Mark Greiner, MD

Contact Information

Office: 11196-N PFP
Phone: 319-356-2861
Faculty Profile

Brief description of current research:

Dr. Greiner is a board-certified ophthalmologist with fellowship training in cornea and external diseases, and the associate medical director at the Iowa Lions Eye Bank. Dr. Greiner’s team focuses on the impact of diabetes on corneal health and cornea transplant outcomes. Specifically, they are working to understand how type II diabetes causes oxidative metabolic dysfunction in corneal endothelial cells, the inner lining of the cornea, which maintains corneal clarity and is essential for successful grafting. Dr. Greiner has discovered that diabetes confers an increased risk of donor tissue wastage during the preparation steps of cornea transplant surgery, and are investigating the metabolic consequences of diabetes on this cell layer. Their approach utilizes metabolic phenotyping, mitochondrial function assays, proteomics, and bioinformatics strategies to ascertain critical differences in donor corneal endothelial cell metabolism from individuals with and without diabetes. Additionally, their metabolic function assay platform supports investigations of bioengineered corneal endothelial cells, drug effects on corneal endothelium, and diagnostics of ocular mitochondrial disorders. 

3 most influential diabetes/obesity/metabolism publications:

  • Greiner MA, Rixen JJ, Wagoner MD, Schmidt GA, Stoeger CG, Straiko MD, Zimmerman MB, Kitzmann AS, Goins KM. Diabetes mellitus increases risk of unsuccessful graft preparation in Descemet membrane endothelial keratoplasty: A multicenter study. Cornea 2014;33(11):1129-33.
  •  Vislisel JM, Liaboe CA, Wagoner MD, Goins KM, Sutphin JE, Schmidt GA, Zimmerman MB, Greiner MA. Graft Survival of Diabetic Versus Non-Diabetic Donor Tissue after Initial Keratoplasty. Cornea 2015;34(4):370-4.
  •  Greiner MA, Burckart KA, Wagoner MD, Schmidt GA, Reed CR, Liaboe CA, Flamme-Wiese MJ, Zimmerman MB, Mullins RF, Kardon RH, Goins KM, Aldrich BT. Regional assessment of energy-producing metabolic activity in the endothelium of donor corneas. Invest Ophthalmol Vis Sci 2015;56(5):2803-10.


“I strive to do everything in my power to be the best possible steward of the gift of cornea donation. The more we know, the more sight we can restore to more individuals.”