Robert A. Philibert, MD, PhD

Portrait
Professor of Psychiatry

Contact Information

Office
2-126B Medical Education Building
Iowa City, IA 52242
319-353-4986

Education

BS, Biology, Ambrose College, Davenport, IA
MD, Medicine, University of Iowa College of Medicine, Iowa City, IA
PhD, Neuroscience, University of Iowa College of Medicine, Iowa City, IA
Resident, Psychiatry, Department of Psychiatry, University of Iowa, Iowa City, IA
Postdoctoral Fellow, Pharmacology, NIH, Bethesda, MD
Fellow, Clinical Neuroscience, Clinical Neuroscience Branch, NIMH, Bethesda, MD

Licensure and Certifications

Medical license - Georgia Composite Medical Board

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Neuroscience

Research Summary

I have three major foci of research in my laboratory. The first focus is molecular gene-environment (GxE) studies of large longitudinal cohorts. The second focus is centered on my work with MED12 in human health and behavior. The third area is the development of transcriptional profiling techniques in behavioral health. Molecular Studies of GxE Effects in Behavioral Illness. The importance of GxE effects in complex behavior illnesses has become increasingly appreciated over the past several years. In order to study these interactions, I have assembled one of the largest collections of biomaterial from longitudinal cohorts in the United States. From these individual, my group has prepared DNA, RNA and cell lines for each of the individuals in the study. Using these materials, we are taking a radical approach by using our lymphoblast cell models to construct an integrated view of gene variation, methylation, mRNA expression and clinical phenotype for each individual study. For example, in a direct follow-up to our earlier study that described and characterized the role of a CpG island that regulates mRNA transcription from the serotonin transporter (5HTT, SLC6A4; U.S. Patent pending) locus we have submitted a manuscript which will detail the relationship of each SNP, haplotype, CpG residue methylation status at this locus with mRNA expression and clinical phenotype at this locus. The Role of MED12 (HOPA) In Human Health and Behavior MED12 regulates monoaminergic neurodifferentiation. Our group has identified and patented a protein variant which alters dopaminergic cell fate and increases risk for psychosis. In the past several years, my laboratory has gained increasing traction on the understanding of the differential biology associated by coupling our clinical studies this gene variant with more basic approaches using stable, doubly transfected, inducible PC63 cell lines and our newly developed transcriptional profiling techniques. This approach has been extremely productive with nduction of constructs antagonizing Opa domain function alters PC63 morphology. Most excitingly, transcriptional profiling of lymphoblast cell lines derived from psychotic subjects with the HOPA12bp demonstrates a differential expression profile that implicates Wnt dysfunction. This fall we have begun direct translation of these finding into humans and have begun construction of transgenic human embryonic stems, a first here at the University of Iowa. Transcriptional Profiling in Neuropsychiatric Syndromes. The Holy Grail in most medical disciplines is to define the biological diatheses for illness. Psychiatry is no exception. As we have demonstrated in several high profile studies, by conducting genome wide transcriptional profiling studies coupled with a systems biology analytic paradigm, is possible to identify not only genes, but gene pathways involved in the etiology of many common mental disorders. Furthermore, in collaboration with private companies, we are developing specific transcriptional approaches for use as diagnostic tools in the clinic.

Publications

Beach SRH,, Lei, M. K., Simons, R. L., Dogan, M. V., Gibbons, F. X. & Philibert, R. A. (2018). MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. PMID: 29745998.

Philibert, R., Dogan, M., Noel, A., Miller, S., Krukow, B., Papworth, E., Cowley, J., Knudsen, A., Beach SRH, & Black, D. (2018). Genome-wide and digital polymerase chain reaction epigenetic assessments of alcohol consumption. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. PMID: 29704316.

Philibert, R., Dogan, M., Noel, A., Miller, S., Krukow, B., Papworth, E., Cowley, J., Long, J. D., Beach SRH, & Black, D. W. (2018). Dose Response and Prediction Characteristics of a Methylation Sensitive Digital PCR Assay for Cigarette Consumption in Adults. Frontiers in genetics, 9, 137. PMID: 29740475.

Dogan, M. V., Grumbach, I. M., Michaelson, J. J. & Philibert, R. A. (2018). Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study. PloS one, 13(1), e0190549. PMID: 29293675.

Berg, M. T., Simons, R. L., Barr, A., Beach SRH, & Philibert, R. A. (2017). Childhood/Adolescent stressors and allostatic load in adulthood: Support for a calibration model. Social science & medicine (1982), 193, 130-139. PMID: 28982528.

Anderson, A. M., Philibert, R. A., Gibbons, F. X., Simons, R. L. & Long, J. (2017). Accuracy and utility of an epigenetic biomarker for smoking in populations with varying rates of false self-report. Am J Med Genet B Neuropsychiatr Genet, 174(6), 641-650.

Dogan, M. V., Beach, S. R. & Philibert, R. A. (2017). Genetically contextual effects of smoking on genome wide DNA methylation. Am J Med Genet B Neuropsychiatr Genet.

Beach, S. H., Lei, M. K., Ong, M. L., Brody, G. H., Dogan, M. V. & Philibert, R. A. (2017). MTHFR methylation moderates the impact of smoking on DNA methylation at AHRR for African American young adults. Am J Med Genet B Neuropsychiatr Genet.

Simons, R. L., Lei, M. K., Beach, S. R., Barr, A. B., Cutrona, C. E., Gibbons, F. X. & Philibert, R. A. (2017). An index of the ratio of inflammatory to antiviral cell types mediates the effects of social adversity and age on chronic illness. Social Science Medicine. PMID: 28356188.

Lei, M. K., Simons, R. L., Beach, S. R. & Philibert, R. A. (2017). Neighborhood disadvantage and biological aging: using marginal structural models to assess the link between neighborhood census variables and epigenetic aging. Journal of Gerontology. PMID: 28329838.

Lei, M. K., Beach, S. R., Dogan, M. V. & Philibert, R. A. (2017). A pilot investigation of the impact of smoking cessation on biological age. Am J Addict. PMID: 28106943.

Lei, M. K., Beach, S. R., Simons, R. L., Barr, A. B., Cutrona, C. E. & Philibert, R. A. (2016). Stress, relationship satisfaction, and health among African American women: Genetic moderation of effects. J Fam Psychol, 30(2), 221-232.

...,, Philibert, R. A., Rietschel, M., Roy, A., Rujescu, D., Saarikoski, S. T., Swan, G. E., Todorov, A. A., Vanyukov, M. M., Weiss, R. B., Bierut, L. J. & Saccone, N. L. (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet, 46(2), 151-169.

Beach, S. R., Lei, M. K., Brody, G. H., Miller, G. E., Chen, E., Mandara, J. & Philibert, R. A. (2016). Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, proinflammatory epitype, and young adult stress. (Vols. 20). pp. 1-13. Dev Psycholpathol. PMID: 27760580.

Dogan, M. V., Lei, M. K., Beach, S. R., Brody, G. H. & Philibert, R. A. (2016). Alcohol and tobacco consumption after hypothalamic pituitary adrenal axis DNA methylation. Psychoneuroendocrinol, 66, 176-184. PMID: 4788520.

Philibert, R., Hollenbeck, N., Andersen, E., McElroy, S., Wilson, S., Vercande, K., Beach, S. R., Osborn, T., Gerrard, M., Gibbons, F. X. & Wang, K. (2016). Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation. Front Psychiatry, 7, 55.

Cutrona, C. E., Abraham, W. T., Russell, D. W., Beach, S. R., Gibbons, F. X., Gerrard, M., Monick, M. & Philibert, R. (2014). Financial strain, inflammatory factors, and haemoglobin A1c levels in African American women. Br J Health Psychol. PMID: 25327694.

Philibert, R. A., Penaluna, B., White, T., Shires, S., Gunter, T., Liesveld, J., Erwin, C., Hollenbeck, N. & Osborn, T. (2014). A pilot examination of the genome-wide DNA Methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. Epigenetics, 9(9), 1212-9. PMID: 25147915.

Sales, J. M., Diclemente, R. J., Brody, G. H., Philibert, R. A. & Rose, E. (2014). Interaction Between 5-HTTLPR Polymorphism and Abuse History on Adolescent African-American Females' Condom Use Behavior Following Participation in an HIV Prevention Intervention. Prev Sci, 15(3), 257-67. PMID: 23479192.

Brody, G. H., Yu, T., Chen, Y. F., Kogan, S. M., Evans, G. W., Beach, S. R., Windle, M., Simons, R. L., Gerrard, M., Gibbons, F. X. & Philibert, R. A. (2013). Cumulative socioeconomic status risk, allostatic load, and adjustment: a prospective latent profile analysis with contextual and genetic protective factors. Dev Psychol, 49(5), 913-27. PMID: 22709130.

Brody, G. H., Yu, T., Beach, S. R., Kogan, S. M., Windle, M. & Philibert, R. A. (2013). Harsh Parenting and Adolescent Health: A Longitudinal Analysis With Genetic Moderation. Health Psychol, 33(5), 401-9. PMID: 23668852.

Brody, G. H., Chen, Y. F., Beach, S. R., Kogan, S. M., Yu, T., Diclemente, R. J., Wingood, G. M., Windle, M. & Philibert, R. A. (2013). Differential Sensitivity to Prevention Programming: A Dopaminergic Polymorphism-Enhanced Prevention Effect on Protective Parenting and Adolescent Substance Use. Health Psychology, 33(2), 182-91. PMID: 23379386.

Beach, S. R., Brody, G. H., Lei, M. K., Gibbons, F. X., Gerrard, M., Simons, R. L., Cutrona, C. E. & Philibert, R. A. (2013). Impact of child sex abuse on adult psychopathology: a genetically and epigenetically informed investigation. Journal of Family Psychology, 27(1), 3-11. PMID: 23421829.

Brody, G. H., Yu, T., Chen, Y. F., Kogan, S. M., Evans, G. W., Windle, M., Gerrard, M., Gibbons, F. X., Simons, R. L. & Philibert, R. A. (2013). Supportive family environments, genes that confer sensitivity, and allostatic load among rural african american emerging adults: a prospective analysis. J Fam Psychol, 27(1), 22-9. PMID: 22468688.

Gunter, T. D., Chibnall, J. T., Antoniak, S. K., Philibert, R. A. & Black, D. W. (2013). Childhood trauma, traumatic brain injury, and mental health disorders associated with suicidal ideation and suicide-related behavior in a community corrections sample. J Am Acad Psychiatry Law, 41(2), 245-255. PMID: 23771938.

Philibert, R. A., Beach, S. R. & Brody, G. H. (2012). Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers. Epigenetics, 7(11), 1331-8. PMID: 23070629.

Philibert, R. A., Sears, R. A., Powers, L. S., Nash, E., Bair, T., Gerke, A. K., Hassan, I., Thomas, C. P., Gross, T. J. & Monick, M. M. (2012). Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. Journal of Leukocyte Biology, 92(3), 621-31. PMID: 22427682.

Brody, G. H., Chen, Y. F., Yu, T., Beach, S. R., Kogan, S. M., Simons, R. L., Windle, M. & Philibert, R. A. (2012). Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: a longitudinal, multilevel, mediated moderation analysis. Development and Psychopathology, 24(3), 941-51. PMID: 22781864.

Vijayendran, M., Cutrona, C., Beach, S. R., Brody, G. H., Russell, D. & Philibert, R. A. (2012). The relationship of the serotonin transporter (SLC6A4) extra long variant to gene expression in an African American sample. American Journal of Medical Genetics, 159B(5), 611-2. PMID: 22553133.

Gibbons, F. X., Roberts, M. E., Gerrard, M., Li, Z., Beach, S. R., Simons, R. L., Weng, C. Y. & Philibert, R. A. (2012). The impact of stress on the life history strategies of African American adolescents: cognitions, genetic moderation, and the role of discrimination. Developmental Psychology, 48(3), 722-39. PMID: 22251000.

Monick, M. M., Beach, S. R., Plume, J., Sears, R., Gerrard, M., Brody, G. H. & Philibert, R. A. (2012). Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 159B(2), 141-51. PMID: 22232023.

Beach, S. R., Lei, M. K., Brody, G. H., Simons, R. L., Cutrona, C. & Philibert, R. A. (2012). Genetic moderation of contextual effects on negative arousal and parenting in African-American parents. Journal of Family Psychology, 26(1), 46-55. PMID: 22081909.

Plume, J. M., Beach, S. R., Brody, G. H. & Philibert, R. A. (2012). A cross-platform genome-wide comparison of the relationship of promoter DNA methylation to gene expression. Front Genet, 3, 12. PMID: 22363339.

Kuyper, B., Labuschagne, C., Philibert, R., Moyo, N., Waldron, H., Reason, C. & Palmer, C. (2012). Development of a simplified, cost effective GC-ECD methodology for the sensitive detection of bromoform in the troposphere. Sensors, 12(10), 13583-97. PMID: 23202011.

Vijayendran, M., Beach, S. R., Plume, J. M., Brody, G. H. & Philibert, R. A. (2012). Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter. Front Psych, 3, 55. PMID: 22707942.

Erhardt, A., Akula, N., Schumacher, J., Czamara, D., Karbalai, N., Müller-Myhsok, B., Mors, O., Borglum, A., Kristensen, A. S., Woldbye, D. P., Koefoed, P., Eriksson, E., Maron, E., Metspalu, A., Nurnberger, J., Philibert, R. A., Kennedy, J., Domschke, K., Reif, A., Deckert, J., Otowa, T., Kawamura, Y., Kaiya, H., Okazaki, Y., Tanii, H., Tokunaga, K., Sasaki, T., Ioannidis, J. P., McMahon, F. J. & Binder, E. B. (2012). Replication and meta-analysis of TMEM132D gene variants in panic disorder. Translational Psychiatry, 2, e156. PMID: 22948381.

Sears, R., Powers, L. S., Gerke, A., Gross, T. J., Philibert, R. A. & Monick, M. M. (2012). Smoking-altered DNA methylation in alveolar macrophages correlates with gene expression. Proceedings of the American Thoracic Society, 9(2), 84-85.

Philibert, R. A., Plume, J. M., Gibbons, F. X., Brody, G. H. & Beach, S. R. (2012). The impact of recent alcohol use on genome wide DNA methylation signatures. Frontiers In Genetics, 3, 54. PMID: 22514556.

Simons, R. L., Lei, M. K., Beach, S. R., Brody, G. H., Philibert, R. A. & Gibbons, F. X. (2011). Social Environmental Variation, Plasticity Genes, and Aggression: Evidence for the Differential Susceptibility Hypothesis. American Sociological Review, 76(6), 833-912. PMID: 22199399.

Philibert, R., Wernett, P., Plume, J., Packer, H., Brody, G. H. & Beach, S. R. (2011). Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder. Biological Psychology, 87(3), 366-71. PMID: 21554924.

Philibert, R., Beach, S. R., Gunter, T. D., Todorov, A. A., Brody, G. H., Vijayendran, M., Elliott, L., Hollenbeck, N., Russell, D. & Cutrona, C. (2011). The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations. American Journal of Medical Genetics, 156(5), 593-9. PMID: 21563302.

Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Caspers, K. & Philibert, R. (2011). DRD4 genotype moderates the impact of parental problems on unresolved loss or trauma. Attachment and Human Development, 13(3), 253-69. PMID: 21506030.

Beach, S. R., Brody, G. H., Todorov, A. A., Gunter, T. D. & Philibert, R. A. (2011). Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample. Psychosomatic Medicine, 73(1), 83-7. PMID: 20947778.

Beach, S. R., Brody, G. H., Lei, M. K. & Philibert, R. (2010). Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis. The Journal of Family Psychology, 24(5), 513-21. PMID: 20954761.

Kogan, S. M., Beach, S. R., Philibert, R., Brody, G. H., Chen, Y. F. & Lei, M. K. (2010). 5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior. Health Psychology, 29(5), 471-6.

van IJzendoorn, M. H., Caspers, K., Bakermans-Kranenburg, M. J., Beach, S. R. & Philibert, R. (2010). Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biological Psychiatry, 68(5), 405-7. PMID: 20591416.

Philibert, R., Beach, S. R., Gunter, T. D., Brody, G. H., Madan, A. & Gerrard, M. (2010). The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. American Journal of Medical Genetics, 153B(2), 619-28. PMID: 19777560.

Beach, S. R., Brody, G. H., Todorov, A. A., Gunter, T. D. & Philibert, R. A. (2010). Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. American Journal of Medical Genetics, 153B(2), 710-3. PMID: 19739105.

Beach, S. R., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P. & Philibert, R. A. (2010). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. Journal of Family Psychology, 24(1), 12-20. PMID: 20175604.

Gunter, T. D., Vaughn, M. G. & Philibert, R. (2010). Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature. Behavioral Sciences & the Law, 28(2), 148-73. PMID: 20422643.

Kochanska, G., Philibert, R. & Barry, R. A. (2009). Interplay of genes and early mother-child relationship in the development of self-regulation from toddler to preschool age. Journal of Child Psychology and Psychiatry, 50(11), 1331-8. PMID: 19207629.

Brody, G. H., Chen, Y. F., Beach, S. R., Philibert, R. A. & Kogan, S. M. (2009). Participation in a family-centered prevention program decreases genetic risk for adolescents' risky behaviors. Pediatrics, 124(3), 911-7. PMID: 19706565.

Philibert, R. A., Gunter, T. D., Beach, S. R., Brody, G. H., Hollenbeck, N., Andersen, A. & Adams, W. (2009). Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. Psychiatric Genetics, 19(2), 91-8. PMID: 19672139.

Philibert, R. A., Todorov, A., Andersen, A., Hollenbeck, N., Gunter, T., Heath, A. & Madden, P. (2009). Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. Nicotine & Tobacco Research, 11(3), 286-92. PMID: 19307444.

Beach, S. R., Brody, G. H., Kogan, S. M., Philibert, R. A., Chen, Y. F. & Lei, M. K. (2009). Change in caregiver depression in response to parent training: genetic moderation of intervention effects. Journal of Family Psychology, 23(1), 112-7. PMID: 19203166.

Brody, G. H., Beach, S. R., Philibert, R. A., Chen, Y. F., Lei, M. K., Murry, V. M. & Brown, A. C. (2009). Parenting moderates a genetic vulnerability factor in longitudinal increases in youths' substance use. Journal of Consulting and Clinical Psychology, 77(1), 1-11. PMID: 19170449.

Caspers, K. M., Paradiso, S., Yucuis, R., Troutman, B., Arndt, S. & Philibert, R. (2009). Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment. Developmental Psychology, 45(1), 64-76.

Gunter, T. D., Philibert, R. & Hollenbeck, N. (2009). Medical and psychiatric problems among men and women in a community corrections residential setting. Behavioral Sciences & the Law, 27(5), 695-711. PMID: 19743513.

Brody, G. H., Beach, S. R., Philibert, R. A., Chen, Y. F. & Murry, V. M. (2009). Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design. Child Development, 80(3), 645-61. PMID: 19489894.

Philibert, R. A., Zadorozhnyaya, O., Beach, S. R. & Brody, G. H. (2008). Comparison of the genotyping results using DNA obtained from blood and saliva. Psychiatric Genetics, 18(6), 275-81. PMID: 19018232.

Barry, R. A., Kochanska, G. & Philibert, R. (2008). G x E interaction in the organization of attachment: mothers' responsiveness as a moderator of children's genotypes. Journal of Child Psychology and Psychiatry, 49(12), 1313-20. PMID: 19120710.

Fiedorowicz, J. G., Hotsenpiller, G., Kijewski, V. & Philibert, R. A. (2008). Can affective instability complicate neuropsychiatric assessment?. Acta Neuropsychiatrica, 20(5), 232-235.

Philibert, R. A., Gunter, T. D., Beach, S. R., Brody, G. H. & Madan, A. (2008). MAOA methylation is associated with nicotine and alcohol dependence in women. American Journal of Medical Genetics, 147B(5), 565-70. PMID: 18454435.

Philibert, R. A., Sandhu, H. K., Hollenbeck, N., Gunter, T., Adams, W. J. & Madan, A. (2008). The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet, 147B.

Philibert, R. A., Todorov, A. A., Gunter, T. D., Heath, A. C., Orzack, S. & Madden, P. (2007). The Extension and Replication of Prior Nicotine Dependence Associations in the Iowa Adoption Studies. American Society for Human Genetics.

Philibert, R. A., Bohle, P., Secrest, D., Deaderick, J., Sandhu, H., Crowe, R. & Black, D. W. (2007). The association of the HOPA(12bp) polymorphism with schizophrenia in the NIMH Genetics Initiative for Schizophrenia sample. American Journal of Medical Genetics, 144B(6), 743-7. PMID: 17299734.

Philibert, R. A., Madan, A. (2007). Role of MED12 in transcription and human behavior. Pharmacogenomics, 8(8), 909-16. PMID: 17716226.

Philibert, R. A., Gershenfeld, H. K. (2007). Therapeutic potential of targeting gene variants in schizophrenia. Expert Review of Neurotherapeutics, 7(7), 757-60. PMID: 17610381.

Philibert, R. A., Crowe, R., Ryu, G. Y., Yoon, J. G., Secrest, D., Sandhu, H. & Madan, A. (2007). Transcriptional profiling of lymphoblast lines from subjects with panic disorder. American Journal of Medical Genetics, 144B(5), 674-82. PMID: 17342723.

Philibert, R., Madan, A., Andersen, A., Cadoret, R., Packer, H. & Sandhu, H. (2007). Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. American Journal of Medical Genetics, 144B(1), 101-5. PMID: 16958039.

Philibert, R., Gunter, T., Hollenbeck, N., Adams, W. J., Bohle, P., Packer, H. & Sandhu, H. (2006). No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia. Psychiatric Genetics, 16(5), 221-3. PMID: 16969279.

Philibert, R. A., Crowe, R., Ryu, G., Yoon, J., Secrest, D., Sandhu, H. K. & Madan, A. (2006). Transcriptional Profiling of Lymphoblast Lines from Subjects with Panic Disorder. American Society for Human Genetics.

Philibert, R. A., Ryu, G., Yoon, J., Sandhu, H. K., Hollenbeck, N., Gunter, T., Barkhurst, A., Adams, W. J. & Madan, A. (2006). Transcriptional Profiling of Nicotine Dependence. American Society for Human Genetics.

Forman-Hoffman, V., Philibert, R. (2006). Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults. Acta Psychiatrica Scandinavica, 114(2), 132-9. PMID: 16836601.

Langbehn, D. R., Philibert, R., Caspers, K. M., Yucuis, R. & Cadoret, R. J. (2006). Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality. Drug and Alcohol Dependence, 83(1), 33-41. PMID: 16289859.

Philibert, R. A., Madan, A., Anderson, A., Cadoret, R., Packer, H. & Sandhu, H. K. (2006). A New Structure and regulatory element for the Serotonin Transporter Gene. Society for Biological Psychiatry.

Philibert, R. A., Hoffman-Forman, V. (2006). State Dependent Changes in Thyroid Function are associated with Acute but not Lifetime History of Depression. Society for Biological Psychiatry.

Philibert, R. (2006). A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia. Psychiatr Genet, 16(2), 73-6. PMID: 16538184.

Philibert, R. A. (2006). A Tribute to Remi Cadoret. Annals of Clinical Psychiatry, 18, 215.

Philibert, R. A., Gunter, T. D., Black, D. W., Hollenbeck, N., Secrest, D., Barkhurst, A. & Adams, W. J. (2006). Correlation of Thyroxine Levels with Mood Symptoms in Persons Presenting for Inpatient Treatment of a Chronic Psychotic Disorder. Schizophrenia Research, 114, 132-139.

Philibert, R. (2006). Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression. Annals of Clinical Psychiatry, 18(4), 219-22. PMID: 17162620.

Erwin, C., Philibert, R. (2006). Shocking treatment: The use of tasers in psychiatric care. The Journal of Law, Medicine & Ethics, 34(1), 116-20. PMID: 16489991.

Gershenfeld, H. K., Philibert, R. A. & Boehm, G. W. (2005). Looking forward in geriatric anxiety and depression: implications of basic science for the future. The American Journal of Geriatric Psychiatry, 13(12), 1027-40. PMID: 16319295.

Philibert, R. A. (2005). A Meta-analysis of the Association of the HOPA12bp Polymorphism and Schizophrenia. American Society for Human Genetics.

Bradley, S. L., Dodelzon, K., Sandhu, H. K. & Philibert, R. (2005). Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. American Journal of Medical Genetics, 136B(1), 58-61. PMID: 15858822.

Dodelzon, K., Bradley, S. L., Sandhu, H. K. & Philibert, R. A. (2004). The Effect of LDHA exon 5 Polymorphism on mRNA Production. American Society for Human Genetics.

Bradley, S. L., Dodelzon, K., Sandhu, H. K. & Philibert, R. A. (2004). The Relationship of Serotonin Transporter Gene Polymorphisms and Haplotypes to mRNA Transcription. American Society for Human Genetics.

Sandhu, H. K., Hollenbeck, N., Wassink, T. & Philibert, R. (2004). An association study of PCQAP polymorphisms and schizophrenia. Psychiatric Genetics, 14(3), 169-72. PMID: 15318033.

Spinks, R., Sandhu, H. K., Andreasen, N. C. & Philibert, R. A. (2004). Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophrenia. American Journal of Medical Genetics, 127B(1), 20-7. PMID: 15108174.

Philibert, R., Mac, J. (2004). An association of Ephedra use with psychosis and autonomic hyperactivity. Annals of Clinical Psychiatry, 16(3), 167-9. PMID: 15517849.

Philibert, R. A., Cadoret, R. J. & Gershenfeld, H. K. (2004). Refining Genetic Approaches for Identifying Behavioral Loci. Current Genomics, 5, 169-174.

Sandhu, H. K., Sarkar, M., Turner, B. M., Wassink, T. H. & Philibert, R. A. (2003). Polymorphism analysis of HOPA: a candidate gene for schizophrenia. American Journal of Medical Genetics, 123B(1), 33-8. PMID: 14582143.

Philibert, R., Caspers, K., Langbehn, D., Troughton, E. P., Yucuis, R., Sandhu, H. K. & Cadoret, R. J. (2003). The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women. American Journal of Medical Genetics, 121B(1), 39-43. PMID: 12898573.

Philibert, R. A., Caspers, K., Langbehn, D., Troughton, E. P., Yucuis, R., Sandhu, H. K. & Cadoret, R. J. (2003). Association of MAO-A and D2S2944 Genotype with Substance Use and Antisocial Personality Disorders in Iowa Adoptees. Behavioral Genetics Association.

Philibert, R. A., Sarkar, M., Turner, B. T., Wassink, T. H. & Sandhu, H. K. (2003). Polymorphism Analysis of HOPA, A Candidate Gene for Schizophrenia. Society for Biological Psychiatry.

Philibert, R. A., Nelson, J. J., Sandhu, H. K., Crowe, R. R. & Coryell, W. H. (2003). Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. American Journal of Medical Genetics, 117B(1), 11-17. PMID: 12555229.

Philibert, R., Nelson, J. J., Bedell, B., Goedken, R., Sandhu, H. K., Noyes, R. & Crowe, R. R. (2003). Role of elastin polymorphisms in panic disorder. American Journal of Medical Genetics, 117B(1), 7-10. PMID: 12555228.

Philibert, R. A., Caspers, K., Langbehn, D., Yucuis, R., Sandhu, H. K. & Cadoret, R. J. (2003). The Association of the D2S2944 4 bp allele with Recurrent Early Onset Major Depressive Disorder in Women. Guze Symposium.

Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K. & Philibert, R. (2003). Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry, 44(2), 88-101. PMID: 12658617.

Philibert, R. A., Nelson, J. J., Sandhu, H. K., Crowe, R. R. & Coryell, W. H. (2002). Probands at High Risk for Panic Disorder. Society for Biological Psychiatry.

Philibert, R., Caspers, K., Langbehn, D., Troughton, E. P., Yucuis, R., Sandhu, H. K. & Cadoret, R. J. (2002). The association of a HOPA polymorphism with major depression and phobia. Comprehensive Psychiatry, 43(5), 404-10. PMID: 12216017.

Philibert, R., Cheung, D., Welsh, N., Damschroder-Williams, P., Thiel, B., Ginns, E. I. & Gershenfeld, H. K. (2001). Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish. American Journal of Medical Genetics, 105(3), 291-4. PMID: 11353452.

Philibert, R. A., Adam, L. A., Frank, F. M. & Carney-Doebbeling, C. (2001). Olanzapine usage associated with neuroleptic malignant syndrome. Psychosomatics, 42(6), 528-9. PMID: 11815691.

Philibert, R. A., Sandhu, H. K., Hutton, A. M., Wang, Z., Arndt, S., Andreasen, N. C., Crowe, R. & Wassink, T. H. (2001). Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism. American Journal of Medical Genetics, 105(1), 130-4. PMID: 11424983.

Philibert, R. A., Kaspers, K., Langbehn, D., Troughton, E. P., Yucuis, R., Sandhu, H. K. & et, a. l. (2000). Association of HOPA polymorphisms with Major Depression and Phobia.

Philibert, R. A., Sandhu, H. K., Hutton, A. M., Wang, Z., Arndt, S., Andreasen, N. C. & et, a. l. (2000). HOPA polymorphisms are associated with an increased risk for hypothyroidism and psychosis.

DeLisi, L. E., Smith, A. B., Razi, K., Stewart, J., Wang, Z., Sandhu, H. K. & Philibert, R. A. (2000). Investigation of a candidate gene for schizophrenia on Xq13 previously associated with mental retardation and hypothyroidism. American Journal of Medical Genetics, 96(3), 398-403. PMID: 10898921.

Philibert, R. A., Smith, A. B., Razi, K., Stewart, J., Wang, Z., Sandhu, H. K. & DeLisi, L. E. (2000). The segregation of HOPA mutations with respect to hypothyroidism in a cohort of schizophrenic families. Society for Biological Psychiatry.

Philibert, R., Winfield, S. L., Sandhu, H. K., Martin, B. M. & Ginns, E. I. (2000). The structure and expression of the human neuroligin-3 gene. Gene, 246(1-2), 303-10. PMID: 10767552.

Philibert, R., Caspers, K., Langbehn, D., Troughton, E. P., Yucuis, R., Sandhu, H. K. & Cadoret, R. J. (2000). The association of HOPA polymorphism with major depression and phobia. Comprehensive Psychiatry, 43(5), 404-10. PMID: 12216017.

Philibert, R. A., Damschroder-Williams, P., Theil, B., Ginns, E. I. & Gershenfeld, H. K. (1999). Absence of A Significant Association between Na+, K+ ATPase subunit (ATP1A3 and ATP1B3) genoptypes and Bipolar Disorder in the Old Order Amish. World Congress on Psychiatric Genetics.

Sandhu, H. K., Tengstrom, C. & Philibert, R. A. (1999). Conservation of a Unique Haplotype at the HOPA Gene locus in a group of Mentally Retarded Probands from a Population Isolate. World Congress on Psychiatric Genetics.

Philibert, R. A., Winfield, S., Damschroder-Williams, P., Martin, B. & Ginns, E. I. (1999). The Genomic Structure and Developmental Expression Patterns of the Human OPA Containing Gene (HOPA), a QTL for Mental Cognition. Clinical Neuroscience Branch, National Institute of Mental Health.

Philibert, R. A., Winfield, S. L., Damschroder-Williams, P., Tengstrom, C., Martin, B. M. & Ginns, E. I. (1999). The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA). Human Genetics, 105(1-2), 174-8. PMID: 10480376.

Ginns, E. I., St Jean, P., Philibert, R. A., Galdzicka, M., Damschroder-Williams, P., Thiel, B., Long, R. T., Ingraham, L. J., Dalwaldi, H., Murray, M. A., Ehlert, M., Paul, S., Remortel, B. G., Patel, A. P., Anderson, M. C., Shaio, C., Lau, E., Dymarskaia, I., Martin, B. M., Stubblefield, B., Falls, K. M., Carulli, J. P., Keith, T. P., Fann, C. S., Lacy, L. G., Allen, C. R., Hostetter, A. M., Elston, R. C., Schork, N. J., Egeland, J. A. & Paul, S. M. (1998). A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish. Proceedings of the National Academy of Sciences, 95(26), 15531-6. PMID: 9861003.

Philibert, R. A., King, B. H., Winfield, S., Cook, E. H., Lee, Y. H., Stubblefield, B., Damschroder-Williams, P., Dea, C., Palotie, A., Tengstrom, C., Martin, B. M. & Ginns, E. I. (1998). Association of an X-chromosome dodecamer insertional variant allele with mental retardation. Molecular Psychiatry, 3(4), 303-9. PMID: 9702738.

Sidransky, E., Burgess, C., Ikeuchi, T., Lindblad, K., Long, R. T., Philibert, R. A., Rapoport, J., Schalling, M., Tsuji, S. & Ginns, E. I. (1998). A triplet repeat on 17q accounts for most expansions detected by the repeat-expansion-detection technique. American Journal of Human Genetics, 62(6), 1548-51. PMID: 9585604.

Philibert, R. A., Horelli-Kuitunen, N., Robb, A. S., Lee, Y. H., Long, R. T., Damschroder-Williams, P., Martin, B. M., Brennan, M. B., Palotie, A. & Ginns, E. I. (1998). The characterization and sequence analysis of thirty CTG-repeat containing genomic cosmid clones. European Journal of Human Genetics, 6(1), 89-94. PMID: 9781019.

Philibert, R. A., St Jean, P. L., Schork, N. J., Anderson, M. C., Dalwadi, H., Damschroder-Williams, P. J. & et, a. l. (1997). A genome-wide search for chromosome regions linked to bipolar affective disorder in the old order Amish identifies several candidate loci. World Congress on Psychiatric Genetics.

Philibert, R. A., St Jean, P. L., Sahbatou, M., Egeland, J. A., Paul, S. M. & Ginns, E. I. (1997). A multivariate model using haplotype sharing: results for bipolar affective disorder in the old order amish. World Congress on Psychiatric Genetics.

Philibert, R. A., Richards, L., Lynch, C. F. & Winokur, G. (1997). The effect of gender and age at onset of depression on mortality. The Journal of Clinical Psychiatry, 58(8), 355-60. PMID: 9515974.

Philibert, R. A., Egeland, J. A., Paul, S. M. & Ginns, E. I. (1997). The inheritance of bipolar affective disorder: abundant genes coming together. Journal of Affective Disorders, 43(1), 1-3. PMID: 9127824.

Philibert, R. A., Dea, C., Lee, Y., Stubblefield, B. S. & Ginns, E. I. (1996). The direct sequencing of CCG repeats from a cosmid genomic DNA template. Epicentre Forum, 3, 1-3.

Philibert, R. A., Richards, L., Lynch, C. F. & Winokur, G. (1995). Effect of ECT on mortality and clinical outcome in geriatric unipolar depression. The Journal of Clinical Psychiatry, 56(9), 390-4. PMID: 7665536.

Philibert, R. A., Hawkins, G. A., Damschroder-Williams, P., Stubblefield, B. K., Martin, B. M. & Ginns, E. I. (1995). Direct sequencing of trinucleotide repeats from cosmid genomic DNA template. Analytical Biochemistry, 225(2), 372-4. PMID: 7762809.

Philibert, R. A., Robb, A. S., Brennan, M. B., Long, R. T., Damschroder-Williams, P., Stubblefield, B., Martin, B. & Ginns, E. I. (1995). Systematic characterization of large genomic CTG-containing trinucleotide repeats from the human genome. (Vols. 57). (4), pp. 853. The American Journal of Human Genetics.

Richards, L. L., Philibert, R. A. & Winokur, G. (1994). Effect of ECT on mortality and clinical outcome in elderly patients. American Psychiatric Association.

Rogers, K. L., Philibert, R. & Dutton, G. R. (1991). K(+)-stimulated amino acid release from cultured cerebellar neurons: comparison of static and dynamic stimulation paradigms. Neurochemical Research, 16(8), 899-904. PMID: 1686299.

Dutton, G. R., Barry, M., Simmons, M. L. & Philibert, R. (1991). Astrocyte taurine. Annals of the New York Academy of Sciences, 633, 489-500. PMID: 1665036.

Tigges, G. A., Philibert, R. & Dutton, G. R. (1990). K(+)- and temperature-evoked taurine efflux from hypothalamic astrocytes. Neuroscience Letters, 119(1), 23-6. PMID: 2097579.

Rogers, K. L., Philibert, R. & Dutton, G. R. (1990). Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture. European Journal of Pharmacology, 177(3), 195-9. PMID: 2155809.

Rogers, K. L., Philibert, R. A. & Dutton, G. R. (1990). Comparison of statis and dynamic cerebellar neurons. (Vols. 16). pp. 61. Society for Neuroscience Abstracts.

Philibert, R. A., Rogers, K. L. & Dutton, G. R. (1990). Neuron morphology amino acids and release unchanged by phorbol and cAMP. (Vols. 20). pp. 166. The American Society for Neurochemistry.

Dutton, G. R., Philibert, R. A. (1990). Taurine release from cultured astrocytes. Differentiation and Function of Glial Cells, 235-241.

Dutton, G. R., Philibert, R. A., Simmons, M. L., Miyazaki, R. & Eastburn, J. (1989). Excitatory amino acid agonist-evoked taurine release from cultured astrocytes. Society for Neuroscience.

Philibert, R. A., Dutton, G. R. (1989). Dihydropyridines modulate K+-evoked amino acid and adenosine release from cerebellar neuronal cultures. Neuroscience Letters, 102(1), 97-102. PMID: 2476690.

Dutton, G. R., Philibert, R. A. (1989). Taurine efflux from cultural astrocytes. ISN Satellite Symposium on Differentiation and Function of Glial Cells.

Philibert, R., Rogers, K. L. & Dutton, G. R. (1989). Stimulus-coupled taurine efflux from cerebellar neuronal cultures: on the roles of Ca++ and Na+. Journal of Neuroscience Research, 22(2), 167-71. PMID: 2468785.

Philibert, R., Rogers, K. L. & Dutton, G. R. (1989). K+-evoked taurine efflux from cerebellar astrocytes: on the roles of Ca2+ and Na+. Neurochemical Research, 14(1), 43-8. PMID: 2469025.

Philibert, R., Dutton, G. R. (1988). Phorbol ester and dibutyryl cyclic AMP reduce content and efflux of taurine in primary cerebellar astrocytes in culture. Neuroscience Letters, 95(1-3), 323-8. PMID: 2852322.

Dutton, G. R., Rogers, K. L. & Philibert, R. A. (1988). Na+ and Ca++ channel agonists stimulate endogenous amino acid release from primary cerebellar neuronal cultures. Society for Neuroscience.

Philibert, R. A., Dutton, G. R. (1988). Phorbol ester and dbcAMP reduce taurine content and efflux in primary astrocyte cultures. Society for Neuroscience.

Philibert, R., Rogers, K. L., Allen, A. J. & Dutton, G. R. (1988). Dose-dependent, K+-stimulated efflux of endogenous taurine from primary astrocyte cultures is Ca2+-dependent. Journal of Neurochemistry, 51(1), 122-6. PMID: 2898000.

Rogers, K. L., Philibert, R. A. & Dutton, G. R. (1988). Glutamate agonists release amino acids from cerebellar cell cultures. (Vols. 19). pp. 266. American Society for Neurochemistry Abstracts.

Dutton, G. R., Philibert, R. A. (1988). Nifedipine/CgTX-insensitive, Na+-dependent taurine release from astrocytes. Society for Neurochemistry.

Rogers, K. L., Philibert, R. A., Allen, A. J., Molitor, J., Wilson, E. J. & Dutton, G. R. (1987). HPLC analysis of putative amino acid neurotransmitters released from primary cerebellar cultures. Journal of Neuroscience Methods, 22(2), 173-9. PMID: 2893861.

Philibert, R. A., Theis, J., Rogers, K. L., Allen, A. J. & Dutton, G. R. (1987). A23187 stimulates endogenous taurine efflux from primary rat cerebellar astrocyte cultures. International Society for Neurochemistry.

Rogers, K. L., Philibert, R. A., Allen, A. J. & Dutton, G. R. (1987). Effects of kainic acid on release of endogenous neuroactive substances from primary cerebellar cell cultures. International Society for Neurochemistry.

Philibert, R. A., Allen, A. J., Wilson, E. J. & Dutton, G. R. (1986). Dose-dependent K+-stimulated efflux of endogenous taurine from primary astrocyte cultures is Ca2+-dependent. Society for Neuroscience.

Dutton, G. R., Allen, A. J., Molitor, J. A., Rogers, K. L. & Philibert, R. A. (1986). HPLC analysis of amino acids released from cerebellar cultures. Society for Neurochemistry.