., Grobe, J. L. & Sigmund, C. D. (2014). Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. Am J Physiol Regul Integr Comp Physiol, 307(4), R376-86. DOI: 10.1152/ajpregu.00216.2014.

Coble, J. P., Johnson, R. F., Cassell, M. D., Johnson, A. K., Grobe, J. L. & Sigmund, C. D. (2014). Activity of protein kinase C-alpha within the subfornical organ is necessary for fluid intake in response to brain angiotensin. Hypertension, 64(1), 141-8. DOI: 10.1161/hypertensionaha.114.03461.

Ramkumar, N., Stuart, D., Rees, S., Hoek, A. V., Sigmund, C. D. & Kohan, D. E. (2014). Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. Am J Physiol Renal Physiol, 307(8), F931-8. DOI: 10.1152/ajprenal.00367.2014.

Grobe, J. L., Sigmund, C. D. (2014). Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. Hypertension, 64(6), 1182-3. DOI: 10.1161/hypertensionaha.114.04075.

Carrillo-Sepulveda, M. A., Keen, H. L., Davis, D. R., Grobe, J. L. & Sigmund, C. D. (2014). Role of vascular smooth muscle PPARgamma in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS One, 9(8), e103786. DOI: 10.1371/journal.pone.0103786.

Chu, Y., Lund, D. D., Weiss, R. M., Brooks, R. M., Doshi, H., Hajj, G. P., Sigmund, C. D. & Heistad, D. D. (2013). Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arterioscler Thromb Vasc Biol, 33(3), 523-32.

Sigmund, C. D. (2013). A clinical link between peroxisome proliferator-activated receptor ? and the renin-angiotensin system. Arterioscler Thromb Vasc Biol, 33(4), 676-8. PMID: 23486770.

Prasad, A. M., Nuno, D. W., Koval, O. M., ketsawatsomkron, P., Li, W., Shen, F. Y., Joiner, J. M., Kutschke, W., Weiss, R. M., Sigmund, C. D., Anderson, M. E., Lamping, K. G. & Grumbach, I. M. (2013). Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Hypertension, 62(2), 434-41. PMID: 23753415.

Pelham, C. J., Keen, H. L., Lentz, S. R. & Sigmund, C. D. (2013). Dominant negative PPAR? promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. Am J Physiol Regul Integr Comp Physiol, 304(9), R690-701.

Littlejohn, N. K., Siel Jr., R. B., Ketsawatsomkron, P., Pelham, C. J., Pearson, N. A., Hilzendeger, A. M., Buehrer, B. A., Weidemann, B. J., Li, H., Davis, D. R., Thompson, A. P., Liu, X., Cassell, M. D., Sigmund, C. D. & Grobe, J. L. (2013). Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol, 304(10), R818-28.

Park, S., Lu, K., Liu, X., Chatterjee, T. K., Rudich, S. M., Weintraub, N. L., Kwitek, A. E. & Sigmund, C. D. (2013). Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. Hypertension, 62(1), 41-7.

Hilzendeger, A. M., Cassell, M. D., Davis, D. R., Stauss, H. M., Mark, A. L., Grobe, J. L. & Sigmund, C. D. (2013). Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension, 61(3), 716-22.

Grobe, J. L., Rahmouni, K., Liu, X. & Sigmund, C. D. (2013). Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Archiv - European J of Physiol, 465(1), 164-75.

Quelle, F. W., Sigmund, C. D. (2013). PPAR?: no SirT, no service. Circulation Research, 112(3), 411-4.

Hilzendeger, A. M., Morgan, D. A., Brooks, L., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D. & Mark, A. L. (2012). A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. Am J Physiol Heart Circ Physiol, 303(2), H197-206.

Cai, J., Keen, H. L., Sigmund, C. D. & Casavant, T. L. (2012). Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. J Integr Bioinform, 9(1), 208.

Sigmund, C. D. (2012). Ernest H. Starling Distinguished Lectureship: Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol, 302(3), R313-20.

Norris, A. W., Sigmund, C. D. (2012). A second chance for a PPAR? targeted therapy? A Commentary on "Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation". Circulation Research, 110(1), 8-11.

Park, S., Liu, X., Davis, D. R. & Sigmund, C. D. (2012). Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. Hypertension, 59(6), 1212-9.

Modrick, M. L., Kinzenbaw, D. A., Chu, Y., Sigmund, C. D. & Faraci, F. M. (2012). Peroxisome proliferator-activated receptor-? protects against vascular aging. Am J Physiol Regul Integr Comp Physiol, 302(10), R1184-90.

Pelham, C. J., Ketsawatsomkron, P., Groh, S., Grobe, J. L., de Lange, W. J., Ibeawuchi, S. R., keen, H. L., Weatherford, E. T., Faraci, F. M. & Sigmund, C. D. (2012). Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPAR? and RhoA/Rho-kinase. Cell Metabolism, 16(4), 462-72.

Ketsawatsomkron, P., Lorca, R. A., Keen, H. L., Weatherford, E. T., Liu, X., Pelham, C. J., Grobe, J. L., Faraci, F. M., England, S. K. & Sigmund, C. D. (2012). PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circulation Research, 111(11), 1446-58.

Weatherford, E. T., Liu, X. & Sigmund, C. D. (2012). Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. Am J Physiol Renal Physiol, 302(8), F1025-33.

Grobe, J. L., Buehrer, B. A., Hilzendeger, A. M., Liu, X., R, D. D., D, X. & Sigmund, C. D. (2011). Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension, 57(3), 600-7.

Ostedgaard, L. S., Meyerholz, D. K., Vermeer, D. W., Karp, P. H., Schneider, L., Sigmund, C. D. & Welsh, M. J. (2011). Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proc Natl Acad Sci USA, 108(7), 2921-6.

Rahmouni, K., Davisson, R. L. & Sigmund, C. D. (2011). Preview: Inflaming hypothalamic neurons raises blood pressure. Cell Metabolism, 14(1), 3-4.

Xu, D., Borges, G. R., Davis, D. R., Agassandian, K., Sequeira Lopez, M. L., Gomez, R. A., Cassell, M. D., Grobe, J. L. & Sigmund, C. D. (2011). Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiological Genomics, 43(6), 286-94.

Li, H., Weatherford, E. T., Davis, D. R., Keen, H. L., Grobe, J. L., Daugherty, A., Cassis, L. A., Allen, A. M. & Sigmund, C. D. (2011). Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol, 301(4), R1067-77.

Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D. F., Cassell, M. D., Sigmund, C. D., Mark, A. L. & Rahmouni, K. (2011). Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circulation Research, 108(7), 808-12.

He, B. J., Joiner, M. L., Singh, M. V., Luczak, E. D., Swaminathan, P. D., Koval, O. M., Yang, J., Guan, X., Zimmerman, K., Grumbach, M., Weiss, R. M., Spitz, D. R., Sigmund, C. D., Blankestein, W. M., Mohler, P. J. & Anderson, M. E. (2011). Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine, 17(12), 1610-8.

Ketsawatsomkron, P., Pelham, C. J., Groh, S., Keen, H. L., Faraci, F. M. & Sigmund, C. D. (2010). Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?. The Journal of biological chemistry, 285(13), 9311-6. PMID: 20129921.

Sequeira-Lopez, M. L., Weatherford, E. T., Borges, G. R., Monteagudo, M. C., Pentz, E. S., Harfe, B. D., Carretero, O., Sigmund, C. D. & Gomez, R. A. (2010). The microRNA-processing enzyme dicer maintains juxtaglomerular cells. Journal of the American Society of Nephrology : JASN, 21(3), 460-7. PMID: 20056748.

Sigmund, C. D. (2010). Editorial AJP: Regulatory, Integrative and Comparative Physiology: Team exercise. (Vols. 298). (1), pp. R1. Am J Physiol Regul Integr Comp Physiol. PMID: 19923356.

Feng, Y., Xia, H., Cai, Y., Halabi, C. M., Becker, L. K., Santos, R. A., Speth, R. C., Sigmund, C. D. & Lazartigues, E. (2010). Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circulation research, 106(2), 373-82. PMID: 19926873.

Keen, H. L., Halabi, C. M., Beyer, A. M., de Lange, W. J., Liu, X., Maeda, N., Faraci, F. M., Casavant, T. L. & Sigmund, C. D. (2010). Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arteriosclerosis, thrombosis, and vascular biology, 30(3), 518-25. PMID: 20018933.

Sigmund, C. D. (2010). Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension, 55(2), 437-44. PMID: 20038751.

Desch, M., Schreiber, A., Schweda, F., Madsen, K., Friis, U. G., Weatherford, E. T., Sigmund, C. D., Sequeira Lopez, M. L., Gomez, R. A. & Todorov, V. T. (2010). Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. Hypertension, 55(3), 660-6. PMID: 20065157.

Grobe, J. L., Dickson, M. E., Park, S., Davis, D. R., Born, E. J. & Sigmund, C. D. (2010). Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension, 56(5), 981-7.

Grobe, J. L., Grobe, C. L., Beltz, T. G., Westphal, S. G., Morgan, D. A., Xu, D., de Lange, W. J., Li, H., Sakai, K., Thedens, D. R., Cassis, L. A., Rahmouni, K., Mark, A. L., Johnson, A. K. & Sigmund, C. D. (2010). The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metabolism, 12(5), 431-42.

Gross, K. W., Gomez, R. A. & Sigmund, C. D. (2010). Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin". American journal of physiology. Regulatory, integrative and comparative physiology, 298(5), R1209-11. PMID: 20237305.

Sigmund, C. D. (2010). Structural biology: On stress and pressure. Nature, 468(7320), 46-7. PMID: 21048758.

Redding, K. M., Chen, B. L., Singh, A., Re, R. N., Navar, L. G., Seth, D. M., Sigmund, C. D., Tang, W. W. & Cook, J. L. (2010). Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. American journal of physiology. Heart and circulatory physiology, 298(6), H1807-18. PMID: 20363893.

Bianco, R. A., Agassandian, K., Cassell, M. D., Spector, A. A. & Sigmund, C. D. (2009). Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain research, 1291, 60-72. PMID: 19643090.

Chen, S., Li, G., Zhang, W., Wang, J., Sigmund, C. D., Olson, J. E. & Chen, Y. (2009). Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. American journal of physiology. Regulatory, integrative and comparative physiology, 297(5), R1526-31. PMID: 19759335.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. K. (2009). From molecules to medicine: a future cure for preeclampsia?. Drug news & perspectives, 22(9), 531-41. PMID: 20072730.

Xu, D., Borges, G. R., Grobe, J. L., Pelham, C. J., Yang, B. & Sigmund, C. D. (2009). Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension, 54(6), 1240-7. PMID: 19822797.

Itani, H., Liu, X., Sarsour, E. H., Goswami, P. C., Born, E., Keen, H. L. & Sigmund, C. D. (2009). Regulation of renin gene expression by oxidative stress. Hypertension, 53(6), 1070-6. PMID: 19433777.

Rahmouni, K., Sigmund, C. D., Haynes, W. G. & Mark, A. L. (2009). Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes, 58(3), 536-42. PMID: 19066310.

Grobe, J. L., Venegas-Pont, M., Sigmund, C. D. & Ryan, M. J. (2009). PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". American journal of physiology. Regulatory, integrative and comparative physiology, 296(5), R1325-6. PMID: 19261916.

Modrick, M. L., Didion, S. P., Sigmund, C. D. & Faraci, F. M. (2009). Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. American journal of physiology. Heart and circulatory physiology, 296(6), H1914-9. PMID: 19395552.

Sigmund, C. D. (2008). Editorial AJP: Regulatory, Integrative and Comparative Physiology: One Year Later…. (Vols. 295). pp. R1007-R1008. Am J Physiol Regul Integr Comp Physiol.

Grobe, J. L., Xu, D. & Sigmund, C. D. (2008). An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. Physiology (Bethesda, Md.), 23, 187-93. PMID: 18697992.

de Lange, W. J., Halabi, C. M., Beyer, A. M. & Sigmund, C. D. (2008). Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiological genomics, 35(1), 1-4. PMID: 18612081.

Rahmouni, K., Sigmund, C. D. (2008). Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression. Circulation research, 103(6), 565-7. PMID: 18796641.

Beyer, A. M., de Lange, W. J., Halabi, C. M., Modrick, M. L., Keen, H. L., Faraci, F. M. & Sigmund, C. D. (2008). Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circulation research, 103(6), 654-61. PMID: 18676352.

Dickson, M. E., Tian, X., Liu, X., Davis, D. R. & Sigmund, C. D. (2008). Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. Circulation research, 103(9), 940-7. PMID: 18802024.

Harlan, S. M., Reiter, R. S., Sigmund, C. D., Lin, J. L. & Lin, J. J. (2008). Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. Anatomical record (Hoboken, N.J. : 2007), 291(12), 1574-86. PMID: 18951515.

Zhou, X., Weatherford, E. T., Liu, X., Born, E., Keen, H. L. & Sigmund, C. D. (2008). Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. American journal of physiology. Renal physiology, 295(3), F642-53. PMID: 18632798.

Zhou, X., Sigmund, C. D. (2008). Chorionic enhancer is dispensable for regulated expression of the human renin gene. American journal of physiology. Regulatory, integrative and comparative physiology, 294(2), R279-87. PMID: 18077515.

Halabi, C. M., Beyer, A. M., de Lange, W. J., Keen, H. L., Baumbach, G. L., Faraci, F. M. & Sigmund, C. D. (2008). Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell metabolism, 7(3), 215-26. PMID: 18316027.

Shi, P. P., Cao, X. R., Sweezer, E. M., Kinney, T. S., Williams, N. R., Husted, R. F., Nair, R., Weiss, R. M., Williamson, R. A., Sigmund, C. D., Snyder, P. M., Staub, O., Stokes, J. B. & Yang, B. (2008). Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. American journal of physiology. Renal physiology, 295(2), F462-70. PMID: 18524855.

Beyer, A. M., Baumbach, G. L., Halabi, C. M., Modrick, M. L., Lynch, C. M., Gerhold, T. D., Ghoneim, S. M., de Lange, W. J., Keen, H. L., Tsai, Y. S., Maeda, N., Sigmund, C. D. & Faraci, F. M. (2008). Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension, 51(4), 867-71. PMID: 18285614.

Sigmund, C. D. (2008). A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al. American journal of physiology. Regulatory, integrative and comparative physiology, 295(6), R1846-8. PMID: 18971347.

Li, H., Zhou, X., Davis, D. R., Xu, D. & Sigmund, C. D. (2008). An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. American journal of physiology. Renal physiology, 294(6), F1481-6. PMID: 18385272.

Wakisaka, Y., Miller, J. D., Chu, Y., Baumbach, G. L., Wilson, S., Faraci, F. M., Sigmund, C. D. & Heistad, D. D. (2008). Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 28(6), 1175-85. PMID: 18301433.

deLange, W. J., Sigmund, C. D. (2007). Gene Targeting in Mice to Study Blood Pressure Regulation: Role of the Renin-Angiotensin System. In A. F. Dominiczak , J. M. Connell (Eds.) Genetics of Hypertension. Elsevier.

Sigmund, C. D., Hall, J. E. (2007). To the Readers of Hypertension. Hypertension, 49, 1195.

Itani, H. A., Liu, X., Pratt, J. H. & Sigmund, C. D. (2007). Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology, 148(3), 1424-30. PMID: 17158202.

Driskell, R. R., Goodheart, M., Neff, T., Liu, X., Luo, M., Moothart, C., Sigmund, C. D., Hosokawa, R., Chai, Y. & Engelhardt, J. F. (2007). Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Developmental biology, 305(1), 90-102. PMID: 17335794.

Weatherford, E. T., Itani, H., Keen, H. L. & Sigmund, C. D. (2007). Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?. Hypertension, 50(5), 844-6. PMID: 17785627.

Sigmund, C. D. (2007). AJP: Regulatory, Integrative and Comparative Physiology: 2007 and Beyond. (Vols. 293). pp. R1-R2. Am J Physiol Regul Integr Comp Physiol.

Kobori, H., Ozawa, Y., Satou, R., Katsurada, A., Miyata, K., Ohashi, N., Hase, N., Suzaki, Y., Sigmund, C. D. & Navar, L. G. (2007). Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. American journal of physiology. Renal physiology, 293(3), F938-45. PMID: 17634399.

Sakai, K., Agassandian, K., Morimoto, S., Sinnayah, P., Cassell, M. D., Davisson, R. L. & Sigmund, C. D. (2007). Local production of angiotensin II in the subfornical organ causes elevated drinking. The Journal of clinical investigation, 117(4), 1088-95. PMID: 17404622.

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., Meyerholz, D. K., Kirby, P., Look, D. C. & Perlman, S. (2007). Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. Journal of virology, 81(2), 813-21. PMID: 17079315.

Dickson, M. E., Zimmerman, M. B., Rahmouni, K. & Sigmund, C. D. (2007). The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. Hypertension, 49(3), 631-9. PMID: 17200439.

Sethi, S., Iida, S., Sigmund, C. D. & Heistad, D. D. (2006). Renal thrombotic microangiopathy in a genetic model of hypertension in mice. Experimental biology and medicine (Maywood, N.J.), 231(2), 196-203. PMID: 16446496.

Sigmund, C. D., Davisson, R. L. (2006). Targeting brain AT1 receptors by RNA interference. Hypertension, 47(2), 145-6. PMID: 16380514.

Kiss, P. J., Knisz, J., Zhang, Y., Baltrusaitis, J., Sigmund, C. D., Thalmann, R., Smith, R. J., Verpy, E. & Banfi, B. (2006). Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Current biology : CB, 16(2), 208-13. PMID: 16431374.

Keen, H. K., Sigmund, C. D. (2006). Microarray analysis: models of hypertension. In R. N. Re , D. J. DePette , E. L. Schiffren , J. R. Sowers (Eds.) Molecular Mechanisms in Hypertension. Taylor and Francis.

Sachetelli, S., Liu, Q., Zhang, S. L., Liu, F., Hsieh, T. J., Brezniceanu, M. L., Guo, D. F., Filep, J. G., Ingelfinger, J. R., Sigmund, C. D., Hamet, P. & Chan, J. S. (2006). RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney international, 69(6), 1016-23. PMID: 16528251.

Zhou, X., Davis, D. R. & Sigmund, C. D. (2006). The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. The Journal of biological chemistry, 281(46), 35296-304. PMID: 16990260.

Dickson, M. E., Sigmund, C. D. (2006). Genetic basis of hypertension: revisiting angiotensinogen. Hypertension, 48(1), 14-20. PMID: 16754793.

Sinnayah, P., Lazartigues, E., Sakai, K., Sharma, R. V., Sigmund, C. D. & Davisson, R. L. (2006). Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circulation research, 99(10), 1125-31. PMID: 17053195.

Lavoie, J. L., Liu, X., Bianco, R. A., Beltz, T. G., Johnson, A. K. & Sigmund, C. D. (2006). Evidence supporting a functional role for intracellular renin in the brain. Hypertension, 47(3), 461-6. PMID: 16446393.

Liu, X., Shi, Q. & Sigmund, C. D. (2006). Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells. Endocrinology, 147(12), 6011-8. PMID: 16959849.

Cao, X. R., Shi, P. P., Sigmund, R. D., Husted, R. F., Sigmund, C. D., Williamson, R. A., Stokes, J. B. & Yang, B. (2006). Mice heterozygous for beta-ENaC deletion have defective potassium excretion. American journal of physiology. Renal physiology, 291(1), F107-15. PMID: 16571596.

Faraci, F. M., Lamping, K. G., Modrick, M. L., Ryan, M. J., Sigmund, C. D. & Didion, S. P. (2006). Cerebral vascular effects of angiotensin II: new insights from genetic models. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 26(4), 449-55. PMID: 16094317.

Brand, M., Lamande, N., Sigmund, C. D., Larger, E., Corvol, P. & Gasc, J. M. (2006). Angiotensinogen modulates renal vasculature growth. Hypertension, 47(6), 1067-74. PMID: 16636191.

Rahmouni, K., Sigmund, C. D. (2005). Local Production of Angiotensinogen: Insights from Genetic Manipulation of Mice. In M. K. Raizada , J. F. Paton , S. Kasparov , M. J. Katovich (Eds.) Contemporary Cardiology: Cardiovascular Genomics. Humana Press.

Halabi, C. M., Sigmund, C. D. (2005). Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. American journal of cardiovascular drugs : drugs, devices, and other interventions, 5(6), 389-98. PMID: 16259527.

Iida, S., Baumbach, G. L., Lavoie, J. L., Faraci, F. M., Sigmund, C. D. & Heistad, D. D. (2005). Spontaneous stroke in a genetic model of hypertension in mice. Stroke; a journal of cerebral circulation, 36(6), 1253-8. PMID: 15914769.

Sherrod, M., Davis, D. R., Zhou, X., Cassell, M. D. & Sigmund, C. D. (2005). Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. American journal of physiology. Regulatory, integrative and comparative physiology, 289(6), R1763-9. PMID: 16109805.

Fath, M. A., Mullins, R. F., Searby, C., Nishimura, D. Y., Wei, J., Rahmouni, K., Davis, R. E., Tayeh, M. K., Andrews, M., Yang, B., Sigmund, C. D., Stone, E. M. & Sheffield, V. C. (2005). Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Human molecular genetics, 14(9), 1109-18. PMID: 15772095.

Sherrod, M., Liu, X., Zhang, X. & Sigmund, C. D. (2005). Nuclear localization of angiotensinogen in astrocytes. American journal of physiology. Regulatory, integrative and comparative physiology, 288(2), R539-46. PMID: 15388495.

Sakai, K., Sigmund, C. D. (2005). Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. Current hypertension reports, 7(2), 135-40. PMID: 15748539.

Lavoie, J. L., Cassell, M. D., Gross, K. W. & Sigmund, C. D. (2004). Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiological genomics, 16(2), 240-6. PMID: 14625376.

Ryan, M. J., Sigmund, C. D. (2004). ACE, ACE inhibitors, and other JNK. Circulation research, 94(1), 1-3. PMID: 14715529.

Ma, X., Sigmund, C. D., Hingtgen, S. D., Tian, X., Davisson, R. L., Abboud, F. M. & Chapleau, M. W. (2004). Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension, 43(2), 312-6. PMID: 14699002.

Rahmouni, K., Mark, A. L., Haynes, W. G. & Sigmund, C. D. (2004). Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. American journal of physiology. Endocrinology and metabolism, 286(6), E891-5. PMID: 14749209.

Ryan, M. J., Didion, S. P., Mathur, S., Faraci, F. M. & Sigmund, C. D. (2004). PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension, 43(3), 661-6. PMID: 14744930.

Dayal, S., Arning, E., Bottiglieri, T., Boger, R. H., Sigmund, C. D., Faraci, F. M. & Lentz, S. R. (2004). Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke; a journal of cerebral circulation, 35(8), 1957-62. PMID: 15178827.

Liu, X., Driskell, R. R., Luo, M., Abbott, D., Filali, M., Cheng, N., Sigmund, C. D. & Engelhardt, J. F. (2004). Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. The Journal of investigative dermatology, 123(2), 264-74. PMID: 15245424.

Rahmouni, K., Morgan, D. A., Morgan, G. M., Liu, X., Sigmund, C. D., Mark, A. L. & Haynes, W. G. (2004). Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. The Journal of clinical investigation, 114(5), 652-8. PMID: 15343383.

Driskell, R. R., Liu, X., Luo, M., Filali, M., Zhou, W., Abbott, D., Cheng, N., Moothart, C., Sigmund, C. D. & Engelhardt, J. F. (2004). Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. American journal of physiology. Lung cellular and molecular physiology, 287(4), L752-63. PMID: 15194563.

Sakai, K., Chapleau, M. W., Morimoto, S., Cassell, M. D. & Sigmund, C. D. (2004). Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. Physiological genomics, 20(1), 66-72. PMID: 15467015.

Baumbach, G. L., Sigmund, C. D. & Faraci, F. M. (2004). Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circulation research, 95(8), 822-9. PMID: 15388643.

Stunz, L. L., Busch, L. K., Munroe, M. E., Sigmund, C. D., Tygrett, L. T., Waldschmidt, T. J. & Bishop, G. A. (2004). Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity, 21(2), 255-66. PMID: 15308105.

Lavoie, J. L., Bianco, R. A., Sakai, K., Keen, H. L., Ryan, M. J. & Sigmund, C. D. (2004). Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta physiologica Scandinavica, 181(4), 571-7. PMID: 15283772.

Nistala, R., Zhang, X. & Sigmund, C. D. (2004). Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiological genomics, 17(1), 4-10. PMID: 14709678.

Wemmie, J. A., Coryell, M. W., Askwith, C. C., Lamani, E., Leonard, A. S., Sigmund, C. D. & Welsh, M. J. (2004). Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America, 101(10), 3621-6. PMID: 14988500.

Lavoie, J. L., Lake-Bruse, K. D. & Sigmund, C. D. (2004). Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. American journal of physiology. Renal physiology, 286(5), F965-71. PMID: 15075192.

Li, W. G., Gavrila, D., Liu, X., Wang, L., Gunnlaugsson, S., Stoll, L. L., McCormick, M. L., Sigmund, C. D., Tang, C. & Weintraub, N. L. (2004). Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation, 109(18), 2221-6. PMID: 15117840.

Keen, H. L., Ryan, M. J., Beyer, A., Mathur, S., Scheetz, T. E., Gackle, B. D., Faraci, F. M., Casavant, T. L. & Sigmund, C. D. (2004). Gene expression profiling of potential PPARgamma target genes in mouse aorta. Physiological genomics, 18(1), 33-42. PMID: 15054141.

Lavoie, J. L., Cassell, M. D., Gross, K. W. & Sigmund, C. D. (2004). Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension, 43(5), 1116-9. PMID: 15037561.

Ryan, M. J., Didion, S. P., Mathur, S., Faraci, F. M. & Sigmund, C. D. (2004). Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension, 43(5), 1074-9. PMID: 15007032.

Morimoto, M., Lavoie, J. L., Nistala, R., Sakai, K., Curt, D. & Sigmund, C. D. (2004). Transgenic Approaches to Understand the Physiology of Tissue Renin-Angiotensin Systems.

Ryan, M. J., Sigmund, C. D. (2003). HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression. Arteriosclerosis, thrombosis, and vascular biology, 23(11), 1960-2. PMID: 14617618.

Chen, C. C., Lamping, K. G., Nuno, D. W., Barresi, R., Prouty, S. J., Lavoie, J. L., Cribbs, L. L., England, S. K., Sigmund, C. D., Weiss, R. M., Williamson, R. A., Hill, J. A. & Campbell, K. P. (2003). Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (New York, N.Y.), 302(5649), 1416-8. PMID: 14631046.

Bianco, R. A., Keen, H. L., Lavoie, J. L. & Sigmund, C. D. (2003). Untraditional methods for targeting the kidney in transgenic mice. American journal of physiology. Renal physiology, 285(6), F1027-33. PMID: 14600026.

Baumbach, G. L., Sigmund, C. D. & Faraci, F. M. (2003). Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension, 41(1), 50-5. PMID: 12511529.

Lavoie, J. L., Sigmund, C. D. (2003). Minireview: Overview of the renin-angiotensin system--an endocrine and paracrine system. Endocrinology, 144(6), 2179-83. PMID: 12746271.

Tran, N. D., Liu, X., Yan, Z., Abbote, D., Jiang, Q., Kmiec, E. B., Sigmund, C. D. & Engelhardt, J. F. (2003). Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Molecular therapy : the journal of the American Society of Gene Therapy, 7(2), 248-53. PMID: 12597913.

Liu, X., Huang, X. & Sigmund, C. D. (2003). Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circulation research, 92(9), 1033-40. PMID: 12690040.

Glueck, S. B., Sigmund, C. D. (2002). Meeting report: Physiological Genomics of Cardiovascular Disease: from Technology to Physiology. Physiological genomics, 9(3), 135-6. PMID: 12045293.

Morimoto, S., Cassell, M. D. & Sigmund, C. D. (2002). Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. Physiological genomics, 9(2), 113-20. PMID: 12006677.

Sigmund, C. D. (2002). Regulation of renin expression and blood pressure by vitamin D3. A Commentary on: 1, 25-dihydroxyvitamin D3 is a nevative endocrine regulator of the renin-angiotensin system. J Clin Invest, 110(115-156).

Morimoto, S., Sigmund, C. D. (2002). Angiotensin mutant mice: a focus on the brain renin-angiotensin system. Neuropeptides, 36(2-3), 194-200. PMID: 12359509.

Ryan, M. J., Sigmund, C. D. (2002). Use of transgenic and knockout strategies in mice. Seminars in nephrology, 22(2), 154-60. PMID: 11891509.

Sigmund, C. D. (2002). Regulation of renin expression and blood pressure by vitamin D(3). The Journal of clinical investigation, 110(2), 155-6. PMID: 12122105.

Nistala, R., Sigmund, C. D. (2002). A reliable and efficient method for deleting operational sequences in PACs and BACs. Nucleic acids research, 30(10), e41. PMID: 12000846.

Lazartigues, E., Dunlay, S. M., Loihl, A. K., Sinnayah, P., Lang, J. A., Espelund, J. J., Sigmund, C. D. & Davisson, R. L. (2002). Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circulation research, 90(5), 617-24. PMID: 11909827.

Morimoto, S., Cassell, M. D. & Sigmund, C. D. (2002). Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. The Journal of biological chemistry, 277(36), 33235-41. PMID: 12080069.

Cvetkovic, B., Keen, H. L., Zhang, X., Davis, D., Yang, B. & Sigmund, C. D. (2002). Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. Physiological genomics, 11(3), 253-62. PMID: 12388794.

Didion, S. P., Ryan, M. J., Didion, L. A., Fegan, P. E., Sigmund, C. D. & Faraci, F. M. (2002). Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circulation research, 91(10), 938-44. PMID: 12433839.

Baumbach, G. L., Sigmund, C. D., Bottiglieri, T. & Lentz, S. R. (2002). Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circulation research, 91(10), 931-7. PMID: 12433838.

Didion, S. P., Ryan, M. J., Baumbach, G. L., Sigmund, C. D. & Faraci, F. M. (2002). Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. American journal of physiology. Heart and circulatory physiology, 283(4), H1569-76. PMID: 12234811.

Stec, D. E., Keen, H. L. & Sigmund, C. D. (2002). Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. Hypertension, 39(2 Pt 2), 629-33. PMID: 11882621.

Morimoto, S., Cassell, M. D. & Sigmund, C. D. (2002). The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circulation research, 90(1), 80-6. PMID: 11786522.

Ryan, M. J., Didion, S. P., Davis, D. R., Faraci, F. M. & Sigmund, C. D. (2002). Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. Arteriosclerosis, thrombosis, and vascular biology, 22(1), 42-8. PMID: 11788459.

Ding, Y., Sigmund, C. D. (2001). Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. American journal of physiology. Renal physiology, 280(1), F54-60. PMID: 11133514.

Shi, Q., Gross, K. W. & Sigmund, C. D. (2001). Retinoic acid-mediated activation of the mouse renin enhancer. The Journal of biological chemistry, 276(5), 3597-603. PMID: 11058598.

Keen, H. L., Sigmund, C. D. (2001). Paradoxical regulation of short promoter human renin transgene by angiotensin ii. Hypertension, 37(2 Pt 2), 403-7. PMID: 11230308.

Khan, A. H., Thurmond, D. C., Yang, C., Ceresa, B. P., Sigmund, C. D. & Pessin, J. E. (2001). Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. The Journal of biological chemistry, 276(6), 4063-9. PMID: 11054418.

Myung, P. S., Derimanov, G. S., Jordan, M. S., Punt, J. A., Liu, Q. H., Judd, B. A., Meyers, E. E., Sigmund, C. D., Freedman, B. D. & Koretzky, G. A. (2001). Differential requirement for SLP-76 domains in T cell development and function. Immunity, 15(6), 1011-26. PMID: 11754821.

Shi, Q., Gross, K. W. & Sigmund, C. D. (2001). NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension, 38(3), 332-6. PMID: 11566900.

Sigmund, C. D. (2001). Genetic manipulation of the renin-angiotensin system in the kidney. Acta physiologica Scandinavica, 173(1), 67-73. PMID: 11678728.

Pan, L., Black, T. A., Shi, Q., Jones, C. A., Petrovic, N., Loudon, J., Kane, C., Sigmund, C. D. & Gross, K. W. (2001). Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. The Journal of biological chemistry, 276(49), 45530-8. PMID: 11564732.

Ding, Y., Stec, D. E. & Sigmund, C. D. (2001). Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. The Journal of biological chemistry, 276(10), 7431-6. PMID: 11096065.

Wilson, K., Fry, G. L., Chappell, D. A., Sigmund, C. D. & Medh, J. D. (2001). Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arteriosclerosis, thrombosis, and vascular biology, 21(11), 1809-15. PMID: 11701470.

Sigmund, C. D. (2001). Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney. American journal of hypertension, 14(6 Pt 2), 33S-37S. PMID: 11411763.

Morimoto, S., Cassell, M. D., Beltz, T. G., Johnson, A. K., Davisson, R. L. & Sigmund, C. D. (2001). Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circulation research, 89(4), 365-72. PMID: 11509454.

Stec, D. E., Sigmund, C. D. (2001). Physiological insights from genetic manipulation of the renin-angiotensin system. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 16, 80-4. PMID: 11390954.

Stec, D. E., Morimoto, S. & Sigmund, C. D. (2001). Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. BioTechniques, 31(2), 256-8, 260. PMID: 11515356.

Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M. R., Sigmund, C. D., Heistad, D. D., Faraci, F. M. & Lentz, S. R. (2001). Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circulation research, 88(11), 1203-9. PMID: 11397788.

Sigmund, C. D., Stec, D. E. (2000). Genetic Manipulation of the Renin-Angiotensin System using CRE-LOXP-Recombinase. In D. Wang (Eds.) In: Methods in Molecular Medicine: Angiotensin Protocols. Humana Press.

Sinn, P. L., Sigmund, C. D. (2000). Understanding the Regulation of Renin Gene Expression through In Vitro and In Vivo Models. In A. Husain , R. M. Graham (Eds.) In: Drugs, Enzymes and Receptors of the Renin Angiotensin System Celebrating a Century of Discovery. pp. 259-278. Harwood Academic Publishers.

Wang, Q., Sigmund, C. D. & Lin, J. J. (2000). Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circulation research, 86(4), 478-84. PMID: 10700454.

Lake-Bruse, K. D., Sigmund, C. D. (2000). Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Current hypertension reports, 2(2), 211-6. PMID: 10981151.

Sinn, P. L., Sigmund, C. D. (2000). Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiological genomics, 3(1), 25-31. PMID: 11015597.

Davisson, R. L., Oliverio, M. I., Coffman, T. M. & Sigmund, C. D. (2000). Divergent functions of angiotensin II receptor isoforms in the brain. The Journal of clinical investigation, 106(1), 103-6. PMID: 10880053.

Sigmund, C. D. (2000). Viewpoint: are studies in genetically altered mice out of control?. Arteriosclerosis, thrombosis, and vascular biology, 20(6), 1425-9. PMID: 10845854.

Sinn, P. L., Sigmund, C. D. (2000). Transgenic models as tools for studying the regulation of human renin expression. Regulatory peptides, 86(1-3), 77-82. PMID: 10672905.

Didion, S. P., Sigmund, C. D. & Faraci, F. M. (2000). Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Stroke; a journal of cerebral circulation, 31(3), 760-4; discussion 765. PMID: 10700516.

Cvetkovic, B., Sigmund, C. D. (2000). Understanding hypertension through genetic manipulation in mice. Kidney international, 57(3), 863-74. PMID: 10720939.

Cvetkovic, B., Yang, B., Williamson, R. A. & Sigmund, C. D. (2000). Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. The Journal of biological chemistry, 275(2), 1073-8. PMID: 10625648.

Stec, D. E., Sigmund, C. D. (1999). Hypertension Research in the 21st Century: Tissue-Specific Deletion of Gene Function to Study Mechanisms of Hypertension. Newsletter of the American Heart Association: Council for High Blood Pressure Research, 1, 16-19.

Faraci, F. M., Sigmund, C. D. (1999). Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circulation research, 85(12), 1214-25. PMID: 10590250.

Lake-Bruse, K. D., Faraci, F. M., Shesely, E. G., Maeda, N., Sigmund, C. D. & Heistad, D. D. (1999). Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. The American journal of physiology, 277(2 Pt 2), H770-6. PMID: 10444505.

Shi, Q., Black, T. A., Gross, K. W. & Sigmund, C. D. (1999). Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circulation research, 85(6), 479-88. PMID: 10488050.

Sinn, P. L., Zhang, X. & Sigmund, C. D. (1999). JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. The American journal of physiology, 277(4 Pt 2), F634-42. PMID: 10516288.

Sinn, P. L., Davis, D. R. & Sigmund, C. D. (1999). Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. The Journal of biological chemistry, 274(50), 35785-93. PMID: 10585461.

Mark, A. L., Shaffer, R. A., Correia, M. L., Morgan, D. A., Sigmund, C. D. & Haynes, W. G. (1999). Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. Journal of hypertension, 17(12 Pt 2), 1949-53. PMID: 10703894.

Stec, D. E., Davisson, R. L., Haskell, R. E., Davidson, B. L. & Sigmund, C. D. (1999). Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. The Journal of biological chemistry, 274(30), 21285-90. PMID: 10409686.

Yang, G., Gray, T. S., Sigmund, C. D. & Cassell, M. D. (1999). The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain research, 817(1-2), 123-31. PMID: 9889347.

Davisson, R. L., Ding, Y., Stec, D. E., Catterall, J. F. & Sigmund, C. D. (1999). Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiological genomics, 1(1), 3-9. PMID: 11015555.

Sinn, P. L., Sigmund, C. D. (1999). Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension, 33(3), 900-5. PMID: 10082506.

Yan, Y., Chen, R., Pitarresi, T., Sigmund, C. D., Gross, K. W., Sealey, J. E., Laragh, J. H. & Catanzaro, D. F. (1998). Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circulation research, 83(12), 1279-88. PMID: 9851945.

Stec, D. E., Sigmund, C. D. (1998). Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Experimental nephrology, 6(6), 568-75. PMID: 9807030.

Sigmund, C. D. (1998). Transgenesis and Gene Targeting: Tools for Studying the Renin-Angiotensin System. Newsletter of the American Heart Association: Council on Kidney in Cardiovascular Disease, 1, 7-13.

Yang, G., Sigmund, C. D. (1998). Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension, 31(3), 734-40. PMID: 9495255.

Yang, G., Sigmund, C. D. (1998). Developmental expression of human angiotensinogen in transgenic mice. The American journal of physiology, 274(5 Pt 2), F932-9. PMID: 9612331.

Stec, D. E., Davisson, R. L. & Sigmund, C. D. (1998). Transgenesis and gene targeting in the mouse: Tools for studying genetic determinants of hypertension. Trends in cardiovascular medicine, 8(6), 256-64. PMID: 14987561.

Davisson, R. L., Yang, G., Beltz, T. G., Cassell, M. D., Johnson, A. K. & Sigmund, C. D. (1998). The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circulation research, 83(10), 1047-58. PMID: 9815152.

Faraci, F. M., Sigmund, C. D., Shesely, E. G., Maeda, N. & Heistad, D. D. (1998). Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. The American journal of physiology, 274(2 Pt 2), H564-70. PMID: 9486260.

Ding, Y., Davisson, R. L., Hardy, D. O., Zhu, L. J., Merrill, D. C., Catterall, J. F. & Sigmund, C. D. (1997). The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. The Journal of biological chemistry, 272(44), 28142-8. PMID: 9346970.

Davisson, R. L., Kim, H. S., Krege, J. H., Lager, D. J., Smithies, O. & Sigmund, C. D. (1997). Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. The Journal of clinical investigation, 99(6), 1258-64. PMID: 9077534.

Petrovic, N., Kane, C. M., Sigmund, C. D. & Gross, K. W. (1997). Downregulation of renin gene expression by interleukin-1. Hypertension, 30(2 Pt 1), 230-5. PMID: 9260985.

Merrill, D. C., Granwehr, B. P., Davis, D. R. & Sigmund, C. D. (1997). Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. Proceedings of the Association of American Physicians, 109(6), 533-46. PMID: 9394415.

Yan, Y., Jones, C. A., Sigmund, C. D., Gross, K. W. & Catanzaro, D. F. (1997). Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circulation research, 81(4), 558-66. PMID: 9314837.

Jones, C. A., Petrovic, N., Novak, E. K., Swank, R. T., Sigmund, C. D. & Gross, K. W. (1997). Biosynthesis of renin in mouse kidney tumor As4.1 cells. European journal of biochemistry / FEBS, 243(1-2), 181-90. PMID: 9030738.

Ying, L., Morris, B. J. & Sigmund, C. D. (1997). Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. The Journal of biological chemistry, 272(4), 2412-20. PMID: 8999953.

Lang, J. A., Ying, L. H., Morris, B. J. & Sigmund, C. D. (1996). Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. The American journal of physiology, 271(1 Pt 2), F94-100. PMID: 8760248.

Davisson, R. L., Nuutinen, N., Coleman, S. T. & Sigmund, C. D. (1996). Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic acids research, 24(20), 4023-8. PMID: 8918807.

Merrill, D. C., Thompson, M. W., Carney, C. L., Granwehr, B. P., Schlager, G., Robillard, J. E. & Sigmund, C. D. (1996). Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. The Journal of clinical investigation, 97(4), 1047-55. PMID: 8613528.

Davisson, R. L., Sigmund, C. D. (1996). Transgenic animal models as tools for studying renal developmental physiology. Pediatric nephrology (Berlin, Germany), 10(6), 798-803. PMID: 8971910.

Petrovic, N., Black, T. A., Fabian, J. R., Kane, C., Jones, C. A., Loudon, J. A., Abonia, J. P., Sigmund, C. D. & Gross, K. W. (1996). Role of proximal promoter elements in regulation of renin gene transcription. The Journal of biological chemistry, 271(37), 22499-505. PMID: 8798416.

Thompson, M. W., Smith, S. B. & Sigmund, C. D. (1996). Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension, 28(2), 290-6. PMID: 8707396.

Smith, D. L., Jeyapalan, S., Lang, J. A., Guo, X. H., Sigmund, C. D. & Morris, B. J. (1995). Human renin 5'-flanking DNA to nucleotide-2750. DNA sequence : the journal of DNA sequencing and mapping, 5(5), 319-21. PMID: 7579588.

Thompson, H. A., Burson, J. M., Lang, J. A., Gross, K. W. & Sigmund, C. D. (1995). Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology, 136(7), 3037-45. PMID: 7789330.

Thompson, M. W., Merrill, D. C., Yang, G., Robillard, J. E. & Sigmund, C. D. (1995). Transgenic animals in the study of blood pressure regulation and hypertension. The American journal of physiology, 269(5 Pt 1), E793-803. PMID: 7491928.

Lang, J. A., Yang, G., Kern, J. A. & Sigmund, C. D. (1995). Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension, 25(4 Pt 2), 704-10. PMID: 7721420.

Held, W. A., O'Brien, J. G., Kerns, K., Gallagher, J. F., Sigmund, C. D. & Gross, K. W. (1994). Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. Cancer research, 54(24), 6496-9. PMID: 7987848.

Lang, J. A., Sinclair, N. L., Burson, J. M. & Sigmund, C. D. (1994). Transgenic animals as tools in hypertension research. Proceedings of the Society for Experimental Biology and Medicine, 205(2), 106-18. PMID: 8108459.

Catanzaro, D. F., Sun, J., Gilbert, M. T., Yan, Y., Black, T., Sigmund, C. & Gross, K. W. (1994). A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells. Kidney international, 46(6), 1513-5. PMID: 7699993.

Yang, G., Merrill, D. C., Thompson, M. W., Robillard, J. E. & Sigmund, C. D. (1994). Functional expression of the human angiotensinogen gene in transgenic mice. The Journal of biological chemistry, 269(51), 32497-502. PMID: 7798251.

Burson, J. M., Aguilera, G., Gross, K. W. & Sigmund, C. D. (1994). Differential expression of angiotensin receptor 1A and 1B in mouse. The American journal of physiology, 267(2 Pt 1), E260-7. PMID: 8074205.

Jones, C. A., Fabian, J. R., Abel, K., Sigmund, C. D. & Gross, K. W. (1993). The Regulation of Renal and Extrarenal Renin Gene Expression in the Mouse. In M. K. Raizada , M. I. Phillips , C. Sumners (Eds.) In: Cellular and Molecular Biology of the Renin-Angiotensin System. pp. 33-57. CRC Press.

Sigmund, C. D. (1993). Expression of the human renin gene in transgenic mice throughout ontogeny. Pediatric nephrology (Berlin, Germany), 7(5), 639-45. PMID: 8251339.

Sigmund, C. D. (1993). Major approaches for generating and analyzing transgenic mice. An overview. Hypertension, 22(4), 599-607. PMID: 8406666.

Sigmund, C. D., Fabian, J. R. & Gross, K. W. (1992). Expression and regulation of the renin gene. Trends in cardiovascular medicine, 2(6), 237-45. PMID: 21239248.

Lim, S. K., Sigmund, C. D., Gross, K. W. & Maquat, L. E. (1992). Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Molecular and cellular biology, 12(3), 1149-61. PMID: 1545796.

Sigmund, C. D., Jones, C. A., Kane, C. M., Wu, C., Lang, J. A. & Gross, K. W. (1992). Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circulation research, 70(5), 1070-9. PMID: 1568298.

Sigmund, C. D., Jones, C. A., Fabian, J. R., Wu, C., Kane, C. M., Ellsowrth, M. K., Pachotec, F. D. & Gross, K. W. (1991). Transgenic Mice and the Development of Animal Models and Resources for Hypertension Research. In K. Berg , V. Bulyzhenkov , Y. Chrinsten , P. Corvol (Eds.) In: Genetic Approaches for the Prevention and Control of Coronary Heart Disease and Hypertension. Springer-Verlag.

Sigmund, C. D., Gross, K. W. (1991). Structure, expression, and regulation of the murine renin genes. Hypertension, 18(4), 446-57. PMID: 1916990.

Sigmund, C. D., Jones, C. A., Jacob, H. J., Ingelfinger, J., Kim, U., Gamble, D., Dzau, V. J. & Gross, K. W. (1991). Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. The American journal of physiology, 260(2 Pt 2), F249-57. PMID: 1996675.

Jacob, H. J., Sigmund, C. D., Shockley, T. R., Gross, K. W. & Dzau, V. J. (1991). Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension, 17(6 Pt 2), 1167-62. PMID: 2045162.

Jones, C. A., Sigmund, C. D., McGowan, R. A., Kane-Haas, C. M. & Gross, K. W. (1990). Expression of murine renin genes during fetal development. Molecular Endocrinology, 4(3), 375-83. PMID: 2188116.

Sigmund, C. D., Jones, C. A., Fabian, J. R., Mullins, J. J. & Gross, K. W. (1990). Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice. Biochemical and biophysical research communications, 170(1), 344-50. PMID: 1695507.

Sigmund, C. D., Okuyama, K., Ingelfinger, J., Jones, C. A., Mullins, J. J., Kane, C., Kim, U., Wu, C. Z., Kenny, L. & Rustum, Y. (1990). Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. The Journal of biological chemistry, 265(32), 19916-22. PMID: 2174057.

Sigmund, C. D., Jones, C. A., Mullins, J. J., Kim, U. & Gross, K. W. (1990). Expression of murine renin genes in subcutaneous connective tissue. Proceedings of the National Academy of Sciences of the United States of America, 87(20), 7993-7. PMID: 2172970.

Sigmund, C. D., Gross, K. W. (1990). Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue. Biochemical and biophysical research communications, 173(1), 218-23. PMID: 1979487.

Fabian, J. R., Field, L. J., McGowan, R. A., Mullins, J. J., Sigmund, C. D. & Gross, K. W. (1989). Allele-specific expression of the murine Ren-1 genes. The Journal of biological chemistry, 264(29), 17589-94. PMID: 2677011.

Mullins, J. J., Sigmund, C. D., Kane-Haas, C., Gross, K. W. & McGowan, R. A. (1989). Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. The EMBO journal, 8(13), 4065-72. PMID: 2480233.

Mullins, J. J., Sigmund, C. D., Kane-Haas, C., Wu, C. Z., Pacholec, F., Zeng, Q. & Gross, K. W. (1988). Studies on the regulation of renin genes using transgenic mice. Clinical and experimental hypertension. Part A, Theory and practice, 10(6), 1157-67. PMID: 3066526.

Sigmund, C. D., Morgan, E. A. (1988). Effects of Escherichia coli Nus A protein on transcription termination in vitro are not increased or decreased by DNA sequences sufficient for antitermination in vivo. Biochemistry, 27(15), 5628-35. PMID: 2846045.

Sigmund, C. D., Morgan, E. A. (1988). Nus A protein affects transcriptional pausing and termination in vitro by binding to different sites on the transcription complex. Biochemistry, 27(15), 5622-7. PMID: 2846044.

Sigmund, C. D., Ettayebi, M. & Morgan, E. A. (1988). Antibiotic resistance mutations in 16S adn 23S ribosomal RNA genes of Escherichia coli. Methods Enzymol, 164, 673-90. PMID: 3071688.

Morgan, E. A., Gregory, S. T., Sigmund, C. D. & Borden, A. (1985). Antibiotic Resistance Mutations in Escherichia coli Ribosomal RNA Genes and Their Uses.

Sigmund, C. D., Ettayebi, M., Prasad, S. M., Flatow, B. M. & Morgan, E. A. (1985). Antibiotic Resistance Mutations in 16S and 23S Ribosomal RNA Genes of Escherichia coli. In In: Sequence Specificity in Transcription and Translation. pp. 409-417. Alan R. Liss, Inc.

Sigmund, C. D., Ettayebi, M. & Morgan, E. A. (1984). Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic acids research, 12(11), 4653-63. PMID: 6330677.

Mark, L. G., Sigmund, C. D. & Morgan, E. A. (1983). Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. Journal of bacteriology, 155(3), 989-94. PMID: 6193099.

Sigmund, C. D., Morgan, E. A. (1982). Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 79(18), 5602-6. PMID: 6752954.