Lung Biology & Cystic Fibrosis Research Center

Lung Biology & CF Research Group

The goal of the Lung Biology and Cystic Fibrosis Research Center is to advance fundamental knowledge related to the causes and treatment of disease. For more than four decades basic and clinical scientists and trainees at the University of Iowa have brought a broad and multidisciplinary approach to bear upon a variety of pulmonary diseases, and their research has changed the lives of patients and brought international recognition. 

The burden of lung disease for children and adults worldwide is substantial. Asthma and pneumonia are the most common diagnoses for children admitted to hospital. Cystic fibrosis is the most common lethal genetic disease among people of northern European ancestry, causing chronic lung infection and inflammation among affected children and adults. Adults with chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis and interstitial lung disease experience significant disability and premature death. Understanding the causes and creating better treatments for these progressive disorders is the goal of the Lung Biology and Cystic Fibrosis Research Center. 

To that end, areas of research expertise in this center include airway epithelial cell biology, animal models, antimicrobial peptides, asthma, COPD, cystic fibrosis, lung development, genomics, gene therapy, host defense, host-pathogen interactions, imaging, ion transport, respiratory infections, stem cell biology, and virology. 

Lung Biology and Cystic Fibrosis Research Center investigators are committed to making advances that will impact the lives of those affected by lung disease. We are also dedicated to training and mentoring the next generation of scientists who will devote their careers to this area of research. Our approaches include collaborative laboratory research and the development of new technologies, all informed through experience with patient care and clinical studies.

Faculty in the Lung Biology and Cystic Fibrosis Research Center