Michael J. Welsh, MD
Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
Introduction
The Welsh laboratory emphasizes research in two main areas. The first focuses on cystic fibrosis (CF), a common lethal genetic disease in which lung disease is the major cause of morbidity and mortality. Welsh and his colleagues are discovering the pathogenesis of airway disease and developing novel treatments. The second focuses on neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Welsh and his colleagues are investigating the pathophysiological basis of protein aggregates and developing treatments to prevent or delay the progressive neuron loss.
Current Positions
- Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
- Professor of Molecular Physiology and Biophysics
- Professor of Neurobiology
- Professor of Neurosurgery
- Investigator, Howard Hughes Medical Institute
- Director, Pappajohn Biomedical Institute
Education
- MD, The University of Iowa College of Medicine, Iowa City, Iowa
- Resident, Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, Iowa
- Fellow, University of California, San Francisco, California
- Fellow, University of Texas Medical School, Houston, Texas
Graduate Program Affiliations
Center, Program and Institute Affiliations
Selected Publications
- Schultz JL, Brinker AN, Xu J, Ernst SE, Tayyari F, Rauckhorst AJ, Liu L, Uc EY, Taylor EB, Simmering JE, Magnotta VA, Welsh MJ, Narayanan NS. A pilot to assess target engagement of terazosin in parkinson’s disease. Parkinsonism Relat Disord. 2022 Jan;94:79-83. doi: 10.1016/j.parkreldis.2021.11.022. Epub 2021 Nov 27. PMID: 34894470; PMCID: PMC8862665.
- Yu W, Moninger TO, Thurman AL, Xie Y, Jain A, Zarei K, Powers LS, Pezzulo AA, Stoltz DA, Welsh MJ. Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2119759119. doi: 10.1073/pnas.2119759119. PMID: 35046051; PMCID: PMC8794846.
- Pino-Argumedo MI, Fischer AJ, Hilkin BM, Gansemer ND, Allen PD, Hoffman EA, Stoltz DA, Welsh MJ, Abou Alaiwa MH. Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2121731119. doi: 10.1073/pnas.2121731119. Epub 2022 Mar 24. PMID: 35324331.
- Thurman AL, Li X, Villacreses R, Yu W, Gong H, Mather SE, Romano-Ibarra GS, Meyerholz DK, Stoltz DA, Welsh MJ, Thornell IM, Zabner J, Pezzulo AA. A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis. Am J Respir Cell Mol Biol. 2022 Jun;66(6):612-622. doi: 10.1165/rcmb.2021-0499OC. PubMed PMID: 35235762; PubMed Central PMCID: PMC9163647.
- Yu W, Moninger TO, Rector MV, Stoltz DA, Welsh MJ. Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction. Dev Cell. 2022 Sep 26;57(18):2221-2236.e5. doi: 10.1016/j.devcel.2022.08.010. Epub 2022 Sep 14. PubMed PMID: 36108628; PubMed Central PMCID: PMC9762774.
- Rehman T, Karp PH, Thurman AL, Mather SE, Jain A, Cooney AL, Sinn PL, Pezzulo AA, Duffey ME, Welsh MJ. WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia. Am J Respir Cell Mol Biol. 2022 Oct;67(4):491-502. doi: 10.1165/rcmb.2022-0172OC. PMID: 35849656; PMCID: PMC9564924.
- Simmering JE, Welsh MJ, Schultz J, Narayanan NS. Use of Glycolysis-Enhancing Drugs and Risk of Parkinson's Disease. Mov Disord. 2022 Nov;37(11):2210-2216. doi: 10.1002/mds.29184. Epub 2022 Aug 22. PubMed PMID: 36054705; PubMed Central PMCID: PMC9669185.
- Cooney, A. L., Abou Alaiwa, M. H., Shah, V. S., Bouzek, D. C., Stroik, M. R., Powers, L. S., Gansemer, N. D., Meyerholz, D. K., Welsh, M. J., Stoltz, D. A., Sinn, P. L. & McCray, Jr, P. B. (2016). Lentiviral-mediated phenotypic correction of cystic fibrosis pigs. JCI insight 1 (14). DOI: 10.1172/jci.insight.88730. PMID: 27656681.
- Taft, P. J., Thorne, P. S., Welsh, M. J., Stoltz, D. A., Zabner, J., Abou Alaiwa, M. H., Launspach, J. L., Sheets, K. A., Rivera, J. A. & Gansemer, N. D. (2016). Repurposing tromethamine as inhaled therapy to treat CF airway disease. JCI insight 1 (8). PMID: 27390778. DOI: 10.1172/jci.insight.87535.
- Shah, V. S., Ernst, S., Tang, X. X., Karp, P. H., Parker, C. P., Ostedgaard, L. S. & Welsh, M. J. (2016). Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies. Proceedings of the National Academy of Sciences of the United States of America 113 (19) 5382-7. DOI: 10.1073/pnas.1604905113. PMID: 27114540.